Asymmetric strand segregation: Epigenetic costs of genetic fidelity?

PLoS Genetics

Volumn 5, Issue 6, 2009, Pages

  Genereux, Diane P ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL STRUCTURE; CRYPT CELL; DNA METHYLATION; DNA STRAND; EPIGENETICS; FEMALE; GENE SEGREGATION; HUMAN; HUMAN CELL; MALE; MATHEMATICAL MODEL; MOLECULAR MECHANICS; ANIMAL; DNA REPLICATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; THEORETICAL MODEL;

MAMMALIA;

DNA;

ANIMALS; DNA; DNA METHYLATION; DNA REPLICATION; EPIGENESIS, GENETIC; HUMANS; MODELS, THEORETICAL;

EID: 67651040859     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000509     Document Type: Article

References (43)

1. Cairns J (1975) Mutation, selection and the natural history of cancer. Nature 255: 197-200.
2. Lark KG, Consigli RA, Minocha HC (1966) Segregation of sister chromatids in mammalian cells. Science 154: 1202-1205.
3. Karpowicz P, Morshead C, Kam A, Jervis E, Ramunas J, et al. (2005) Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro. J Cell Biol 170: 721-732. (Pubitemid 41242105)
4. Smith GH (2005) Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands. Development 132: 681-687.
5. Shinin V, Gayraud-Morel B, Gomes D, Tajbakhsh S (2006) Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nat Cell Biol 8: 677-687.
6. Kiel MJ, He S, Ashkenazi R, Gentry SN, Teta M, et al. (2007) Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU. Nature 449: 238-242. (Pubitemid 47402371)
7. Sotiropoulou P, Candi A, Blanpain C (2008) The majority of multipotent epidermal stem cells do not protect their genome by asymmetrical chromosome segregation. Stem Cells 26: 2964-2973
8. Klar AJ (1987) Differentiated parental DNA strands confer developmental asymmetry on daughter cells in fission yeast. Nature 326: 466-470.
9. Klar AJ (1994) A model for specification of the left-right axis in vertebrates. Trends Genet 10: 392-396.
10. Klar AJS (2004) A genetic mechanism implicates chromosome 11 in schizophrenia and bipolar diseases. Genetics 167: 1833-1840.
11. Merok JR, Lansita JA, Tunstead JR, Sherley JL (2002) Cosegregation of chromosomes containing immortal DNA strands in cells that cycle with asymmetric stem cell kinetics. Cancer Res 62: 6791-6795.
12. Liu SV (2005) Linking DNA aging with cell aging and combining genetics with epigenetics. Logical Biology 5: 51-55.
13. Cairns J (2006) Cancer and the immortal strand hypothesis. Genetics 174: 1069-1072.
14. Rando TA (2007) The immortal strand hypothesis: segregation and reconstruction. Cell 129: 1239-1243.
15. Lew DJ, Burke DJ, Dutta A (2008) The immortal strand hypothesis: how could it work? Cell 133: 21-23.
16. Lorincz MC, Schubeler D, Hutchinson SR, Dickerson DR, Groudine M (2002) DNA methylation density inuences the stability of an epigenetic imprint and Dnmt3a/b-independent de novo methylation. Mol Cell Biol 22: 7572-7580.
17. Lansdorp PM (2007) Immortal strands? Give me a break. Cell 129: 1244-1247.
18. Kim JY, Tavare S, Shibata D (2005) Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A 102: 17739-17744. (Pubitemid 41803567)
19. Kim JY, Beart RW, Shibata D (2005) Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. BMC Gastroenterol 5: 19.
20. Stöger R, Kajimura TM, Brown WT, Laird CD (1997) Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1. Hum Mol Genet 6: 1791-1801. (Pubitemid 27460352)
21. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, et al. (2008) Intra-individual change over time in DNA methylation with familial clustering. JAMA 299: 2877-2883. (Pubitemid 351930887)
