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Volumn 59, Issue 7, 2009, Pages 462-470

Immunohistochemical staining for P1 and P2 promoter-driven hepatocyte nuclear factor-4α may complement mucin phenotype of differentiated-type early gastric carcinoma

Author keywords

Gastric carcinoma; Intestinal metaplasia; Mucin phenotype; P1 and P2 promoter driven HNF4

Indexed keywords

COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; ISOPROTEIN; MUCIN 1; MUCIN 2; MUCIN 5AC; MUCIN 6; P1 HEPATOCYTE NUCLEAR FACTOR 4ALPHA; P2 HEPATOCYTE NUCLEAR FACTOR 4ALPHA; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG;

EID: 67650789849     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2009.02394.x     Document Type: Article
Times cited : (16)

References (41)
  • 1
    • 12644292106 scopus 로고
    • The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma
    • Lauren P. The two histological main types of gastric carcinoma: Diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965 64 : 31 49.
    • (1965) Acta Pathol Microbiol Scand , vol.64 , pp. 31-49
    • Lauren, P.1
  • 2
    • 0007827089 scopus 로고
    • Pathological studies of human gastric cancer
    • Sugano H, Nakamura K, Kato Y. Pathological studies of human gastric cancer. Acta Pathol Jpn 1982 32 (Suppl 2 329 47.
    • (1982) Acta Pathol Jpn , vol.32 , Issue.SUPPL2 , pp. 329-47
    • Sugano, H.1    Nakamura, K.2    Kato, Y.3
  • 3
    • 0018085431 scopus 로고
    • Special features of intestinal metaplasia and its relation to early gastric carcinoma in man: Observation by a method in which leucine aminopeptidase activity is used
    • Nakahara K. Special features of intestinal metaplasia and its relation to early gastric carcinoma in man: Observation by a method in which leucine aminopeptidase activity is used. J Natl Cancer Inst 1978 61 : 693 701.
    • (1978) J Natl Cancer Inst , vol.61 , pp. 693-701
    • Nakahara, K.1
  • 4
    • 0034663036 scopus 로고    scopus 로고
    • Distinction of differentiated type early gastric carcinoma with gastric type mucin expression
    • Koseki K, Takizawa T, Koike M, Ito M, Nihei Z, Sugihara K. Distinction of differentiated type early gastric carcinoma with gastric type mucin expression. Cancer 2000 89 : 724 32.
    • (2000) Cancer , vol.89 , pp. 724-32
    • Koseki, K.1    Takizawa, T.2    Koike, M.3    Ito, M.4    Nihei, Z.5    Sugihara, K.6
  • 6
    • 0036154052 scopus 로고    scopus 로고
    • Relationship between biologic behavior and phenotypic expression in intramucosal gastric carcinomas
    • DOI 10.1053/hupa.2002.30182
    • Kabashima A, Yao T, Sugimachi K, Tsuneyoshi M. Relationship between biological behavior and phenotypic expression in intramucosal gastric carcinomas. Hum Pathol 2002 33 : 80 86. (Pubitemid 34112955)
    • (2002) Human Pathology , vol.33 , Issue.1 , pp. 80-86
    • Kabashima, A.1    Yao, T.2    Sugimachi, K.3    Tsuneyoshi, M.4
  • 7
    • 2642542474 scopus 로고    scopus 로고
    • Re-evaluation of mucin phenotypes of gastric minute well-differentiated- type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2 and CD10 stains
    • Shiroshita H, Watanabe H, Ajioka Y, Watanabe G, Nishikura K, Kitano S. Re-evaluation of mucin phenotypes of gastric minute well-differentiated-type adenocarcinomas using a series of HGM, MUC5AC, MUC6, M-GGMC, MUC2 and CD10 stains. Pathol Int 2004 54 : 311 21.
    • (2004) Pathol Int , vol.54 , pp. 311-21
    • Shiroshita, H.1    Watanabe, H.2    Ajioka, Y.3    Watanabe, G.4    Nishikura, K.5    Kitano, S.6
  • 8
    • 0035883673 scopus 로고    scopus 로고
    • MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: Their roles as prognostic indicators
    • Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH. MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas: Their roles as prognostic indicators. Cancer 2001 92 : 1427 34.
