메뉴 건너뛰기




Volumn 367, Issue 1896, 2009, Pages 2203-2223

From in vivo plasma composition to in vitro cardiac electrophysiology and in silico virtual heart: The extracellular calcium enigma

Author keywords

Cardiac models; Extracellular calcium; Virtual physiological human

Indexed keywords

BLOOD; CALCIUM; CALCIUM ALLOYS; CELL MEMBRANES; CHEMICAL ANALYSIS; ELECTROPHYSIOLOGY; NEUROLOGY; SENSITIVITY ANALYSIS; SIMULATORS; VIRTUAL REALITY;

EID: 67650898591     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2009.0032     Document Type: Article
Times cited : (33)

References (66)
  • 3
    • 0013683332 scopus 로고
    • The ECG and electrolyte abnormalities
    • ed. E. Braunwald, pp, 4th edn. Philadelphia, PA: Saunders
    • Braunwald, E., Sonnenblick, E. & Ross, J. 1992 The ECG and electrolyte abnormalities. In Heart disease (ed. E. Braunwald), pp. 149-151, 4th edn. Philadelphia, PA: Saunders.
    • (1992) Heart disease , pp. 149-151
    • Braunwald, E.1    Sonnenblick, E.2    Ross, J.3
  • 4
    • 33750856807 scopus 로고    scopus 로고
    • Ionic mechanisms underlying human atrial action potential properties: Insights from a mathematical model
    • Courtemanche, M., Ramirez, R. J. & Nattel, S. 1998 Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model. Am. J. Physiol. Heart Circ. Physiol. 275, H301-H321.
    • (1998) Am. J. Physiol. Heart Circ. Physiol , vol.275
    • Courtemanche, M.1    Ramirez, R.J.2    Nattel, S.3
  • 5
    • 0036900601 scopus 로고    scopus 로고
    • Haemodialysis increases QTc interval but not QTc dispersion in ESRD patients without manifest cardiac disease
    • doi:10. 1093/ndt/17.12.2170
    • Covic, A., Diaconita, M., Gusbeth-Tatomir, P., Covic, M., Botezan, A., Ungureanu, G. & Goldsmith, D. J. 2002 Haemodialysis increases QTc interval but not QTc dispersion in ESRD patients without manifest cardiac disease. Nephrol. Dial. Transplant. 17, 2170-2177. (doi:10. 1093/ndt/17.12.2170)
    • (2002) Nephrol. Dial. Transplant , vol.17 , pp. 2170-2177
    • Covic, A.1    Diaconita, M.2    Gusbeth-Tatomir, P.3    Covic, M.4    Botezan, A.5    Ungureanu, G.6    Goldsmith, D.J.7
  • 6
    • 85020797914 scopus 로고    scopus 로고
    • Demir, S. S., Clark, J. W., Murphey, C. R. & Giles, W. R. 1994 A mathematical model of a rabbit sinoatrial node cell. Am. J. Physiol. Cell Physiol. 266, C832-C852. Diercks, D. B., Shumaik, G. M., Harrigan, R. A., Brady, W. J. & Chan, T. C. 2004 Electrocardiographic manifestations: electrolyte abnormalities. J. Emerg. Med. 27, 153-160. (doi:10.1016/j.jemermed.2004.04.006)
    • Demir, S. S., Clark, J. W., Murphey, C. R. & Giles, W. R. 1994 A mathematical model of a rabbit sinoatrial node cell. Am. J. Physiol. Cell Physiol. 266, C832-C852. Diercks, D. B., Shumaik, G. M., Harrigan, R. A., Brady, W. J. & Chan, T. C. 2004 Electrocardiographic manifestations: electrolyte abnormalities. J. Emerg. Med. 27, 153-160. (doi:10.1016/j.jemermed.2004.04.006)
  • 7
    • 0022422465 scopus 로고
    • A model of cardiac electrical activity incorporating ionic pumps and concentration changes
    • doi:10.1098/rstb.1985.0001
    • DiFrancesco, D. & Noble, D. 1985 A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Phil. Trans. R. Soc. Lond. B 307, 353-398. (doi:10.1098/rstb.1985.0001)
    • (1985) Phil. Trans. R. Soc. Lond. B , vol.307 , pp. 353-398
    • DiFrancesco, D.1    Noble, D.2
  • 8
    • 0030573811 scopus 로고    scopus 로고
    • Vagal control of sinoatrial rhythm: A mathematical model
    • doi:10.1006/jtbi.1996.0141
