QSAR analysis of 1,3-diaryl-2-propen-1-ones and their indole analogs for designing potent antibacterial agents

Chemical Papers

Volumn 63, Issue 4, 2009, Pages 456-463

  Bhatia, Neela M ^a   Mahadik, Kakasaheb R ^b   Bhatia, Manish S ^a  

^a BHARATI VIDYAPEETH COLLEGE OF PHARMACY   (India)

^b BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

Author keywords

Antibacterial screening; Prop 2 enones; QSAR; Synthesis

Indexed keywords

EID: 67650591040     PISSN: 03666352     EISSN: 13369075     Source Type: Journal    
DOI: 10.2478/s11696-009-0026-6     Document Type: Article

References (25)

1. F. Al-Omran A. A. El-Khair 2004 Synthesis of polyfunctionally substituted heteroaromatic compounds via benzotriazolyl chalcones with antimicrobial and antifungal activities Journal of Heterocyclic Chemistry 41 327 333 (Pubitemid 38850029)
2. E. Audry J. P. Dubost J. C. Colleter P. Dallet 1986 A new approach to structure-activity relations: the molecular lipophilicity potential European Journal of Medicinal Chemistry 21 71 72 (Pubitemid 16114129)
3. I. Berber C. Cokmus E. Atalan 2003 Characterization of Staphylococcus species by SDS-PAGE of whole cell and extracellular proteins Microbiology 72 54 57
4. J. Deng T. Sanchez L. Q. Al-Mawsawi R. Dayam R. A. Yunes A. Garofalo M. B. Bolger N. Neamati 2007 Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore Bioorganic & Medicinal Chemistry 15 4985 5002 (Pubitemid 46836825)
5. Furniss, B. S., Hannaford, A. J., Smith, P. W. G., & Tatchell, A. R. (1989). Vogel's textbook of practical organic chemistry, (5th ed., p. 1034.). London: Longman Scientific & Technical.
6. E. I. Gasull J. J. Silber S. E. Blanco F. Tomas F. H. Ferretti 2000 A theoretical and experimental study of the formation mechanism of 4-X-chalcones by the Claisen-Schmidt reaction Journal of Molecular Structure: THEOCHEM 503 131 144
7. Hall, L. H., & Kier, L. B. (1991). The molecular connectivity chi indexes and kappa shape indexes in structure-property modeling. In K. B. Lipkowitz & D. B. Boyd (Eds.), Reviews of computational chemistry (Vol. 2, Chap. 9, pp. 367-422). New York: VCH Publishers. DOI: 002/9780470125793.ch9.
8. A. Hasan K. M. Khan M. Sher G. M. Maharvi S. A. Nawaz M. I. Choudhary Atta-ur-Rahman C. T. Supuran 2005 Synthesis and inhibitory potential towards acetylcholinesterase, butyrylcholinesterase and lipoxigenase of some variably substituted chalcones Journal of Enzyme Inhibition and Medicinal Chemistry 20 41 47 (Pubitemid 40520615)
9. F. Herencia M. L. Ferrándiz A. Ubeda J. N. Dominguez J. E. Charris G. M. Lobo M. J. Alcaraz 1998 Synthesis and anti-inflammatory activity of chalcone derivatives Bioorganic & Medicinal Chemistry Letters 8 1169 1174 (Pubitemid 28231392)
10. F. Herencia M. P. Lopez-Garcia A. Ubeda M. L. Ferrándiz 2002 Nitric oxide-scavenging properties of some chalcone derivatives Nitric Oxide: Biology and Chemistry 6 242 246 (Pubitemid 34848448)
11. M. S. Y. Khan S. M. Hasan 2003 Synthesis, antiinflammatory and antibacterial activity of some new flavonoidal derivatives Indian Journal of Chemistry, Section B 42 1970 1974
12. L. B. Kier L. H. Hall 1977 The nature of structure-activity relationships and their relation to molecular connectivity European Journal of Medicinal Chemistry 12 307 312 (Pubitemid 8254319)
13. K. L. Lahtchev D. I. Batovska P. St. Parushev V. M. Ubiyvovk A. A. Sibirny 2008 Antifungal activity of chalcones: A mechanistic study using various yeast strains European Journal of Medicinal Chemistry 43 2220 2228
14. V. J. Lee S. J. Hecker 1999 Antibiotic resistance versus small molecules, the chemical evolution Medicinal Research Reviews 19 521 542 (Pubitemid 29521755)
15. M. Liu P. Wilairat S. L. Croft A. L.-C. Tan M.L. Go 2003 Structure-activity relationships of antileishmanial and antimalarial chalcones Bioorganic & Medicinal Chemistry 11 2729 2738 (Pubitemid 36682997)
16. S. N. López M. V. Castelli S. A. Zacchino J. N. Dominguez G. Lobo J. Charris-Charris J. C. G. Cortes J. C. Ribas C. Devia A. M. Rodriguez R. D. Enriz 2001 In vitro antifungal evaluation and structure.activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall Bioorganic & Medicinal Chemistry 9 1999 2013 (Pubitemid 32739188)
17. N. Mishra P. Arora B. Kumar L. C. Mishra A. Bhattacharya S. K. Awasthi V. K. Bhasin 2008 Synthesis of novel substituted 1,3-diaryl propenone derivatives and their antimalarial activity in vitro European Journal of Medicinal Chemistry 43 1530 1535 (Pubitemid 351885216)
18. L. A. Mitscher S. P. Pillai E. J. Gentry D. M. Shankel 1999 Multiple drug resistance Medicinal Research Reviews 19 477 496 (Pubitemid 29521753)
19. Z. Nowakowska 2007 A review of anti-infective and anti-inflammatory chalcones European Journal of Medicinal Chemistry 42 125 137 (Pubitemid 46282233)
20. M. Ono M. Hori M. Haratake T. Tomiyama H. Mori M. Nakayama 2007 Structure.activity relationship of chalcones and related derivatives as ligands for detecting of β-amyloid plaques in the brain Bioorganic & Medicinal Chemistry 15 6388 6396 (Pubitemid 47212733)
21. J. L. Pellerin P. Bourdeau H. Sebbag J. M. Person 1998 Epidemiosurveillance of antimicrobial compound resistance of Staphylococcus intermedius clinical isolates from canine pyodermas Comparative Immunology Microbiology & Infectious Diseases 21 115 133 (Pubitemid 28209722)
22. P. M. Sivakumar S. Prabu Seenivasan V. Kumar M. Doble 2007 Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives Bioorganic & Medicinal Chemistry Letters 17 1695 1700 (Pubitemid 46316778)
23. A. Solankee J. Patel 2004 Synthesis of chalcones, pyrazolines, aminopyrimidines and pyrimidinethiones as antibacterial agents Indian Journal of Chemistry, Section B 43 1580 1584
24. W. S. Sung H. J. Jung K. Park H. S. Kim I.-S. Lee,. D. G. Lee 2007 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF); antimicrobial compound with cell cycle arrest in nosocomial pathogens Life Sciences 80 586 591 (Pubitemid 46038330)
25. Y. C. Xu S. W. S. Leung D. K. Y. Yeung L. H. Hu G. H. Chen C. M. Che R. Y. K. Man 2007 Structure. activity relationships of flavonoids for vascular relaxation in porcine coronary artery Phytochemistry 68 1179 1188 (Pubitemid 46528458)