-
1
-
-
2942752374
-
The IL-12Rbeta2 gene functions as a tumor suppressor in human B cell malignancies
-
Airoldi I, Di Carlo E, Banelli B, Moserle L, Cocco C, et al. (2004) The IL-12Rbeta2 gene functions as a tumor suppressor in human B cell malignancies. J Clin Invest 113: 1651-1659.
-
(2004)
J Clin Invest
, vol.113
, pp. 1651-1659
-
-
Airoldi, I.1
Di Carlo, E.2
Banelli, B.3
Moserle, L.4
Cocco, C.5
-
2
-
-
0027239503
-
Antitumor and antimetastatic activity of interleukin 12 against murine tumors
-
Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, et al. (1993) Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 178: 1223-1230.
-
(1993)
J Exp Med
, vol.178
, pp. 1223-1230
-
-
Brunda, M.J.1
Luistro, L.2
Warrier, R.R.3
Wright, R.B.4
Hubbard, B.R.5
-
3
-
-
0036005890
-
Interleukin-12 in anti-tumor immunity and immunotherapy
-
Colombo MP, Trinchieri G (2002) Interleukin-12 in anti-tumor immunity and immunotherapy. Cytokine Growth Factor Rev 13: 155-168.
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 155-168
-
-
Colombo, M.P.1
Trinchieri, G.2
-
4
-
-
0032578703
-
IL-12 regulates VEGF and MMPs in a murine breast cancer model
-
Dias S, Boyd R, Balkwill F (1998) IL-12 regulates VEGF and MMPs in a murine breast cancer model. Int J Cancer 78: 361-365.
-
(1998)
Int J Cancer
, vol.78
, pp. 361-365
-
-
Dias, S.1
Boyd, R.2
Balkwill, F.3
-
5
-
-
0029922177
-
Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10
-
Sgadari C, Angiolillo AL, Tosato G (1996) Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10. Blood 87: 3877-3882.
-
(1996)
Blood
, vol.87
, pp. 3877-3882
-
-
Sgadari, C.1
Angiolillo, A.L.2
Tosato, G.3
-
6
-
-
0028897739
-
Inhibition of angiogenesis in vivo by interleukin 12
-
Voest EE, Kenyon BM, O'Reilly MS, Truitt G, D'Amato RJ, et al. (1995) Inhibition of angiogenesis in vivo by interleukin 12. J Natl Cancer Inst 87: 581-586.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 581-586
-
-
Voest, E.E.1
Kenyon, B.M.2
O'Reilly, M.S.3
Truitt, G.4
D'Amato, R.J.5
-
7
-
-
0034652459
-
Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12
-
Duda DG, Sunamura M, Lozonschi L, Kodama T, Egawa S, et al. (2000) Direct in vitro evidence and in vivo analysis of the antiangiogenesis effects of interleukin 12. Cancer Res 60: 1111-1116.
-
(2000)
Cancer Res
, vol.60
, pp. 1111-1116
-
-
Duda, D.G.1
Sunamura, M.2
Lozonschi, L.3
Kodama, T.4
Egawa, S.5
-
8
-
-
0030445948
-
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits
-
Presky DH, Yang H, Minetti LJ, Chua AO, Nabavi N, et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A 93: 14002-14007.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14002-14007
-
-
Presky, D.H.1
Yang, H.2
Minetti, L.J.3
Chua, A.O.4
Nabavi, N.5
-
9
-
-
33646247193
-
Methylation of the IL-12Rbeta2 gene as novel tumor escape mechanism for pediatric B-acute lymphoblastic leukemia cells
-
Airoldi I, Cocco C, Di Carlo E, Disaro S, Ognio E, et al. (2006) Methylation of the IL-12Rbeta2 gene as novel tumor escape mechanism for pediatric B-acute lymphoblastic leukemia cells. Cancer Res 66: 3978-3980.
