Antitumor effects of dehydroxymethylepoxyquinomicin, a novel nuclear factor-κB inhibitor, in human liver cancer cells are mediated through a reactive oxygen species-dependent mechanism

Molecular Pharmacology

Volumn 76, Issue 2, 2009, Pages 290-300

  Lampiasi, Nadia ^a   Azzolina, Antonina ^a   D'Alessandro, Natale ^b   Umezawa, Kazuo ^c   McCubrey, James A ^d   Montalto, Giuseppe ^b   Cervello, Melchiorre ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

^c KEIO UNIVERSITY   (Japan)

^d EAST CAROLINA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CALCIUM ION; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; DEHYDROXYMETHYLEPOXYQUINOMICIN; HISTONE H2AX; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOPROTEIN; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SURVIVIN; TRANSCRIPTION FACTOR RELA; TRIBBLES HOMOLOG 3 PROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; LIVER CANCER; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DNA BINDING; RNA SPLICING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZAMIDES; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOHEXANONES; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; HUMANS; LIVER NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES;

EID: 67650812043     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.055418     Document Type: Article

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