An improved method to assess torsional properties of rodent long bones

Journal of Biomechanics

Volumn 42, Issue 11, 2009, Pages 1720-1725

  Nazarian, Ara ^a,c   Entezari, Vahid ^a   Vartanians, Vartan ^a   Müller, Ralph ^c   Snyder, Brian D ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c ETH ZURICH   (Switzerland)

Author keywords

Mechanical properties; Ovariectomy; Partial nephrectomy; Rat bone; Torsion; Virtual biomechanics

Indexed keywords

ANALYSIS TECHNIQUES; APPARENT DENSITY; BONE DENSITY; BONE VOLUME FRACTION; CORTICAL BONE; DIFFERENT SIZES; FRACTURE RISKS; GEOMETRICAL VARIATIONS; IMPROVED METHODS; LONG BONE; MATERIAL PROPERTY; MULTI-SLICE MODEL; NON-INVASIVE; OVARIECTOMY; PARTIAL NEPHRECTOMY; RAT FEMUR; REGRESSION MODEL; SHEAR MODULUS; STRUCTURAL RESPONSE; STRUCTURAL RIGIDITY; TORSION; TORSIONAL PROPERTIES; TORSIONAL SHEAR; VIRTUAL BIOMECHANICS;

BIOMECHANICS; BONE; CONCURRENT ENGINEERING; ELASTIC MODULI; JOB ANALYSIS; MINING; RAPID PROTOTYPING; REGRESSION ANALYSIS; RISK ANALYSIS; RISK ASSESSMENT; RISK MANAGEMENT; SHEAR STRENGTH; TITRATION; TORSION TESTING; TORSIONAL STRESS;

MECHANICAL PROPERTIES;

PLASTIC;

ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE DENSITY; BONE STRENGTH; BONE STRUCTURE; CONTROLLED STUDY; CORTICAL BONE; FEMALE; FEMUR; LONG BONE; MATERIALS TESTING; MECHANICAL TORSION; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; PRIORITY JOURNAL; RAT; SHEAR STRENGTH; YOUNG MODULUS;

ANIMALS; BIOMECHANICS; BONE AND BONES; BONE DENSITY; COMPRESSIVE STRENGTH; FEMALE; FEMUR; FRACTURES, BONE; NEPHRECTOMY; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; STRESS, MECHANICAL; TENSILE STRENGTH; X-RAY MICROTOMOGRAPHY;

EID: 67651146376     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2009.04.019     Document Type: Article

References (45)

