Improving the dissolution and oral bioavailability of the poorly water-soluble drug aloe-emodin by solid dispersion with polyethylene glycol 6000

Drug Development Research

Volumn 70, Issue 5, 2009, Pages 363-369

  Duan, Hao Gang ^a   Wei, Yu Hui ^a   Li, Bo Xia ^a   Qin, Hong Yan ^a   Wu, Xin An ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Aloe emodin; Dissolution; Oral bioavailability; Polyethylene glycol 6000; Solid dispersion

Indexed keywords

ALOE EMODIN; MACROGOL 6000;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG RELEASE; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE; MALE; NONHUMAN; RAT; SCANNING ELECTRON MICROSCOPY;

EID: 67650681150     PISSN: 02724391     EISSN: 10982299     Source Type: Journal    
DOI: 10.1002/ddr.20312     Document Type: Article

References (36)

1. Agarwal SK, Singh SS, Verma S. 2000. Antifungal activity of anthraquinone derivatives from Rheum emodi. J Ethnol Pharmacol 72:43-46. (Pubitemid 30680034)
2. Barnard DL, Huffman JH, Morris JL. 1992. Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. Antiviral Res 17:63-77.
3. Beatrice A, Nicoletta G, Lorena MPF. 2000. Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon Tetrachlor. Pharmacol Toxicol 87:229-233. (Pubitemid 30948945)
4. Cardenas C, Quesada AR, Medina MA. 2006. Evaluation of the anti-angiogenic effect of aloe-emodin. Cell Mol Life Sci 63:3083-3089.
5. Chiou WL, Riegelman S. 1971. Pharmaceutical applications of solid dispersion systems. J Pharm Sci 60:1281-1302.
6. Desai J, Alexander K, Riga Desai A. 2006. Characterization of polymeric dispersions of dimenhydrinate in ethyl cellulose for controlled release. Int J Pharm 308:115-123. (Pubitemid 43097242)
7. Doshi DH, Ravis WR, Betageri GV. 1997. Carbamazepine and polyethylene glycol solid dispersion preparation, in vitro dissolution, and characterisation. Drug Dev Ind Pharm 23:1167-1176. (Pubitemid 28030017)
8. Dressman JB, Lennernas H, editors. 2000. Oral drug absorption: prediction and assessment. New York: Marcel Dekker. p 330.
9. Drug Examination and Approval Office of the Public Health Ministry. 1992. Instructive principle for the bioavailability test pharmaceutical formulations in volunteers. Chin Clin Pharm 8:189.
10. Elaine ML, Gary GL, Eugene RC. 2003. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur J Pharm Sci 18:113-120. (Pubitemid 36184748)
11. Franco M, Trapani G, Latrof A. 2001. Dissolution properties and anticonvulsant activity of phenytoin-polyethylene glycol 6000 and -polyvinylpyrrolidone K-30 solid dispersions. Int J Pharm 225: 63-73. (Pubitemid 32728200)
12. Gohel MC, Patel LD. 2003. Processing of Nimesulide-PEG 400-PG-PVP solid dispersions: preparation, characterization, and vitro dissolution. Drug Dev Ind Pharm 29:299-310. (Pubitemid 36528620)
13. Hart LA, Nibbering PH, Barselaar MT, Dijk H, Berg AJJ, Labadie RP. 1990. Effects of low molecular constituents from Aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human neutrophils. Int J Immunopharm12:427-434. (Pubitemid 20203636)
14. Kim CK, Cho YJ, Gao ZG. 2001. Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. J Control Rel 70:149-155. (Pubitemid 32144799)
15. Lheritier J, Chauvet A, Abramovici B. 1995. Improvement of the dissolution kinetics of SR 33557 by means of solid dispersions containing PEG 6000. Int J Pharm 123:273-279.
16. Leuner C, Dressman J. 2000. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 50:47-60. (Pubitemid 30326688)
17. Mijatovic S, Maksimovic-Ivanic D, Radovic J. 2005. Anti-glioma action of aloe emodin: the role of ERK inhibition. Cell Mol Life Sci 62:589-598. (Pubitemid 40386337)
18. Moneghini M, Kikic I, Voinovich D. 2001. Processing of carbamazepine- PEG 4000 solid dispersions with supercritical carbon dioxide: preparation, characterisation, and in vitro dissolution. Int J Pharm 222:129-138. (Pubitemid 32525794)
19. Naima Z, Chantal C, Philippe A. 2001. In vitro and in vivo evaluation of carbamazepine-PEG 6000 solid dispersions. Int J Pharm 225:49-62.
20. Naveen A, Katare OP, Bhupinder S. 2007. Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm 65:26-38. (Pubitemid 44827692)
21. Passerini N, Gonzalez-Rodriguez ML, Cavallari C. 2002. Preparation and characterisation of ibuprofen-poloxamer 188 granules obtained by melt granulation. Eur J Pharm Sci 15:71-78. (Pubitemid 34136970)
22. Pecere T, Gazzola MV, Mucignat C. 2000. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res 60:2800-2804. (Pubitemid 30395795)
23. Rajewski RA, Stella VJ. 1996. Pharmaceutical applications of cyclodextrins 2. In vivo drug delivery. J Pharm Sci 85:1142-1169.
24. Seo A, Holm P, Kristensen HG. 2003. The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer. Int J Pharm 259:161-171. (Pubitemid 36638562)
25. Serajuddin ATM. 1999. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent break-throughs. J Pharm Sci 88:1058-1066. (Pubitemid 29480600)
26. Serajuddin ATM, Sheen PC, Mufson D. 1988. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions. J Pharm Sci 77:414-417. (Pubitemid 19080862)
27. Serajuddin ATM, Sheen PC, Augustine MA. 1990. Improved dissolution of poorly water-soluble drug from solid dispersions in polyethylene: polysorbate 80 mixture. J Pharm Sci 79:463-464. (Pubitemid 20152186)
28. Sethia S, Squillante E. 2003. Solid dispersions: revival with greater possibilities and applications in oral drug delivery. Crit Rev Ther Drug Carrier Syst 20:215-247. (Pubitemid 37237280)
29. Streubel A, Siepmann J, Bodmeier R. 2006. Drug delivery to the upper small intestine window using gastroretentive technologies. Curr Opin Pharm 6:501-508. (Pubitemid 44340666)
30. Teofilo V, Bruno S, Paulo C. 2007. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today 12:1068-1075. (Pubitemid 350186132)
31. Thomson RH. 1971. Naturally occurring quinones. New York: Academic Press.
32. Usui F, Maeda K, Kusai A. 1998. Dissolution improvement of RS-8359 by the solid dispersion prepared by the solvent method. Int J Pharm 170:247-256. (Pubitemid 28473292)
33. Vilhelmsen T, Eliasen H, Schaefer T. 2005. Effect of a melt agglomeration process on agglomerates containing solid dispersions. Int J Pharm 303:132-142. (Pubitemid 41318030)
34. Won DH, Kim MS, Lee S. 2005. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. Int J Pharm 301: 199-208. (Pubitemid 41206604)
35. Yalcin O, Nazan D, Necati D. 2000. Enhanced release of solid dispersions of etodolac in polyethylene glycol. Il Farmacol 55:433-438.
36. Yen GC, Duh PD, Chuang DY. 2000. Antioxidant activity of anthraquinones and anthrone. Food Chem 70:437-441.