Optimization of l-methionine feeding strategy for improving S-adenosyl-l-methionine production by methionine adenosyltransferase overexpressed Pichia pastoris

Applied Microbiology and Biotechnology

Volumn 83, Issue 6, 2009, Pages 1105-1114

  Hu, Hui ^a   Qian, Jiangchao ^a   Chu, Ju ^a   Wang, Yonghong ^a   Zhuang, Yingping ^a   Zhang, Siliang ^a  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

ATP; L methionine; Methionine adenosyltransferase; Pichia pastoris; S adenosyl L methionine

Indexed keywords

ATP; L-METHIONINE; METHIONINE ADENOSYLTRANSFERASE; PICHIA PASTORIS; S-ADENOSYL-L-METHIONINE;

ADENOSINETRIPHOSPHATE; ENZYME ACTIVITY;

FEEDING;

ADENOSINE TRIPHOSPHATE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; S ADENOSYLMETHIONINE;

AMINO ACID; ENZYME ACTIVITY; FEEDING BEHAVIOR; GENE EXPRESSION; OPTIMIZATION; RECOMBINATION; YEAST;

ARTICLE; BACTERIAL GENE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; GLYCOLYSIS; NONHUMAN; PICHIA PASTORIS; PROCESS OPTIMIZATION; SYNTHESIS;

ADENOSINE TRIPHOSPHATE; CITRIC ACID CYCLE; GLYCOLYSIS; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; PICHIA; S-ADENOSYLMETHIONINE;

PICHIA PASTORIS;

EID: 67650751061     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-1975-y     Document Type: Article

References (36)