1. An Y. Animal Models in Orthopaedic Research (1999), Boca Raton, CRC Press
2. Beaupied H., Lespessailles E., and Benhamou C.L. Evaluation of macrostructural bone biomechanics. Jt. Bone Spine 74 (2007) 233-239
3. Brkovic D., Linke J., Jakse G., and Bauss F. Changes in bone structure after augmentation cystoplasty in chronic uraemic rats. BJU Int. 95 (2005) 1066-1070
4. Brodt M.D., Ellis C.B., and Silva M.J. Growing C57Bl/6 mice increase whole bone mechanical properties by increasing geometric and material properties. J. Bone Miner. Res. 14 (1999) 2159-2166
5. Burr D., Milgrom C., Fyhrie D., Forwood M., Nyska M., Finestone A., Hoshaw S., Saiag E., and Simkin A. In vivo measurement of human tibial strains during vigorous activity. Bone 18 (1996) 405-410
6. Burstein A.H., and Frankel V.H. A standard test for laboratory animal bone. J. Biomech. 4 (1971) 155-158
7. Cowin S.C. Torsion of cylinders with shape intrinsic orthotropy. Trans. ASME: J. Appl. Mech. 54 (1987)
8. Einhorn T.A., Boskey A.L., Gundberg C.M., Vigorita V.J., Devlin V.J., and Beyer M.M. The mineral and mechanical properties of bone in chronic experimental diabetes. J. Orthop. Res. 6 (1988) 317-323
9. Ekeland A., Engesoeter L.B., and Langeland N. Influence of age on mechanical properties of healing fractures and intact bones in rats. Acta Orthop. Scand. 53 (1982) 527-534
10. Ekenman I., Halvorsen K., Westblad P., Fellander-Tsai L., and Rolf C. Local bone deformation at two predominant sites for stress fractures of the tibia: an in vivo study. Foot Ankle Int. 19 (1998) 479-484
11. Engesaeter L.B., Ekeland A., and Langeland N. Methods for testing the mechanical properties of the rat femur. Acta Orthop. Scand. 49 (1978) 512-518
12. Feng J.Q., Ward L.M., Liu S., Lu Y., Xie Y., Yuan B., Yu X., Rauch F., Davis S.I., Zhang S., Rios H., Drezner M.K., Quarles L.D., Bonewald L.F., and White K.E. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat. Genet. 38 (2006) 1310-1315
13. Forwood M.R., and Parker A.W. Repetitive loading, in vivo, of the tibiae and femora of rats: effects of repeated bouts of treadmill-running. Bone Miner. 13 (1991) 35-46
14. Freesmeyer M.G., Abendroth K., Faldum A., Krauss C., and Stein G. Comparison of peripheral bone and body axis skeleton in a rat model of mild-to-moderate renal failure in the presence of physiological serum levels of calcitropic hormones. Bone 29 (2001) 258-264
15. Guo X.E., and Goldstein S.A. Vertebral trabecular bone microscopic tissue elastic modulus and hardness do not change in ovariectomized rats. J. Orthop. Res. 18 (2000) 333-336
16. Hong J., Cabe G.D., Tedrow J.R., Hipp J.A., and Snyder B.D. Failure of trabecular bone with simulated lytic defects can be predicted non-invasively by structural analysis. J. Orthop. Res. 22 (2004) 479-486
17. Hornby S.B., Evans G.P., Hornby S.L., Pataki A., Glatt M., and Green J.R. Long-term zoledronic acid treatment increases bone structure and mechanical strength of long bones of ovariectomized adult rats. Calcif. Tissue Int. 72 (2003) 519-527
18. Ito M., Nishida A., Aoyagi K., Uetani M., Hayashi K., and Kawase M. Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia. Osteoporos. Int. 16 (2005) 1042-1048
19. Jokihaara J., Jarvinen T.L., Jolma P., Koobi P., Kalliovalkama J., Tuukkanen J., Saha H., Sievanen H., Kannus P., and Porsti I. Renal insufficiency-induced bone loss is associated with an increase in bone size and preservation of strength in rat proximal femur. Bone 39 (2006) 353-360
20. Kaczmarczyk-Sedlak I., Janiec W., Pytlik M., Sliwinski L., Folwarczna J., Cegeila U., Nowinska B., and Barnas M. Effect of administration of etidronate and trtinol on bone mechanical properties in ovariectomized rats. Pharamcological Rep. 57 (2005) 203-211
21. Kasra M., and Grynpas M.D. On shear properties of trabecular bone under torsional loading: effects of bone marrow and strain rate. J. Biomech. 40 (2007) 2898-2903
22. Kazama J.J., Iwasaki Y., Yamato H., Murayama H., Sato M., Gejyo F., Kurokawa M., and Fukagawa K. Microfocus computed tomography analysis of early changes in bone microstructure in rats with chronic renal failure. Nephron Exp. Nephrol. 95 (2003) e152-e157
