Ultrastructural changes in platelet aggregates of HIV patients: A scanning electron microscopy study

Ultrastructural Pathology

Volumn 32, Issue 3, 2008, Pages 75-79

  Pretorius, Etheresia ^a,b   Oberholzer, Helena M ^a   Smit, Eureke ^a   Steyn, Elmarie ^a   Briedenhann, Sharon ^a   Franz, Carl R ^a  

^a University of Pretoria   (South Africa)

^b UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

Bleb like morphology; Canalicular system; Platelet aggregates; Scanning electron microscopy; Shrunken apoptosis appearance; Thrombocytopenia

Indexed keywords

APOPTOSIS; ARTICLE; CASE REPORT; CELL MEMBRANE; CELL ULTRASTRUCTURE; CONTROLLED STUDY; FIBRIN CLOT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; SCANNING ELECTROCHEMICAL MICROSCOPY; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTE RICH PLASMA; ULTRASTRUCTURE ANALYSIS AND ELECTRON MICROSCOPY;

APOPTOSIS; BLOOD PLATELETS; HIV INFECTIONS; HUMANS; MICROSCOPY, ELECTRON, SCANNING; THROMBOCYTOPENIA;

EID: 45849105608     PISSN: 01913123     EISSN: 15210758     Source Type: Journal    
DOI: 10.1080/01913120802034793     Document Type: Article

References (24)

1. Surendran A. AIDS infections, deaths hit record high in 2003. Nat Med. 2004;10:4.
2. Puoane T, Hughes GD. Impact of the HIV/AIDS pandemic on non-communicable disease prevention. SAMJ. 2005;95:228-229.
3. Myer L, Ehrlich RI, Susser ES. Social epidemiology in South Africa. Epidemiol Rev. 2004;26:112-123.
4. Bamberg R. Segmented neutrophil size and platelet morphology in HIV/AIDS patients. Clin Lab Sci. 2002;15:18.
5. Smith PD, Meng G, Sellers MT, Rogers TS, Shaw GM. Biological parameters of HIV-1 infection in primary intestinal lymphocytes and macrophages. J Leukoc Biol. 2000;68:360-365.
6. Izmailova E, Bertley FM, Huang Q, et al. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Nat Med. 2003;9:191-197.
7. Poliakova AM, Kravchenko AV, Astrina OS, et al. The thrombocytic link in hemostasis and the immune system of patients with HIV infection. Zh Mikrobiol Epidemiol Immunobiol. 1995;3:80-82.
8. Leissinger CA. Platelet kinetics in immune thrombocytopenic purpura and human immunodeficiency virus thrombocytopenia. Curr Opin Hematol. 2001;8:299-305.
9. Kravechenko AV, Poliakova AM, Iurin OG, Astrina OS, Pokrovski VV. Hemostatic disorders in patients with HIV infection. Vestn Ross Akad Med Nauk. 1992;9-10:19-21.
10. Cole JL, Marzec UM, Gunthel CJ, et al. Ineffective platelet production in thrombocytopenic human immunodeficiency virus-infected patients. Blood. 1998;91:3239-3246.
11. Lim ST, Levine AM. Hematologic aspects of human immunodeficiency syndrome. In: Marshall A, Lichtman MD, eds. Williams' Hematology, ed 7. New York: McGraw-Hill Medical; 2007:1109.
12. Ballem PJ, Belzberg A, Devine DV, et al. Kinetic studies of the mechanism of thrombocytopenia in patients with human immunodeficiency virus infection. N Engl J Med. 1992;327:1779-1784.
13. Walsh CM, Nardi MA, Karpatkin S. On the mechanism of thrombocytopenic purpura in sexually active homosexual men. N Engl J Med. 1984;311:635-639.
14. Zucker-Franklin D, Termin CS, Cooper MC. Structural changes in the megakaryocytes of patients infected with the human immunodeficiency virus (HIV-1). Am J Pathol. 1989;134:1295-1303.
15. De Man AM, Smulders YM, Roozendaal KJ, Frissen PH. HIV-related thrombotic thrombocytopenic purpura: report of 2 cases and a review of the literature. Nethl J Med. 1997;51:103-109.
16. Toulon P. Hemostasis and human immunodeficiency virus (HIV) infection. Ann Biol Clin (Paris). 1998;56:153-160.
17. Gottlieb RA. Apoptosis. In: Lichtman MA, Kipps J, Kaushansky K, Beutler E, Seligsohn U, Prehal JT, eds. Williams' Haemotology, ed 7. New York: McGraw Hill; 2006.
18. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol. 1980;68:251-306.
19. Poliakova AM, Kravchenko AV, Astrina OS, et al. Disorders in the plasma and cellular hemostatic components of patients with HIV infection. Ter Arkh. 1994;66:44-48.
20. Youssefian T, Drouin A, Masse JM, Guichard J, Cramer EM. Host-defence role of platelets: HIV and Staphylococcus aureus engulfment occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood. 2002;99:4021-4029.
21. White JG. Platelets are covercytes, not phagocytes. Blood. 2004;104:3533.
22. Davis BR, Zauli G. Effect of human immunodeficiency virus infection on haematopoiesis. Baillieres Clin Haematol. 1995;8:113-130.
23. Zauli G, Catani L, Gibellini D, et al. Impaired survival of bone marrow GbIIb/IIIa[+] megakaryocytic cells as an additional pathogenetic mechanism of HIV-1-related thrombocytopenia. Br J Haematol. 1996;92:711-717.
24. Ahmad R, Menezes J, Knafo L, Ahmad A. Activated human platelets express Fas-L and induce apoptosis in Fas-positive tumor cells. J Leukoc Biol. 2001;69:123-128.