Biochemical evaluation of antihyperglycemic and antioxidative effects of Morinda citrifolia fruit extract studied in streptozotocin-induced diabetic rats

Medicinal Chemistry Research

Volumn 18, Issue 6, 2009, Pages 433-446

  Mahadeva Rao, U S ^a   Subramanian, S ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Antidiabetic; Antioxidants; Morinda citrifolia; Noni; STZ induced diabetes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CREATININE; GLICLAZIDE; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HYDROPEROXIDE; INSULIN; MORINDA CITRIFOLIA EXTRACT; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG ACTIVITY; DRUG SCREENING; EXPERIMENTAL RAT; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; MORINDA CITRIFOLIA; NONHUMAN; PATHOPHYSIOLOGY; RAT; STREPTOZOCIN DIABETES; UREA BLOOD LEVEL;

EID: 67650725973     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-008-9140-1     Document Type: Article

References (65)

1. E Adeghate P Schattner E Dunn 2006 An update on the etiology and epidemiology of diabetes mellitus Ann N Y Acad Sci 1084 1 29 10.1196/annals.1372.029
2. L Al-Shamanoy SM Al-Khazraji HA Twaij 1994 Hypoglycemic effect of Artemisia herba alba-II. Effect of a valuable extract on some blood parameters in diabetes animals J Ethnopharmacol 43 167 171 10.1016/0378-8741(94)90038-8
3. Alyassin D, Ibrahim (1981) A minor hemoglobin fraction and the level of fasting blood glucose. J Fac Med Baghdad 23:373-380
4. K Asayama T Nakane N Uchida H Hayashibe K Dobashi S Nakazawa 1994 Serum antioxidant status in streptozotocin-induced diabetic rat Horm Metab Res 26 313 315 (Pubitemid 24230253)
5. S Bastaki 2005 Diabetes mellitus and its treatment Int J Diabetes Metab 13 111 134 (Pubitemid 44783783)
6. JW Baynes 1991 Role of oxidative stress in development of complications in diabetes Diabetes 40 405 412 10.2337/diabetes.40.4.405
7. C Borek 2001 Antioxidant health effects of aged garlic extract J Nutr 131 1010S 1015S (Pubitemid 32194999)
8. H Bräunlich F Marx C Fleck G Stein 1997 Kidney function in rats after 5/6 nephrectomy (5/6 NX); effort of treatment with vitamin E Exp Toxicol Pathol 49 135 139 (Pubitemid 27113360)
9. J Brod JH Sirota 1948 The renal clearance of endogenous "creatinine" in man J Clin Invest 27 645 654 10.1172/JCI102012
10. ET Cánepa EB Llambías M Grinstein 1990 Studies on regulatory mechanisms of heme biosynthesis in hepatocytes from normal and experimental-diabetic rats. Role of insulin Biochem Cell Biol 68 914 921 (Pubitemid 20271416)
11. RR Chattopadhyay 1999 A comparative evaluation of some blood sugar lowering agents of plant origin J Ethnopharmacol 67 367 372 10.1016/S0378- 8741(99)00095-1
12. S Chearskul S Kooptiwut S Chatchawalvanit S Onreabroi M Churintrapun P Saralamp N Soonthornchareonnon 2004 Morinda citrifolia has very weak estrogenic activity in vivo Thai J Physiol Sci 17 22 29
13. Desai JD (1984) In: Parker (ed) Methods in enzymology, vol. 105, Academic, New York, pp.138
14. A Dittmar 1993 Morinda citrifolia L use in indigenous Samoan medicine J Herbs Spices Med Plants 1 77 92 10.1300/J044v01n03-08
15. AR Dixon H McMillan NL Atkin 1999 Ferment this: the transformation of noni, a traditional Polynesian medicine (Morinda citrifolia, Rubiaceae) Econ Bot 53 51 68 (Pubitemid 29194681)
16. DL Drabkin JH Austin 1932 Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood J Biol Chem 98 719 733
17. CD Egan 2002 Addressing use of herbal medicine in the primary care setting J Am Acad Nurse Pract 14 166 171 10.1111/j.1745-7599.2002.tb00108.x
18. FM El-Demerdash MI Yousef NI El-Naga 2005 Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats Food Chem Toxicol 43 57 63 10.1016/j.fct.2004.08.012
19. M Elvin-Lewis 2001 Should we be concerned about herbal remedies J Ethnopharmacol 75 141 164 10.1016/S0378-8741(00)00394-9