    • Dokos, S., Celler, B. G. & Lovell, N. H. 1996 Vagal control of sinoatrial rhythm: a mathematical model. J. Theor. Biol. 182, 21-44. (doi:10.1006/jtbi.1996.0141)
    • (1996) J. Theor. Biol , vol.182 , pp. 21-44
    • Dokos, S.1    Celler, B.G.2    Lovell, N.H.3
  • 9
    • 0034026881 scopus 로고    scopus 로고
    • +](i) overloaded cardiac myocytes: A simulation study
    • doi:10.1016/S0006-3495(00)76783-X
    • +](i) overloaded cardiac myocytes: a simulation study. Biophys. J. 78, 2392-2404. (doi:10.1016/S0006-3495(00)76783-X)
    • (2000) Biophys. J , vol.78 , pp. 2392-2404
    • Faber, G.M.1    Rudy, Y.2
  • 10
    • 0034828762 scopus 로고    scopus 로고
    • Hypocalcaemic cardiomyopathy; the relationship between myocardial damage, left ventricular function, calcium and ECG changes in a patient with idiopathic hypocalcaemia
    • doi:10.1016/S1388-9842(01)00125-8
    • Fisher, N. G., Armitage, A., McGonigle, R. J. & Gilbert, T. J. 2001 Hypocalcaemic cardiomyopathy; the relationship between myocardial damage, left ventricular function, calcium and ECG changes in a patient with idiopathic hypocalcaemia. Eur. J. Heart Fail. 3, 373-376. (doi:10.1016/S1388-9842(01)00125-8)
    • (2001) Eur. J. Heart Fail , vol.3 , pp. 373-376
    • Fisher, N.G.1    Armitage, A.2    McGonigle, R.J.3    Gilbert, T.J.4
  • 11
    • 0000450921 scopus 로고
    • Thresholds and plateaus in the Hodgkin-Huxley nerve equations
    • doi:10.1085/jgp.43.5. 867
    • Fitzhugh, R. 1960 Thresholds and plateaus in the Hodgkin-Huxley nerve equations. J. Gen. Physiol. 43, 867-896. (doi:10.1085/jgp.43.5. 867)
    • (1960) J. Gen. Physiol , vol.43 , pp. 867-896
    • Fitzhugh, R.1
  • 14
    • 0142042332 scopus 로고    scopus 로고
    • Dynamic QT interval analysis in uraemic patients receiving chronic haemodialysis
    • doi:10.1097/00004872-200310000-00020
    • Genovesi, S. et al. 2003 Dynamic QT interval analysis in uraemic patients receiving chronic haemodialysis. J. Hypertens. 21, 1921-1926. (doi:10.1097/00004872-200310000-00020)
    • (2003) J. Hypertens , vol.21 , pp. 1921-1926
    • Genovesi, S.1
  • 16
    • 50049095303 scopus 로고    scopus 로고
    • Preclinical Torsades-de-Pointes screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk
    • doi:10.1016/j.pharmthera. 2008.04.010
    • Gintant, G. A. 2008 Preclinical Torsades-de-Pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk. Pharmacol. Ther. 119, 199-209. (doi:10.1016/j.pharmthera. 2008.04.010)
    • (2008) Pharmacol. Ther , vol.119 , pp. 199-209
    • Gintant, G.A.1
  • 17
    • 0022647324 scopus 로고
    • Analytical reviews in clinical biochemistry: Calcium measurement
    • Gosling, P. 1986 Analytical reviews in clinical biochemistry: calcium measurement. Ann. Clin. Biochem. 23(Pt 2), 146-156.
    • (1986) Ann. Clin. Biochem , vol.23 , Issue.PART 2 , pp. 146-156
    • Gosling, P.1
  • 19
    • 33646128234 scopus 로고    scopus 로고
    • Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte
    • doi:10.1529/ biophysj.105.065169
    • Greenstein, J. L., Hinch, R. & Winslow, R. L. 2006 Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophys. J. 90, 77-91. (doi:10.1529/ biophysj.105.065169)
    • (2006) Biophys. J , vol.90 , pp. 77-91
    • Greenstein, J.L.1    Hinch, R.2    Winslow, R.L.3
  • 21
    • 0003244449 scopus 로고
    • Effect of several cations on transmembrane potentials of cardiac muscle
    • Hoffman, B. F. & Suckling, E. E. 1956 Effect of several cations on transmembrane potentials of cardiac muscle. Am. J. Physiol. 186, 317-324.