-
(2006)
Cancer Res
, vol.66
, pp. 3978-3980
-
-
Airoldi, I.1
Cocco, C.2
Di Carlo, E.3
Disaro, S.4
Ognio, E.5
-
10
-
-
28444443017
-
Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy
-
Airoldi I, Di Carlo E, Cocco C, Sorrentino C, Fais F, et al. (2005) Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy. Blood 106: 3846-3853.
-
(2005)
Blood
, vol.106
, pp. 3846-3853
-
-
Airoldi, I.1
Di Carlo, E.2
Cocco, C.3
Sorrentino, C.4
Fais, F.5
-
11
-
-
36849012237
-
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
-
Gao SP, Mark KG, Leslie K, Pao W, Motoi N, et al. (2007) Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 117: 3846-3856.
-
(2007)
J Clin Invest
, vol.117
, pp. 3846-3856
-
-
Gao, S.P.1
Mark, K.G.2
Leslie, K.3
Pao, W.4
Motoi, N.5
-
12
-
-
17644368573
-
Interleukin-6: From basic science to medicine - 40 years in immunology
-
Kishimoto T (2005) Interleukin-6: from basic science to medicine - 40 years in immunology. Annu Rev Immunol 23: 1-21.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 1-21
-
-
Kishimoto, T.1
-
13
-
-
33746238953
-
Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion
-
Yeh HH, Lai WW, Chen HH, Liu HS, Su WC (2006) Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene 25: 4300-4309.
-
(2006)
Oncogene
, vol.25
, pp. 4300-4309
-
-
Yeh, H.H.1
Lai, W.W.2
Chen, H.H.3
Liu, H.S.4
Su, W.C.5
-
16
-
-
0033950286
-
Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: Results of an Eastern Cooperative Oncology Group trial
-
Bonomi P, Kim K, Fairclough D, Cella D, Kugler J, et al. (2000) Comparison of survival and quality of life in advanced non-small-cell lung cancer patients treated with two dose levels of paclitaxel combined with cisplatin versus etoposide with cisplatin: results of an Eastern Cooperative Oncology Group trial. J Clin Oncol 18: 623-631.
-
(2000)
J Clin Oncol
, vol.18
, pp. 623-631
-
-
Bonomi, P.1
Kim, K.2
Fairclough, D.3
Cella, D.4
Kugler, J.5
-
17
-
-
33646676706
-
Antiangiogenic drugs in non-small cell lung cancer treatment
-
Cascone T, Troiani T, Morelli MP, Gridelli C, Ciardiello F (2006) Antiangiogenic drugs in non-small cell lung cancer treatment. Curr Opin Oncol 18: 151-155.
-
(2006)
Curr Opin Oncol
, vol.18
, pp. 151-155
-
-
Cascone, T.1
Troiani, T.2
Morelli, M.P.3
Gridelli, C.4
Ciardiello, F.5
-
18
-
-
50949131990
-
-
Blood
-
Airoldi I, Cocco C, Giuliani N, Ferrarini M, Colla S, et al. (2008) Constitutive expression of IL-12RB2 on human multiple myeloma cells delineates a novel therapeutic target. Blood.
-
(2008)
Constitutive expression of IL-12RB2 on human multiple myeloma cells delineates a novel therapeutic target
-
-
Airoldi, I.1
Cocco, C.2
Giuliani, N.3
Ferrarini, M.4
Colla, S.5
-
19
-
-
34247277021
-
Endogenous IL-12 triggers an antiangiogenic program in melanoma cells
-
Airoldi I, Di Carlo E, Cocco C, Taverniti G, D'Antuono T, et al. (2007) Endogenous IL-12 triggers an antiangiogenic program in melanoma cells. Proc Natl Acad Sci U S A 104: 3996-4001.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3996-4001
-
-
Airoldi, I.1
Di Carlo, E.2
Cocco, C.3
Taverniti, G.4
D'Antuono, T.5
-
20
-
-
34548556471
-
Aberrant methylation of IL-12Rbeta2 gene in lung adenocarcinoma cells is associated with unfavorable prognosis
-
Suzuki M, Iizasa T, Nakajima T, Kubo R, Iyoda A, et al. (2007) Aberrant methylation of IL-12Rbeta2 gene in lung adenocarcinoma cells is associated with unfavorable prognosis. Ann Surg Oncol 14: 2636-2642.
