메뉴 건너뛰기




Volumn 13, Issue 7, 2002, Pages 673-683

The clinical development of the bryostatins

Author keywords

Bryostatin; Protein kinase C; Signal transduction

Indexed keywords

ANALGESIC AGENT; BRYOSTATIN; BRYOSTATIN 1; BRYOSTATIN 10; BRYOSTATIN 4; BRYOSTATIN 5; BRYOSTATIN 7; BRYOSTATIN 8; CISPLATIN; CLADRIBINE; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOTOXIC AGENT; DOXORUBICIN; FLUDARABINE; GABAPENTIN; GEMCITABINE; GLYCOPROTEIN P; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; INTERLEUKIN 3; IONOMYCIN; PACLITAXEL; PREDNISOLONE; PREDNISONE; PROTEIN KINASE C; RETINOIC ACID; UNCLASSIFIED DRUG; VINCRISTINE; ANTINEOPLASTIC AGENT; LACTONE; MACROLIDE;

EID: 0036667939     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200208000-00001     Document Type: Review
Times cited : (86)

References (83)
  • 9
    • 0029892167 scopus 로고    scopus 로고
    • The bryostatins inhibit growth of B16/F10 melanoma cells in vitro through a protein kinase C-independent mechanism: Dissociation of activities using 26-epi-bryostatin-1
    • (1996) Cancer Res , vol.56 , pp. 2105-2111
    • Szallasi, Z.1    Du, L.2    Levine, R.3
  • 13
    • 0032877433 scopus 로고    scopus 로고
    • Bax:bcl-2 ratio modulation by bryostatin-1 and novel anti-tubulin agents is important for susceptibility to drug-induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh
    • (1999) Leuk Res , vol.23 , pp. 881-888
    • Wall, N.R.1    Mohammad, R.M.2    Al-Katib, A.M.3
  • 31
  • 32
    • 0027893113 scopus 로고
    • Modulation of the activity of a human granulocyte-macrophage-colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) by the macrocyclic lactone protein kinase C activator bryostatin 1
    • (1993) Exp Hematol , vol.21 , pp. 893-900
    • McCrady, C.W.1    Li, F.2    Pettit, G.R.3    Grant, S.4
  • 36
    • 0026531518 scopus 로고
    • Effect of bryostatin-1 on the in vitro radioprotective capacity of recombinant granulocyte-macrophage colony-stimulating factor (rGM-CSF) toward committed human myeloid progenitor cells (CFU-GM)
    • (1992) Exp Hematol , vol.20 , pp. 34-42
    • Grant, S.1    Pettit, G.R.2    McCrady, C.3
  • 37
    • 0028089219 scopus 로고
    • The macrocyclic lactone protein kinase C activator, bryostatin 1, either alone or in conjunction with recombinant murine granulocyte-macrophage colony-stimulating factor, protects Balb/c and C3H/HeN mice from the lethal in vivo effects of ionizing radiation
    • (1994) Blood , vol.83 , pp. 663-667
    • Grant, S.1    Traylor, R.2    Pettit, G.R.3    Lin, P.S.4
  • 42
    • 0026628279 scopus 로고
    • Sensitization of human cervical carcinoma cells to cisdiamminedichloroplatinum(II) by bryostatin 1
    • (1992) Cancer Res , vol.52 , pp. 3119-3124
    • Basu, A.1    Lazo, J.S.2
  • 49
    • 0030063389 scopus 로고    scopus 로고
    • Preclinical pharmacology of the natural product anticancer agent bryostatin 1, an activator of protein kinase C
    • (1996) Cancer Res , vol.56 , pp. 802-808
    • Zhang, X.1    Zhang, R.2    Zhao, H.3
  • 73
    • 0001496649 scopus 로고    scopus 로고
    • Phase I trial of the PKC activator/downregulator bryostatin 1 (NSC 339555) and high dose ara-C (HiDAC) in patients with refractory acute leukemia
    • (1999) Blood , vol.94
    • Grant, S.1    Cragg, L.2    Roberts, J.3
  • 75
    • 0001496649 scopus 로고    scopus 로고
    • Phase I trial of the PKC activator bryostatin 1 (NSC339555) and F-Ara-Amp (fludarabine) in patients with progressive CLL and refractory indolent non-Hodgkins lymphoma
    • (1999) Blood , vol.94
    • Grant, S.1    Cragg, L.2    Roberts, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.