Total synthesis of the fumiquinazoline alkaloids: Solution-phase studies

Journal of Organic Chemistry

Volumn 65, Issue 4, 2000, Pages 1022-1030

  Wang, Haishan ^b   Ganesan, A ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; QUINAZOLINE DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CYCLIZATION; DEHYDRATION; DRUG SYNTHESIS; REACTION ANALYSIS; SOLID PHASE EXTRACTION;

ALKALOIDS; ANTHRANILIC ACIDS; ANTINEOPLASTIC AGENTS; FUNGI; QUINAZOLINES; SUBSTANCE P; TRYPTOPHAN;

EID: 0034712334     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9914364     Document Type: Article

References (34)

1. Abbreviations: Ala = Alanine, EDC = 1-ethyl-3-(3-(diethylamino)-propyl)carbodiimide·HCl, Fmoc = (9H-fluoren-9-ylmethoxy)carbonyl, Gly = glycine, Phe = phenylalanine, PyBrOP = bromo-tris-pyrrolidinophosphonium hexafluorophosphate, Trp = tryptophan, Val = valine.
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29. Although we use a neutral solvent, it is possible that the reaction is catalyzed by the piperidine byproduct released.
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32. 2.
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