Pancreatic regenerating gene I and acinar cell differentiation: Influence on cellular lineage

Pancreas

Volumn 38, Issue 5, 2009, Pages 572-577

  Sanchez, Didier ^a   Mueller, Cathy M ^a   Zenilman, Michael E ^a  

^a SUNY Downstate Medical Center   (United States)

Author keywords

Acinar cells; Antisense inhibition; AR42J; Pancreatic reg I; Sense overexpression

Indexed keywords

AMYLASE; BETA ACTIN; COMPLEMENTARY DNA; CYTOKERATIN; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR PDX 1;

ACINAR CELL; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; DNA ISOLATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSFECTION; GENOME; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS CELL; PANCREAS DUCT; PANCREAS ISLET BETA CELL; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REG I GENE; WESTERN BLOTTING;

AMYLASES; ANIMALS; BLOTTING, WESTERN; CARCINOMA, ACINAR CELL; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL LINEAGE; CELL PROLIFERATION; DNA, COMPLEMENTARY; HOMEODOMAIN PROTEINS; INSULIN; LITHOSTATHINE; MICROSCOPY, PHASE-CONTRAST; PANCREATIC NEOPLASMS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSFECTION;

EID: 67651115610     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e3181a1d9f9     Document Type: Article

References (30)

1. Unno M, Yonekura H, Nakagawara K, et al. Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J Biol Chem. 1993;268:15974-15982. (Pubitemid 23222104)
2. Terazono K, Yamamoto H, Takasawa S, et al. A novel gene activated in regenerating islets. J Biol Chem. 1988;263:2111-2114. (Pubitemid 18060259)
3. Zenilman ME, Perfetti R, Swinson K, et al. Pancreatic regeneration (reg) gene expression in a rat model of islet hyperplasia. Surgery. 1996;119:576-584. (Pubitemid 26141035)
4. Zenilman ME, Magnuson TH, Swinson K, et al. Pancreatic thread protein is mitogenic to pancreatic-derived cells in culture. Gastroenterology. 1996;110:1208-1214. (Pubitemid 26113761)
5. Kobayashi S, Akiyama T, Nata K, et al. Identification of a receptor for reg (regenerating gene) protein, a pancreatic beta-cell regeneration factor. J Biol Chem. 2000;275:10723-10726. (Pubitemid 30212698)
6. Watanabe T, Yonekura H, Terazono K, et al. Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem. 1990;265:7432-7439. (Pubitemid 20162486)
7. Zenilman ME, Magnuson TH, Perfetti R, et al. Pancreatic reg gene expression is inhibited during cellular differentiation. Ann Surg. 1997;225:327-332. (Pubitemid 27131570)
8. Sanchez D, Gmyr V, Kerr-Conte J, et al. Implication of Reg I in human pancreatic duct-like cells in vivo in the pathological pancreas and in vitro during exocrine dedifferentiation. Pancreas. 2004;29:14-21. (Pubitemid 38857261)
9. Zenilman ME, Kim S, Levine BA, et al. Ectopic expression of reg protein: a marker of colorectal mucosa at risk for neoplasia. J Gastrointest Surg. 1997;1:194-201. (Pubitemid 127433839)
10. Minami K, Okuno M, Miyawaki K, et al. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci U S A. 2005;102:15116-15121. (Pubitemid 41513344)
11. Lipsett MA, Castellarin ML, Rosenberg L. Acinar plasticity: development of a novel in vitro model to study human acinar-to-duct-to-islet differentiation. Pancreas. 2007; 34:452-457. (Pubitemid 46725787)
12. Christophe J. Pancreatic tumoral cell line AR42J : an amphicrine model. Am J Physiol. 1994;266:G963-G971. (Pubitemid 2110753)
13. Mashima H, Ohnishi H, Wakabayashi K, et al. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. J Clin Invest. 1996;97:1647-1654. (Pubitemid 26105476)
14. Levine JL, Patel KJ, Zheng Q, et al. A recombinant rat regenerating protein is mitogenic to pancreatic derived cells. J Surg Res. 2000;89:60-65. (Pubitemid 30127443)
15. Nudel U, Zakut R, Shani M, et al. The nucleotide sequence of the rat cytoplasmic A-actin gene. Nucleic Acids Res. 1983;11(6):1759-1771.
16. MacDonald RJ, Crerar MM, Swain WF, et al. Structure of a family of rat amylase genes. Nature. 1980;287(5778):117-122.
17. Miller CP, McGehee RE Jr, Habener JF. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 1994;13(5):1145-1156.
18. Lomedico P, Rosenthal N, Efstratidadis A, et al. The structure and evolution of the two nonallelic rat preproinsulin genes. Cell. 1979;18(2):545-558. (Pubitemid 10248376)
19. Bouwens L, Braet F, Heimberg H. Identification of rat pancreatic duct cells by their expression of cytokeratins 7, 19, and 20 in vivo and after isolation and culture. J Histochem Cytochem. 1995;43:245-253.
20. Zenilman ME, Chen J, Magnuson TH. Effect of reg protein on rat pancreatic ductal cells. Pancreas. 1998;17:256-261. (Pubitemid 28455710)
21. De La OJ, Emerson LL, Goodman JL, et al. Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia. Proc Natl Acad Sci U S A. 2008;105:18907-18912.
22. Miyaoka Y, Kadowaki Y, Ishihara S, et al. Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages. Oncogene. 2004;23:3572-3579. (Pubitemid 38658423)
23. Levine JL, Killcullen J, Steinberg JJ, et al. Reg I protein in colonic mucosa at risk for neoplasia. Gastroenterology. 1998;114:A635.
24. Wu H, Fan Z, Patel S, et al. Reg I receptor expression increases during acute pancreatitis. Gastroenterology. 2001;120:A338.
25. Mueller CM, Zhang H, Zenilman ME. Pancreatic reg I binds MKP-1 and regulates cyclin D in pancreatic-derived cells. J Surg Res. 2008;150:137-143.
26. Terazono K, Uchiyama Y, Ide M, et al. Expression of reg protein in rat regenerating islets and its co-localization with insulin in the beta cell secretory granules. Diabetologia. 1990;33:250-252. (Pubitemid 20136243)
27. Bockman DE. Morphology of the exocrine pancreas related to pancreatitis. Microsc Res Tech. 1997;37:509-519.
28. Mashima H, Yamada S, Tajima T, et al. Genes expressed during the differentiation of pancreatic AR42J cells into insulin-secreting cells. Diabetes. 1999;48:304-309. (Pubitemid 29061103)
29. Zhou J, Wang X, Pineyro MA, et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes. 1999;48:2358-2366. (Pubitemid 30395427)
30. Huang X, Sheu L, Kang Y, et al. Effects of selective endocrine or exocrine induction of AR42J on SNARE and Munc18 protein expression. Pancreas. 2002;25:e56-e63.