Role of p38 MAPK in Burn-Induced Intestinal Barrier Breakdown1

Journal of Surgical Research

Volumn 156, Issue 1, 2009, Pages 64-69

  Costantini, Todd W ^a   Peterson, Carrie Y ^a   Kroll, Lauren ^a   Loomis, William H ^a   Eliceiri, Brian P ^a   Baird, Andrew ^a   Bansal, Vishal ^a   Coimbra, Raul ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

burn; gut; inflammation; intestinal barrier; intestinal permeability; intestine; myosin light chain kinase; p38 MAPK; tight junction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA ACTIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; MITOGEN ACTIVATED PROTEIN KINASE P38; MYOSIN LIGHT CHAIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; IN VIVO STUDY; INFLAMMATION; INJURY SEVERITY; INTESTINAL BARRIER; INTESTINE EPITHELIUM; MALE; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; TIGHT JUNCTION; UPREGULATION;

ANIMALS; BURNS; ENZYME ACTIVATION; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED BALB C; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN KINASE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PERMEABILITY; PHOSPHORYLATION;

EID: 67650673060     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.03.066     Document Type: Article

References (18)

1. Shen L., and Turner J.R. Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: Tight junction dynamics exposed. Am J Physiol Gastrointest Liver Physiol 290 (2006) G577
2. Costantini T.W., Deree J., Loomis W., et al. Phosphodiesterase inhibition attenuates alterations to the tight junction proteins occludin and ZO-1 in immunostimulated Caco-2 intestinal monolayers. Life Sci 84 (2009) 18
3. Deitch E.A. Bacterial translocation or lymphatic drainage of toxic products from the gut: What is important in human beings?. Surgery 131 (2002) 241
4. Masuno T., Moore E.E., Cheng A.M., et al. Bioactivity of postshock mesenteric lymph depends on the depth and duration of hemorrhagic shock. Shock 26 (2006) 285
5. Costantini T.W., Loomis W.H., Putnam J.G., et al. Burn-induced gut barrier injury is attenuated by phosphodiesterase inhibition: Effects on tight junction structural proteins. Shock 31 (2009) 416
6. Al-Sadip R., Ye D., Dokladny K., et al. Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. J Immunol 180 (2008) 5653
7. Costantini T.W., Loomis W.H., Putnam J.G., et al. Pentoxifylline modulates intestinal tight junction signaling after burn injury: Effects on myosin light chain kinase. J Trauma 66 (2009) 17 discussion 24
8. Wang Q., Guo X.L., Wells-Byrum D., et al. Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells. Shock 29 (2008) 531
9. Badger A.M., Bradbeer J.N., Votta B., et al. Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J Pharmacol Exp Ther 279 (1996) 1453
10. Turner J.R. Molecular basis of epithelial barrier regulation: From basic mechanisms to clinical application. Am J Pathol 169 (2006) 1901
11. Madara J.L., Moore R., and Carlson S. Alteration of intestinal tight junction structure and permeability by cytoskeletal contraction. Am J Physiol 253 (1987) C854
12. Boivin M.A., Ye D., Kennedy J.C., et al. Mechanism of glucocorticoid regulation of the intestinal tight junction barrier. Am J Physiol Gastrointest Liver Physiol 292 (2007) G590
13. Shen L., Black E.D., Witkowski E.D., et al. Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci 119 (2006) 2095
14. Turner J.R., Rill B.K., Carlson S.L., et al. Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation. Am J Physiol 273 (1997) C1378
15. Ma T.Y., Boivin M.A., Ye D., et al. Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: Role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 288 (2005) G422
16. Graham W.V., Wang F., Clayburgh D.R., et al. Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. J Biol Chem 281 (2006) 26205
17. Varfolomeev E.E., and Ashkenazi A. Tumor necrosis factor: An apoptosis JuNKie?. Cell 116 (2004) 491
18. Choi E.Y., Park Z.Y., Choi E.J., et al. Transcriptional regulation of IL-8 by iron chelator in human epithelial cells is independent from NF-kappaB but involves ERK1/2- and p38 kinase-dependent activation of AP-1. J Cell Biochem 102 (2007) 1442