HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase

Blood

Volumn 114, Issue 1, 2009, Pages 85-94

  Harman, Andrew N ^a   Kraus, Marianne ^b   Bye, Chris R ^a   Byth, Karen ^a   Turville, Stuart G ^a   Tang, Owen ^a   Mercier, Sarah K ^a   Nasr, Najla ^a   Stern, Josh L ^a   Slobedman, Barry ^a   Driessen, Christoph ^b   Cunningham, Anthony L ^a  

^a WESTMEAD HOSPITAL   (Australia)

^b CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CATHEPSIN S; DIPEPTIDYL PEPTIDASE I; ENVELOPE PROTEIN; LYSOSOME ENZYME; RNA; CATHEPSIN; CYSTATIN; GLYCOPROTEIN GP 120; GP120 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; PRIMER DNA;

ARTICLE; DENDRITIC CELL; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REPLICATION; ANTIGEN PRESENTATION; BIOLOGICAL MODEL; DNA MICROARRAY; ENZYMOLOGY; GENETICS; IMMUNOLOGY; IN VITRO STUDY; KINETICS; LYSOSOME; METABOLISM; PATHOGENICITY; PHYSIOLOGY; VIROLOGY; VIRUS ENTRY; VIRUS GENE;

ANTIGEN PRESENTATION; BASE SEQUENCE; CATHEPSINS; CYSTATINS; DENDRITIC CELLS; DNA PRIMERS; GENE EXPRESSION; GENES, VIRAL; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; KINETICS; LYSOSOMES; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; T-LYMPHOCYTES; VIRUS INTERNALIZATION; VIRUS REPLICATION;

EID: 67651065500     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-12-194845     Document Type: Article

References (56)