    • (1956) Am. J. Physiol , vol.186 , pp. 317-324
    • Hoffman, B.F.1    Suckling, E.E.2
  • 22
    • 0033928141 scopus 로고    scopus 로고
    • Corrected QT interval (QTc) prolongation and syncope associated with pseudohypoparathyroidism and hypocalcemia
    • doi:10.1067/mpd.2000.103447
    • Huang, T. C., Cecchin, F. C., Mahoney, P. & Portman, M. A. 2000 Corrected QT interval (QTc) prolongation and syncope associated with pseudohypoparathyroidism and hypocalcemia. J. Pediatr. 136, 404-407. (doi:10.1067/mpd.2000.103447)
    • (2000) J. Pediatr , vol.136 , pp. 404-407
    • Huang, T.C.1    Cecchin, F.C.2    Mahoney, P.3    Portman, M.A.4
  • 23
    • 4444320725 scopus 로고    scopus 로고
    • A computational model of the human left-ventricular epicardial myocyte
    • doi:10.1529/biophysj.104.043299
    • Iyer, V., Mazhari, R. & Winslow, R. L. 2004 A computational model of the human left-ventricular epicardial myocyte. Biophys. J. 87, 1507-1525. (doi:10.1529/biophysj.104.043299)
    • (2004) Biophys. J , vol.87 , pp. 1507-1525
    • Iyer, V.1    Mazhari, R.2    Winslow, R.L.3
  • 24
    • 0031594597 scopus 로고    scopus 로고
    • 2+ dynamics: The roles of ryanodine receptor adaptation and sarcoplasmic reticulum load
    • doi:10.1016/ S0006-3495(98)77832-4
    • 2+ dynamics: the roles of ryanodine receptor adaptation and sarcoplasmic reticulum load. Biophys. J. 74, 1149-1168. (doi:10.1016/ S0006-3495(98)77832-4)
    • (1998) Biophys. J , vol.74 , pp. 1149-1168
    • Jafri, M.S.1    Rice, J.J.2    Winslow, R.L.3
  • 25
    • 0015162306 scopus 로고
    • Heart: Excitation and contraction
    • doi:10.1146/ annurev.ph.33.030171.002403
    • Johnson, E. A. & Lieberman, M. 1971 Heart: excitation and contraction. Annu. Rev. Physiol. 33, 479-532. (doi:10.1146/ annurev.ph.33.030171.002403)
    • (1971) Annu. Rev. Physiol , vol.33 , pp. 479-532
    • Johnson, E.A.1    Lieberman, M.2
  • 26
    • 0017069570 scopus 로고
    • Control of action potential duration by calcium ions in cardiac Purkinje fibers
    • doi:10.1085/jgp.67.5.599
    • Kass, R. S. & Tsien, R. W. 1976 Control of action potential duration by calcium ions in cardiac Purkinje fibers. J. Gen. Physiol. 67, 599-617. (doi:10.1085/jgp.67.5.599)
    • (1976) J. Gen. Physiol , vol.67 , pp. 599-617
    • Kass, R.S.1    Tsien, R.W.2
  • 27
    • 0036838501 scopus 로고    scopus 로고
    • Dynamical description of sinoatrial node pacemaking: Improved mathematical model for primary pacemaker cell
    • Kurata, Y., Hisatome, I., Imanishi, S. & Shibamoto, T. 2002 Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell. Am. J. Physiol. Heart Circ. Physiol. 283, H2074-H2101.
    • (2002) Am. J. Physiol. Heart Circ. Physiol , vol.283
    • Kurata, Y.1    Hisatome, I.2    Imanishi, S.3    Shibamoto, T.4
  • 28
    • 75949134135 scopus 로고
    • Net cation equivalency ('base binding power') of the plasma proteins
    • Leeuwen, A. M. 1964 Net cation equivalency ('base binding power') of the plasma proteins. Acta Med. Scand. 176(Suppl.), 422.
