Antibiotic resistance versus small molecules, the chemical evolution

Medicinal Research Reviews

Volumn 19, Issue 6, 1999, Pages 521-542

  Lee, Ving J ^a,b   Hecker, Scott J ^a  

^a Microcide Pharmaceuticals Inc   (United States)

^b PFIZER INC   (United States)

Author keywords

Antibiotic resistance; Bacterial translocase (transferase); Cephalosporins; Dihydropacidamycins enterococci; Methicillin resistant S. aureus (MRSA); P. aeruginosa; Penicillin binding protein 2A (PBP2a); Pharmacokinetic pharmacodynamic modeling; Protein binding; Uridyl peptide antibiotics (UPAs)

Indexed keywords

7 [[(2 AMINO 5 CHLORO 4 THIAZOLYL)(HYDROXYIMINO)ACETYL]AMINO] 3 [[3 [[(2 AMINOETHYL)THIO]METHYL] 4 PYRIDINYL]THIO] 8 OXO 5 THIA 1 AZABICYCLO[4.2.0]OCT 2 ENE 2 CARBOXYLIC ACID; AMFOMYCIN; AMPICILLIN; CARRIER PROTEIN; CEFOTAXIME; CEPHALOSPORIN DERIVATIVE; CIPROFLOXACIN; DIAMINOBUTYRIC ACID; ENZYME INHIBITOR; IMIPENEM; LIPOSIDOMYCIN A; LIPOSIDOMYCIN B; LIPOSIDOMYCIN C; METICILLIN; MUREIDOMYCIN A; MUREIDOMYCIN B; MUREIDOMYCIN C; NAPSAMYCIN A; NAPSAMYCIN B; NAPSAMYCIN C; NAPSAMYCIN D; PACIDAMYCIN; PENICILLIN BINDING PROTEIN; PENICILLIN G; SM 17466; TOC 39; TUNICAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; BACTERIAL CELL WALL; DIASTEREOISOMER; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECIUM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; REACTION ANALYSIS; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG RESISTANCE, MICROBIAL; HUMANS;

EID: 0032730597     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-1128(199911)19:6<521::AID-MED4>3.0.CO;2-9     Document Type: Review

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