1. PR Alp EA Newsholme VA Zammit 1976 Activities of citrate synthetase and NAD-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates Biochem 154 689 700
2. HA Barcelo JC Wiemeyer CL Sagasta M Macias JC Barreira 1990 Experimental osteoarthritis and its course when treated with S-adenosyl-l-methionine Rev Clin Esp 187 2 74 78 (Pubitemid 20274681)
3. PM Bruinenberg R Jonker JP van Dijken WA Scheffers 1985 Utilization of formate as an additional energy source by glucose-limited chemostat cultures of Candida utilis CBS 621 and Saccharomyces cerevisiae CBS 8066: evidence for absence of transhydrogenase activity in yeasts Arch Microbiol 142 302 306 (Pubitemid 15049918)
4. JL Cereghino JM Cregg 2000 Heterologous protein expression in the methylotrophic yeast Pichia pastoris FEMS Microbiol Rev 24 45 66 (Pubitemid 30047114)
5. SY Chan DR Appling 2003 Regulation of S-adenosylmethionine levels in Saccharomyces cerevisiae J Biol Chem 278 43051 43059 (Pubitemid 37345920)
6. HX Chen J Chu SL Zhang YP Zhuang JC Qian YH Wang XQ Hu 2007 Intracellular expression of Vitreoscilla hemoglobin improves S-adenosylmethionine production in a recombinant Pichia pastoris Appl Microbiol Biotechnol 74 6 1205 1212 (Pubitemid 46674059)
7. SA Christopher S Melnyk SJ James WD Kruger 2002 S-adenosylhomocysteine, but not homocysteine, is toxic to yeast lacking cystathionine-β synthase Mol Genet Metab 75 335 343 (Pubitemid 34971583)
8. JM Cregg KR Madden 1988 Development of the methylotrophic yeast, Pichia pastoris, as a host system for the production of foreign proteins Dev Ind Microbiol 29 33 41
9. David LN, Michael MC (2004) Lehninger principles of biochemistry, 4th edn. Freeman, Madison, pp 621-623
10. A Felix Y Mireille N Michele C Emilie D Jerome B Pascal 2004 Identification and functional analysis of the gene encoding methionine-γ- lyase in Brevibacterium linens Appl Environ Microbiol 70 12 7348 7354
11. MT Flikweert P Johannes JP van Dijken JT Pronk 1997 Metabolic responses of pyruvate decarboxylase-negative Saccharomyces cerevisiae to glucose excess Appl Environ Microbiol 63 3399 3404 (Pubitemid 27383129)
12. J He J Deng Y Zheng J Gu 2006 A synergistic effect on the production of S-adenosyl-l-methionine in Pichia pastoris by knocking in of S-adenosyl-l-methionine synthase and knocking out of cystathionine-β synthase J Biotechnol 126 4 519 527 (Pubitemid 44634815)
13. XQ Hu J Chu SL Zhang YP Zhuang YH Wang S Zhu ZG Zhu ZY Yuan 2007 A novel feeding strategy during the production phase for enhancing the enzymatic synthesis of S-adenosyl-l- methionine by methylotrophic Pichia pastoris Enzyme Microb Technol 40 669 674 (Pubitemid 46329059)
14. Hu H, Qian JC, Chu J, Wang Y, Zhuang YP, Zhang SL (2009) DNA shuffling of methionine adenosyltransferase gene leads to improved 5-adenosyl-L-methionine production in Pichia pastoris J Biotechnol. doi: 10.1016/j.jbiotec.2009.03.006
15. DM Kagkli P Bonnarme C Neuvéglise TM Cogan S Casaregola 2006 l-Methionine degradation pathway in Kluyveromyces lactis: identification and functional analysis of the genes encoding l-methionine aminotransferase Appl Environ Microbiol 72 5 3330 3335 (Pubitemid 43727983)
16. Y Kawahara K Takahashi-Fuke E Shimizu T Nakamatsu S Nakamori 1997 Relationship between glutamate production and the activity of 2-oxoglutarate dehydrogenase in Brevibacterium lactofermentum Biosci Biotechnol Biochem 61 1109 1112 (Pubitemid 127473029)
17. DY Li J Yu LW Tian XS Ji ZY Yuan 2002 Production of SAM by recombinant Pichia pastoris Chin J Biotechnol 3 295 299
18. CS Lieber 1999 Role of S-adenosyl-l-methionine in the treatment of liver diseases J Hepatol 30 1155 1159 (Pubitemid 29278764)
19. PY Liu DH Zhu TW Tan 2006 Effect of feeding pre-l-methionine on high-cell-density fermentation for S-adenosyl-l-methionine production Chin J Biotechnol 22 2 268 272
20. SC Lu 2000 S-Adenosylmethionine Int J Biochem Cell Biol 32 391 395 (Pubitemid 30101619)
21. Mato JM, Pajares MA, Mingorance J, Avarez L (1995) Production of S-adenosyl-methionine (SAM) by fermentation of transformed bacteria. European Patent 0647712A1
22. S Megumi F Tsutomu I Haruyuki 2007 Effects of accumulated S-adenosylmethionine on growth of yeast cells Biosci Biotechnol Biochem 71 6 1595 1597
23. A Mikael LN Torben N Jens V John RM Jan HH Barbel CKR Morten 1999 Expression of the Escherichia coli pntA and pntB genes, encoding nicotinamide nucleotide transhydrogenase, in Saccharomyces cerevisiae and its effect on product formation during anaerobic glucose fermentation Appl Environ Microbiol 65 6 2333 2340
24. KP Mincheva VM Balutsov 2002 Isolation of S-adenosyl-l-methionine from an enriched Kluyveromyces lactis mutant grown in whey media Prikl Biokhim Mikrobiol 38 4 389 392
25. S Minning A Serrano P Ferrer C Sola RD Schmid F Valero 2001 Optimization of the high-level production of Rhizopus oryzae lipase in Pichia pastoris J Biotechnol 86 59 70 (Pubitemid 32167014)
26. Pierro DD, Tavazzi B, Perno CF, Bartolini M, Balestra E, Calio R, Giardina B, Lazzarino G (1995) An ion-pairing high-performance liquid chromatographic method for the direct simultaneous determination of nucleotides, deoxynucleotides, nicotinic coenzymes, oxypurines, nucleosides, and bases in perchloric acid cell extracts. Anal Biochem 231(2):407-412
27. S Shen G Sulter TW Jeffries JM Cregg 1998 A strong nitrogen source-related promoter for controlled expression of foreign genes in the yeast Pichia pastoris Gene 216 93 102 (Pubitemid 28389106)
28. S Shiozaki S Shimizu H Yamada 1986 Production of S-adenosyl-l-methionine by Saccharomyces sake J Biotechnol 4 6 345 354 (Pubitemid 17228071)
29. M Shobayashi N Mukai K Iwashita Y Hiraga H Lefuji 2005 A new method for isolation of S-adenosylmethionine (SAM)-accumulating yeast Appl Microbiol 69 704 710
30. RC Stanton JL Seifter DC Boxer E Zimmerman LC Cantley 1991 Rapid release of bound glucose-6-phosphate dehydrogenase by growth factors: correlation with increased enzymatic activity J Biol Chem 266 12442 12448 (Pubitemid 21907114)
31. D Thomas R Rothstein N Rosenberg Y Surdin-Kerjan 1988 SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes Mol Cell Biol 8 12 5132 5139
32. R Torta A Cicolin R Keller 1998 Transmethylation and affective disorders Arch Gerontol Geriatr Suppl 6 499 506
33. IJ van der Klei LV Bystrykh W Harder 1990 Alcohol oxidase from Hansenula polymorpha CBS 4732 Methods Enzymol 188 420
34. J Wagner C Danzin S Huot-Olivier N Claveric MG Palfreyman 1984 High performance liquid chromatographic analysis of S-adenosylmethionine and its metabolites in rat tissues: interrelationship with changes in biogenic catechol levels following treatment with l-DOPA J Chromatogr 290 247 262 (Pubitemid 14101670)
35. J Yang M Wang J Sun PH Wei WG Tang 2002 Cloning of S-adenosyl-l- methionine synthetase gene from Saccharomyces cerevisiae and its expression in E. coli J China Pharm U 3 253 255 (Pubitemid 43026851)
36. ZL Yu XJ Wu DY Li S Yang Z Zhou J Cai ZY Yuan 2003 Enhancement of the production of SAM by overexpression of SAM synthetase in Pichia pastoris Chin J Biochem Biophys 35 2 127 132 (Pubitemid 36419129)