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Volumn 4, Issue 7, 2009, Pages

Synergy between proteasome inhibitors and imatinib mesylate in chronic myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; BETA CATENIN; BORTEZOMIB; BRUTON TYROSINE KINASE; CASPASE; CYTOCHROME C; IMATINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEASOME INHIBITOR; TRANSCRIPTION FACTOR E2F1; ANTINEOPLASTIC AGENT; PIPERAZINE DERIVATIVE; PROTEASOME; PROTEINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

EID: 67650888562     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006257     Document Type: Article
Times cited : (42)

References (71)
  • 1
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia
    • Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, et al. (2001) Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia. N Engl J Med 344: 1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3    Peng, B.4    Buchdunger, E.5
  • 2
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia
    • O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, et al. (2003) Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia. N Engl J Med 348: 994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3    Gathmann, I.4    Baccarani, M.5
  • 3
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, et al. (2006) Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N Engl J Med 355: 2408-2417.
    • (2006) N Engl J Med , vol.355 , pp. 2408-2417
    • Druker, B.J.1    Guilhot, F.2    O'Brien, S.G.3    Gathmann, I.4    Kantarjian, H.5
  • 4
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, et al. (2001) Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome. N Engl J Med 344: 1038-1042.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3    Resta, D.J.4    Reese, S.F.5
  • 5
    • 0037459344 scopus 로고    scopus 로고
    • Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
    • Azam M, Latek RR, Daley GQ (2003) Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell 112: 831-843.
    • (2003) Cell , vol.112 , pp. 831-843
    • Azam, M.1    Latek, R.R.2    Daley, G.Q.3
  • 6
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, Gorre ME, Paquette RL, et al. (2002) Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2: 117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3    Gorre, M.E.4    Paquette, R.L.5
  • 7
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, et al. (2001) Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293: 876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5
  • 8
    • 0037438640 scopus 로고    scopus 로고
    • BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
    • Donato NJ, Wu JY, Stapley J, Gallick G, Lin H, et al. (2003) BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 101: 690-698.
    • (2003) Blood , vol.101 , pp. 690-698
    • Donato, N.J.1    Wu, J.Y.2    Stapley, J.3    Gallick, G.4    Lin, H.5
  • 9
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H, Sawyers C, Hochhaus A, Guilhot F, Schiffer C, et al. (2002) Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med 346: 645-652.
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3    Guilhot, F.4    Schiffer, C.5
  • 10
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E, Goldman JM, Miller CB, et al. (2002) Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood 99: 3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3    Goldman, J.M.4    Miller, C.B.5
  • 11
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ, Goldman JM, Gambacorti-Passerini C, et al. (2002) Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood 99: 1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3    Goldman, J.M.4    Gambacorti-Passerini, C.5
  • 12
    • 34247480545 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
    • Force T, Krause DS, Van Etten RA (2007) Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer 7: 332-344.
    • (2007) Nat Rev Cancer , vol.7 , pp. 332-344
    • Force, T.1    Krause, D.S.2    Van Etten, R.A.3
  • 13
    • 33749256415 scopus 로고    scopus 로고
    • BNP as a marker of the heart failure in the treatment of imatinib mesylate
    • Park YH, Park HJ, Kim BS, Ha E, Jung KH, et al. (2006) BNP as a marker of the heart failure in the treatment of imatinib mesylate. Cancer Lett 243: 16-22.
    • (2006) Cancer Lett , vol.243 , pp. 16-22
    • Park, Y.H.1    Park, H.J.2    Kim, B.S.3    Ha, E.4    Jung, K.H.5
  • 14
    • 33746845181 scopus 로고    scopus 로고
    • Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
    • Kerkela R, Grazette L, Yacobi R, Iliescu C, Patten R, et al. (2006) Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 12: 908-916.
    • (2006) Nat Med , vol.12 , pp. 908-916
    • Kerkela, R.1    Grazette, L.2    Yacobi, R.3    Iliescu, C.4    Patten, R.5
  • 15
    • 33746646032 scopus 로고    scopus 로고
    • The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway
    • Noren NK, Foos G, Hauser CA, Pasquale EB (2006) The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 8: 815-825.