    • (1964) Acta Med. Scand , vol.176 , Issue.SUPPL. , pp. 422
    • Leeuwen, A.M.1
  • 29
    • 0029996461 scopus 로고    scopus 로고
    • Effect of raised extracellular calcium on characteristics of the guinea-pig ventricular action potential
    • doi:10.1006/jmcc. 1996.0050
    • Leitch, S. P. & Brown, H. F. 1996 Effect of raised extracellular calcium on characteristics of the guinea-pig ventricular action potential. J. Mol. Cell. Cardiol. 28, 541-551. (doi:10.1006/jmcc. 1996.0050)
    • (1996) J. Mol. Cell. Cardiol , vol.28 , pp. 541-551
    • Leitch, S.P.1    Brown, H.F.2
  • 31
    • 0032401951 scopus 로고    scopus 로고
    • Control of L-type calcium current during the action potential of guinea-pig ventricular myocytes
    • doi:10.1111/j.1469-7793. 1998.425bb.x
    • Linz, K. W. & Meyer, R. 1998 Control of L-type calcium current during the action potential of guinea-pig ventricular myocytes. J. Physiol. (Lond.) 513, 425-442. (doi:10.1111/j.1469-7793. 1998.425bb.x)
    • (1998) J. Physiol. (Lond.) , vol.513 , pp. 425-442
    • Linz, K.W.1    Meyer, R.2
  • 32
    • 0034012462 scopus 로고    scopus 로고
    • Profile and kinetics of L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits
    • doi:10.1007/s004240050982
    • Linz, K. W. & Meyer, R. 2000 Profile and kinetics of L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits. Pflufgers Arch. Eur. J. Physiol. 439, 588-599. (doi:10.1007/s004240050982)
    • (2000) Pflufgers Arch. Eur. J. Physiol , vol.439 , pp. 588-599
    • Linz, K.W.1    Meyer, R.2
  • 33
    • 3242784826 scopus 로고    scopus 로고
    • Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes
    • doi:10.1016/j.cardiores. 2004.03.004
    • Lonardo, G. et al. 2004 Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes. Cardiovasc. Res. 63, 528-536. (doi:10.1016/j.cardiores. 2004.03.004)
    • (2004) Cardiovasc. Res , vol.63 , pp. 528-536
    • Lonardo, G.1
  • 34
    • 0028233422 scopus 로고
    • A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes
    • Luo, C. H. & Rudy, Y. 1994 A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes. Circ. Res. 74, 1071-1096.
    • (1994) Circ. Res , vol.74 , pp. 1071-1096
    • Luo, C.H.1    Rudy, Y.2
  • 35
    • 38349013614 scopus 로고    scopus 로고
    • A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates
    • doi:10.1529/biophysj.106.98160
    • Mahajan, A. et al. 2008 A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys. J. 94, 392-410. (doi:10.1529/biophysj.106.98160)
    • (2008) Biophys. J , vol.94 , pp. 392-410
    • Mahajan, A.1
  • 36
    • 0041742200 scopus 로고    scopus 로고
    • Role of individual ionic current systems in ventricular cells hypothesized by a model study
    • doi:10. 2170/jjphysiol.53. 105
    • Matsuoka, S., Sarai, N., Kuratomi, S., Ono, K. & Noma, A. 2003 Role of individual ionic current systems in ventricular cells hypothesized by a model study. Jpn J. Physiol. 53, 105-123. (doi:10. 2170/jjphysiol.53. 105)
    • (2003) Jpn J. Physiol , vol.53 , pp. 105-123
    • Matsuoka, S.1    Sarai, N.2    Kuratomi, S.3    Ono, K.4    Noma, A.5
  • 37
    • 0033624766 scopus 로고    scopus 로고
    • QTc dispersion increases during hemodialysis with low-calcium dialysate
    • doi:10.1046/j.1523-1755.2000.00062.x
    • Nappi, S. E., Virtanen, V. K., Saha, H. H. T., Mustonen, J. T. & Pasternack, A. I. 2000 QTc dispersion increases during hemodialysis with low-calcium dialysate. Kidney Int. 57, 2117-2122. (doi:10.1046/j.1523-1755.2000.00062.x)
    • (2000) Kidney Int , vol.57 , pp. 2117-2122
    • Nappi, S.E.1    Virtanen, V.K.2    Saha, H.H.T.3    Mustonen, J.T.4    Pasternack, A.I.5
  • 38
    • 0013905462 scopus 로고
    • The dual effect of calcium on the action potential of the frog's heart
    • Niedergerke, R. & Orkand, R. K. 1966 The dual effect of calcium on the action potential of the frog's heart. J. Physiol. 184, 291-311.
