Gender differences in early alcohol-induced liver injury: Role of CD14, NF-κB, and TNF-α

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 278, Issue 4 41-4, 2000, Pages

  Kono, Hiroshi ^a   Wheeler, Michael D ^a   Rusyn, Ivan ^a   Lin, Min ^b   Seabra, Vitor ^a   Rivera, Chantal A ^a   Bradford, Blair U ^a   Forman, Donald T ^a   Thurman, Ronald G ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Endotoxin; Kupffer cells

Indexed keywords

ALCOHOL; ASPARTATE AMINOTRANSFERASE; CD14 ANTIGEN; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; KUPFFER CELL; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

EID: 0033996137     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.278.4.g652     Document Type: Article

References (49)

1. Adachi Y, Bradford BU, Gao W, Bojes HK, and Thurman RG. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 20: 453-460, 1994.
2. Adachi Y, Moore LE, Bradford BU, Gao W, and Thurman RG. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108: 218-224, 1995.
3. Ashley MJ, Olin JS, le Riche WH, Kornaczewski A, Schmidt W, and Rankin JG. Morbidity in alcoholics: evidence for accelerated development of physical disease in women. Arch Intern Med 137: 883-887, 1977.
4. Badger TM, Crouch J, Irby D, and Shahare M. Episodic excretion of ethanol during chronic intragastric ethanol infusion in the male rat: continuous vs. cyclic ethanol and nutrient infusions. J Pharmacol Exp Ther 264: 938-943, 1993.
5. Baeuerle PA and Baltimore D. A 65 KD subunit of active NF-kB is required for inhibition of NF-kB by IkB. Genes Dev 3: 1689-1698, 1989.
6. Bellezzo JM, Britton RS, Bacon BR, and Fox ES. LPS-mediated NF-κB activation in rat Kupffer cells can be induced independently of CD14. Am J Physiol Gastrointest Liver Physiol 270: G956-G961, 1996.
7. Bergmeyer HU. Methods of enzymatic analysis. New York: Academic, 1988.
8. Conner EM and Grisham MB. . Inflammation, free radicals, and antioxidants. Nutrition 12: 274-277, 1996.
9. Corrao G, Lepore AR, Torchio P, Galatola G, Arico S, and Di Orio F. Interaction between dietary pattern and alcohol intake on the risk of liver cirrhosis. The provincial group for the study of chronic liver disease. Rev Epidemiol Sante Publique 43: 7-17, 1997.
10. Enomoto N, Ikejima K, Bradford BU, Rivera CA, Kono H, Brenner DA, and Thurman RG. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 115: 443-451, 1998.
11. Enomoto N, Schemmer P, Rivera CA, Bradford BU, Enomoto A, Nishimura T, Nishiura T, Brenner DA, and Thurman RG. Estriol sensitizes rat Kupffer cells by increasing permeability to gut-derived endotoxin. Am J Physiol Gastrointest Liver Physiol 277: G671-G677, 1999.
12. French SW. Nutrition in the pathogenesis of alcoholic liver disease. Alcohol Alcohol 28: 97-109, 1993.
13. French SW, Miyamoto K, and Tsukamoto H. Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res 10, Suppl 6: 13S-19S, 1986.
14. Hobbs J, Boutagy J, and Shenfield GM. Interactions between ethanol and oral contraceptive steroids. Clin Pharmacol Ther 38: 371-380, 1985.
15. Iimuro Y, Frankenberg Mv, Arteel GE, Bradford BU, Wall CA, and Thurman RG. Female rats exhibit greater susceptibility to early alcohol-induced injury than males. Am J Physiol Gastrointest Liver Physiol 272: G1186-G1194, 1997.
16. Iimuro Y, Gallucci RM, Luster MI, Kono H, and Thurman RG. Antibodies to tumor necrosis factor-α attenuate hepatic necrosis and inflammation due to chronic exposure to ethanol in the rat. Hepatology 26: 1530-1537, 1997.
17. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT, Brenner DA, and Thurman RG. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Am J Physiol Gastrointest Liver Physiol 274: G669-G676, 1998.
18. Jarvelainen HA, Fang C, Ingelman-Sundberg M, and Lindros KO. Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and antiinflammatory cytokines. Hepatology 29: 1503-1510, 1999.
19. Knecht KT, Adachi Y, Bradford BU, Iimuro Y, Kadiiska M, Qun-hui X, and Thurman RG. Free radical adducts in the bile of rats treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells. Mol Pharmacol 47: 1028-1034 1995.
20. Kono H, Yin M, Bradford BU, Gonzalez FJ, and Thurman RG. Development of a new enteral mouse model using knockout technology to study alcohol-induced liver injury: Is CYP2E1 involved? (Abstract). Hepatology 28: A330, 1998.
21. Kubasik NP, Hallauer GD, and Brodows RG. Evaluation of a direct, solid-phase radioimmunoassay for progesterone. Clin Chem 30: 284-286, 1984.
22. Levin J and Bang FB. Clottable protein in Limulus: its localization and kinetics of its coagulation by endotoxin. Thromb Diath Haemorrh 19: 186-197, 1996.