    • (2006) Nat Cell Biol , vol.8 , pp. 815-825
    • Noren, N.K.1    Foos, G.2    Hauser, C.A.3    Pasquale, E.B.4
  • 16
    • 11244309014 scopus 로고    scopus 로고
    • Proteolysis: From the lysosome to ubiquitin and the proteasome
    • Ciechanover A (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6: 79-87.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 79-87
    • Ciechanover, A.1
  • 17
  • 18
    • 0028148227 scopus 로고
    • A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
    • Traenckner EB, Wilk S, Baeuerle PA (1994) A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B. EMBO J 13: 5433-5441.
    • (1994) EMBO J , vol.13 , pp. 5433-5441
    • Traenckner, E.B.1    Wilk, S.2    Baeuerle, P.A.3
  • 21
    • 28544438389 scopus 로고    scopus 로고
    • Sensitivity of human multiple myelomas and myeloid leukemias to the proteasome inhibitor I
    • Servida F, Soligo D, Delia D, Henderson C, Brancolini C, et al. (2005) Sensitivity of human multiple myelomas and myeloid leukemias to the proteasome inhibitor I. Leukemia 19: 2324-2331.
    • (2005) Leukemia , vol.19 , pp. 2324-2331
    • Servida, F.1    Soligo, D.2    Delia, D.3    Henderson, C.4    Brancolini, C.5
  • 22
    • 0035000515 scopus 로고    scopus 로고
    • The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI
    • Soligo D, Servida F, Delia D, Fontanella E, Lamorte G, et al. (2001) The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSI. Br J Haematol 113: 126-135.
    • (2001) Br J Haematol , vol.113 , pp. 126-135
    • Soligo, D.1    Servida, F.2    Delia, D.3    Fontanella, E.4    Lamorte, G.5
  • 23
    • 0242493856 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571
    • Yu C, Rahmani M, Conrad D, Subler M, Dent P, et al. (2003) The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571. Blood 102: 3765-3774.
    • (2003) Blood , vol.102 , pp. 3765-3774
    • Yu, C.1    Rahmani, M.2    Conrad, D.3    Subler, M.4    Dent, P.5
  • 24
    • 3142554015 scopus 로고    scopus 로고
    • Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/ Abl-dependent and -independent mechanisms
    • Dai Y, Rahmani M, Pei XY, Dent P, Grant S (2004) Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/ Abl-dependent and -independent mechanisms. Blood 104: 509-518.
    • (2004) Blood , vol.104 , pp. 509-518
    • Dai, Y.1    Rahmani, M.2    Pei, X.Y.3    Dent, P.4    Grant, S.5
  • 25
    • 0141761420 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/ Abl-positive cell lines sensitive and resistant to imatinib mesylate
    • Gatto S, Scappini B, Pham L, Onida F, Milella M, et al. (2003) The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/ Abl-positive cell lines sensitive and resistant to imatinib mesylate. Haematologica 88: 853-863.
    • (2003) Haematologica , vol.88 , pp. 853-863
    • Gatto, S.1    Scappini, B.2    Pham, L.3    Onida, F.4    Milella, M.5
  • 26
    • 0032923624 scopus 로고    scopus 로고
    • Proteasome inhibition leads to significant reduction of Bcr-Abl expression and subsequent induction of apoptosis in K562 human chronic myelogenous leukemia cells
    • Dou QP, McGuire TF, Peng Y, An B (1999) Proteasome inhibition leads to significant reduction of Bcr-Abl expression and subsequent induction of apoptosis in K562 human chronic myelogenous leukemia cells. J Pharmacol Exp Ther 289: 781-790.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 781-790
    • Dou, Q.P.1    McGuire, T.F.2    Peng, Y.3    An, B.4
  • 27
    • 0032533620 scopus 로고    scopus 로고
    • Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: A novel model for chronic myelogenous leukemia
    • Zhang X, Ren R (1998) Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia. Blood 92: 3829-3840.
