S- and C-nucleosidoquinazoline as new nucleoside analogs with potential analgesic and anti-inflammatory activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2009, Pages 4249-4258

  El Gazzar, Abdel Rahman B A ^a   Hafez, Hend N ^a   Abbas, Hebat Allah S ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

2 Thioxo quinazoline; Analgesic; Anti inflammatory; S and C nucleosidoquinazolines; Ulcerogenic activities

Indexed keywords

3 (ARABINOSYL) 4 (4 CHLOROPHENYL) 7 DIMETHYL 1,4,6,8 TETRAHYDRO 1,2,4 TRIAZOLO[3,4 B]QUINAZOLIN 6 ONE; 4 (4 ANISYL) 7 DIMETHYL 3,4,6,8 TETRAHYDROQUINAOLIN 5 ONE 2 THIONE; 4 (4 CHLOROPHENYL) 7 DIMETHYL 3,4,6,8 TETRAHYDRO 2 (2',3',4',6' TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYLTHIO) 3H QUINAZOLIN 5 ONE 2 THIONE; 4 (4 CHLOROPHENYL) 7 DIMETHYL 3,4,6,8 TETRAHYDROQUINAZOLIN 5 ONE 2 THIONE; 4 PHENYL 7 DIMETHYL 3,4,6,8 TETRAHYDROQUINAZOLIN 5 ONE 2 THIONE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; GLYCOSIDE; IBUPROFEN; NUCLEOSIDE ANALOG; QUINAZOLINE DERIVATIVE; THIOGLYCOSIDE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; MALE; MOLECULAR STABILITY; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MICE; NUCLEOSIDES; QUINAZOLINES; RATS; RATS, INBRED BB; RATS, SPRAGUE-DAWLEY;

EID: 67749088018     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.05.025     Document Type: Article

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