Mutations of arginine 222 in pre-transmembrane domain I of mouse 5-HT 3A receptor abolish 20(R)- but not 20(S)-ginsenoside Rg3 inhibition of 5-HT-mediated ion currents

Biological and Pharmaceutical Bulletin

Volumn 30, Issue 9, 2007, Pages 1721-1726

  Lee, Byung Hwan ^a   Lee, Jun Ho ^a   Yoon, In Soo ^a   Lee, Joon Hee ^a   Choi, Sun Hye ^a   Shin, Tae Joon ^a   Pyo, Mi Kyung ^a   Choi, Woo Sung ^a   Lee, Sang Mok ^a   Lim, Yoongho ^a   Rhim, Hyewhon ^b   Nah, Seung Yeol ^a  

^a Konkuk University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

5 HT3A receptor; Ginseng; Ginsenoside stereoisomer; Ligand gated ion channel; Xenopus oocyte

Indexed keywords

AMINO ACID; ARGININE; GINSENOSIDE RG 3; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN 3A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPIMER; FACILITATION; GENE EXPRESSION; GENE INDUCTION; GENE LOCATION; GENE MUTATION; GINSENG; ION CURRENT; NONHUMAN; OOCYTE; POINT MUTATION; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP; WILD TYPE; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARGININE; GINSENOSIDES; MEMBRANE POTENTIALS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, SEROTONIN, 5-HT3; RECOMBINANT PROTEINS; RNA, COMPLEMENTARY; SEROTONIN; SEROTONIN ANTAGONISTS; XENOPUS;

EID: 34548639937     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.30.1721     Document Type: Article

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