1. Kim SY, Li J, Bentsman G, Brooks AI, Volsky DJ. Microarray analysis of changes in cellular gene expression induced by productive infection of primary human astrocytes: implications for HAD. J Neuroimmunol. 2004;157:17-26. (Pubitemid 39585214)
2. Amini S, Saunders M, Kelley K, Khalili K, Sawaya BE. Interplay between HIV-1 Vpr and Sp1 modulates p21(WAF1) gene expression in human astrocytes. J Biol Chem. 2004;279:46046-46056. (Pubitemid 39491598)
3. Wang Z, Trillo-Pazos G, Kim SY, et al. Effects of human immunodeficiency virus type 1 on astrocyte gene expression and function: potential role in neuropathogenesis. J Neurovirol. 2004; 10(suppl 1):25-32. (Pubitemid 38325090)
4. Coberley CR, Kohler JJ, Brown JN, et al. Impact on genetic networks in human macrophages by a CCR5 strain of human immunodeficiency virus type 1. J Virol. 2004;78:11477-11486. (Pubitemid 39390735)
5. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001;106:255-258. (Pubitemid 32772607)
6. Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature. 1998;392:245-252.
7. Hu J, Gardner MB, Miller CJ. Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells. J Virol. 2000;74: 6087-6095. (Pubitemid 30412980)
8. Knight SC. Dendritic cells and HIV infection; immunity with viral transmission versus compromised cellular immunity? Immunobiology. 2001; 204:614-621.
9. Sewell AK, Price DA. Dendritic cells and transmission of HIV-1. Trends Immunol. 2001;22:173-175.
10. Turville SG, Cameron PU, Arthos J, et al. Bittersweet symphony: defining the role of dendritic cell gp120 receptors in HIV infection. J Clin Virol. 2001;22:229-239. (Pubitemid 32846553)
11. Harman AN, Wilkinson J, Bye CR, et al. HIV induces maturation of monocyte-derived dendritic cells and Langerhans cells. J Immunol. 2006;177: 7103-7113. (Pubitemid 44715078)
12. de Witte L, Nabatov A, Pion M, et al. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat Med. 2007;13:367-371. (Pubitemid 46376681)
13. Kawamura T, Koyanagi Y, Nakamura Y, et al. Significant virus replication in Langerhans cells following application of HIV to abraded skin: relevance to occupational transmission of HIV. J Immunol. 2008;180:3297-3304.
14. Turville SG, Santos JJ, Frank I, et al. Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells. Blood. 2004;103: 2170-2179. (Pubitemid 38326235)
15. Hladik F, Sakchalathorn P, Ballweber L, et al. Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1. Immunity. 2007;26:257-270. (Pubitemid 46329434)
16. Sugaya M, Lore K, Koup RA, Douek DC, Blauvelt A. HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clusters. J Immunol. 2004;172:2219-2224. (Pubitemid 38182369)
17. McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science. 2003;300:1295-1297. (Pubitemid 36618241)
18. Geiss GK, Bumgarner RE, An MC, et al. Largescale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology. 2000;266:8-16.
19. van't Wout AB, Lehrman GK, Mikheeva SA, et al. Cellular gene expression upon human immunodeficiency virus type 1 infection of CD4(+)-T-cell lines. J Virol. 2003;77:1392-1402.
20. Kartvelishvili A, Lesner A, Szponar M, Simm M. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. Immunol Lett. 2004;93:79-86. (Pubitemid 38591524)
21. Vahey MT, Nau ME, Jagodzinski LL, et al. Impact of viral infection on the gene expression profiles of proliferating normal human peripheral blood mononuclear cells infected with HIV type 1 RF. AIDS Res Hum Retroviruses. 2002;18:179-192.
22. Cicala C, Arthos J, Selig SM, et al. HIV envelope induces a cascade of cell signals in non- proliferating target cells that favor virus replication. Proc Natl Acad Sci U S A. 2002;99:9380-9385. (Pubitemid 34764622)
23. Izmailova E, Bertley FM, Huang Q, et al. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. Nat Med. 2003;9:191-197. (Pubitemid 36227721)
24. Turville SG, Arthos J, Donald KM, et al. HIV gp120 receptors on human dendritic cells. Blood. 2001;98:2482-2488.
25. Smed-Sorensen A, Lore K, Vasudevan J, et al. Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells. J Virol. 2005;79:8861-8869. (Pubitemid 40934796)
26. Dimitrov DS, Willey RL, Sato H, Chang LJ, Blumenthal R, Martin MA. Quantitation of human immunodeficiency virus type 1 infection kinetics. J Virol. 1993;67:2182-2190. (Pubitemid 23088394)
27. Chen HY, Di Mascio M, Perelson AS, Ho DD, Zhang L. Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. Proc Natl Acad Sci U S A. 2007;104:19079-19084.
28. Münch J, Rucker E, Standker L, et al. Semenderived amyloid fibrils drastically enhance HIV infection. Cell. 2007;131:1059-1071. (Pubitemid 350235017)
29. Li Q, Duan L, Estes JD, et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature. 2005;434: 1148-1152. (Pubitemid 40663495)
30. Chertova E, Bess JW Jr, Crise BJ, et al. Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU): is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol. 2002;76:5315-5325. (Pubitemid 34517882)
31. Montefiori DC. Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays. Curr Protoc Immunol. 2005; Chapter 12:Unit 12.11.
32. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004;3:Article 3.
33. Lonnstedt I, Speed, T. Replicated microarray data. Stat Sinica. 2002;12:31-46.
34. Huang da W, Sherman BT, Tan Q, et al. The DAVID Gene Functional Classification Tool: a novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol. 2007;8:R183. (Pubitemid 351895482)
35. Dennis G Jr, Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003;4: P3.
36. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402-408. (Pubitemid 34164012)
37. Watson S, Mercier S, Bye C, Wilkinson J, Cunningham AL, Harman AN. Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses. Virol J. 2007;4:130. (Pubitemid 351178235)
38. van Swieten PF, Maehr R, van den Nieuwendijk AM, et al. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorg Med Chem Lett. 2004;14:3131-3134. (Pubitemid 38624577)
39. Lutzner N, Kalbacher H. Quantifying cathepsin S activity in antigen presenting cells using a novel specific substrate. J Biol Chem. 2008;283:36185-36194.
40. Altman DG, Bland JM. Diagnostic tests 3: receiver operating characteristic plots. BMJ. 1994; 309:188. (Pubitemid 24216486)
41. Kinter A, Arthos J, Cicala C, Fauci AS. Chemokines, cytokines and HIV: a complex network of interactions that influence HIV pathogenesis. Immunol Rev. 2000;177:88-98.
42. National Center for Biotechnology Information. GenBank. http://www.ncbi.nlm.nih.gov/Genbank.
43. Barrett AJ, Rawlings ND, Davies ME, Machleidt W, Salvesen G, Turk V. Cysteine proteinase inhibitors of the cystatin superfamily. In: Salvesen G, Barrett AJ, ed. Proteinase Inhibitors. Amsterdam, The Netherlands: Elsevier; 1986:515-569.
44. Hamilton G, Colbert JD, Schuettelkopf AW, Watts C. Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis. EMBO J. 2008; 27:499-508. (Pubitemid 351225679)
45. Greiner A, Lautwein A, Overkleeft HS, Weber E, Driessen C. Activity and subcellular distribution of cathepsins in primary human monocytes. J Leukoc Biol. 2003;73:235-242. (Pubitemid 36158298)
46. Mocarski ES Jr. Immunomodulation by cytomegaloviruses: manipulative strategies beyond evasion. Trends Microbiol. 2002;10:332-339.
47. Boehme KW, Guerrero M, Compton T. Human cytomegalovirus envelope glycoproteins B and H are necessary for TLR2 activation in permissive cells. J Immunol. 2006;177:7094-7102. (Pubitemid 44715077)
48. Preston CM, Harman AN, Nicholl MJ. Activation of interferon response factor-3 in human cells infected with herpes simplex virus type 1 or human cytomegalovirus. J Virol. 2001;75:8909-8916. (Pubitemid 32851895)
49. Sodhi A, Montaner S, Gutkind JS. Viral hijacking of G-protein-coupled- receptor signalling networks. Nat Rev Mol Cell Biol. 2004;5:998-1012. (Pubitemid 39611536)
50. Weissman D, Rabin RL, Arthos J, et al. Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature. 1997;389:981-985. (Pubitemid 27485691)
51. Hodges A, Sharrocks K, Edelmann M, et al. Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication. Nat Immunol. 2007;8:569-577. (Pubitemid 46785120)
52. Maddocks S, Scandurra GM, Nourse C, et al. Gene expression in HIV-1/Mycobacterium tuberculosis co-infected macrophages is dominated by M. tuberculosis. Tuberculosis. 2009 June 9. [Epub ahead of print]
53. Moris A, Nobile C, Buseyne F, Porrot F, Abastado JP, Schwartz O. DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation. Blood. 2004;103:2648-2654. (Pubitemid 38393020)
54. Cunningham AL, Harman AN, Donaghy H. DCSIGN 'AIDS' HIV immune evasion and infection. Nat Immunol. 2007;8:556-558. (Pubitemid 46785117)
55. Del Corno M, Liu QH, Schols D, et al. HIV-1 gp120 and chemokine activation of Pyk2 and mitogen-activated protein kinases in primary macrophages mediated by calcium-dependent, pertussis toxin-insensitive chemokine receptor signaling. Blood. 2001;98:2909-2916.
56. Turville SG, Aravantinou M, Stossel H, Romani N, Robbiani M. Resolution of de novo HIV production and trafficking in immature dendritic cells. Nat Methods. 2008;5:75-85.