    • (1966) J. Physiol , vol.184 , pp. 291-311
    • Niedergerke, R.1    Orkand, R.K.2
  • 39
    • 73849164199 scopus 로고
    • A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pace-maker potentials
    • Noble, D. 1962 A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pace-maker potentials. J. Physiol. (Lond.) 160, 317-352.
    • (1962) J. Physiol. (Lond.) , vol.160 , pp. 317-352
    • Noble, D.1
  • 40
    • 0021226282 scopus 로고
    • A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations
    • doi:10.1098/ rspb.1984.0065
    • Noble, D. & Noble, S. J. 1984 A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations. Proc. R. Soc. Lond. B 222, 295-304. (doi:10.1098/ rspb.1984.0065)
    • (1984) Proc. R. Soc. Lond. B , vol.222 , pp. 295-304
    • Noble, D.1    Noble, S.J.2
  • 42
    • 0040909217 scopus 로고
    • Heart action potential: Dependence on external calcium and sodium ions
    • doi:10.1126/science.146.3648.1176
    • Orkand, R. K. & Niedergerke, R. 1964 Heart action potential: dependence on external calcium and sodium ions. Science 146, 1176-1177. (doi:10.1126/science.146.3648.1176)
    • (1964) Science , vol.146 , pp. 1176-1177
    • Orkand, R.K.1    Niedergerke, R.2
  • 43
    • 50449134799 scopus 로고
    • Proposal of a new method of treating the blue epidemic cholera by the injection of highly-oxygenated salts into the venous system
    • doi:10.1016/ S0140-6736(02)94163-2
    • O'Shaughnessy, W. 1831 Proposal of a new method of treating the blue epidemic cholera by the injection of highly-oxygenated salts into the venous system. Lancet 17, 366-371. (doi:10.1016/ S0140-6736(02)94163-2)
    • (1831) Lancet , vol.17 , pp. 366-371
    • O'Shaughnessy, W.1
  • 44
    • 0035200488 scopus 로고    scopus 로고
    • A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes
    • doi:10.1016/S0006-3495(01)75943-7
    • Pandit, S. V., Clark, R. B., Giles, W. R. & Demir, S. S. 2001 A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes. Biophys. J. 81, 3029-3051. (doi:10.1016/S0006-3495(01)75943-7)
    • (2001) Biophys. J , vol.81 , pp. 3029-3051
    • Pandit, S.V.1    Clark, R.B.2    Giles, W.R.3    Demir, S.S.4
  • 45
    • 0033084193 scopus 로고    scopus 로고
    • 2+-dependent inactivation of L-type calcium channels
    • doi:10.1016/ S0896-6273(00)80709-6
    • 2+-dependent inactivation of L-type calcium channels. Neuron 22, 549-558. (doi:10.1016/ S0896-6273(00)80709-6)
    • (1999) Neuron , vol.22 , pp. 549-558
    • Peterson, B.Z.1    DeMaria, C.D.2    Adelman, J.P.3    Yue, D.T.4
  • 47
    • 0032216690 scopus 로고    scopus 로고
    • Effect of 5-HT4 receptor stimulation on the pacemaker current If in human isolated atrial myocytes
    • doi:10.1016/S0008- 6363(98)00198-9
    • Pino, R., Cerbai, E., Calamai, G., Alajmo, F., Borgioli, A., Braconi, L., Cassai, M., Montesi, G. F. & Mugelli, A. 1998 Effect of 5-HT4 receptor stimulation on the pacemaker current If in human isolated atrial myocytes. Cardiovasc. Res. 40, 516-522. (doi:10.1016/S0008- 6363(98)00198-9)
    • (1998) Cardiovasc. Res , vol.40 , pp. 516-522
    • Pino, R.1    Cerbai, E.2    Calamai, G.3    Alajmo, F.4    Borgioli, A.5    Braconi, L.6    Cassai, M.7    Montesi, G.F.8    Mugelli, A.9
  • 48
    • 0032526920 scopus 로고    scopus 로고
    • Simulation study of cellular electric properties in heart failure
    • Priebe, L. & Beuckelmann, D. J. 1998 Simulation study of cellular electric properties in heart failure. Circ. Res. 82, 1206-1223.
