메뉴 건너뛰기




Volumn 13, Issue 3, 2009, Pages 365-373

Antifibrotics for Chronic Hepatitis C

Author keywords

Antifibrotics; Caspase inhibitors; Hepatitis C virus; Interferon gamma 1b; Long term pegylated interferons

Indexed keywords

3 [2 [(2 TERT BUTYLPHENYLAMINOOXALYL)AMINO]PROPIONYLAMINO] 4 OXO 5 (2,3,5,6 TETRAFLUOROPHENOXY)PENTANOIC ACID; ALPHA INTERFERON; ANTIFIBROTIC AGENT; CASPASE INHIBITOR; COLCHICINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ESTRADIOL; FARNESOID X RECEPTOR AGONIST; GAMMA INTERFERON; GAMMA1B INTERFERON; GLYCYRRHIZIC ACID; HALOFUGINONE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LIPOXYGENASE INHIBITOR; OCTREOTIDE; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; PENTOXIFYLLINE; PLACEBO; PREDNISOLONE; PROSTAGLANDIN E2; QUERCETIN; RAPAMYCIN; RETINOIC ACID; SILYMARIN; SOLUBLE PLATELET DERIVED GROWTH FACTOR ANTAGONIST; SOLUBLE TYPE II FUSION MOLECULE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 67650555649     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2009.05.005     Document Type: Review
Times cited : (3)