23. Keaveny T.M., Borchers R.E., Gibson L.J., and Hayes W.C. Trabecular bone modulus and strength can depend on specimen geometry. J. Biomech. 26 (1993) 991-1000
24. Keaveny T.M., Pinilla T.P., Crawford R.P., Kopperdahl D.L., and Lou A. Systematic and random errors in compression testing of trabecular bone. J. Orthop. Res. 15 (1997) 101-110
25. Kennedy J.G., and Carter D.R. Long bone torsion I: effects of heterogeneity, anisotropy and geometric irregularity. J. Biomech. Eng. 107 (1985) 183-188
26. Lang S.B. Ultrasonic method of measuring elastic coefficients of bone and results on fresh and dried bovine bones. IEEE Trans. Biomed. Eng. 17 (1970) 101-105
27. Lepola V., Vaananen K., and Jalovaara P. The effect of immobilization on the torsional strength of the rat tibia. Clin. Orthop. Relat. Res. (1993) 55-61
28. Levenston M.E., Beaupre G.S., and van der Meulen M.C. Improved method for analysis of whole bone torsion tests. J. Bone Miner. Res. 9 (1994) 1459-1465
29. Manigrasso M.B., and O'Connor J.P. Characterization of a closed femur fracture model in mice. J. Orthop. Trauma 18 (2004) 687-695
30. Miller M.A., Chin J., Miller S.C., and Fox J. Disparate effects of mild, moderate, and severe secondary hyperparathyroidism on cancellous and cortical bone in rats with chronic renal insufficiency. Bone 23 (1998) 257-266
31. Miller S.C., and Wronski T.J. Long-term osteopenic changes in cancellous bone structure in ovariectomized rats. Anat. Rec. 236 (1993) 433-441
32. Mow V.C., and Hayes W.C. Basic Orthopaedic Biomechanics (1997), Lippencott-Raven, Philadelphia
33. Nazarian A., Bauernschmitt M., Eberle C., Meier D., Müller R., and Snyder B.D. Design and validation of a testing system to assess torsional cancellous bone failure in conjunction with time-lapsed micro-computed tomographic imaging. J. Biomech. 41 (2008) 3496-3501
34. Ogawa K., Hori M., Takao R., and Sakurada T. Effects of combined elcatonin and alendronate treatment on the architecture and strength of bone in ovariectomized rats. J. Bone Miner. Metab. 23 (2005) 351-358
35. Piziali R.L., Hight T.K., and Nagel D.A. Geometric properties of human leg bones. J. Biomech. 13 (1980) 881-885
36. Reddy Nagareddy P., and Lakshmana M. Assessment of experimental osteoporosis using CT-scanning, quantitative X-ray analysis and impact test in calcium deficient ovariectomized rats. J. Pharmacol. Toxicol. Methods 52 (2005) 350-355
37. Reilly D.T., and Burstein A.H. The elastic and ultimate properties of compact bone tissue. J. Biomech. 8 (1975) 393-405
38. Silva M.J., and Ulrich S.R. In vitro sodium fluoride exposure decreases torsional and bending strength and increases ductility of mouse femora. J. Biomech. 33 (2000) 231-234
39. Snyder B.D., Hauser-Kara D.A., Hipp J.A., Zurakowski D., Hecht A.C., and Gebhardt M.C. Predicting fracture through benign skeletal lesions with quantitative computed tomography. J. Bone Joint Surg. Am. 88 (2006) 55-70
40. Turner C.H., and Burr D.B. Basic biomechanical measurements of bone: a tutorial. Bone 14 (1993) 595-608
41. Turner C.H., Owan I., Brizendine E.J., Zhang W., Wilson M.E., and Dunipace A.J. High fluoride intakes cause osteomalacia and diminished bone strength in rats with renal deficiency. Bone 19 (1996) 595-601
42. van der Meulen M.C., Jepsen K.J., and Mikic B. Understanding bone strength: size isn't everything. Bone 29 (2001) 101-104
43. Wang L., Orhii P.B., Banu J., and Kalu D.N. Effects of separate and combined therapy with growth hormone and parathyroid hormone on lumbar vertebral bone in aged ovariectomized osteopenic rats. Bone 28 (2001) 202-207
44. Yao W., Hadi T., Jiang Y., Lotz J., Wronski T.J., and Lane N.E. Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats. Osteoporos. Int. 16 (2005) 1939-1947
45. Yoon H.S., and Katz J.L. Ultrasonic wave propagation in human cortical bone-I. Theoretical considerations for hexagonal symmetry. J. Biomech. 9 (1976) 407-412