Cause-specific treatment in patients with high sperm DNA damage resulted in significant DNA improvement

Systems Biology in Reproductive Medicine

Volumn 55, Issue 2-3, 2009, Pages 109-115

  Moskovtsev, Sergey I ^a   Lecker, Irene ^a   Mullen, J Brendan M ^a   Jarvi, Keith ^a   Willis, Jennifer ^a   White, John ^a   Lo, Kirk C ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Antioxidants; Bacteriospermia; Male infertility; Sperm DNA damage; Varicocele

Indexed keywords

ALPHA TOCOPHEROL; AMOXICILLIN; ASCORBIC ACID; AZITHROMYCIN; CARNITINE; CIPROFLOXACIN; CYANOCOBALAMIN; DNA; FERTILE ONE; FERULIC ACID; FOLIC ACID; GARLIC EXTRACT; GINSENG EXTRACT; PYRIDOXINE; SELENIUM; UBIDECARENONE; UNCLASSIFIED DRUG; ZINC;

ADULT; ARTICLE; BACTERIAL INFECTION; BACTERIOSPERMIA; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE COURSE; DNA DAMAGE; DNA FRAGMENTATION; GROUPS BY AGE; HUMAN; IDIOPATHIC DISEASE; INFERTILITY; MAJOR CLINICAL STUDY; MALE; PATIENT CARE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SPERM; UREAPLASMA INFECTION; VARICOCELE; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ANTI-BACTERIAL AGENTS; ANTIOXIDANTS; DNA DAMAGE; DNA FRAGMENTATION; HUMANS; INFERTILITY, MALE; MALE; SPERMATOZOA; VARICOCELE;

EID: 67650989371     PISSN: 19396368     EISSN: 19396368     Source Type: Journal    
DOI: 10.1080/19396360902787944     Document Type: Article

References (34)