    • (1998) Circ. Res , vol.82 , pp. 1206-1223
    • Priebe, L.1    Beuckelmann, D.J.2
  • 49
    • 0014127686 scopus 로고
    • The dependence of slow inward current in Purkinje fibres on the extracellular calcium-concentration
    • Reuter, H. 1967 The dependence of slow inward current in Purkinje fibres on the extracellular calcium-concentration. J. Physiol. 192, 479-492.
    • (1967) J. Physiol , vol.192 , pp. 479-492
    • Reuter, H.1
  • 50
    • 84944811856 scopus 로고
    • A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart
    • Ringer, S. 1883 A further contribution regarding the influence of the different constituents of the blood on the contraction of the heart. J. Physiol. (Lond.) 4, 29-42.
    • (1883) J. Physiol. (Lond.) , vol.4 , pp. 29-42
    • Ringer, S.1
  • 51
    • 0033760508 scopus 로고    scopus 로고
    • Dietary calcium and phosphate restriction in guinea-pigs during pregnancy: Fetal mineralization induces maternal hypocalcaemia despite increased 1a,25-dihydroxycholecalciferol concentrations
    • Rummens, K., Van Herck, E., van Bree, R., Bouillon, R., Van Assche, F. A. & Verhaeghe, J. 2000 Dietary calcium and phosphate restriction in guinea-pigs during pregnancy: fetal mineralization induces maternal hypocalcaemia despite increased 1a,25-dihydroxycholecalciferol concentrations. Br. J. Nutr. 84, 495-504.
    • (2000) Br. J. Nutr , vol.84 , pp. 495-504
    • Rummens, K.1    Van Herck, E.2    van Bree, R.3    Bouillon, R.4    Van Assche, F.A.5    Verhaeghe, J.6
  • 52
    • 42949178645 scopus 로고    scopus 로고
    • Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: In vivo and in silicoanalysis
    • doi:10.1093/ndt/gfm765
    • Severi, S., Grandi, E., Pes, C., Badiali, F., Grandi, F. & Santoro, A. 2008 Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: in vivo and in silicoanalysis. Nephrol. Dial. Transplant. 23, 1378-1386. (doi:10.1093/ndt/gfm765)
    • (2008) Nephrol. Dial. Transplant , vol.23 , pp. 1378-1386
    • Severi, S.1    Grandi, E.2    Pes, C.3    Badiali, F.4    Grandi, F.5    Santoro, A.6
  • 53
    • 0030621841 scopus 로고    scopus 로고
    • The MATLAB ODE suite
    • doi:10.1137/S1064827594276424
    • Shampine, L. F. & Reichelt, M. W. 1997 The MATLAB ODE suite. SIAM J. Sci. Comput. 18, 1-22. (doi:10.1137/S1064827594276424)
    • (1997) SIAM J. Sci. Comput , vol.18 , pp. 1-22
    • Shampine, L.F.1    Reichelt, M.W.2
  • 54
    • 16344373083 scopus 로고    scopus 로고
    • A mathematical treatment of integrated Ca dynamics within the ventricular myocyte
    • doi:10. 1529/biophysj.104. 047449
    • Shannon, T. R., Wang, F., Puglisi, J., Weber, C. & Bers, D. M. 2004 A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys. J. 87, 3351-3371. (doi:10. 1529/biophysj.104. 047449)
    • (2004) Biophys. J , vol.87 , pp. 3351-3371
    • Shannon, T.R.1    Wang, F.2    Puglisi, J.3    Weber, C.4    Bers, D.M.5
  • 55
    • 0026733599 scopus 로고
    • Theory of excitation-contraction coupling in cardiac muscle
    • doi:10.1016/S0006-3495(92)81615- 6
    • Stern, M. D. 1992 Theory of excitation-contraction coupling in cardiac muscle. Biophys. J. 63, 497-517. (doi:10.1016/S0006-3495(92)81615- 6)
    • (1992) Biophys. J , vol.63 , pp. 497-517
    • Stern, M.D.1
  • 56
    • 0003070292 scopus 로고
    • The interrelationship of electrolyte abnormalities and arrhythmias
    • ed. W. J. Mandel, pp, Philadelphia, PA: J. P. Lippincott
    • Surackwicz, B. 1995 The interrelationship of electrolyte abnormalities and arrhythmias. In Cardiac arrhythmias. Their mechanisms, diagnosis & management (ed. W. J. Mandel), pp. 89-108. Philadelphia, PA: J. P. Lippincott.
