Inhibition of sequestration of human B2 bradykinin receptor by phenylarsine oxide or sucrose allows determination of a receptor affinity shift and ligand dissociation in intact cells

Biological Chemistry

Volumn 385, Issue 9, 2004, Pages 835-843

  Faussner, Alexander ^a   Schuessler, Steffen ^a   Seidl, Cornelia ^a   Jochum, Marianne ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

G protein coupled receptor; Internalization; Kinin; NPXXY

Indexed keywords

AMINO ACID; ARSENOSOBENZENE; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; CELL PROTEIN; G PROTEIN COUPLED RECEPTOR; LIGAND; MUTANT PROTEIN; NPC 17731; SUCROSE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR AFFINITY; RECEPTOR BINDING; TEMPERATURE MEASUREMENT;

ARSENICALS; BRADYKININ; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; PROTEIN BINDING; RECEPTOR, BRADYKININ B2; SUCROSE;

EID: 5044233534     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2004.109     Document Type: Article

References (33)

1. Clements, J., Hooper, J., Dong, Y. and Harvey, T. (2001). The expanded human kallikrein (KLK) gene family: genomic organization, tissue-specific expression and potential functions. Biol. Chem. 382, 5-14.
2. De Lamirande, E. and Gagnon, C. (1998). Paradoxical effect of reagents for sulfhydryl and disulfide groups on human sperm capacitation and superoxide production. Free Radic. Biol. Med. 25, 803-817.
3. 2 kinin receptors on receptor sequestration, ligand internalization, and signal transduction. J. Biol. Chem. 273, 2617-2623.
4. 2 receptors to agonist stimulation. Immunopharmacology 45, 13-20.
5. 2 kinin receptor affinity of agonists but not of antagonists: discussion of a model proposing receptor precoupling to G protein. Biol. Chem. 381, 295-302
6. 2 bradykinin receptors in transfected cells. Am. J. Physiol. Heart 284, 1892-1898.
7. Fletcher, M.C., Samelson, L.E. and June, C.H. (1993). Complex effects of phenylarsine oxide in T cells. J. Biol. Chem. 268, 23697-23703.
8. Fredriksson, R., Lagerström, M.C., Lundin, L. and Schiöth, H.B. (2003). The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol. Pharmacol. 63, 1256-1272.
9. Gether, U. (2000). Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocrine Rev. 21, 90-113.
10. Gurevich, V.V., Pals-Rylaarsdam, R., Benovic, J.L., Hosey, M.M. and Onorato, J.J. (1997). Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity. J. Biol. Chem. 272, 28849-28852.
11. Hertel, C., Coulter, S.J. and Perkins, J.P. (1985). A comparison of catecholamine-induced internalization of β-adrenergic receptors and receptor-mediated endocytosis of epidermal growth factor in human astrocytoma cells. J. Biol. Chem. 260, 12547-12553.
12. Hess, J.F., Borkowski, J.A., Young, G.S., Strader, C.D. and Ransom, R.W. (1992). Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor. Biochem. Biophys. Res. Commun. 184, 260-268.
13. Heuser, J.E. and Anderson, R.G.W. (1989). Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. J. Cell Biol. 108, 389-400.
14. Hunyady, L., Mara, B., Baukal, A.J., Balla, T. and Catt, K.J. (1995). A conserved NPFLY sequence contributes to agonist binding and signal transduction but is not an internalization signal for the type 1 angiotensin II receptor. J. Biol. Chem. 270, 16602-16609.
15. 2 Bradykinin receptor reveal a different pattern of contacts for peptidic agonist and peptidic antagonists. J. Biol. Chem. 271, 28277-28286.
16. 2 bradykinin receptor. J. Biol. Chem. 279, 31268-31276.
17. Koenig, J.A. and Edwardson, J.M. (1997). Endocytosis and recycling of G protein-coupled receptors. Trends Pharmacol. Sci. 18, 276-287.
18. Kyle, D.J., Chakravarty, S., Sinsko, J.A. and Stormann, T.M. (1994). A proposed model of bradykinin bound to the rat B2 receptor and its utility for drug design. J. Med. Chem. 37, 1347-1354.
19. 35S]GTPγS binding assays. Trends Pharmacol. Sci. 24, 87-90.
20. Mitchell, R., McCulloch, D., Lutz, E., Johnson, M., MacKenzie, C., Fennell, M., Fink, G., Zhou, W. and Sealfon, S.C. (1998). Rhodopsin-family receptors associate with small G proteins to activate phospholipase D. Nature 392, 411-414.
21. 4. Mol. Pharmacol. 61, 455-462.
22. Pierce, K.L., Premont, R.T. and Lefkowitz, R.J. (2002). Seven-transmembrane receptors. Nature Rev. 3, 639-650.
23. 2 receptor. J. Biol. Chem. 273, 1309-1315.
24. Proud, D. (1988). Kinin formation: mechanisms and role in inflammatory disorders. Annu. Rev. Immunol. 6, 49-83.
25. s. peptides mimic Gs and evoke high affinity agonist binding to β-adrenergic receptors J. Biol. Chem. 269, 21519-21525.
26. Regoli, D., Rizzi, A., Perron, S.I. and Gobeil Jr., F. (2001). Classification of kinin receptors. Biol. Chem. 382, 31-35.
27. Rokutan, K., Miyoshi, M., Teshima, S., Kawai, T., Kawahara, T. and Kishi, K. (2000). Phenylarsine oxide inhibits heat shock protein 70 induction in cultured guinea pig gastric mucosal cells. Am. J. Physiol. Cell. Physiol. 279, C1506-1515.
28. 2 muscarinic acetylcholine receptor proceeds through an atypical pathway in HEK293 cells that is independent of clathrin and caveolae. J. Cell Sci. 114, 739-746.
29. 2c receptor. Mol. Brain Res. 84, 90-96.
30. 1 receptor to caveolae-related rafts. Mol. Pharmacol. 61, 546-553.
31. Weiland, G.A., Minnemann, K.P. and Molinoff, P.B. (1979). Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptor. Nature 281, 114-117.
32. + pump. Eur. J. Pharmacol. 406, 49-52.
33. ia3 in the rat fetus. J. Biol. Chem. 271, 15026-15033.