Modulation of NKT cells and Th1/Th2 imbalance after α-GalCer treatment in progressive load-trained rats

International Journal of Biological Sciences

Volumn 5, Issue 4, 2009, Pages 338-343

  Ru, Wang ^a   Peijie, Chen ^a  

^a SHANGHAI UNIVERSITY OF SPORT   (China)

Author keywords

Exercise induced immunosuppression; Immunomodulation; Natural killer t cells; T help 1 T helpe 2 lymphocytes; galactosylceramide

Indexed keywords

RATTUS;

ALPHA GALACTOSYLCERAMIDE; ALPHA-GALACTOSYLCERAMIDE; CORTICOSTERONE; GALACTOSYLCERAMIDE; GAMMA INTERFERON; HEMOGLOBIN; IMMUNOLOGIC FACTOR; INTERLEUKIN 4; TESTOSTERONE;

ANALYSIS OF VARIANCE; ANIMAL; ANIMAL EXPERIMENT; ARTICLE; BLOOD; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOLOGY; METABOLISM; NATURAL KILLER T CELL; RAT; SPRAGUE DAWLEY RAT; TH1 CELL; TH2 CELL;

ANALYSIS OF VARIANCE; ANIMALS; CORTICOSTERONE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GALACTOSYLCERAMIDES; HEMOGLOBINS; IMMUNOLOGIC FACTORS; INTERFERON-GAMMA; INTERLEUKIN-4; NATURAL KILLER T-CELLS; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; TESTOSTERONE; TH1 CELLS; TH2 CELLS;

EID: 67651159044     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.5.338     Document Type: Article

References (31)

1. Smith LL. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med.2003; 33 (5): 347-64.
2. Steensberg A, Toft AD, Bruunsgaard H, et al. Strenuous exercise decreases the percentage of type T cells in the circulation. J Appl Physiol. 2001; 91(4):1708-12.
3. Kronenberg M, Gapin L. The unconventional lifestyle of NKT cells. Nat Rev Immunol. 2002; 2(8): 557-68.
4. Tian W, Peijie C, Binghong G. Effects of Simulated Hypoxic Training on Such Indexes as Lymphocyte Subsets of Female Rowers. Sports Sci. 2006; 26(6): 59-61.
5. Zheng Z, Peijie C. Characteristics of Runners'Immune Cell Changes with Acupuncture Interference after 4 Hours'Half-Marathon Race. J Shanghai Uni Sport. 2007; 31(2):64-73.
6. Stanley AC, Zhou Y, Amante FH, et al. Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis. PLoS Pathog. 2008; 4(2):e1000028.
7. Wang Y, Hu X, Guo C, et al. Polarization of natural killer T cells towards an NKT2 subpopulation occurs after stimulation with alpha-galactosylceramide and rhG-CSF in aplastic anemia. Acta Haematol. 2008; 119(3):178-86.
8. Sidobre S, Hammond KJ, Bénazet-Sidobre L, et al. The T cell antigen receptor expressed by Valpha14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Proc Natl Acad Sci U S A. 2004; 101(33):12254-9.
9. Peijie C, Hongwu L, Fengpeng X, et al. Heavy load exercise induced dysfunction of immunity and neuroendocrine responses in rats. Life Sci. 2003; 72(20):2255-62.
10. Kawano T, Cui J, Koezuka Y, et al. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science. 1997; 278(5343):1626-9.
11. Yang JQ, Saxena V, Xu H, et al. Repeated alpha-galactosylceramide administration results in expansion of NK T Cells and alleviates inflammatory dermatitis in MRL-lpr/lpr Mice. J Immunol. 2003; 171(8): 4439-46.
12. Sedgwick JD, Holt PG. A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells. J Immunol Methods.1983; 57(1-3): 301-9.
13. Czerkinsky CC, Nilsson LA, Nygren H, et al. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J Immunol Methods. 1983; 65(1-2): 109-21.
14. Morris DL, Komocsar WJ. Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats. J Pharmacol Toxicol Methods. 1997; 37(1): 37-46.
15. Nelson DJ, McMenamin C, McWilliam AS, et al. Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (la)-negative precursors: differential regulation of la expression at different levels of the respiratory tract. J Exp Med. 1994; 179(1): 203-12.
16. Kraus E, Lambracht D, Wonigeit K, et al. Negative regulation of rat natural killer cell activity by major histocompatibility complex class I recognition. Eur J Jmmunol. 1996; 26(11): 2582-6.
17. Ohkawa A, Ito T, Yumiba T, et al. Immunological characteristics of intragraft NKR-P1+ TCR alpha beta + T (NKT) cells in rat hepatic allografts. Transplant Proc.1999; 31(7): 2699-700.
18. Kiyomoto T, Ito T, Uchikoshi F, et al. The potent role of graft-derived NKR-P1+TCRalphabeta+ T (NKT) cells in the spontaneous acceptance of rat liver allografts. Transplant. 2005; 80(12): 1749-55.
19. McKenzie DC. Markers of Excessive Exercise. Can J Appl Physiol 1999; 24(1):66-73.
20. Peijie C, Hongwu L, Fengpeng X, et al. Heavy load exercise induced dysfunction of immunity and neuroendocrine responses in rats. Life Sci. 2003; 72 (20): 2255-62.
21. Kimura F, Aizawa K, Tanabe K, et al. A rat model of saliva secretory immunoglobulin: a suppression caused by intense exercise. Scand J Med Sci Sports. 2008;18(3):367-72.
22. Hong S, Wilson MT, Serizawa I, et al. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat Med. 2001; 7(9): 1052-6.
23. Sharif S, Arreaza GA, Zucker P, et al. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes. Nat Med. 2001; 7(9): 1057-62.
24. Jahng AW, Maricic I, Pedersen B, et al. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J Exp Med. 2001; 194(12): 1789-99.
25. Miyamoto K, Miyake S, Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature. 2001; 41(6855): 531-4.
26. Zhang Y, Rogers KH, Lewis DB. ß2-microglobulin-dependent T cells are dispensable for allergen-induced T helper 2 responses. J Exp Med. 1996; 184(4): 1507-12.
27. Chang YJ, Huang JR, Tsai YC, et al. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids. Proc Natl Acad Sci U S A. 2007; 104(25): 10299-304.
28. Hermans IF, Silk JD, Gileadi U, et al. NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells. J Immunol. 2003; 171(10): 5140-7.
29. Iwamura C, Nakayama T. Role of alpha-galactosylceramide-activated Valpha14 natural killer T cells in the regulation of allergic diseases. Allergol Int. 2007; 56: 1-6.
30. Stober D, Jomantaite I, Schirmbeck R, et al. NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo. J Immunol. 2003; 170(5): 2540-8.
31. Matsuda H, Suda T, Sato J, et al. alpha-Galactosylceramide, a ligand of natural killer T Cells, inhibits allergic airway inflammation. Am J Respir Cell Mol Biol. 2005; 33(1): 22-31.