-
(2007)
Ann Surg Oncol
, vol.14
, pp. 2636-2642
-
-
Suzuki, M.1
Iizasa, T.2
Nakajima, T.3
Kubo, R.4
Iyoda, A.5
-
21
-
-
2942677282
-
Crosstalk between angiogenesis and lymphangiogenesis in tumor progression
-
Scavelli C, Vacca A, Di Pietro G, Dammacco F, Ribatti D (2004) Crosstalk between angiogenesis and lymphangiogenesis in tumor progression. Leukemia 18: 1054-1058.
-
(2004)
Leukemia
, vol.18
, pp. 1054-1058
-
-
Scavelli, C.1
Vacca, A.2
Di Pietro, G.3
Dammacco, F.4
Ribatti, D.5
-
22
-
-
65549118866
-
Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade
-
Spinella F, Garrafa E, Di Castro V, Rosano L, Nicotra MR, et al. (2009) Endothelin-1 stimulates lymphatic endothelial cells and lymphatic vessels to grow and invade. Cancer Res 69: 2669-2676.
-
(2009)
Cancer Res
, vol.69
, pp. 2669-2676
-
-
Spinella, F.1
Garrafa, E.2
Di Castro, V.3
Rosano, L.4
Nicotra, M.R.5
-
23
-
-
0032418043
-
An improved method to obtain highly differentiated monolayers of human bronchial epithelial cells
-
Galietta LJ, Lantero S, Gazzolo A, Sacco O, Romano L, et al. (1998) An improved method to obtain highly differentiated monolayers of human bronchial epithelial cells. In Vitro Cell Dev Biol Anim 34: 478-481.
-
(1998)
In Vitro Cell Dev Biol Anim
, vol.34
, pp. 478-481
-
-
Galietta, L.J.1
Lantero, S.2
Gazzolo, A.3
Sacco, O.4
Romano, L.5
-
24
-
-
4244175718
-
An electrogenic amino acid transporter in the apical membrane of cultured human bronchial epithelial cells
-
Galietta LJ, Musante L, Romio L, Caruso U, Fantasia A, et al. (1998) An electrogenic amino acid transporter in the apical membrane of cultured human bronchial epithelial cells. Am J Physiol 275: L917-923.
-
(1998)
Am J Physiol
, vol.275
-
-
Galietta, L.J.1
Musante, L.2
Romio, L.3
Caruso, U.4
Fantasia, A.5
-
25
-
-
0033946122
-
Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma
-
Galietta LJ, Folli C, Marchetti C, Romano L, Carpani D, et al. (2000) Modification of transepithelial ion transport in human cultured bronchial epithelial cells by interferon-gamma. Am J Physiol Lung Cell Mol Physiol 278: L1186-1194.
-
(2000)
Am J Physiol Lung Cell Mol Physiol
, vol.278
-
-
Galietta, L.J.1
Folli, C.2
Marchetti, C.3
Romano, L.4
Carpani, D.5
-
26
-
-
0037080350
-
IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro
-
Galietta LJ, Pagesy P, Folli C, Caci E, Romio L, et al. (2002) IL-4 is a potent modulator of ion transport in the human bronchial epithelium in vitro. J Immunol 168: 839-845.