    • (2001) Cancer , vol.92 , pp. 1427-34
    • Lee, H.S.1    Lee, H.K.2    Kim, H.S.3    Yang, H.K.4    Kim, Y.I.5    Kim, W.H.6
  • 9
    • 3543039429 scopus 로고    scopus 로고
    • Prognostic significance of mucin expression in gastric carcinoma
    • Kocer B, Soran A, Kiyak G et al. Prognostic significance of mucin expression in gastric carcinoma. Dig Dis Sci 2004 49 : 954 64.
    • (2004) Dig Dis Sci , vol.49 , pp. 954-64
    • Kocer, B.1    Soran, A.2    Kiyak, G.3
  • 10
    • 0025690311 scopus 로고
    • Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
    • Sladek FM, Zhong WM, Lai E, Darnell JE Jr. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev 1990 4 : 2353 65.
    • (1990) Genes Dev , vol.4 , pp. 2353-65
    • Sladek, F.M.1    Zhong, W.M.2    Lai, E.3    Darnell, Jr.J.E.4
  • 11
    • 0027662208 scopus 로고
    • Orphan receptor HNF-4 and liver-specific gene expression
    • Sladek FM. Orphan receptor HNF-4 and liver-specific gene expression. Receptor 1993 3 : 223 32.
    • (1993) Receptor , vol.3 , pp. 223-32
    • Sladek, F.M.1
  • 12
    • 0029113123 scopus 로고
    • Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors
    • Jiang G, Nepomuceno L, Hopkins K, Sladek FM. Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol Cell Biol 1995 15 : 5131 43.
    • (1995) Mol Cell Biol , vol.15 , pp. 5131-43
    • Jiang, G.1    Nepomuceno, L.2    Hopkins, K.3    Sladek, F.M.4
  • 14
    • 2442673685 scopus 로고    scopus 로고
    • Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats
    • Jiang S, Tanaka T, Iwanari H et al. Expression and localization of P1 promoter-driven hepatocyte nuclear factor-4alpha (HNF4alpha) isoforms in human and rats. Nucl Recept 2003 1 : 5.
    • (2003) Nucl Recept , vol.1 , pp. 5
    • Jiang, S.1    Tanaka, T.2    Iwanari, H.3
  • 15
    • 33645215441 scopus 로고    scopus 로고
    • Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer
    • Tanaka T, Jiang S, Hotta H et al. Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer. J Pathol 2006 208 : 662 72.
    • (2006) J Pathol , vol.208 , pp. 662-72
    • Tanaka, T.1    Jiang, S.2    Hotta, H.3
  • 17
    • 58149280144 scopus 로고    scopus 로고
    • Protein expression of nuclear receptors in human and murine tissues
    • Takegoshi S, Jiang S, Ohashi R et al. Protein expression of nuclear receptors in human and murine tissues. Pathol Int 2009 59 : 61 72.
    • (2009) Pathol Int , vol.59 , pp. 61-72
    • Takegoshi, S.1    Jiang, S.2    Ohashi, R.3
  • 18
    • 53549086916 scopus 로고    scopus 로고
    • Expression of hepatocyte nuclear factor 4α in primary ovarian mucinous tumors
    • Sugai M, Umezu H, Yamamoto T et al. Expression of hepatocyte nuclear factor 4α in primary ovarian mucinous tumors. Pathol Int 2008 58 : 681 6.
    • (2008) Pathol Int , vol.58 , pp. 681-6
    • Sugai, M.1    Umezu, H.2    Yamamoto, T.3
  • 19
    • 0003398138 scopus 로고
    • Japanese Research Society for Gastric Cancer. Tokyo. Kanehara Publication
    • Japanese Research Society for Gastric Cancer. Japanese Classification of Gastric Carcinoma. Tokyo : Kanehara Publication, 1995.
    • (1995) Japanese Classification of Gastric Carcinoma.
  • 20
    • 0025194097 scopus 로고
    • Gastrin and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry
    • Tatematsu M, Ichinose M, Miki K, Hasegawa R, Kato T, Ito N. Gastric and intestinal phenotypic expression of human stomach cancers as revealed by pepsinogen immunohistochemistry and mucin histochemistry. Acta Pathol Jpn 1990 40 : 494 504. (Pubitemid 20295352)
    • (1990) Acta Pathologica Japonica , vol.40 , Issue.7 , pp. 494-504
    • Tatematsu, M.1    Ichinose, M.2    Miki, K.3    Hasegawa, R.4    Kato, T.5    Ito, N.6
  • 21
    • 0038748298 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms
