Essentials for starting a pediatric clinical study (2): Role of environment and immunity in the development of childhood allergic and immunologic disorders

Journal of Toxicological Sciences

Volumn 34, Issue 2 SPEC. ISS., 2009, Pages

  Saito, Hirohisa ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

Helper T cells; Interleukin 17; Mast cells; Regulatory T cells; Thymic stromal lymphopoietin

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 17; TUMOR NECROSIS FACTOR ALPHA;

ALLERGY; AUTOIMMUNE DISEASE; CELL COUNT; CELL POPULATION; CLINICAL STUDY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENVIRONMENTAL FACTOR; EOSINOPHIL; HUMAN; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOLOGY; IMMUNOPATHOLOGY; INFLAMMATION; NONHUMAN; PATHOGENESIS; PEDIATRICS; REGULATORY T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 67651154476     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.SP313     Document Type: Conference Paper

References (31)

1. Akdis, M., Verhagen, J., Taylor, A., Karamloo, F., Karagiannidis, C., Crameri, R., Thunberg, S., Deniz, G., Valenta, R., Fiebig, H., Kegel, C., Disch, R., Schmidt-Weber, C.B., Blaser, K. and Akdis, C.A. (2004): Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J. Exp. Med., 199, 1567-1575.
2. Allan, S.E., Crome, S.Q., Crellin, N.K., Passerini, L., Steiner, T.S., Bacchetta, R., Roncarolo, M.G. and Levings, M.K. (2007): Activation-induced Foxp3 in human T effector cells does not suppress proliferation or cytokine production. Int. Immunol., 19, 345-354.
3. Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Fili, L., Ferri, S., Frosali, F., Giudici, F., Romagnani, P., Parronchi, P., Tonelli, F., Maggi, E. and Romagnani, S. (2007): Phenotypic and functional features of human Th17 cells. J. Exp. Med., 204, 1849-1861.
4. Bacchetta, R., Gambineri, E. and Roncarolo, M.G. (2007): Role of regulatory T cells and Foxp3 in human diseases. J. Allergy Clin. Immunol., 120, 227-235.
5. Bach, J.F. (2002): The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med., 347, 911-920.
6. Betts, G., Twohig, J., Van den Broek, M., Sierro, S., Godkin, A. and Gallimore, A. (2007): The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br. J. Cancer., 18;96:1849-1854.
7. Bluestone, J.A. and Abbas, A.K. (2003): Natural versus adaptive regulatory T cells. Nat. Rev. Immunol., 3, 253-257.
8. Braun-Fahrländer, C., Riedler, J., Herz, U., Eder, W., Waser, M., Grize, L., Maisch, S., Carr, D., Gerlach, F., Bufe, A., Lauener, R.P., Schierl, R., Renz, H., Nowak, D., von Mutius, E. and Allergy and Endotoxin Study Team. (2002): Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Engl. J. Med., 347, 869-877.
9. Bullens, D.M., Truyen, E., Coteur, L., Dilissen, E., Hellings, P.W., Dupont, L.J. and Ceuppens, J.L. (2006): IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx? Respir. Res., 7, 135. (Pubitemid 44774212)
10. Evans, H.G., Suddason, T., Jackson, I., Taams, L.S. and Lord, G.M. (2007): Optimal induction of T helper 17 cells in humans requires T cell receptor ligation in the context of Toll-like receptor-activated monocytes. PNAS., 104, 17034-17039. (Pubitemid 350210986)
11. Gern, J.E., Vrtis, R., Grindle, K.A., Swenson, C. and Busse. W.W. (2000): Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection. Am. J. Respir. Crit. Care Med., 162, 2226-2231.
12. Hori, S., Nomura, T. and Sakaguchi, S. (2003): Control of regulatory T cell development by the transcription factor Foxp3. Science, 299, 1057-1061. (Pubitemid 36222930)
13. Linden, A. (2006): Interleukin-17 and airway remodelling. Pulm Pharmacol. Ther., 19, 47-50.
14. Liu, Y.J. (2007): Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation. J. Allergy Clin. Immunol., 120, 238-244.
15. Lu, L.F., Lind, E.F., Gondek, D.C., Bennett, K.A., Gleeson, M.W., Pino-Lagos, K., Scott, Z.A., Coyle, A.J., Reed, J.L., Van Snick J., Strom, T.B., Zheng, X.X. and Noelle, R.J. (2006): Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature., 442, 997-1002. (Pubitemid 44330250)
16. - cells. PNAS., 102, 4103-4108. (Pubitemid 40388562)
17. Miyara, M. and Sakaguchi, S. (2007): Natural regulatory T cells: mechanisms of suppression. Trends Mol. Med., 13, 108-116.
18. Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A. and Coffman, R.L. (1986): Two types of murine helper T cell clone. 1. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol., 136, 2348-2357.
19. Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M. and Iwakura, Y. (2002): Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity., 17, 375-387. (Pubitemid 35279557)
20. Nakae, S., Suto, H., Berry, G.J. and Galli, S.J. (2007): Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood, 109, 3640-3648. (Pubitemid 46641710)
21. + mast cells in allergic rhinitis during seasonal allergen exposure: effect of immunotherapy. J. Allergy Clin. Immunol., 116, 73-79.
22. + cell numbers in atopic patients and healthy control subjects. J. Allergy Clin. Immunol., 11, 960-962.
23. Romagnani, S. (2006): Regulation of the T cell response. Clin. Exp. Allergy., 36, 1357-1366.
24. Roncarolo, M.G., Gregori. S., Battaglia, M., Bacchetta, R., Fleischhauer, K. and Levings, M.K. (2006): Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol. Rev., 212, 28-50.
25. Sakaguchi, S., Yamaguchi, T., Nomura, T. and Ono, M. (2008): Regulatory T cells and immune tolerance. Cell., 133, 775-787.
26. Schmidt-Weber, C.B., Akdis, M. and Akdis, C.A. (2007): TH17 cells in the big picture of immunology. J. Allergy Clin. Immunol., 120, 247-254.
27. Schubert, L.A., Jeffery, E., Zhang, Y., Ramsdell, F. and Ziegler, S.F. (2001): Scurfin (Foxp3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem., 276, 37672-37679.
28. Steinman, L. (2007): A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell-mediated tissue damage. Nat. Med., 13, 139-145.
29. Svensson, M., Maroof, A., Ato, M. and Kaye, P.M. (2004): Stromal cells direct local differentiation of regulatory dendritic cells. Immunity., 21, 805-816. (Pubitemid 39626671)
30. Verhagen, J., Akdis, M., Traidl-Hoffmann, C., Schmid-Grendelmeier, P., Hijnen, D., Knol, E.F., Behrendt, H., Blaser, K. and Akdis, C.A. (2006): Absence of T-regulatory cell expression and function in atopic dermatitis skin. J. Allergy Clin. Immunol., 117, 176-183.
31. Wildin, R.S., Smyk-Pearson, S. and Filipovich, A.H. (2002): Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J. Med. Genet., 39, 537-545.