-
(2002)
J Immunol
, vol.168
, pp. 839-845
-
-
Galietta, L.J.1
Pagesy, P.2
Folli, C.3
Caci, E.4
Romio, L.5
-
27
-
-
34848908049
-
Vascular endothelial growth factor-C and its receptor VEGFR-3 in nonsmall-cell lung cancer: Concurrent expression in cancer cells from primary tumour and metastatic lymph node
-
Saintigny P, Kambouchner M, Ly M, Gomes N, Sainte-Catherine O, et al. (2007) Vascular endothelial growth factor-C and its receptor VEGFR-3 in nonsmall-cell lung cancer: concurrent expression in cancer cells from primary tumour and metastatic lymph node. Lung Cancer 58: 205-213.
-
(2007)
Lung Cancer
, vol.58
, pp. 205-213
-
-
Saintigny, P.1
Kambouchner, M.2
Ly, M.3
Gomes, N.4
Sainte-Catherine, O.5
-
28
-
-
33745550002
-
The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer
-
Takizawa H, Kondo K, Fujino H, Kenzaki K, Miyoshi T, et al. (2006) The balance of VEGF-C and VEGFR-3 mRNA is a predictor of lymph node metastasis in non-small cell lung cancer. Br J Cancer 95: 75-79.
-
(2006)
Br J Cancer
, vol.95
, pp. 75-79
-
-
Takizawa, H.1
Kondo, K.2
Fujino, H.3
Kenzaki, K.4
Miyoshi, T.5
-
29
-
-
36849017497
-
IL-6 involvement in epithelial cancers
-
Schafer ZT, Brugge JS (2007) IL-6 involvement in epithelial cancers. J Clin Invest 117: 3660-3663.
-
(2007)
J Clin Invest
, vol.117
, pp. 3660-3663
-
-
Schafer, Z.T.1
Brugge, J.S.2
-
30
-
-
33846479526
-
IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo
-
Watkins SK, Egilmez NK, Suttles J, Stout RD (2007) IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. J Immunol 178: 1357-1362.
-
(2007)
J Immunol
, vol.178
, pp. 1357-1362
-
-
Watkins, S.K.1
Egilmez, N.K.2
Suttles, J.3
Stout, R.D.4
-
31
-
-
0037314662
-
Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: Its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer
-
Chen JJ, Yao PL, Yuan A, Hong TM, Shun CT, et al. (2003) Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer. Clin Cancer Res 9: 729-737.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 729-737
-
-
Chen, J.J.1
Yao, P.L.2
Yuan, A.3
Hong, T.M.4
Shun, C.T.5
-
32
-
-
34250315638
-
The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis
-
Kaspar M, Trachsel E, Neri D (2007) The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis. Cancer Res 67: 4940-4948.
-
(2007)
Cancer Res
, vol.67
, pp. 4940-4948
-
-
Kaspar, M.1
Trachsel, E.2
Neri, D.3
-
33
-
-
13844267706
-
Inhibition of metastasis by inhibition of tumor-derived CCL5
-
Stormes KA, Lemken CA, Lepre JV, Marinucci MN, Kurt RA (2005) Inhibition of metastasis by inhibition of tumor-derived CCL5. Breast Cancer Res Treat 89: 209-212.
-
(2005)
Breast Cancer Res Treat
, vol.89
, pp. 209-212
-
-
Stormes, K.A.1
Lemken, C.A.2
Lepre, J.V.3
Marinucci, M.N.4
Kurt, R.A.5
-
34
-
-
39649103854
-
Granulocyte-macrophage colony stimulating factor induces endothelial capillary formation through induction of membrane-type 1 matrix metalloproteinase expression in vitro
-
Krubasik D, Eisenach PA, Kunz-Schughart LA, Murphy G, English WR (2008) Granulocyte-macrophage colony stimulating factor induces endothelial capillary formation through induction of membrane-type 1 matrix metalloproteinase expression in vitro. Int J Cancer 122: 1261-1272.
-
(2008)
Int J Cancer
, vol.122
, pp. 1261-1272
-
-
Krubasik, D.1
Eisenach, P.A.2
Kunz-Schughart, L.A.3
Murphy, G.4
English, W.R.5
-
35
-
-
33847622522
-
Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation
-
Luppi F, Longo AM, de Boer WI, Rabe KF, Hiemstra PS (2007) Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation. Lung Cancer 56: 25-33.
