Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 15, 2009, Pages 5656-5664

  Petrelli, Riccardo ^a   Sham, Yuk Yin ^a   Chen, Liqiang ^a   Felczak, Krzysztof ^a   Bennett, Eric ^a   Wilson, Daniel ^a   Aldrich, Courtney ^a   Yu, Jose S ^a   Cappellacci, Loredana ^b   Franchetti, Palmarisa ^b   Grifantini, Mario ^b   Mazzola, Francesca ^c   Di Stefano, Michele ^c   Magni, Giulio ^c   Pankiewicz, Krzysztof W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF CAMERINO   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Dithioadenosine analogues, NAD conformation; Enzyme inhibition; NAD kinase; NADP; Tiazofurin

Indexed keywords

8 BROMOADENOSINE ADENOSINE DISULFIDE; ADENINE NUCLEOTIDE DERIVATIVE; DISULFIDE; INOSINATE DEHYDROGENASE; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE KINASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG SPECIFICITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; HUMAN; IC 50; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADENOSINE; BINDING SITES; DISULFIDES; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MYCOBACTERIUM TUBERCULOSIS; NAD; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RIBAVIRIN;

LISTERIA MONOCYTOGENES; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 67651102849     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.06.013     Document Type: Article

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