20. G Evan TA Littlewood 1998 Matter of life and cell death Science 28 1317 10.1126/science.281.5381.1317
21. JL Fando T Jolin M Salinas F Dominguez E Herrera 1985 The effect of streptozotocin diabetes on brain protein synthesis in the rat Diabete Metab 11 92 97 (Pubitemid 15041595)
22. JC Fang S Kinlay J Beltrame H Hikiti M Wainstein D Behrendt J Suh B Frei GH Mudge AP Selwyn P Ganz 2002 Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial Lancet 359 1108 1113 10.1016/S0140-6736(02)08154-0
23. MC Garg DD Bansal 2000 Protective antioxidant effect of vitamins C and E in streptozotocin induced diabetic rats Indian J Exp Biol 38 101 104 (Pubitemid 30091959)
24. J Grove AK Daly MF Bassendine CP Day 1997 Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis Hepatology 26 143 146 10.1002/hep.510260119 (Pubitemid 27280318)
25. JK Grover V Vats 2001 Shifting paradigm from conventional to alternative medicine. An introduction on Traditional Indian Medicine Asia Pac Biotechnol News 5 28 32 10.1142/S0219030301001811
26. WH Habig MJ Pabst WB Jakoby 1974 Glutathione S-transferases. The first enzymatic step in mercapturic acid formation J Biol Chem 249 7130 7139
27. RM Heinicke 1995 The Pharmacologically active ingredient of noni Bull Natl Trop Bot Garden 15 10 14
28. A Hirazumi E Furusawa SC Chou Y Hokama 1996 Immunomodulation contributes to the anticancer activity of Morinda citrifolia (noni) fruit juice Proc West Pharmacol Soc 39 7 9 (Pubitemid 26341767)
29. ZY Jiang JV Hunt SP Wolff 1992 Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein Anal Biochem 202 384 389 10.1016/0003-2697(92)90122-N
30. K Kamiya Y Tanaka H Endang M Umar T Satake 2005 New anthraquinone and iridoid from the fruits of Morinda citrifolia Chem Pharm Bull (Tokyo) 53 1597 1599 10.1248/cpb.53.1597 (Pubitemid 41744493)
31. K Kamiya W Hamabe S Harada R Murakami S Tokuyama T Satake 2008 Chemical constituents of Morinda citrifolia roots exhibit hypoglycemic effects in streptozotocin-induced diabetic mice Biol Pharm Bull 31 935 938 10.1248/bpb.31.935
32. SW Kim BK Jo JH Jeong SU Choi YI Hwang 2005 Induction of extracellular matrix synthesis in normal human fibroblasts by anthraquinone isolated from Morinda citrifolia (Noni) fruit J Med Food 8 552 555 10.1089/jmf.2005.8.552
33. King J (1965a) The transaminases: alanine and aspartate transaminases. In: Practical clinical enzymology, Van Nostrand Reinhold, London, pp 363-395
34. King J (1965b) The hydorlases-acid and alkaline phosphatases. In: Practical clinical enzymology. Van Nostrand Reinhold, London, pp 199-208
35. RJ Koenig CM Peterson RL Jones C Saudek M Lehrman A Cerami 1976 Correlation of glucose regulation and hemoglobin AIc in diabetes mellitus N Engl J Med 295 417 420
36. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the Folin phenol reagent J Biol Chem 193 265 275
37. A Mancebo I Scull Y Gonzales ME Arteaga BO Gonzales D Fuentes O Hernandez M Correa 2002 Ensayo de toxicidad a dosis repetidas (28 dias) por via oral del extracto acuoso de Morinda citrifolia en rata Sprague Dawley Rev Toxicol 19 73 77
38. Matkovics B, Kotorman M, Varga IS, Hai DQ, Varga C (1997-1998) Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol Hung 85:29-38.
39. W McClatchey 2002 From Polynesian healers to health food stores: changing perspectives of Morinda citrifolia (Rubiaceae) Integr Cancer Ther 1 110 120 10.1177/1534735402001002002 (Pubitemid 36834917)
40. HP Misra I Fridovich 1972 The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase J Biol Chem 247 3170 3175
41. Y Miyazaki H Kawano T Yoshida S Miyamoto J Hokamaki Y Nagayoshi H Yamabe H Nakamura J Yodoi H Ogawa 2007 Pancreatic B-cell function is altered by oxidative stress induced by acute hyperglycaemia Diabet Med 24 154 160 10.1111/j.1464-5491.2007.02058.x