    • (1998) Blood , vol.92 , pp. 3829-3840
    • Zhang, X.1    Ren, R.2
  • 28
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Buchdunger E, Zimmermann J, Mett H, Meyer T, Muller M, et al. (1996) Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res 56: 100-104.
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Buchdunger, E.1    Zimmermann, J.2    Mett, H.3    Meyer, T.4    Muller, M.5
  • 29
    • 0033585504 scopus 로고    scopus 로고
    • In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor
    • le Coutre P, Mologni L, Cleris L, Marchesi E, Buchdunger E, et al. (1999) In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor. J Natl Cancer Inst 91: 163-168.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 163-168
    • le Coutre, P.1    Mologni, L.2    Cleris, L.3    Marchesi, E.4    Buchdunger, E.5
  • 30
    • 0036735298 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
    • LeBlanc R, Catley LP, Hideshima T, Lentzsch S, Mitsiades CS, et al. (2002) Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 62: 4996-5000.
    • (2002) Cancer Res , vol.62 , pp. 4996-5000
    • LeBlanc, R.1    Catley, L.P.2    Hideshima, T.3    Lentzsch, S.4    Mitsiades, C.S.5
  • 31
    • 34147131374 scopus 로고    scopus 로고
    • Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo
    • Zhou GB, Kang H, Wang L, Gao L, Liu P, et al. (2007) Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo. Blood 109: 3441-3450.
    • (2007) Blood , vol.109 , pp. 3441-3450
    • Zhou, G.B.1    Kang, H.2    Wang, L.3    Gao, L.4    Liu, P.5
  • 32
    • 10344225622 scopus 로고    scopus 로고
    • Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein
    • Yin T, Wu YL, Sun HP, Sun GL, Du YZ, et al. (2004) Combined effects of As4S4 and imatinib on chronic myeloid leukemia cells and BCR-ABL oncoprotein. Blood 104: 4219-4225.
    • (2004) Blood , vol.104 , pp. 4219-4225
    • Yin, T.1    Wu, Y.L.2    Sun, H.P.3    Sun4    GL, D.Y.5
  • 33
    • 0035080416 scopus 로고    scopus 로고
    • Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells
    • Topaly J, Zeller WJ, Fruehauf S (2001) Synergistic activity of the new ABL-specific tyrosine kinase inhibitor STI571 and chemotherapeutic drugs on BCR-ABL-positive chronic myelogenous leukemia cells. Leukemia 15: 342-347.
    • (2001) Leukemia , vol.15 , pp. 342-347
    • Topaly, J.1    Zeller, W.J.2    Fruehauf, S.3
  • 34
    • 0019882480 scopus 로고
    • Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors
    • Chou TC, Talalay P (1981) Generalized equations for the analysis of inhibitions of Michaelis-Menten and higher-order kinetic systems with two or more mutually exclusive and nonexclusive inhibitors. Eur J Biochem 115: 207-216.
    • (1981) Eur J Biochem , vol.115 , pp. 207-216
    • Chou, T.C.1    Talalay, P.2
  • 35
    • 27644569730 scopus 로고    scopus 로고
    • The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein
    • Neviani P, Santhanam R, Trotta R, Notari M, Blaser BW, et al. (2005) The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein. Cancer Cell 8: 355-368.
    • (2005) Cancer Cell , vol.8 , pp. 355-368
    • Neviani, P.1    Santhanam, R.2    Trotta, R.3    Notari, M.4    Blaser, B.W.5
  • 36
    • 33646406554 scopus 로고    scopus 로고
    • Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine", is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    • Yang H, Chen D, Cui QC, Yuan X, Dou QP (2006) Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine", is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res 66: 4758-4765.
    • (2006) Cancer Res , vol.66 , pp. 4758-4765
    • Yang, H.1    Chen, D.2    Cui, Q.C.3    Yuan, X.4    Dou, Q.P.5
  • 37
    • 27644562277 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
    • Chauhan D, Catley L, Li G, Podar K, Hideshima T, et al. (2005) A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib. Cancer Cell 8: 407-419.
