Effects of combined elcatonin and alendronate treatment on the architecture and strength of bone in ovariectomized rats

Journal of Bone and Mineral Metabolism

Volumn 23, Issue 5, 2005, Pages 351-358

  Ogawa, Koko ^a   Hori, Masayuki ^a   Takao, Ryoko ^a   Sakurada, Toyozo ^a  

^a ASAHI KASEI PHARMA CORPORATION   (Japan)

Author keywords

Alendsronate; Bone architecture; Bone strength; Combined treatment; Elcatonin

Indexed keywords

ALENDRONIC ACID; ELCATONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE RADIOGRAPHY; BONE STRENGTH; BONE STRUCTURE; COMPRESSIVE STRENGTH; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CYTOARCHITECTURE; DRUG EFFECT; FEMALE; FEMUR; METAPHYSIS; NONHUMAN; OVARIECTOMY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RAT; SHAM FEEDING; SPECIES COMPARISON; THREE DIMENSIONAL IMAGING; TRABECULAR BONE;

ALENDRONATE; ANIMALS; BODY WEIGHT; BONE AND BONES; BONE DENSITY; CALCITONIN; COMPRESSIVE STRENGTH; DRUG THERAPY, COMBINATION; FEMALE; FEMUR; HUMANS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 24044442908     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-005-0612-9     Document Type: Article

References (30)

