Retinoid X receptor α participation in dexamethasone-induced rat bile acid coenzyme A-amino acid N-acyltransferase expression in septic liver

Shock

Volumn 32, Issue 2, 2009, Pages 164-171

  Chen, Bi Chun ^a,b   Kuo, Kung Kai ^a,b   Chen, Kung Yen Hsu ^a   Liu, Chia Hsiung ^a   Tsai, Li Yen ^a   Hsu, Hseng Kuang ^a   Hsu, Chin ^a,b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Corticosteroid; Hepatic dysfunction; Nuclear receptor; rBAT; Sepsis

Indexed keywords

AMINO ACID ACETYLTRANSFERASE; BILE ACID COENZYME A AMINO ACID N ACYLTRANSFERASE; CHOLESTEROL 7ALPHA MONOOXYGENASE; DEXAMETHASONE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; RETINOID X RECEPTOR ALPHA; SMALL INTERFERING RNA; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; LIVER METABOLISM; MALE; NONHUMAN; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEPTIC SHOCK; SURVIVAL RATE;

ACYLTRANSFERASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; BILE DUCTS; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DEXAMETHASONE; GENE EXPRESSION REGULATION; MALE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RATS, SPRAGUE-DAWLEY; RESPONSE ELEMENTS; RETINOID X RECEPTOR ALPHA; RNA, SMALL INTERFERING; SEPSIS; SYMPORTERS;

EID: 67749084236     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318193e063     Document Type: Article

References (33)

