Experimental ischaemia-reperfusion injury induces vascular endothelial growth factor expression in the rat testis

Andrologia

Volumn 41, Issue 4, 2009, Pages 216-221

  Hashimoto, H ^a,b   Ishikawa, T ^a   Yamaguchi, K ^a   Shiotani, M ^b   Fujisawa, M ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Hanabusa Women's Clinic   (Japan)

Author keywords

Ischaemia reperfusion injury; Testis; Torsion; VEGF

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; GERM CELL; IMMUNOHISTOCHEMISTRY; ISCHEMIA; MALE; MALE INFERTILITY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS INJURY; TESTIS TORSION; WESTERN BLOTTING;

ANIMALS; MALE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SPERMATIC CORD TORSION; TESTIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 67650711476     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2009.00918.x     Document Type: Article

References (22)

1. Adrian LH (2001) Hypoxia-A key regulatory factor in tumor growth. Nat Rev Cancer 2 : 38 47.
2. Akgür FM, Kilinç K, Aktù T (1993) Reperfusion injury after detorsion of unilateral testicular torsion. Urol Res 21 : 395 399. (Pubitemid 24053897)
3. Anderson JB, Williamson RCN (1986) The fate of human testes following unilateral torsion of the spermatic cord. Br J Urol 58 : 698 704. (Pubitemid 17215766)
4. Bott RC, McFee RM, Clopton DT, Toombs C, Cupp AS (2006) Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat. Biol Reprod 75 : 56 67. (Pubitemid 43948357)
5. Dvorak HF, Brown LF, Detmar M, Dvorak AM (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146 : 1029 1039.
6. Ergün S, Kiliç N, Fiedler W, Mukhopadhyay AK (1997) Vascular endothelial growth factor and its receptors in normal human testicular tissue. Mol Cell Endocrinol 131 : 9 20. (Pubitemid 27343228)
7. Ferrara N (1999) Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 56 : 794 814. (Pubitemid 29411709)
8. Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N (2000) A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3-kinase activation and endothelial cell migration. EMBO J 19 : 4064 4073. (Pubitemid 30608545)
9. Gospodarowicz D, Abraham JA, Schilling J (1989) Isolation and characterization of vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci U S A 86 : 7311 7315. (Pubitemid 19254450)
10. Hayashi T, Abe K, Itoyama Y (1998) Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J Cereb Blood Flow Metab 18 : 887 895. (Pubitemid 28359907)
11. Hierholzer C, Harbercht B, Menezes JM, Kane J, MacMicking J, Nathan CF (1998) Essential role of induced nitric oxide in the initiation of inflammatory responses after hemorrhagic shock. J Exp Med 187 : 917 928. (Pubitemid 28141665)
12. Houck KA, Ferrara N, Winner J, Cachianes G, Li B, Leung DW (1991) The vascular endothelial growth factor family-identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 5 : 1806 1814.
13. Hwang GS, Wang SW, Tseng WM, Yu CH, Wang PS (2007) Effect of hypoxia on the release of vascular endothelial growth factor and testosterone in mouse TM3 Leydig cells. Am J Physiol Endocrinol Metab 292 : E1763 E1769.
14. Ishikawa T, Kondo Y, Goda K, Fujisawa M (2005) Overexpression of endothelial nitric oxide synthase in transgenic mice accelerates testicular germ cell apoptosis induced by experimental cryptorchidism. J Androl 26 : 281 288. (Pubitemid 40293715)
15. Korpelainen EI, Karkkainen MJ, Tehunen A, Lakso M, Rauvala H, Vierula M, Parvinen M, Alitalo K (1998) Overexpression of VEGF in the testis and epididymis causes infertility in transgenic mice: evidence for nonendothelial targets for VEGF. J Cell Biol 143 : 1705 1712. (Pubitemid 29006513)
16. Kupatt C, Hinkel R, Vachenauer R, Horstkotte J, Raake P, Sandner T, Kreuzpointner R, Müllere F, Dimmeler S, Feron O, Boekstegers P (2003) VEGF165 transfection decreases postischemic NF-kappa B-dependent myocardial reperfusion injury in vivo: role of eNOS phosphorylation. FASEB J 17 : 705 707.
17. Lissbrant E, Löfmark U, Collin O, Bergh A (1997) Is nitric oxide involved in the regulation of the rat testicular vasculature? Biol Reprod 56 : 1221 1227. (Pubitemid 27184507)
18. Moriga T, Arii S, Takeda Y, Furuyama H, Muzimoto M, Mori A, Hanaki K, Nakamura T, Fujioka M, Imamura M (2000) Protection by vascular endothelial growth factor against sinusoidal endothelial damage and apoptosis induced by cold preservation. Transplantation 69 : 141 147. (Pubitemid 30062621)
19. Tunçkiran A, Cayan S, Bozlu M, Yilmaz N, Acar D, Akbay E (2005) Protective effect of vascular endothelial growth factor on histologic changes in testicular ischemia-reperfusion injury. Fertil Steril 84 : 468 473. (Pubitemid 41125272)
20. Turner TT, Tung KSK, Tomomasa H, Wilson LW (1997) Acute testicular ischemia results in germ cell-specific apoptosis in the rat. Biol Reprod 57 : 1267 1274. (Pubitemid 27516628)
21. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J (2000) Vascular-specific growth factors and blood vessel formation. Nature 407 : 242 248.
22. Young KA, Nelson RJ (2000) Short photoperiods reduce vascular endothelial growth factor in the testes of Peromyscus leucopus. Am J Physiol Regul Integr Comp Physiol 279 : R1132 R1137.