1. Agarwal, A., Nallella, K. P., Allamaneni, S. S. and Said, T. M. (2004) Role of antioxidants in treatment of male infertility: An overview of the literature. Reprod Biomed Online 8:616-627. (Pubitemid 38744936)
2. Agarwal, A. and Said, T. M. (2003) Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update 9:331-345. (Pubitemid 36987282)
3. Aitken, R. J., Gordon, E., Harkiss, D., Twigg, J. P., Milne, P., Jennings, Z. and Irvine, D. S. (1998) Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa. Biol Reprod 59:1037-1046. (Pubitemid 28498912)
4. Benchaib, M., Lornage, J., Mazoyer, C., Lejeune, H., Salle, B. and Guerin, J. F. (2007) Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome. Fertil Steril 87:93-100. (Pubitemid 46013863)
5. Bungum, M., Humaidan, P., Axmon, A., Spano, M., Bungum, L., Erenpreiss, J. and Giwercman, A. (2007) Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod 22:174-179. (Pubitemid 44942682)
6. Carrell, D. T., Liu, L., Peterson, C.M., Jones, K. P., Hatasaka, H., Erickson, L. and Campbell, B. (2003) Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss. Arch Androl 49:49-55. (Pubitemid 36061302)
7. Erenpreiss, J., Hlevicka, S., Zalkalns, J. and Erenpreisa, J. (2002) Effect of leukocytospermia on sperm DNA integrity: A negative effect in abnormal semen samples. J Androl 23:717-723. (Pubitemid 34977529)
8. Eskenazi, B., Kidd, S. A., Marks, A. R., Sloter, E., Block, G. and Wyrobek, A. J. (2005) Antioxidant intake is associated with semen quality in healthy men. Hum Reprod 20:1006-1012. (Pubitemid 40667848)
9. Evenson, D. P., Larson, K. L. and Jost, L. K. (2002) Sperm chromatin structure assay: Its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 23:25-43.
10. Gallegos, G., Ramos, B., Santiso, R., Goyanes, V., Gosalvez, J. and Fernandez, J. L. (2008) Sperm DNA fragmentation in infertile men with genitourinary infection by Chlamydia trachomatis and Mycoplasma. Fertil Steril 90:328-334. (Pubitemid 352040698)
11. Gandini, L., Lombardo, F., Paoli, D., Caponecchia, L., Familiar, G., Verlengia, C., Dondero, F. and Lenzi, A. (2000) Study of apoptotic DNA fragmentation in human spermatozoa. Hum Reprod 15:830-839. (Pubitemid 30192731)
12. Goldstein, M., Gilbert, B. R., Dicker, A. P., Dwosh, J. and Gnecco, C. (1992) Microsurgical inguinal varicocelectomy with delivery of the testis: An artery and lymphatic sparing technique. J Urol 148:1808-1811.
13. Greco, E., Iacobelli, M., Rienzi, L., Ubaldi, F., Ferrero, S. and Tesarik, J. (2005) Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl 26:349-353. (Pubitemid 40628971)
14. Keck, C., Gerber-Schäfer, C., Clad, A., Wilhelm, C. and Breckwoldt, M. (1998) Seminal tract infections: impact on male fertility and treatment options. Hum Reprod Update 4:891-903. (Pubitemid 29082477)
15. Keskes-Ammar, L., Feki-Chakroun, N., Rebai, T., Sahnoun, Z., Ghozzi, H., Hammami, S., Zghal, K., Fki, H., Damak, J. and Bahloul, A. (2003) Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl 49:83-94. (Pubitemid 36269762)
16. Martin, R. H. and Rademaker, A. W. (1987) The effect of age on the frequency of sperm chromosomal abnormalities in normal men. Am J Hum Genet 41:484-492. (Pubitemid 18047477)
17. Menezo, Y. J., Hazout, A., Panteix, G., Robert, F., Rollet, J., Cohen-Bacrie, P., Chapuis, F., Clement, P. and Benkhalifa, M. (2007) Antioxidants to reduce sperm DNA fragmentation: An unexpected adverse effect. Reprod Biomed Online 14:418-421. (Pubitemid 46584375)
18. Moskovtsev, S. I., Willis, J., Azad, A. and Mullen, J. B. M. (2005) Sperm DNA integrity: Correlation with sperm plasma membrane integrity in semen evaluated for male infertility. Arch Androl 51:33-40. (Pubitemid 40052877)
19. Moskovtsev, S. I., Willis, J. and Mullen, J. B. M. (2006) Age-related decline in sperm deoxyribonucleic acid integrity in patients evaluated for male infertility. Fertil Steril 85:496-499. (Pubitemid 43170935)
20. Moskovtsev, S. I., Willis, J., White, J. and Mullen, J. B. M. (2007) Leukocytospermia: Relationship to sperm deoxyribonucleic acid integrity in patients evaluated for male factor infertility. Fertil Steril 88:737-740. (Pubitemid 47368219)
21. Ochsendorf, F. R. (1999) Infections in the male genital tract and reactive oxygen species. Hum Reprod Update 5:399-420.
22. Saleh, R. A., Agarwal, A., Sharma, R. K., Said, T. M., Sikka, S. C. and Thomas, A. J. (2003) Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril 80:1431-1436. (Pubitemid 37532458)
23. Sharpe, R. M. and Skakkebaek, N. E. (1993) Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341:1392-1395.
24. Sikka, S. C. (2004) Role of oxidative stress and antioxidants in andrology and assisted reproductive technology. J Androl 25:5-8.
25. Silver, E. W., Eskenazi, B., Evenson, D. P., Block, G., Young, S. and Wyrobek, A. J. (2005) Effect of antioxidant intake on sperm chromatin stability in healthy non-smoking men. J Androl 26:550-556. (Pubitemid 40847868)
26. Singh, N. P., Muller, C. H. and Berger, R. E. (2003) Effects of age on DNA double-strand breaks and apoptosis in human sperm. Fertil Steril 80:1420-1430. (Pubitemid 37540397)
27. Spano, M., Bonde, J. P., Hjollund, H. I., Kolstad, H. A., Cordelli, E. and Leter, G. (2000) Sperm chromatin damage impairs human fertility. The Danish First Pregnancy Planner Study Team. Fertil Steril 73:43-50. (Pubitemid 30018020)
28. Tesarik, J., Greco, E. and Mendoza, C. (2004a) Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation. Hum Reprod 19:611-615. (Pubitemid 38344525)
29. Tesarik, J., Ubaldi, F., Rienzi, L., Martinez, F., Iacobelli, M., Mendoza, C. and Greco, E. (2004b) Caspase-dependent and -independent DNA fragmentation in Sertoli and germ cells from men with primary testicular failure: Relationship with histological diagnosis. Hum Reprod 19:254-261. (Pubitemid 38219989)
30. Vicari, E. (2000) Effectiveness and limits of antimicrobial treatment on seminal leukocyte concentration and related reactive oxygen species production in patients with male accessory gland infection. Hum Reprod 15:2536-2544.
31. Wong, W. Y., Thomas, C. M., Merkus, J. M., Zielhuis, G. A. and Steegers-Theunissen, R. P. (2000) Male factor subfertility: Possible causes and the impact of nutritional factors. Fertil Steril 73:435-442.
32. World Health Organization (1999) WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th ed. Cambridge, UK: Cambridge University Press.
33. Zini, A., Blumenfeld, A., Libman, J. and Willis, J. (2005) Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity. Hum Reprod 20:1018-1021. (Pubitemid 40667850)
34. Zini, A. (2007) Varicocelectomy: microsurgical subinguinal technique is the treatment of choice. Can Urol Assoc J 1:273-276.