    • Eeckhoute J, Moerman E, Bouckenooghe T et al. Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms. Endocrinology 2003 144 : 1686 94.
    • (2003) Endocrinology , vol.144 , pp. 1686-94
    • Eeckhoute, J.1    Moerman, E.2    Bouckenooghe, T.3
  • 22
    • 0037221727 scopus 로고    scopus 로고
    • Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas
    • DOI 10.1002/path.1246
    • Almeida R, Silva E, Santos-Silva F et al. Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas. J Pathol 2003 199 : 36 40. (Pubitemid 36054727)
    • (2003) Journal of Pathology , vol.199 , Issue.1 , pp. 36-40
    • Almeida, R.1    Silva, E.2    Santos-Silva, F.3    Silberg, D.G.4    Wang, J.5    De Bolos, C.6    David, L.7
  • 23
    • 34247127041 scopus 로고    scopus 로고
    • The expression of hepatocyte nuclear factor-4alpha, a developmental regulator of visceral endoderm, correlates with the intestinal phenotype of gastric adenocarcinomas
    • Kojima K, Kishimoto T, Nagai Y et al. The expression of hepatocyte nuclear factor-4alpha, a developmental regulator of visceral endoderm, correlates with the intestinal phenotype of gastric adenocarcinomas. Pathology 2006 38 : 548 54.
    • (2006) Pathology , vol.38 , pp. 548-54
    • Kojima, K.1    Kishimoto, T.2    Nagai, Y.3
  • 26
    • 0037462878 scopus 로고    scopus 로고
    • Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression
    • Yamamoto H, Bai YQ, Yuasa Y. Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun 2003 300 : 813 18.
    • (2003) Biochem Biophys Res Commun , vol.300 , pp. 813-18
    • Yamamoto, H.1    Bai, Y.Q.2    Yuasa, Y.3
  • 27
    • 9144240744 scopus 로고    scopus 로고
    • Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines
    • Mesquita P, Jonckheere N, Almeida R et al. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 2003 278 : 51 549 56.
    • (2003) J Biol Chem , vol.278 , pp. 51549-56
    • Mesquita, P.1    Jonckheere, N.2    Almeida, R.3
  • 28
    • 0344687341 scopus 로고    scopus 로고
    • CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene
    • Bai YQ, Miyake S, Iwai T, Yuasa Y. CDX2, a homeobox transcription factor, upregulates transcription of the p21/WAF1/CIP1 gene. Oncogene 2003 22 : 7942 9.
    • (2003) Oncogene , vol.22 , pp. 7942-9
    • Bai, Y.Q.1    Miyake, S.2    Iwai, T.3    Yuasa, Y.4
  • 29
    • 8344221886 scopus 로고    scopus 로고
    • CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α
    • DOI 10.1016/j.yexcr.2004.08.014, PII S0014482704004847
    • Chiba H, Itoh T, Satohisa S et al. Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha. Exp Cell Res 2005 302 : 11 21. (Pubitemid 39482364)
    • (2005) Experimental Cell Research , vol.302 , Issue.1 , pp. 11-21
    • Chiba, H.1    Itoh, T.2    Satohisa, S.3    Sakai, N.4    Noguchi, H.5    Osanai, M.6    Kojima, T.7    Sawada, N.8
  • 30
    • 33845693542 scopus 로고    scopus 로고
    • The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli
    • Chiba H, Sakai N, Murata M et al. The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli. J Cell Biol 2006 175 : 971 80.
    • (2006) J Cell Biol , vol.175 , pp. 971-80
    • Chiba, H.1    Sakai, N.2    Murata, M.3
  • 31
    • 28144436041 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: Identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kinase, and mitogen-activated protein kinase pathway
    • Prieur X, Schaap FG, Coste H, Rodriguez JC. Hepatocyte nuclear factor-4alpha regulates the human apolipoprotein AV gene: Identification of a novel response element and involvement in the control by peroxisome proliferator-activated receptor-gamma coactivator-1alpha, AMP-activated protein kinase, and mitogen-activated protein kinase pathway. Mol Endocrinol 2005 19 : 3107 25.
    • (2005) Mol Endocrinol , vol.19 , pp. 3107-25
    • Prieur, X.1    Schaap, F.G.2    Coste, H.3    Rodriguez, J.C.4
  • 32
    • 33845571903 scopus 로고    scopus 로고