42. S Natelson ML Scott C Beffa 1951 A rapid method for the estimation of urea in biologic fluids Am J Clin Pathol 21 275 281
43. SS Nayak TN Pattabiraman 1981 A new colorimetric method for the estimation of glycosylated hemoglobin Clin Chim Acta 109 267 274 10.1016/0009-8981(81)90312-0
44. RM O'Brien DK Granner 1991 Regulation of gene expression by insulin Biochem J 278 609 619
45. H Ohkawa N Ohishi K Yagi 1979 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 351 358 10.1016/0003-2697(79) 90738-3
46. ST Omaye JD Turnbull HE Sauberlich 1979 Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids Methods Enzymol 62 3 11 10.1016/0076-6879(79)62181-X
47. AD Pawlus BN Su WJ Keller AD Kinghorn 2005 An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni) J Nat Prod 68 1720 1722 10.1021/np050383k
48. Product Safety Labs (2000) Guinea pig antigenicity study. Tahitian Noni puree, Tahitian Noni juice, and Tahitian Noni concentrate. Eurofins Scientific, East Brunswick, NJ
49. N Pulido A Suarez B Casanova R Romero E Rodriguez A Rovira 1997 Gliclazide treatment of streptozotocin diabetic rats restores GLUT4 protein content and basal glucose uptake in skeletal muscle Metabolism 46 10 13 10.1016/S0026-0495(97)90310-3
50. N Rakieten ML Rakieten MR Nadkarni 1963 Studies on the diabetogenic action of streptozotocin (NSC-37917) Cancer Chemother Rep 29 91 98
51. BL Rosenlund 1993 Effects of insulin on free amino acids in plasma and the role of the amino acid metabolism in the etiology of diabetic microangiopathy Biochem Med Metab Biol 49 375 391 10.1006/bmmb.1993.1038
52. JT Rotruck AL Pope HE Ganther AB Swanson DG Hafeman WG Hoekstra 1973 Selenium: biochemical role as a component of glutathione peroxidase Science 179 588 590 10.1126/science.179.4073.588
53. S Sang K He G Liu N Zhu X Cheng M Wang Q Zheng Z Dong G Ghai RT Rosen CT Ho 2001 A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L Org Lett 3 1307 1309 10.1021/ol0156648
54. T Sasaki S Matsy A Sonae 1972 Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose estimation Rinsh Kagaku 1 346 353
55. J Sedlak RH Lindsay 1968 Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal Biochem 25 192 205 10.1016/0003-2697(68)90092-4
56. J Seidemann 2001 Noni: Fragwürdige Zauberfrucht aus der Südsee Pharm Ztg 146 36 40 (Pubitemid 32963202)
57. AC Shovic WA Whistler 2001 Food sources of provitamin A and vitamin C in the American Pacific Trop Sci 41 199 202 (Pubitemid 33037309)
58. Soling HD, Kleineke J (1976) Species dependent regulation of hepatic gluconeogenesis in higher animals. In: Hanson RW, Mehlman MA (eds) Gluconeogenesis: its regulation in mammalian species. Wiley Interscience, New York, pp 369-462
59. BN Su AD Pawlus HA Jung WJ Keller JL McLaughlin AD Kinghorn 2005 Chemical constituents of the fruits of Morinda citrifolia (Noni) and their antioxidant activity J Nat Prod 68 592 595 10.1021/np0495985
60. S Takahara HB Hamilton JV Neel TY Kobara Y Ogura ET Nishimura 1960 Hypocatalasemia: a new genetic carrier state J Clin Invest 39 610 619 10.1172/JCI104075
61. MY Wang C Su 2001 Cancer preventive effect of Morinda citrifolia (Noni) Ann N Y Acad Sci 952 161 168 (Pubitemid 34060019)
62. W Wang CC Pang MS Rogers AM Chang 1996 Lipid peroxidation in cord blood at birth Am J Obstet Gynecol 174 62 65 10.1016/S0002-9378(96)70374-5
63. MY Wang BJ West CJ Jensen D Nowicki C Su AK Palu G Anderson 2002 Morinda citrifolia (Noni): a literature review and recent advances in Noni research Acta Pharmacol Sin 23 1127 1141 (Pubitemid 35470338)
64. BJ West CJ Jensen J Westendorf 2006 Noni juice is not hepatotoxic World J Gastroenterol 12 3616 3619
65. S Wild G Roglic A Green R Sicree H King 2004 Global prevalence of diabetes: estimates for the year 2000 and projections for 2030 Diabetes Care 27 1047 1053 10.2337/diacare.27.5.1047