Involvement of matrix metalloproteinases in the inhibition of cell invasion and migration through the inhibition of NF-κB by the new synthesized ethyl 2-[N-p-chlorobenzyl-(2′-methyl)]anilino-4-oxo-4,5-dihydrofuran-3- carboxylate (JOTO1007) in human cervical cancer Ca Ski cells

In Vivo

Volumn 23, Issue 4, 2009, Pages 613-620

  Huang, An Cheng ^a   Hsu, Shu Chun ^b   Kuo, Chao Lin ^b   Liao, Ching Lung ^b   Lai, Kuang Chi ^c,d   Lin, Tsung Ping ^b   Wu, Shin Hwar ^b,e   Lu, Hsu Feng ^f,g   Tang, Nou Ying ^b   Yang, Jai Sing ^b   Chung, Jing Gung ^b,h  

^a Saint Mary's Medicine Nursing and Management College   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

^e Division of Critical Care Medicine   (Taiwan)

^f CHENG HSIN REHABILITATION MEDICAL CENTER   (Taiwan)

^g FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^h ASIA UNIVERSITY   (Taiwan)

Author keywords

Ca Ski cells; Invasion; JOTO1007; Migration; MMPs

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOOXYGENASE 2; ETHYL 2 [N 4 CHLOROBENZYL (2' METHYL)]ANILINO 4 OXO 4,5 DIHYDROFURAN 3 CARBOXYLATE; EXODEOXYRIBONUCLEASE VIII; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; GROWTH FACTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; JOTO 1007; MATRILYSIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 9; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN C JUN; PROTEIN KINASE C; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SOS PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; MIGRATION INHIBITION; PROTEIN EXPRESSION; UTERINE CERVIX CANCER;

EID: 67650983139     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Rossi A, Ciafre S, Balsamo M, Pierimarchi P and Santoro MG: Targeting the heat shock factor 1 by RNA interference: a potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Cancer Res 66(15): 7678-7685, 2006. (Pubitemid 44289226)
2. Cogliano V, Baan R, Straif K, Grosse Y, Secretan B and El Ghissassi F: Carcinogenicity of human papillomaviruses. Lancet Oncol 6(4): 204, 2005.
3. González Martín A: Molecular biology of cervical cancer. Clin Transl Oncol 9(6): 347-354, 2007.
4. Huang AC, Chung JG, Kuo SC, Lu HF and Lin TP: Synthesis and cytotoxic activity of certain 2,3,4,9-tetrahydrofuro [2,3-b] quinolin-3,4-dione and ethyl 2-(substituted aniline)-4-oxo-4,5- dihydrofuran-3-carboxylate derivatives in murine leukemia WEHI-3 cells. In Vivo 21(2): 227-236, 2007.
5. Lin TP, Huang AC, Wei HC, Lin JG and Chung JG: Ethyl 2- [N- p-chlorobenzyl- (2′-methyl)] anilino-4-oxo-4,5-dihydrofuran-3- carboxylate (JOTO1007) induces apoptosis in human cervical cancer Ca Ski cells. In Vivo 21(2): 397-406, 2007. (Pubitemid 46534297)
6. Huang YT, Hwang JJ, Lee LT, Liebow C, Lee PP, Ke FC, Lo TB, Schally AV and Lee MT: Inhibitory effects of a luteinizing hormone-releasing hormone agonist on basal and epidermal growth factor-induced cell proliferation and metastasis- associated properties in human epidermoid carcinoma A431 cells. Int J Cancer 99(4): 505-513, 2002. (Pubitemid 34461602)
7. Hsu SC, Kuo CL, Lin JP, Lee JH, Lin CC, Su CC, Yang MD and Chung JG: Crude extracts of Euchresta formosana radix inhibit invasion and migration of human hepatocellular carcinoma cells. Anticancer Res 27(4B): 2377-2384, 2007. (Pubitemid 47228078)
8. Lu KW, Tsai ML, Chen JC, Hsu SC, Hsia TC, Lin MW, Huang AC, Chang YH, Ip SW, Lu HF and Chung JG: Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFkappaB and matrix metalloproteinase-9. Anticancer Res 28(2A): 1093-1099, 2008.
9. Chen JC, Lu KW, Tsai ML, Hsu SC, Kuo CL, Yang JS, Hsia TC, Yu CS, Chou ST, Kao MC, Chung JG and Gibson Wood W: Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria- dependent pathways in human tongue cancer SCC-4 cells. Oral Oncol, 2008.
10. Ip SW, Wei HC, Lin JP, Kuo HM, Liu KC, Hsu SC, Yang JS, Mei D, Chiu TH, Han SM and Chung JG: Bee venom induced cell cycle arrest and apoptosis in human cervical epidermoid carcinoma Ca Ski cells. Anticancer Res 28(2A): 833-842, 2008.
11. Anand-Apte B and Zetter B: Signaling mechanisms in growth factor-stimulated cell motility. Stem Cells 15(4): 259-267, 1997. (Pubitemid 27315329)
12. Price JT and Thompson EW: Mechanisms of tumour invasion and metastasis: emerging targets for therapy. Expert Opin Ther Targets 6(2): 217-233, 2002.
13. Fenteany G and Zhu S: Small-molecule inhibitors of actin dynamics and cell motility. Curr Top Med Chem 3(6): 593-616, 2003.
14. Kim EK, Song MY, Hwang TO, Kim HJ, Moon WS, Ryu DG, So HS, Park R, Park JW, Kwon KB and Park BH: Radix clematidis extract protects against cytokine- and streptozotocin- induced beta-cell damage by suppressing the NF-kappaB pathway. Int J Mol Med 22(3): 349-356, 2008.
15. Mathes E, O'Dea EL, Hoffmann A and Ghosh G: NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J 27(9): 1357-1367, 2008. (Pubitemid 351655185)
16. Stetler-Stevenson WG: Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix. Am J Pathol 148(5): 1345-1350, 1996.
17. Nagase H and Woessner JF Jr: Matrix metalloproteinases. J Biol Chem 274(31): 21491-21494, 1999.
18. Morozevich GE, Kozlova NI, Cheglakov IB, Ushakova NA, Preobrazhenskaya ME and Berman AE: Implication of alpha5betal integrin in invasion of drug-resistant MCF-7/ADR breast carcinoma cells: a role for MMP-2 collagenase. Biochemistry (Mosc) 73(7): 791-796, 2008.
19. Seufferlein T: Novel protein kinases in pancreatic cell growth and cancer. Int J Gastrointest Cancer 31(1-3): 15-21, 2002. (Pubitemid 36330103)
20. Perona R and Sanchez-Perez I: Signalling pathways involved in clinical responses to chemotherapy. Clin Transi Oncol 9(10): 625-633, 2007.
21. Escarcega RO, Fuentes-Alexandro S, Garcia-Carrasco M, Gatica A and Zamora A: The transcription factor nuclear factor-kappa B and cancer. Clin Oncol (R Coll Radiol) 19(2): 154-161, 2007. (Pubitemid 46172840)