References (30)
  • 1
    • 0033372621 scopus 로고    scopus 로고
    • Evaluation of fibrosis and hepatitis C
    • Friedman S.L. Evaluation of fibrosis and hepatitis C. Am J Med 107 6B (1999) 27S-30S
    • (1999) Am J Med , vol.107 , Issue.6 B
    • Friedman, S.L.1
  • 2
    • 0033854016 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats
    • Nakamura T., Sakata R., Ueno T., et al. Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatology 32 2 (2000) 247-255
    • (2000) Hepatology , vol.32 , Issue.2 , pp. 247-255
    • Nakamura, T.1    Sakata, R.2    Ueno, T.3
  • 3
    • 0028109801 scopus 로고
    • Transforming growth factor beta in tissue fibrosis
    • Border W.A., and Noble N.A. Transforming growth factor beta in tissue fibrosis. N Engl J Med 331 19 (1994) 1286-1292
    • (1994) N Engl J Med , vol.331 , Issue.19 , pp. 1286-1292
    • Border, W.A.1    Noble, N.A.2
  • 4
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway
    • Ulloa L., Doody J., and Massague J. Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature 397 6721 (1999) 710-713
    • (1999) Nature , vol.397 , Issue.6721 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massague, J.3
  • 5
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275 (2000) 2247-2250
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 6
    • 0033592753 scopus 로고    scopus 로고
    • A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis
    • Ziesche R., Hofbauer E., Wittmann K., et al. A preliminary study of long-term treatment with interferon gamma-1b and low-dose prednisolone in patients with idiopathic pulmonary fibrosis. N Engl J Med 341 17 (1999) 1264-1269
    • (1999) N Engl J Med , vol.341 , Issue.17 , pp. 1264-1269
    • Ziesche, R.1    Hofbauer, E.2    Wittmann, K.3
  • 7
    • 0025963882 scopus 로고
    • High doses of recombinant alpha-interferon or gamma-interferon for chronic hepatitis C: a randomized, controlled trial
    • Saez-Royuela F., Porres J.C., Moreno A., et al. High doses of recombinant alpha-interferon or gamma-interferon for chronic hepatitis C: a randomized, controlled trial. Hepatology 13 2 (1991) 327-331
    • (1991) Hepatology , vol.13 , Issue.2 , pp. 327-331
    • Saez-Royuela, F.1    Porres, J.C.2    Moreno, A.3
  • 8
    • 33947362952 scopus 로고    scopus 로고
    • Final results of a double-blind, placebo-controlled trial of the anti-fibrotic efficacy of interferon-gamma 1b in chronic hepatitis C with advanced fibrosis or cirrhosis
    • Pockros P.J., Jeffers L., Afdhal N., et al. Final results of a double-blind, placebo-controlled trial of the anti-fibrotic efficacy of interferon-gamma 1b in chronic hepatitis C with advanced fibrosis or cirrhosis. Hepatology 45 3 (2007) 569-578
    • (2007) Hepatology , vol.45 , Issue.3 , pp. 569-578
    • Pockros, P.J.1    Jeffers, L.2    Afdhal, N.3
  • 9
    • 13544277793 scopus 로고    scopus 로고
    • Interferon gamma-1 for the treatment of chronic hepatitis C infection
    • [abstract]
    • Muir A.J., Sylvestre P.B., and Rockey D.C. Interferon gamma-1 for the treatment of chronic hepatitis C infection. [abstract]. Gastroenterology 124 Suppl 1 (2003) A 718
    • (2003) Gastroenterology , vol.124 , Issue.SUPPL. 1
    • Muir, A.J.1    Sylvestre, P.B.2    Rockey, D.C.3
  • 10
    • 20444375441 scopus 로고    scopus 로고
    • Pilot study of interferon gamma for chronic hepatitis C
    • Soza A., Heller T., Ghany M., et al. Pilot study of interferon gamma for chronic hepatitis C. J Hepatol 43 1 (2005) 67-71
    • (2005) J Hepatol , vol.43 , Issue.1 , pp. 67-71
    • Soza, A.1    Heller, T.2    Ghany, M.3
  • 11
    • 0025275991 scopus 로고
    • Therapy of chronic hepatitis B with recombinant human alpha and gamma interferon
    • Di Bisceglie A.M., Rustgi A.K., Kassianides C., et al. Therapy of chronic hepatitis B with recombinant human alpha and gamma interferon. Hepatology 11 2 (1990) 266-270
    • (1990) Hepatology , vol.11 , Issue.2 , pp. 266-270
    • Di Bisceglie, A.M.1    Rustgi, A.K.2    Kassianides, C.3
  • 12
    • 0025942053 scopus 로고
    • Treatment with human gamma interferon of chronic hepatitis B: comparative study with alpha interferon
    • Kakumu S., Ishikawa T., Mizokami M., et al. Treatment with human gamma interferon of chronic hepatitis B: comparative study with alpha interferon. J Med Virol 35 1 (1991) 32-37
    • (1991) J Med Virol , vol.35 , Issue.1 , pp. 32-37
    • Kakumu, S.1    Ishikawa, T.2    Mizokami, M.3
  • 13
    • 23644444883 scopus 로고    scopus 로고
    • Effect of interferon gamma on hepatic fibrosis in chronic hepatitis B virus infection: a randomized controlled study
    • Weng H.L., Wang B.E., Jia J.D., et al. Effect of interferon gamma on hepatic fibrosis in chronic hepatitis B virus infection: a randomized controlled study. Clin Gastroenterol Hepatol 3 8 (2005) 819-828
    • (2005) Clin Gastroenterol Hepatol , vol.3 , Issue.8 , pp. 819-828
    • Weng, H.L.1    Wang, B.E.2    Jia, J.D.3
  • 14
    • 34247394547 scopus 로고    scopus 로고
    • Progression of fibrosis in advanced chronic hepatitis C: evaluation by morphometric image analysis
    • Goodman Z.D., Becker R.L., Pockros P.J., et al. Progression of fibrosis in advanced chronic hepatitis C: evaluation by morphometric image analysis. Hepatology 45 4 (2007) 886-894
    • (2007) Hepatology , vol.45 , Issue.4 , pp. 886-894
    • Goodman, Z.D.1    Becker, R.L.2    Pockros, P.J.3
  • 15
    • 33749434087 scopus 로고    scopus 로고
    • Fibrosis as an end point for clinical trials in liver disease: a consensus report of the International Fibrosis Group
    • McHutchison J.G., Poynard T., Afdhal N., et al. Fibrosis as an end point for clinical trials in liver disease: a consensus report of the International Fibrosis Group. Clin Gastroenterol Hepatol 4 10 (2006) 1214-1220
    • (2006) Clin Gastroenterol Hepatol , vol.4 , Issue.10 , pp. 1214-1220
    • McHutchison, J.G.1    Poynard, T.2    Afdhal, N.3