1. M Meschia M Brincat P Barbacini PG Crossignani W Albisetti 1993 A clinical trial on the effects of a combination of elcatonin (Carbocalcitonin) and conjugated estrogens on vertebral bone mass in early postmenopausal women Calcif Tissue Int 53 17 20
2. AB Hodsman LJ Fraher PH Watson T Ostbye LW Stitt JD Adachi DH Taves D Drost 1997 A randomized controlled trial to compare the efficacy of cyclical parathyroid hormone and sequential calcitonin to improve bone mass in postmenopausal women with osteoporosis J Clin Endocrinol Metab 82 620 628
3. T Fujita Y Fujii B Goto A Miyauchi Y Takagi 1997 A three-year comparative trial in osteoporosis treatment: effect of combined alfacalcidol and elcatonin J Bone Miner Metab 15 223 226
4. F Cosman J Nieves L Woelfert C Formica S Gordon V Shen R Lindsay 2001 Parathyroid hormone added to established hormone therapy: effects on vertebral fracture and maintenance of bone mass after parathyroid hormone withdrawal J Bone Miner Res 16 925 931
5. V Shen R Birchman R Xu M Otter Wu DaDong R Lindsay DW Dempster 1995 Effects of reciprocal treatment with estrogen and estrogen plus parathyroid hormone on bone structure and strength in ovariectomized rats J Clin Invest 96 2321 2338
6. CH Chesnut S Silverman K Andriano H Genant A Gimona S Harris D Kiel M LeBoff M Maricic P Miller C Moniz M Peacock P Richardson N Watts D Baylink 2000 A randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study Am J Med 109 267 276
7. US Liberman SR Weiss J Broll HW Minne H Quan NH Bell J Rodrguez-Portales RW Downs J Dequeker M Favus E Seeman R Recker T Capizzi 1995 Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The alendronate phase III osteoporosis treatment study group N Engl J Med 333 1437 1443
8. TJ Wronski CF Yen KW Burton RC Mehta PS Newman EE Soltis PP DeLuca 1991 Skeletal effects of calcitonin in ovariectomized rats Endocrinology 129 2246 2250
9. Y Azuma Y Oue H Kantani T Ohta M Kiyoki K Komoriya 1998 Effect of continuous alendronate treatment on bone mass and mechanical properties in ovariectomized rats: comparison with pamidronate and etidronate in growing rats J Pharmacol Exp Ther 286 128 135
10. C Gennari D Agnusdei 1988 Calcitonin in bone pain management Curr Ther Res 44 712 722
11. GP Lyritis N Tsakalakos B Magiasis T Karachalios A Yiatzides M Tsekoura 1991 Analgesic effect of salmon calcitonin in osteoporotic vertebral fracutures: a double-blind placebo-controlled clinical study Calcif Tissue Int 49 369 372
12. A Ito E Kumamoto M Takeda K Shibata H Sagai M Yoshimura 2000 Mechanisms for ovariectomy-induced hyperalgesia and its relief by calcitonin: participation of 5-HT1A-like receptor on C-afferent terminals in substantia gelatinosa of the rat spinal cord J Neurosci 20 6302 6308
13. H Suzuki I Nakamura N Takahashi T Ikuhara K Matsuzaki Y Isogai M Hori T Suda 1996 Calcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclasts Endocrinology 137 4685 4690
14. SP Luckman DE Hughes FP Coxon GG Russell MJ Rogers 1998 Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-transitional prenylation J Bone Miner Res 13 581 589
15. 1,7]-eel-calcitonin: contribution of the disulfide bond to the hormone activity Experientia 32 1104 1106
16. M Hori H Takahashi T Konno J Inoue T Haba T Sakurada T Noda K Fujimoto 1984 Effect of elcatonin on experimental osteoporosis induced by ovariectomy and low calcium diet in beagles (in Japanese) Folia Pharmacol Japon 84 91 98
17. H Orimo H Morii T Inoue K Yamamoto H Minaguchi Y Ishii K Murota E Fujimaki R Watanabe S Harata H Honjo T Fujita 1996 Effect of elcatonin on involutional osteoporosis J Bone Miner Metab 14 73 78
18. R Schenk DP Eggi DP Fleisch S Rosini 1986 Quantitative morphometric evaluation of the inhibitory activity of new amino-bisphosphonates on bone resorption in the rat Calcif Tissue Int 38 342 349
19. M Sato W Grasser 1990 Effect of bisphosphonates on isolated rat osteoclasts as examined by reflected light microscopy J Bone Miner Res 5 31 40
20. A Laib JL Kumer S Majumdar NE Lane 2001 The temporal changes of trabecular artchitecture in ovariectomized rats assessed by microCT Osteoporos Int 12 936 941
21. M Hahn M Vogel M Pompesius-Kempa G Delling 1992 Trabecular bone pattern factor-a new parameter for simple quantification of bone microarchitecture Bone 13 327 330
22. JE Compston RWE Mellish NJX Garrahan 1987 Age-related change in iliac crest trabecular microanatomic bone structure in man Bone 8 289 292
23. L Mosekilde JS Thomsen MS Mackey RJ Phipps 2000 Treatment with risedronate or alendronate prevents hind-limb immobilization-induced loss of bone density and strength in adult female rats Bone 27 639 645
24. N Miyakoshi K Sato Y Tamura T Tsuchida T Kudo Y Kasukawa 2001 Evaluation of long-term sequential changes in bone mass and strength following withdrawal of incadronate disodium (YM175) in ovariectomized rats J Orthop Sci 6 167 176
25. JG Seedor HA Quartuccio DD Thompson 1991 The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats J Bone Miner Res 4 339 346
26. TJ Wronski CF Yen 1991 The ovariectomized rat as an animal model for postmenopausal bone loss Cell Mater Suppl 1 69 74
27. SL Greenspan S Holland L Maitland-Ramsey M Poku A Freeman W Yuan U Kher B Gertz 1996 Alendronate stimulation of nocturnal parathyroid hormone secretion: a mechanism to explain the continued improvement in bone mineral density accompanying alendronate therapy Proc Assoc Am Physicians 108 230 238
28. HG Bone SL Greenspan C McKeever C Mckeever N Bell M Davidson RW Downs R Emkey PJ Meunier SS Miller AL Mulloy RR Recker SR Weiss N Heyden T Musliner S Suryawanshi AJ Yates A Lombardi 2000 Alendronate and estrogen effects in postmenopausal women with low bone mineral density J Clin Endocrinol Metab 85 727 733
29. SJ Wimalawansa 2000 Prevention and treatment of osteoporosis: efficacy of combination of hormone replacement therapy with other antiresorptive agents J Clin Densitom 3 187 201
30. DM Black SL Greenspan KE Ensrud L Palermo JA McGowan TF Lang P Garnero ML Bouxsein JP Bilezikian CJ Rosen 2003 The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis N Engl J Med 349 1207 1215