    • Apolipoprotein A-IV is regulated by nutritional and metabolic stress: Involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha
    • Hanniman EA, Lambert G, Inoue Y, Gonzalez FJ, Sinal CJ. Apolipoprotein A-IV is regulated by nutritional and metabolic stress: Involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha. J Lipid Res 2006 47 : 2503 14.
    • (2006) J Lipid Res , vol.47 , pp. 2503-14
    • Hanniman, E.A.1    Lambert, G.2    Inoue, Y.3    Gonzalez, F.J.4    Sinal, C.J.5
  • 33
    • 22544476811 scopus 로고    scopus 로고
    • Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells
    • Olsen L, Bressendorff S, Troelsen JT, Olsen J. Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells. Am J Physiol Gastrointest Liver Physiol 2005 289 : G220 26.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289 , pp. 220-26
    • Olsen, L.1    Bressendorff, S.2    Troelsen, J.T.3    Olsen, J.4
  • 34
    • 33746471838 scopus 로고    scopus 로고
    • Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4
    • Hu C, Perlmutter DH. Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4. Am J Physiol 1999 276 : G1181 94.
    • (1999) Am J Physiol , vol.276 , pp. 1181-94
    • Hu, C.1    Perlmutter, D.H.2
  • 35
    • 9844223915 scopus 로고    scopus 로고
    • Intestinalization of gastric signet ring cell carcinomas with progression
    • Yamachika T, Inada K, Fujimitsu Y et al. Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch 1997 431 : 103 10.
    • (1997) Virchows Arch , vol.431 , pp. 103-10
    • Yamachika, T.1    Inada, K.2    Fujimitsu, Y.3
  • 36
  • 37
    • 0037648768 scopus 로고    scopus 로고
    • Stem cells and gastric cancer: Role of gastric and intestinal mixed intestinal metaplasia
    • Tatematsu M, Tsukamoto T, Inada K. Stem cells and gastric cancer: Role of gastric and intestinal mixed intestinal metaplasia. Cancer Sci 2003 94 : 135 41.
    • (2003) Cancer Sci , vol.94 , pp. 135-41
    • Tatematsu, M.1    Tsukamoto, T.2    Inada, K.3
  • 38
    • 23844438649 scopus 로고    scopus 로고
    • Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: Lack of a relationship with the histological type and phenotype
    • Mizoshita T, Tsukamoto T, Cao X et al. Microsatellite instability is linked to loss of hMLH1 expression in advanced gastric cancers: Lack of a relationship with the histological type and phenotype. Gastric Cancer 2005 8 : 164 72.
    • (2005) Gastric Cancer , vol.8 , pp. 164-72
    • Mizoshita, T.1    Tsukamoto, T.2    Cao, X.3
  • 39
    • 34247899163 scopus 로고    scopus 로고
    • Relationship between lymph node metastasis and E-cadherin expression in submucosal invasive gastric carcinomas with gastric-phenotype
    • Aoki R, Yasuda M, Torisu R, Nakamoto J, Yamamoto Y, Ito S. Relationship between lymph node metastasis and E-cadherin expression in submucosal invasive gastric carcinomas with gastric-phenotype. J Med Invest 2007 54 : 159 67.
    • (2007) J Med Invest , vol.54 , pp. 159-67
    • Aoki, R.1    Yasuda, M.2    Torisu, R.3    Nakamoto, J.4    Yamamoto, Y.5    Ito, S.6
  • 40
    • 33645644484 scopus 로고    scopus 로고
    • E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: A role for the hepatic nuclear factor 4
    • Peignon G, Thenet S, Schreider C et al. E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: A role for the hepatic nuclear factor 4. J Biol Chem 2006 281 : 3560 68.
    • (2006) J Biol Chem , vol.281 , pp. 3560-68
    • Peignon, G.1    Thenet, S.2    Schreider, C.3
  • 41
    • 33744795211 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver
    • Battle MA, Konopka G, Parviz F et al. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci USA 2006 103 : 8419 24.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8419-24
    • Battle, M.A.1    Konopka, G.2    Parviz, F.3


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