    • (2005) Cancer Cell , vol.8 , pp. 407-419
    • Chauhan, D.1    Catley, L.2    Li, G.3    Podar, K.4    Hideshima, T.5
  • 38
    • 33845532759 scopus 로고    scopus 로고
    • Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells
    • Kraus M, Ruckrich T, Reich M, Gogel J, Beck A, et al. (2007) Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia 21: 84-92.
    • (2007) Leukemia , vol.21 , pp. 84-92
    • Kraus, M.1    Ruckrich, T.2    Reich, M.3    Gogel, J.4    Beck, A.5
  • 39
    • 33947123268 scopus 로고    scopus 로고
    • Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation
    • Coluccia AM, Vacca A, Dunach M, Mologni L, Redaelli S, et al. (2007) Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J 26: 1456-1466.
    • (2007) EMBO J , vol.26 , pp. 1456-1466
    • Coluccia, A.M.1    Vacca, A.2    Dunach, M.3    Mologni, L.4    Redaelli, S.5
  • 40
    • 33846002728 scopus 로고    scopus 로고
    • A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
    • Bonnet S, Archer SL, lalunis-Turner J, Haromy A, Beaulieu C, et al. (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11: 37-51.
    • (2007) Cancer Cell , vol.11 , pp. 37-51
    • Bonnet, S.1    Archer, S.L.2    lalunis-Turner, J.3    Haromy, A.4    Beaulieu, C.5
  • 41
    • 0035968287 scopus 로고    scopus 로고
    • Novel Role for JNK as a Stress-activated Bcl2 Kinase
    • Deng X, Xiao L, Lang W, Gao F, Ruvolo P, et al. (2001) Novel Role for JNK as a Stress-activated Bcl2 Kinase. J Biol Chem 276: 23681-23688.
    • (2001) J Biol Chem , vol.276 , pp. 23681-23688
    • Deng, X.1    Xiao, L.2    Lang, W.3    Gao, F.4    Ruvolo, P.5
  • 42
    • 0036106091 scopus 로고    scopus 로고
    • p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases
    • Di Bacco AM, Cotter TG (2002) p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases. Br J Haematol 117: 588-597.
    • (2002) Br J Haematol , vol.117 , pp. 588-597
    • Di Bacco, A.M.1    Cotter, T.G.2
  • 43
    • 0029080343 scopus 로고
    • Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells
    • Stewart MJ, Litz-Jackson S, Burgess GS, Williamson EA, Leibowitz DS, et al. (1995) Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells. Leukemia 9: 1499-1507.
    • (1995) Leukemia , vol.9 , pp. 1499-1507
    • Stewart, M.J.1    Litz-Jackson, S.2    Burgess, G.S.3    Williamson, E.A.4    Leibowitz, D.S.5
  • 44
    • 0030978351 scopus 로고    scopus 로고
    • beta-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16: 3797-3804.
    • (1997) EMBO J , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 45
    • 0032483439 scopus 로고    scopus 로고
    • Identification of c-MYC as a target of the APC pathway
    • He TC, Sparks AB, Rago C, Hermeking H, Zawel L, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512.
    • (1998) Science , vol.281 , pp. 1509-1512
    • He, T.C.1    Sparks, A.B.2    Rago, C.3    Hermeking, H.4    Zawel, L.5
  • 46
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398: 422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 47
    • 33744489570 scopus 로고    scopus 로고
    • Identification of genes involved in imatinib resistance in CML: A gene-expression profiling approach
    • Villuendas R, Steegmann JL, Pollan M, Tracey L, Granda A, et al. (2006) Identification of genes involved in imatinib resistance in CML: a gene-expression profiling approach. Leukemia 20: 1047-1054.
    • (2006) Leukemia , vol.20 , pp. 1047-1054
    • Villuendas, R.1    Steegmann, J.L.2    Pollan, M.3    Tracey, L.4    Granda, A.5
  • 48
    • 34548097263 scopus 로고    scopus 로고
    • The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib
    • Hantschel O, Rix U, Schmidt U, Burckstummer T, Kneidinger M, et al. (2007) The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. PNAS 104: 13283-13288.
