Basal nitric oxide release attenuates cell migration of HeLa and endothelial cells

Biochemical and Biophysical Research Communications

Volumn 386, Issue 4, 2009, Pages 744-749

  Bulotta, Stefania ^a   Ierardi, Maria Vincenza ^a   Maiuolo, Jessica ^a   Cattaneo, Maria Grazia ^b   Cerullo, Andrea ^a   Vicentini, Lucia M ^b   Borgese, Nica ^a,b,c  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c CNR   (Italy)

Author keywords

Akt; Boyden chambers; cGMP; Chemotaxis; Endothelial NO synthase; HeLa TetOff cells; Human Umbilical Vein Endothelial Cells

Indexed keywords

CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE INHIBITOR; NITRIC OXIDE; NITRIC OXIDE DONOR; PROTEIN KINASE B;

ARTICLE; ATTENUATION; CELL MIGRATION; CHEMOTAXIS; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL MOVEMENT; CHEMOTAXIS; ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE; NITRIC OXIDE DONORS; NITRIC OXIDE SYNTHASE TYPE III; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 67650494793     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.06.118     Document Type: Article

References (27)

1. Lamalice L., Le Boef F., and Huot J. Endothelial cell migration during angiogenesis. Circ. Res. 100 (2007) 782-794
2. Papapetropoulos A., Garcia-Cardena G., Madri J.A., and Sessa W.C. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J. Clin. Invest. 100 (1997) 3131-3139
3. Rudic R.D., Shesely E.G., Maeda N., Smithies O., Segal S.S., and Sessa W.C. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J. Clin. Invest. 101 (1998) 731-736
4. Dimmeler S., Dernbach E., and Zeiher A.M. Phosphorylation of the endothelial nitric oxide synthase at Ser-1177 is required for VEGF-induced endothelial cell migration. FEBS Lett. 477 (2000) 258-262
5. Morales-Ruiz M., Fulton D., Sowa G., Languino L.R., Fujio Y., Walsh K., and Sessa W.C. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circ. Res. 86 (2000) 892-896
6. Noiri E., Hu Y., Bahou W.F., Keese C.R., Giaever I., and Goligorsky M.S. Permissive role of nitric oxide in endothelin-induced migration of endothelial cells. J. Biol. Chem. 272 (1997) 1747-1752
7. Ziche M., Morbidelli L., Masini E., Amerini S., Granger H.J., Maggi C.A., Geppetti P., and Ledda F. Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P. J. Clin. Invest. 94 (1994) 2036-2044
8. Cattaneo M.G., Chini B., and Vicentini L.M. Oxytocin stimulates migration and invasion in human endothelial cells. Br. J. Pharmacol. 153 (2008) 728-736
9. Fulton D., Gratton J.P., McCabe T.J., Fontana J., Fujio Y., Walsh K., Franke T.F., Papapetropoulos A., and Sessa W.C. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399 (1999) 597-601
10. Dimmeler S., Fleming I., Fisslthaler B., Hermann C., Busse R., and Zeiher A.M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399 (1999) 601-605
11. Dubey R.K., Jackson E.K., and Luscher T.F. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell. Role of cyclic-nucleotides and angiotensin1 receptors. J. Clin. Invest. 96 (1995) 141-149
12. Lau Y.-T., and Ma W.-C. Nitric oxide inhibits migration of cultured endothelial cells. Biochem. Biophys. Res. Commun. 221 (1996) 670-674
13. Murohara T., Witzenbichler B., Spyridopoulos I., Asahara T., Ding B., Sullivan A., Losordo D.W., and Isner J.M. Role of endothelial nitric oxide synthase in endothelial cell migration. Arterioscler. Thromb. Vasc. Biol. 19 (1999) 1156-1161
14. Ziche M., Morbidelli L., Coudhuri R., Zhang H.-T., Donnini S., Granger H.J., and Bicknell R. Nitric oxide synthase lies downstream from vascular endothelial growth factor induced but not fibroblast growth factor-induced angiogenesis. J. Clin. Invest. 99 (1997) 2625-2634
15. Morales-Ruiz M., Lee M.J., Zollner S., Gratton J.P., Scotland R., Shiojima I., Walsh K., Hla T., and Sessa W.C. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J. Biol. Chem. 276 (2001) 19672-19677
16. Pyriochou A., Vassilakopoulos T., Zhou Z., and Papapetropoulos A. CGMP-dependent and -independent angiogenesis-related properties of nitric oxide. Life Sci. 81 (2007) 1549-1554
17. Goligorsky M.S., Abedi H., Noiri E., Takhtajan A., Lense S., Romanov V., and Zachary I. Nitric oxide modulation of focal adhesions in endothelial cells. Am. J. Physiol. 276 (1999) C1271-C1281
18. Bulotta S., Barsacchi R., Rotiroti D., Borgese N., and Clementi E. Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha. A novel feedback mechanism regulating cell death. J. Biol. Chem. 276 (2001) 6529-6536
19. Bulotta S., Perrotta C., Cerullo A., De Palma C., Clementi E., and Borgese N. A cellular system to study the role of nitric oxide in cell death, survival, and migration. Neurotoxicology 26 (2005) 841-845
20. Bulotta S., Cerullo A., Barsacchi R., Palma C.D., Rotiroti D., Clementi E., and Borgese N. Endothelial nitric oxide synthase is segregated from caveolin-1 and localizes to the leading edge of migrating cells. Exp. Cell Res. 312 (2006) 877-889
21. Barsacchi R., Perrotta C., Bulotta S., Moncada S., Borgese N., and Clementi E. Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt. Mol. Pharmacol. 63 (2003) 886-895
22. Labarca C., and Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal. Biochem. 102 (1980) 344-352
23. Gossen M., and Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89 (1992) 5547-5551
24. Thomas D.D., Espey M.G., Ridnour L.A., Hofseth L.J., Mancardi D., Harris C.C., and Wink D.A. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proc. Natl. Acad. Sci. USA 101 (2004) 8894-8899
25. Ridnour L.A., Isenberg J.S., Espey M.G., Thomas D.D., Roberts D.D., and Wink D.A. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proc. Natl. Acad. Sci. USA 102 (2005) 13147-13152
26. Manning B.D., and Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 129 (2007) 1261-1274
27. Kawasaki K., Smith Jr. R.S., Hsieh C.M., Sun J., Chao J., and Liao J.K. Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis. Mol. Cell. Biol. 23 (2003) 5726-5737