    • (1995) Cardiac arrhythmias. Their mechanisms, diagnosis & management , pp. 89-108
    • Surackwicz, B.1
  • 57
    • 45449100752 scopus 로고    scopus 로고
    • 2+ channel
    • doi:10.1016/j.cell.2008. 05.025
    • 2+ channel. Cell 133, 1228-1240. (doi:10.1016/j.cell.2008. 05.025)
    • (2008) Cell , vol.133 , pp. 1228-1240
    • Tadross, M.R.1    Dick, I.E.2    Yue, D.T.3
  • 58
    • 0014049290 scopus 로고
    • Effect of calcium concentration on the transmembrane potentials of Purkinje fibers
    • Temte, J. V. & Davis, L. D. 1967 Effect of calcium concentration on the transmembrane potentials of Purkinje fibers. Circ. Res. 20, 32-44.
    • (1967) Circ. Res , vol.20 , pp. 32-44
    • Temte, J.V.1    Davis, L.D.2
  • 59
    • 33748419943 scopus 로고    scopus 로고
    • Alternans and spiral breakup in a human ventricular tissue model
    • doi:10.1152/ ajpheart.00109.2006
    • Ten Tusscher, K. H. W. J. & Panfilov, A. V. 2006 Alternans and spiral breakup in a human ventricular tissue model. Am. J. Physiol. Heart Circ. Physiol. 291, H1088-H1100. (doi:10.1152/ ajpheart.00109.2006)
    • (2006) Am. J. Physiol. Heart Circ. Physiol , vol.291
    • Ten Tusscher, K.H.W.J.1    Panfilov, A.V.2
  • 62
    • 34547125323 scopus 로고    scopus 로고
    • Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model
    • doi:10.1152/ajpheart.01083.2006
    • Tsujimae, K., Suzuki, S., Murakami, S. & Kurachi, Y. 2007 Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model. Am. J. Physiol. Heart Circ. Physiol. 293, H660-H669. (doi:10.1152/ajpheart.01083.2006)
    • (2007) Am. J. Physiol. Heart Circ. Physiol , vol.293
    • Tsujimae, K.1    Suzuki, S.2    Murakami, S.3    Kurachi, Y.4
  • 63
    • 39149106142 scopus 로고    scopus 로고
    • In silico study on the effects of IKur block kinetics on prolongation of human action potential after atrial fibrillation-induced electrical remodeling
    • doi:10.1152/ajpheart. 01229.2007
    • Tsujimae, K., Murakami, S. & Kurachi, Y. 2008 In silico study on the effects of IKur block kinetics on prolongation of human action potential after atrial fibrillation-induced electrical remodeling. Am. J. Physiol. Heart Circ. Physiol. 294, H793-H800. (doi:10.1152/ajpheart. 01229.2007)
    • (2008) Am. J. Physiol. Heart Circ. Physiol , vol.294
    • Tsujimae, K.1    Murakami, S.2    Kurachi, Y.3
  • 64
    • 0346130995 scopus 로고
    • The microelectrode and the heart
    • eds F. Kao, K. Koizumi & M. Vassalle, pp, Bologna, Italy: Gaggi Publisher
    • Weidmann, S. 1971 The microelectrode and the heart. In Research in physiology (eds F. Kao, K. Koizumi & M. Vassalle), pp. 3-24. Bologna, Italy: Gaggi Publisher.
    • (1971) Research in physiology , pp. 3-24
    • Weidmann, S.1
  • 65
    • 0033583266 scopus 로고    scopus 로고
    • Winslow, R. L., Rice, J., Jafri, S., Marban, E. & O'Rourke, B. 1999 Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ. Res. 84, 571-586.
    • Winslow, R. L., Rice, J., Jafri, S., Marban, E. & O'Rourke, B. 1999 Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies. Circ. Res. 84, 571-586.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.