23. Li T-K and Couzigou P. Summary of First Bordeaux Conference in Alcohol, Liver, and Nutrition: utility of Tsukamoto-French model (Abstract). Alcohol Clin Exp Res 22: 773, 1998.
24. Morimoto M, Zern MA, Hagbjork AL, Ingelman-Sundberg M, and French SW. Fish oil, alcohol, and liver pathology: role of cytochrome P4502E1. Proc Soc Exp Biol Med 207: 197-205, 1994.
25. Nanji AA, Khettry U, and Sadrzadeh SMH. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc Soc Exp Biol Med 205: 243-247, 1994.
26. Nanji AA, Mendenhall CL, and French SW. Beef fat prevents alcoholic liver disease in the rat. Alcohol Clin Exp Res 13: 15-19, 1989.
27. Nanji AA, Rahemtulla A, Maio L, Khwaja S, Zhao S, Tahan SR, and Thomas P. Alterations in thromboxane synthase and thromboxane A2 receptors in experimental alcoholic liver disease. J Pharmacol Exp Ther 282: 1037-1043, 1997.
28. Naveau S, Giraud V, Borotto E, Aubert A, Capron F, and Chaput JC. Excess weight risk factor for alcoholic liver disease. Hepatology 25: 108-111, 1997.
29. Pertoft H and Smedsrod B. Separation and characterization of liver cells. In: Cell Separation: Methods and Selected Applications, edited by Pretlow TG II and Pretlow TP. New York: Academic, 1987, vol. 4, p. 1-24.
30. Rachamin G, Macdonald JA, Wahid S, Clapp JJ, Khanna JM, and Israel Y. Modulation of alcohol dehydrogenase and ethanol metabolism by sex hormones in the spontaneously hypertensive rat. Biochem J 186: 483-490, 1980.
31. Rivera CA and Thurman RG. Tips for measuring endotoxin in plasma. Alcohol Clin Exp Res 22: 2192-2194, 1998.
32. Rubin E and Lieber CS. Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. N Engl J Med 290: 128-135, 1974.
33. Sonenshein GE. Rel/NF-κB transcription factors and the control of apoptosis. Semin Cancer Biol 8: 113-119, 1997.
34. Su GL, Rahemtulla A, Thomas P, Klein RD, Wang SC, and Nanji AA. CD14 and lipopolysaccharide binding protein expression in a rat model of alcoholic liver disease. Am J Pathol 152: 841-849, 1998.
35. Thomas ML, Xu X, Norfleet AM, and Watson CS. The presence of functional estrogen receptors in intestinal epithelial cells. Endocrinology 132: 426-430, 1993.
36. Thompson JA and Reitz RC. Effects of ethanol ingestion and dietary fat levels on mitochondrial lipids in male and female rats. Lipids 13: 540-550, 1978.
37. Thurman RG. Mechanisms of Hepatic Toxicity. II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin. Am J Physiol Gastrointest Liver Physiol 275: G605-G611, 1998.
38. Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC, and Largman C. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5: 224-232, 1985.
39. Tsukamoto H, French SW, Reidelberger RD, and Largman C. Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats. Alcohol Clin Exp Res 9: 31-37, 1985.
40. Tsukamoto H, Gaal K, and French SW. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12: 599-608, 1990.
41. Tsukamoto H, Reiderberger RD, French SW, and Largman C. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol Regulatory Integrative Comp Physiol 247: R595-R599, 1984.
42. Tsukamoto H, Towner SJ, Ciofalo LM, and French SW. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology 6: 814-822, 1986.
43. Van Eldere J, Robben J, de Pauw R, Merckx R, and Eyssen H. Isolation and identification of intestinal steroid-desulfating bacteria from rats and humans. Appl Environ Microbiol 54: 2112-2117, 1988.
44. Windier EET, Kovanen P, Chao YS, Brown MS, Havel RJ, and Goldstein JL. The estradiol stimulated lipoprotein receptor of rat liver. A binding site that mediates the uptake of rat lipoprotein containing apoproteins B and E. J Biol Chem 255: 10464-10471, 1980.
45. Xing S, Cekan SZ, Dicafalusy U, Falk O, Gustafsson SA, Akerlof E, and Bjorkhem I. Validation of radioimmunoassay of estradiol-17B by isotope dilution-mass spectrometry and by a test of radiochemical purity. Clin Chim Acta 135: 189-201, 1983.
46. Yin M, Ikejima K, Wheeler MD, Bradford BU, Seabra V, Forman DT, Sato N, and Thurman RG. Estrogen is involved in early alcohol-induced liver injury in a rat enteral feeding model. Hepatology 31: 117-123, 2000.
47. Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, and Thurman RG. Essential role of tumor necrosis factor α in alcohol-induced liver injury. Gastroenterology. 117: 942-952, 1999.
48. 2+ dependence, and differential half-site recognition. J Biol Chem 266: 252-260, 1991.
49. Zeiner AR and Kegg PS. Effects of sex steroids on ethanol pharmacokinetics and autonomic activity. Prog Biochem Pharmacol 18: 130-142, 1981.