-
(2007)
Lung Cancer
, vol.56
, pp. 25-33
-
-
Luppi, F.1
Longo, A.M.2
de Boer, W.I.3
Rabe, K.F.4
Hiemstra, P.S.5
-
36
-
-
11244328119
-
Interleukin-8/CXCL8 is a growth factor for human lung cancer cells
-
Zhu YM, Webster SJ, Flower D, Woll PJ (2004) Interleukin-8/CXCL8 is a growth factor for human lung cancer cells. Br J Cancer 91: 1970-1976.
-
(2004)
Br J Cancer
, vol.91
, pp. 1970-1976
-
-
Zhu, Y.M.1
Webster, S.J.2
Flower, D.3
Woll, P.J.4
-
37
-
-
33645991795
-
Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy
-
Sica A, Schioppa T, Mantovani A, Allavena P (2006) Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy. Eur J Cancer 42: 717-727.
-
(2006)
Eur J Cancer
, vol.42
, pp. 717-727
-
-
Sica, A.1
Schioppa, T.2
Mantovani, A.3
Allavena, P.4
-
38
-
-
34548118760
-
Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier
-
Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, et al. (2007) Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. J Natl Cancer Inst 99: 1257-1269.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 1257-1269
-
-
Seike, M.1
Yanaihara, N.2
Bowman, E.D.3
Zanetti, K.A.4
Budhu, A.5
-
39
-
-
0036194917
-
Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature
-
Halin C, Rondini S, Nilsson F, Berndt A, Kosmehl H, et al. (2002) Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nat Biotechnol 20: 264-269.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 264-269
-
-
Halin, C.1
Rondini, S.2
Nilsson, F.3
Berndt, A.4
Kosmehl, H.5
-
40
-
-
0034103809
-
Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: Ability to maintain IFN-gamma induction is associated with clinical response
-
Gollob JA, Mier JW, Veenstra K, McDermott DF, Clancy D, et al. (2000) Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-gamma induction is associated with clinical response. Clin Cancer Res 6: 1678-1692.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1678-1692
-
-
Gollob, J.A.1
Mier, J.W.2
Veenstra, K.3
McDermott, D.F.4
Clancy, D.5
-
41
-
-
32044452015
-
IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells
-
Broderick L, Brooks SP, Takita H, Baer AN, Bernstein JM, et al. (2006) IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells. Clin Immunol 118: 159-169.
-
(2006)
Clin Immunol
, vol.118
, pp. 159-169
-
-
Broderick, L.1
Brooks, S.P.2
Takita, H.3
Baer, A.N.4
Bernstein, J.M.5
-
43
-
-
0017360990
-
The measurement of observer agreement for categorical data
-
Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33: 159-174.
-
(1977)
Biometrics
, vol.33
, pp. 159-174
-
-
Landis, J.R.1
Koch, G.G.2
-
44
-
-
34250640742
-
The gelatin sponge-chorioallantoic membrane assay
-
Ribatti D, Nico B, Vacca A, Presta M (2006) The gelatin sponge-chorioallantoic membrane assay. Nat Protoc 1: 85-91.
-
(2006)
Nat Protoc
, vol.1
, pp. 85-91
-
-
Ribatti, D.1
Nico, B.2
Vacca, A.3
Presta, M.4
-
45
-
-
0031469270
-
New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: The gelatin sponge/ chorioallantoic membrane assay
-
Ribatti D, Gualandris A, Bastaki M, Vacca A, Iurlaro M, et al. (1997) New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/ chorioallantoic membrane assay. J Vasc Res 34: 455-463.
-
(1997)
J Vasc Res
, vol.34
, pp. 455-463
-
-
Ribatti, D.1
Gualandris, A.2
Bastaki, M.3
Vacca, A.4
Iurlaro, M.5
|