22. Sandovici I, Naumova AK, Leppert M, Linares Y, Sapienza C (2004) A longitudinal study of X-inactivation ratio in human females. Hum Genet 115: 387-392. (Pubitemid 39341712)
23. Sandovici I, Leppert M, Hawk PR, Suarez A, Linares Y, et al. (2003) Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions. Hum Mol Genet 12: 1569-1578. (Pubitemid 36857304)
24. Wong DJ, Foster SA, Galloway DA, Reid BJ (1999) Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrest. Mol Cell Biol 19: 5642-5651.
25. Grady WM (2005) Epigenetic events in the colorectum and in colon cancer. Biochem Soc Trans 33: 684-688.
26. Smith E, De Young NJ, Pavey SJ, Hayward NK, Nancarrow DJ, et al. (2008) Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma. Mol Cancer 7: 75.
27. Leonhardt H, Page AW, Weier HU, Bestor TH (1992) A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71: 865-873.
28. Okano M, Bell DW, Haber DA, Li E (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257. (Pubitemid 29519904)
29. Yokochi T, Robertson KD (2002) Preferential methylation of unmethylated DNA by mammalian de novo DNA methyltransferase Dnmt3a. J Biol Chem 277: 11735-11745. (Pubitemid 34952728)
30. Hsieh CL (1999) In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b. Mol Cell Biol 19: 8211-8218.
31. Genereux DP, Miner BE, Bergstrom CT, Laird CD (2005) A populationepigenetic model to infer site-specific methylation rates from double-stranded DNA methylation patterns. Proc Natl Acad Sci U S A 102: 5802-5807.
32. Razin A, Webb C, Szyf M, Yisraeli J, Rosenthal A, et al. (1984) Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A 81: 2275-2279. (Pubitemid 14148245)
33. Adams RL (1971) Methylation of newly synthesized and older deoxyribonucleic acid. Biochem J 123: 38P.
34. Schneiderman MH, Billen D (1973) Methylation rapidly reannealing DNA during the cell cycle of Chinese hamster cells. Biochim Biophys Acta 308: 352-360.
35. Bird AP (1978) Use of restriction enzymes to study eukaryotic DNA methylation: II. the symmetry of methylated sites supports semi-conservative copying of the methylation pattern. J Mol Biol 118: 49-60. (Pubitemid 8271372)
36. Kappler JW (1970) The kinetics of DNA methylation in cultures of a mouse adrenal cell line. J Cell Physiol 75: 21-31.
37. Otto SP, Walbot V (1990) DNA methylation in eukaryotes: kinetics of demethylation and de novo methylation during the life cycle. Genetics 124: 429-437.
38. Nicolas P, Kim KM, Shibata D, Tavare S (2007) The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol 3: e28. (Pubitemid 46535730)
39. Potten CS (1998) Stem cells in gastrointestinal epithelium: numbers, characteristics and death. Philos Trans R Soc Lond B Biol Sci 353: 821-830.
40. Pfeifer GP, Steigerwald SD, Hansen RS, Gartler SM, Riggs AD (1990) Polymerase chain reactionaided genomic sequencing of an X chromosomelinked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability. Proc Natl Acad Sci U S A 87: 8252-8256.
41. Laird CD, Pleasant ND, Clark AD, Sneeden JL, Hassan KMA, et al. (2004) Hairpin-bisulfite PCR: assessing epigenetic methylation patterns on complementary strands of individual DNA molecules. Proc Natl Acad Sci U S A 101: 204-209.
42. Hermann A, Goyal R, Jeltsch A (2004) The Dnmt1 DNA-(cytosine-C5)- methyltransferase methylates DNA processively with high preference for hemimethylated target sites. J Biol Chem 279: 48350-48359. (Pubitemid 39540991)
43. Vilkaitis G, Suetake I, Klimasauskas S, Tajima S (2005) Processive methylation of hemimethylated CpG sites by mouse Dnmt1 DNA methyltransferase. J Biol Chem 280: 64-72. (Pubitemid 40164965)