1. Lambermont B: Recent therapeutic advances in intensive care: update on severe sepsis/septic shock and on pulmonary embolism [in French]. Rev Med Liege 62:281-283, 2007.
2. Dhainaut JF, Marin N, Mignon A, Vinsonneau C: Hepatic response to sepsis: interaction between coagulation and inflammatory processes. Crit Care Med 29:S42-S47, 2001.
3. Trauner M, Fickert P, Stauber RE: Inflammation-induced cholestasis. J Gastroenterol Hepatol 14:946-959, 1999.
4. Geier A, Fickert P, Trauner M: Mechanisms of disease: mechanisms and clinical implications of cholestasis in sepsis. Nat Clin Pract Gastroenterol Hepatol 3:574-585, 2006.
5. Trauner M, Boyer JL: Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 83:633-671, 2003.
6. Kim PK, Chen J, Andrejko KM, Deutschman CS: Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats. Shock (Augusta, GA) 14:176-181, 2000.
7. Andrejko KM, Raj NR, Kim PK, Cereda M, Deutschman CS: IL-6 modulates sepsis-induced decreases in transcription of hepatic organic anion and bile acid transporters. Shock (Augusta, GA) 29:490-496, 2008.
8. Hsieh YC, Hsu C, Yang RC, Lee PY, Hsu HK, Sun YM: Isolation of bonafide differentially expressed genes in the 18-hour sepsis liver by suppression subtractive hybridization. Shock (Augusta, GA) 21:549-555, 2004.
9. Chen YH, Hong IC, Kuo KK, Hsu HK, Hsu C: Role of retinoid-X receptor-alpha in the suppression of rat bile acid coenzyme A-amino acid N-acyltransferase in liver during sepsis. Shock (Augusta, GA) 28:65-70, 2007.
10. He D, Barnes S, Falany CN: Rat liver bile acid CoA:amino acid N-acyltransferase: expression, characterization, and peroxisomal localization. J Lipid Res 44:2242-2249, 2003.
11. Mangelsdorf DJ, Evans RM: The RXR heterodimers and orphan receptors. Cell 83:841-850, 1995.
12. Eloranta JJ, Meier PJ, Kullak-Ublick GA: Coordinate transcriptional regulation of transport and metabolism. Methods Enzymol 400:511-530, 2005.
13. Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D: Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. EMBO J 19:2592-2601, 2000.
14. Wan YJ, An D, Cai Y, Repa JJ, Hung-Po Chen T, Flores M, Postic C, Magnuson MA, Chen J, Chien KR, et al.: Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 20:4436-4444, 2000.
15. Keh D, Sprung CL: Use of corticosteroid therapy in patients with sepsis and septic shock: an evidence-based review. Crit Care Med 32:S527-S533, 2004.
16. Kubitz R, Wettstein M, Warskulat U, Haussinger D: Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 116:401-410, 1999.
17. Tsao CM, Ho ST, Chen A, Wang JJ, Li CY, Tsai SK, Wu CC: Low-dose dexamethasone ameliorates circulatory failure and renal dysfunction in conscious rats with endotoxemia. Shock (Augusta, GA) 21:484-491, 2004.
18. Wan YJ, Wang L, Wu TC: Dexamethasone increases the expression of retinoid X receptor genes in rat hepatoma cell lines. Lab Invest 70:547-552, 1994.
19. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res 29:189-201, 1980.
20. Little JM, St Pyrek J, Lester R: Hepatic metabolism of 3 alpha-hydroxy-5 beta-etianic acid (3 alpha-hydroxy-5 beta-androstan-17 beta-carboxylic acid) in the adult rat. J Clin Invest 71:73-80, 1983.
21. Gonzalez MA, Roma MG, Bernal CA, Alvarez Mde L, Carrillo MC: Biliary secretory function in rats chronically intoxicated with aluminum. Toxicol Sci 79:189-195, 2004.
22. Turley SD, Dietschy JM: Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile. J Lipid Res 19:924-928, 1978.
23. Geier A, Dietrich CG, Voigt S, Ananthanarayanan M, Lammert F, Schmitz A, Trauner M, Wasmuth HE, Boraschi D, Balasubramaniyan N, et al.: Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver. Am J Physiol 289:G831-G841, 2005.
24. Furutani M, Arii S, Higashitsuji H, Mise M, Fukumoto M, Takano S, Nakayama H, Imamura M, Fujita J: Reduced expression of kan-1 (encoding putative bile acid-CoA-amino acid N-acyltransferase) mRNA in livers of rats after partial hepatectomy and during sepsis. Biochem J 311(Pt 1):203-208, 1995.
25. Reynolds MA, Siow Y, Collet D, Klar E, Richardson JD, Vitale GC: The role of bile acid secretion in the hepatic response to operation and infection. Am Surg 61:469-474, 1995.
26. Pircher PC, Kitto JL, Petrowski ML, Tangirala RK, Bischoff ED, Schulman IG, Westin SK: Farnesoid X receptor regulates bile acid-amino acid conjugation. J Biol Chem 278:27703-27711, 2003.
27. Zimmerman TL, Thevananther S, Ghose R, Burns AR, Karpen SJ: Nuclear export of retinoid X receptor alpha in response to interleukin-1beta-mediated cell signaling: roles for JNK and SER260. J Biol Chem 281:15434-15440, 2006.
28. Arrese M, Ananthanarayanan M: The bile salt export pump: molecular properties, function and regulation. Pflugers Arch 449:123-131, 2004.
29. Cherrington NJ, Slitt AL, Li N, Klaassen CD: Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats. Drug Metab Dispos 32:734-741, 2004.
30. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, et al.: Hydrocortisone therapy for patients with septic shock. N Engl J Med 358:111-124, 2008.
31. Steineger HH, Arntsen BM, Spydevold O, Sorensen HN: Retinoid X receptor (RXR alpha) gene expression is regulated by fatty acids and dexamethasone in hepatic cells. Biochimie 79:107-110, 1997.
32. Yamaguchi S, Murata Y, Nagaya T, Hayashi Y, Ohmori S, Nimura Y, Seo H: Glucocorticoids increase retinoid-X receptor alpha (RXRalpha) expression and enhance thyroid hormone action in primary cultured rat hepatocytes. J Mol Endocrinol 22:81-90, 1999.
33. Stephensen CB, Alvarez JO, Kohatsu J, Hardmeier R, Kennedy JI Jr, Gammon RB Jr: Vitamin A is excreted in the urine during acute infection. Am J Clin Nutr 60:388-392, 1994.