    • (2007) PNAS , vol.104 , pp. 13283-13288
    • Hantschel, O.1    Rix, U.2    Schmidt, U.3    Burckstummer, T.4    Kneidinger, M.5
  • 49
    • 47149085266 scopus 로고    scopus 로고
    • Proteasome dependent auto-regulation of Bruton's tyrosine kinase (Btk) promoter via NF-{kappa}B
    • Yu L, Mohamed AJ, Simonson OE, Vargas L, Blomberg KE, et al. (2008) Proteasome dependent auto-regulation of Bruton's tyrosine kinase (Btk) promoter via NF-{kappa}B. Blood 111: 4617-4626.
    • (2008) Blood , vol.111 , pp. 4617-4626
    • Yu, L.1    Mohamed, A.J.2    Simonson, O.E.3    Vargas, L.4    Blomberg, K.E.5
  • 50
    • 13144305065 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of Rat-1 fibroblasts and promotes differentiation of K562 cells
    • LaMontagne KR Jr., Hannon G, Tonks NK (1998) Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of Rat-1 fibroblasts and promotes differentiation of K562 cells. PNAS 95: 14094-14099.
    • (1998) PNAS , vol.95 , pp. 14094-14099
    • LaMontagne Jr., K.R.1    Hannon, G.2    Tonks, N.K.3
  • 52
    • 0035184651 scopus 로고    scopus 로고
    • MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation
    • Trockenbacher A, Suckow V, Foerster J, Winter J, Krausz S, et al. (2001) MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation. Nat Genet 29: 287-294.
    • (2001) Nat Genet , vol.29 , pp. 287-294
    • Trockenbacher, A.1    Suckow, V.2    Foerster, J.3    Winter, J.4    Krausz, S.5
  • 53
    • 34648832173 scopus 로고    scopus 로고
    • FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia
    • Neviani P, Santhanam R, Oaks JJ, Eiring AM, Notari M, et al. (2007) FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J Clin Invest 117: 2408-2421.
    • (2007) J Clin Invest , vol.117 , pp. 2408-2421
    • Neviani, P.1    Santhanam, R.2    Oaks, J.J.3    Eiring, A.M.4    Notari, M.5
  • 57
    • 33645566250 scopus 로고    scopus 로고
    • Cardiotoxic effects of arsenic trioxide/imatinib mesilate combination in rats
    • Saad SY, Alkharfy KM, Arafah MM (2006) Cardiotoxic effects of arsenic trioxide/imatinib mesilate combination in rats. J Pharm Pharmacol 58: 567-573.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 567-573
    • Saad, S.Y.1    Alkharfy, K.M.2    Arafah, M.M.3
  • 59
    • 10444224552 scopus 로고    scopus 로고
    • Proteasome proteolytic activity in hematopoietic cells from patients with chronic myeloid leukemia and multiple myeloma
    • Magill L, Lynas J, Morris TC, Walker B, Irvine AE (2004) Proteasome proteolytic activity in hematopoietic cells from patients with chronic myeloid leukemia and multiple myeloma. Haematologica 89: 1428-1433.
    • (2004) Haematologica , vol.89 , pp. 1428-1433
    • Magill, L.1    Lynas, J.2    Morris, T.C.3    Walker, B.4    Irvine, A.E.5
  • 60
    • 67650991334 scopus 로고    scopus 로고
    • Heaney N, Pellicano F, Crawford L, Irvine S, Holyoake TL (2007) Bortezomib Has Anti-Proliferative and Apoptotic Effects Against CML Stem Cells, Including the Quiescent Population. ASH Annual Meeting Abstracts 110: 2943.
    • Heaney N, Pellicano F, Crawford L, Irvine S, Holyoake TL (2007) Bortezomib Has Anti-Proliferative and Apoptotic Effects Against CML Stem Cells, Including the Quiescent Population. ASH Annual Meeting Abstracts 110: 2943.
  • 61
    • 33744909144 scopus 로고    scopus 로고
    • Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: A case report
    • Voortman J, Giaccone G (2006) Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: a case report. BMC Cancer 6: 129.
