Synthesis and cytotoxic activity of certain 2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione and ethyl 2-(substituted aniline)-4-oxo-4,5-dihydrofuran-3-carboxylate derivatives in murine leukemia WEHI-3 cells

In Vivo

Volumn 21, Issue 2, 2007, Pages 227-236

  Huang, An Cheng ^a,b   Chung, Jing Gung ^a   Kuo, Sheng Chu ^a   Lu, Hsu Fung ^c   Lin, Tsung Ping ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Han Ming Hospital   (Taiwan)

^c CHENG HSIN REHABILITATION MEDICAL CENTER   (Taiwan)

Author keywords

Cytotoxicity; Furoquinolone derivatives; Intermediate products of furoquinolone; Leukemia WEHI 3 cells

Indexed keywords

2 ,3, 4, 9 TETRAHYDROFURO[2,3 B]QUINOLIN 3, 4 DIONE DERIVATIVE; 4 OXO 4 ,5 DIHYDROFURAN 3 CARBOXYLATE DERIVATIVE; ANTILEUKEMIC AGENT; CYTOTOXIC AGENT; ETHYL 2 ANILO 4 OXO 4 ,5 DIHYDROFURAN 3 CARBOXYLATE; ETHYL 2 [N 4, FLUOROBENZYL(2' METHYL)]ANILINO 4 OXO 4 ,5 DIHYDROFURAN 3 CARBOXYLATE; ETHYL 2 [N BENZYL(3' METOXY)]ANILINO 4 OXO 4 ,5 DIHYDROFURAN 3 CARBOXYLATE; N 3 CHLOROBENZYL 7 METHOXY 2,3,4,9 TETRAHYDROFURO[2,3, B]QUINOLIN 3,4 DIONE; N 4 FLUOROBENZYL 7 METHOXY 4,9 TETRAHYDROFURO[2,3 B]QUINOLIN 4 DIONE; N 4 METHYLBENZYL 7 METHOXY 4,9 DIHYDROFURO[2,3 B]QUINOLIN 4 DIONE; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 34047204741     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Wang LD, Guo DA, Yuan L, He QH, Hu YQ, Tu PF and Zheng JH: Antifungal effect of three natural products on the genetic substance of Saccharomyces cerevisiae GL7 and Prototheca wickerhamii. Yao Xue Xue Bao 35: 860-863, 2000.
2. Chen IS, Lin YC, Tsai IL, Teng CM, Ko FN, Ishikawa T and Ishii H: Coumarins and anti-platelet aggregation constituents from Zanthoxylum schinifolium. Phytochemistry 39: 1091-1097, 1995.
3. 2+ channel blockers. Naunyn Schmiedebergs Arch Pharmacol 345: 349-355, 1992.
4. Schimmer O and Kuhne I: Furoquinoline alkaloids as photosensitizers in Chlamydomonas reinhardtii. Mutat Res 249: 105-110, 1991.
5. Zhao YL, Chen YL, Chang FS and Tzeng CC: Synthesis and cytotoxic evaluation of certain 4-anilino-2-phenylquinoline derivatives. Eur J Med Chem 40: 792-797, 2005.
6. Nam KW, Je KH, Shin YJ, Kang SS and Mar W: Inhibitory effects of furoquinoline alkaloids from Melicope confusa and Dictamnus albus against human phosphodiesterase 5 (hPDE5A) in vitro. Arch Pharm Res 28: 675-679, 2005.
7. Chen JJ, Duh CY, Huang HY and Chen IS: Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia. Planta Med 69: 542-546, 2003.
8. Cheng JT, Chang TK and Chen IS: Skimmianine and related furoquinolines function as antagonists of 5-hydroxytryptamine receptors in animals. J Auton Pharmacol 14: 365-374, 1994.
9. Chen KS, Chang YL, Teng CM, Chen CF and Wu YC: Furoquinolines with antiplatelet aggregation activity from leaves of Melicope confusa. Planta Med 66: 80-81, 2000.
10. Lahey FN and McCamish M: Acrophylline and acrophyllidine. Two new alkaloids from Acronychia haplophylla. Tetrahedron Lett 12: 1525-1527, 1968.
11. Zhao YL, Chen YL, Sheu JY, Chen IL, Wang TC and Tzeng CC: Synthesis and Antimycobacterial Evaluation of Certain Fluoroquinolone Derivatives. Bioorg Med Chem 13: 2005.
12. Sheu JY, Chen YL, Tzeng CC, Hsu SL, Fang KC and Wang TC: Synthesis, antimycobacterial, and cytotoxic evaluation of certain fluoroquinolone derivatives Helv Chim Acta 86: 2481-2489, 2003.
13. Huang AC, Lin TP, Kuo SC and Wang JP: The antiallergic activities of synthetic acrophylline and acrophyllidine. J Nat Prod 58: 117-120, 1995.
14. Chang GJ, Su MJ, Kuo SC, Lin TP and Lee YS: Multiple cellular electrophysiological effects of a novel antiarrhythmic furoquinoline derivative HA-7 [N-benzyl-7-methoxy-2,3,4,9-tetrahydro furo[2,3-b]quinoline-3,4-dione] in guinea pig cardiac preparations. J Pharmacol Exp Ther 316: 380-391, 2006.
15. Su MJ, Chang GJ, Wu MH and Kuo SC: Electrophysiological basis for the antiarrhythmic action and positive inotropy of HA-7, a furoquinoline alkaloid derivative, in rat heart. Br J Pharmacol 122: 1285-1298, 1997.
16. Wang JP, Tsao LT, Raung SL, Hsu MF and Kuo SC: Inhibition by HAJ11 of respiratory burst in neutrophils and the involvement of protein tyrosine phosphorylation and phospholipase D activation. Br J Pharmacol 120: 79-87, 1997.
17. Chuang JY, Tsai YY, Chen SC, Hsieh TJ and Chung JG: Induction of G0/G1 arrest and apoptosis by 3-hydroxycinnamic acid in human cervix epithelial carcinoma (HeLa) cells. In Vivo 19: 683-688, 2005.
18. Lu HF, Sue CC, Yu CS, Chen SC, Chen GW and Chung JG: Diallyl disulfide (DADS) induced apoptosis undergo caspase-3 activity in human bladder cancer T24 cells. Food Chem Toxicol 42: 1543-1552, 2004.