  • 16
    • 57349116772 scopus 로고    scopus 로고
    • Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon
    • Di Bisceglie A.M., Shiffman M.L., Everson G.T., et al. Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon. N Engl J Med 359 23 (2008) 2429-2441
    • (2008) N Engl J Med , vol.359 , Issue.23 , pp. 2429-2441
    • Di Bisceglie, A.M.1    Shiffman, M.L.2    Everson, G.T.3
  • 17
    • 33749425881 scopus 로고    scopus 로고
    • High early viral response (EVR) with PEG-Intron/Rebetol (PR) weight based dosing (WBD) in previous interferon/ribavirin HCV treatment failures; early results of the EPIC3 trial
    • [abstract]
    • Poynard T., Schiff E., Terg R., et al. High early viral response (EVR) with PEG-Intron/Rebetol (PR) weight based dosing (WBD) in previous interferon/ribavirin HCV treatment failures; early results of the EPIC3 trial. [abstract]. Hepatology 40 Suppl 1 (2004) 238A
    • (2004) Hepatology , vol.40 , Issue.SUPPL. 1
    • Poynard, T.1    Schiff, E.2    Terg, R.3
  • 18
    • 67349172961 scopus 로고    scopus 로고
    • Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy
    • Poynard T., Colombo M., Bruix J., et al. Peginterferon alfa-2b and ribavirin: effective in patients with hepatitis C who failed interferon alfa/ribavirin therapy. Gastroenterology 136 5 (2009) 1618-1628
    • (2009) Gastroenterology , vol.136 , Issue.5 , pp. 1618-1628
    • Poynard, T.1    Colombo, M.2    Bruix, J.3
  • 19
    • 53049097017 scopus 로고    scopus 로고
    • Colchicine versus peg-interferon alfa 2B long term therapy: results of the 4 year copilot trial
    • [abstract]
    • Afdhal N.H., Levine R., Brown Jr. R., et al. Colchicine versus peg-interferon alfa 2B long term therapy: results of the 4 year copilot trial. [abstract]. J Hepatol 48 Suppl 2 (2008) S4
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Afdhal, N.H.1    Levine, R.2    Brown Jr., R.3
  • 20
    • 14844316890 scopus 로고    scopus 로고
    • Colchicine versus PEG-Intron long term (COPILOT) trial: interim analysis of clinical outcomes at year 2
    • [abstract]
    • Afdhal N., Frelich B., Levine R., et al. Colchicine versus PEG-Intron long term (COPILOT) trial: interim analysis of clinical outcomes at year 2. [abstract]. Hepatology 40 (2004) 239A
    • (2004) Hepatology , vol.40
    • Afdhal, N.1    Frelich, B.2    Levine, R.3
  • 21
    • 53049094134 scopus 로고    scopus 로고
    • Suppression of serum HCV RNA levels during maintenance peginterferon (PEG-IFN) alfa-2a therapy and clinical outcomes in the HALT-C trial
    • [abstract]
    • Shiffman M.L., Morishima C., Lindsay K.L., et al. Suppression of serum HCV RNA levels during maintenance peginterferon (PEG-IFN) alfa-2a therapy and clinical outcomes in the HALT-C trial. [abstract]. J Hepatol 48 Suppl 2 (2008) S62
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 2
    • Shiffman, M.L.1    Morishima, C.2    Lindsay, K.L.3
  • 22
    • 21044445452 scopus 로고    scopus 로고
    • Apoptosis: a mechanism of acute and chronic liver injury
    • Guicciardi M.E., and Gores G.J. Apoptosis: a mechanism of acute and chronic liver injury. Gut 54 7 (2005) 1024-1033
    • (2005) Gut , vol.54 , Issue.7 , pp. 1024-1033
    • Guicciardi, M.E.1    Gores, G.J.2
  • 24
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: the nexus of liver injury and fibrosis
    • Canbay A., Friedman S., and Gores G.J. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 39 2 (2004) 273-278
    • (2004) Hepatology , vol.39 , Issue.2 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 25
    • 0034808023 scopus 로고    scopus 로고
    • Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection
    • Bantel H., Lugering A., Poremba C., et al. Caspase activation correlates with the degree of inflammatory liver injury in chronic hepatitis C virus infection. Hepatology 34 4 Pt 1 (2001) 758-767
    • (2001) Hepatology , vol.34 , Issue.4 PART 1 , pp. 758-767
    • Bantel, H.1    Lugering, A.2    Poremba, C.3
  • 26
    • 0035552883 scopus 로고    scopus 로고
    • Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection
    • Pianko S., Patella S., Ostapowicz G., et al. Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection. J Viral Hepat 8 6 (2001) 406-413
    • (2001) J Viral Hepat , vol.8 , Issue.6 , pp. 406-413
    • Pianko, S.1    Patella, S.2    Ostapowicz, G.3
  • 27
    • 2142810153 scopus 로고    scopus 로고
    • Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor
    • Hoglen N.C., Chen L.S., Fisher C.D., et al. Characterization of IDN-6556 (3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid): a liver-targeted caspase inhibitor. J Pharmacol Exp Ther 309 2 (2004) 634-640
    • (2004) J Pharmacol Exp Ther , vol.309 , Issue.2 , pp. 634-640
    • Hoglen, N.C.1    Chen, L.S.2    Fisher, C.D.3
  • 28
    • 1342329725 scopus 로고    scopus 로고
    • The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse
    • Canbay A., Feldstein A., Baskin-Bey E., et al. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther 308 3 (2004) 1191-1196
    • (2004) J Pharmacol Exp Ther , vol.308 , Issue.3 , pp. 1191-1196
    • Canbay, A.1    Feldstein, A.2    Baskin-Bey, E.3
  • 29
    • 34548336791 scopus 로고    scopus 로고
    • Oral IDN-6556, an antiapoptotic caspase inhibitor, lowers aminotransferases in patients with chronic hepatitis C
    • Pockros P.J., Schiff E.R., Shiffman M.L., et al. Oral IDN-6556, an antiapoptotic caspase inhibitor, lowers aminotransferases in patients with chronic hepatitis C. Hepatology 46 2 (2007) 324-329
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 324-329
    • Pockros, P.J.1    Schiff, E.R.2    Shiffman, M.L.3
  • 30
    • 67650510580 scopus 로고    scopus 로고
    • Available at: Identifier: NCT00725803. Accessed March 6, 2009
    • Available at:. ClinicalTrials.gov Identifier: NCT00725803. Accessed March 6, 2009


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.