Alanine screening of the intracellular loops of the human bradykinin B 2 receptor - Effects on receptor maintenance, G protein activation and internalization

FEBS Journal

Volumn 276, Issue 13, 2009, Pages 3491-3503

  Faussner, Alexander ^a   Wennerberg, Goeran ^a   Schüssler, Steffen ^a   Feierler, Jens ^a   Seidl, Cornelia ^a   Jochum, Marianne ^a   Proud, David ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Affinity shift; B9430; G protein coupled receptor; Icatibant; Semi active conformation

Indexed keywords

ALANINE; BRADYKININ B2 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITIDE;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN HEK293; CONFORMATION; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYDROLYSIS; INTRACELLULAR SPACE; MUTANT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; WILD TYPE;

ALANINE; AMINO ACID SEQUENCE; BINDING SITES; BRADYKININ; CELL LINE; ENDOCYTOSIS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; INOSITOL PHOSPHATES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTOR, BRADYKININ B2;

EID: 67650489088     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2009.07071.x     Document Type: Article

References (27)

1. Leeb-Lundberg LM, Marceau F, Muller-Esterl W, Pettibone DJ Zuraw BL (2005) International union of pharmacology XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev 57, 27 77. (Pubitemid 40283969)
2. Blaukat A, Alla SA, Lohse MJ Muller-Esterl W (1996) Ligand-induced phosphorylation/dephosphorylation of the endogenous bradykinin B2 receptor from human fibroblasts. J Biol Chem 271, 32366 32374. (Pubitemid 26422278)
3. Lamb ME, De Weerd WF Leeb-Lundberg LM (2001) Agonist-promoted trafficking of human bradykinin receptors: arrestin- and dynamin-independent sequestration of the B2 receptor and bradykinin in HEK293 cells. Biochem J 355, 741 750. (Pubitemid 32434092)
4. Haasemann M, Cartaud J, Muller-Esterl W Dunia I (1998) Agonist-induced redistribution of bradykinin B2 receptor in caveolae. J Cell Sci 111 (Pt 7), 917 928. (Pubitemid 28196075)
5. Miettinen HM, Gripentrog JM, Mason MM Jesaitis AJ (1999) Identification of putative sites of interaction between the human formyl peptide receptor and G protein. J Biol Chem 274, 27934 27942.
6. Amatruda TT III., Dragas-Graonic S, Holmes R Perez HD (1995) Signal transduction by the formyl peptide receptor. Studies using chimeric receptors and site-directed mutagenesis define a novel domain for interaction with G-proteins. J Biol Chem 270, 28010 28013.
7. Burstein ES, Spalding TA Brann MR (1998) The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling. J Biol Chem 273, 24322 24327. (Pubitemid 28454919)
8. Moro O, Lameh J, Hogger P Sadee W (1993) Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling. J Biol Chem 268, 22273 22276.
9. Chan AS, Law PY, Loh HH, Ho PN, Wu WM, Chan JS Wong YH (2003) The first and third intracellular loops together with the carboxy terminal tail of the delta-opioid receptor contribute toward functional interaction with Galpha16. J Neurochem 87, 697 708. (Pubitemid 37310635)
10. Marion S, Oakley RH, Kim KM, Caron MG Barak LS (2006) A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors. J Biol Chem 281, 2932 2938. (Pubitemid 43845759)
11. Hess JF, Borkowski JA, Young GS, Strader CD Ransom RW (1992) Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. Biochem Biophys Res Commun 184, 260 268.
12. Blaukat A, Herzer K, Schroeder C, Bachmann M, Nash N Muller-Esterl W (1999) Overexpression and functional characterization of kinin receptors reveal subtype-specific phosphorylation. Biochemistry 38, 1300 1309.
13. Michineau S, Alhenc-Gelas F Rajerison RM (2006) Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization. Biochemistry 45, 2699 2707. (Pubitemid 43297329)
14. Faussner A, Schuessler S, Seidl C Jochum M (2004) Inhibition of sequestration of human B2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells. Biol Chem 385, 835 843. (Pubitemid 39335306)
15. Huttenrauch F, Nitzki A, Lin FT, Honing S Oppermann M (2002) Beta-arrestin binding to CC chemokine receptor 5 requires multiple C-terminal receptor phosphorylation sites and involves a conserved Asp-Arg-Tyr sequence motif. J Biol Chem 277, 30769 30777. (Pubitemid 34970774)
16. Faussner A, Bauer A, Kalatskaya I, Jochum M Fritz H (2003) Expression levels strongly affect ligand-induced sequestration of B2 bradykinin receptors in transfected cells. Am J Physiol Heart Circ Physiol 284, H1892 H1898.
17. Yu J, Polgar P, Lubinsky D, Gupta M, Wang L, Mierke D Taylor L (2005) Coulombic and hydrophobic interactions in the first intracellular loop are vital for bradykinin B2 receptor ligand binding and consequent signal transduction. Biochemistry 44, 5295 5306. (Pubitemid 40489969)
18. Yeagle PL, Alderfer JL Albert AD (1997) Three-dimensional structure of the cytoplasmic face of the G protein receptor rhodopsin. Biochemistry 36, 9649 9654. (Pubitemid 27364675)
19. Vogel R, Mahalingam M, Ludeke S, Huber T, Siebert F Sakmar TP (2008) Functional role of the 'ionic lock' - an interhelical hydrogen-bond network in family A heptahelical receptors. J Mol Biol 380, 648 655.
20. Fritze O, Filipek S, Kuksa V, Palczewski K, Hofmann KP Ernst OP (2003) Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation. Proc Natl Acad Sci USA 100, 2290 2295. (Pubitemid 36297492)
21. Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG Sprang SR (1995) The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma. Cell 83, 1047 1058.
22. DeGraff JL, Gurevich VV Benovic JL (2002) The third intracellular loop of alpha 2-adrenergic receptors determines subtype specificity of arrestin interaction. J Biol Chem 277, 43247 43252. (Pubitemid 35285711)
23. Faussner A, Proud D, Towns M Bathon JM (1998) Influence of the cytosolic carboxyl termini of human B1 and B2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction. J Biol Chem 273, 2617 2623. (Pubitemid 28133903)
24. Faussner A, Bauer A, Kalatskaya I, Schussler S, Seidl C, Proud D Jochum M (2005) The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B(1) and B(2) bradykinin receptors. Febs J 272, 129 140. (Pubitemid 40083073)
25. Palczewski K, Kumasaka T, Hori T, Behnke CA, Motoshima H, Fox BA, Le Trong I, Teller DC, Okada T, Stenkamp RE et al. (2000) Crystal structure of rhodopsin A G protein-coupled receptor. Science 289, 739 745. (Pubitemid 30650186)
26. Arnold K, Bordoli L, Kopp J Schwede T (2006) The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics 22, 195 201. (Pubitemid 43205406)
27. Okada T, Sugihara M, Bondar AN, Elstner M, Entel P Buss V (2004) The retinal conformation and its environment in rhodopsin in light of a new 2.2 Å crystal structure. J Mol Biol 342, 571 583. (Pubitemid 39149759)