    • (2006) BMC Cancer , vol.6 , pp. 129
    • Voortman, J.1    Giaccone, G.2
  • 62
    • 56649108096 scopus 로고    scopus 로고
    • Acute severe cardiac failure in a myeloma patient due to proteasome inhibitor bortezomib
    • Hacihanefioglu A, Tarkun P, Gonullu E (2008) Acute severe cardiac failure in a myeloma patient due to proteasome inhibitor bortezomib. Int J Hematol 88: 219-222.
    • (2008) Int J Hematol , vol.88 , pp. 219-222
    • Hacihanefioglu, A.1    Tarkun, P.2    Gonullu, E.3
  • 63
    • 34447123834 scopus 로고    scopus 로고
    • Unexpected cardiotoxicity in haematological bortezomib treated patients
    • Enrico O, Gabriele B, Nadia C, Sara G, Daniele V, et al. (2007) Unexpected cardiotoxicity in haematological bortezomib treated patients. Br J Haematol 138: 396-397.
    • (2007) Br J Haematol , vol.138 , pp. 396-397
    • Enrico, O.1    Gabriele, B.2    Nadia, C.3    Sara, G.4    Daniele, V.5
  • 64
    • 0029015690 scopus 로고
    • Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2
    • Sanchez-Garcia I, Grutz G (1995) Tumorigenic activity of the BCR-ABL oncogenes is mediated by BCL2. Proc Natl Acad Sci U S A 92: 5287-5291.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5287-5291
    • Sanchez-Garcia, I.1    Grutz, G.2
  • 65
    • 0034689031 scopus 로고    scopus 로고
    • Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
    • Horita M, Andreu EJ, Benito A, Arbona C, Sanz C, et al. (2000) Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL. J Exp Med 191: 977-984.
    • (2000) J Exp Med , vol.191 , pp. 977-984
    • Horita, M.1    Andreu, E.J.2    Benito, A.3    Arbona, C.4    Sanz, C.5
  • 66
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • marante-Mendes GP, Naekyung KC, Liu L, Huang Y, Perkins CL, et al. (1998) Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 91: 1700-1705.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • marante-Mendes, G.P.1    Naekyung, K.C.2    Liu, L.3    Huang, Y.4    Perkins, C.L.5
  • 67
    • 8644284094 scopus 로고    scopus 로고
    • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release
    • Deming PB, Schafer ZT, Tashker JS, Potts MB, Deshmukh M, et al. (2004) Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. Mol Cell Biol 24: 10289-10299.
    • (2004) Mol Cell Biol , vol.24 , pp. 10289-10299
    • Deming, P.B.1    Schafer, Z.T.2    Tashker, J.S.3    Potts, M.B.4    Deshmukh, M.5
  • 68
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • Klaus A, Birchmeier W (2008) Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8: 387-398.
    • (2008) Nat Rev Cancer , vol.8 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 69
    • 3943088431 scopus 로고    scopus 로고
    • Granulocyte-Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
    • Jamieson CHM, Ailles LE, Dylla SJ, Muijtjens M, Jones C, et al. (2004) Granulocyte-Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML. N Engl J Med 351: 657-667.
    • (2004) N Engl J Med , vol.351 , pp. 657-667
    • Jamieson, C.H.M.1    Ailles, L.E.2    Dylla, S.J.3    Muijtjens, M.4    Jones, C.5
  • 70
    • 36649002031 scopus 로고    scopus 로고
    • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
    • Zhao C, Blum J, Chen A, Kwon HY, Jung SH, et al. (2007) Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. Cancer Cell 12: 528-541.
    • (2007) Cancer Cell , vol.12 , pp. 528-541
    • Zhao, C.1    Blum, J.2    Chen, A.3    Kwon, H.Y.4    Jung, S.H.5
  • 71
    • 0033605639 scopus 로고    scopus 로고
    • Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A
    • Seeling JM, Miller JR, Gil R, Moon RT, White R, et al. (1999) Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A. Science 283: 2089-2091.
    • (1999) Science , vol.283 , pp. 2089-2091
    • Seeling, J.M.1    Miller, J.R.2    Gil, R.3    Moon, R.T.4    White, R.5


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