메뉴 건너뛰기




Volumn 72, Issue 12, 2009, Pages 1095-1099

Do the unintended actions of botulinum toxin at distant sites have clinical implications?

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN A; PROTEINASE; TETANUS TOXIN; TETRAZOLIUM BLUE;

EID: 67650375991     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/01.wnl.0000345010.98495.fc     Document Type: Review
Times cited : (62)

References (51)
  • 1
    • 43149084857 scopus 로고    scopus 로고
    • Assessment: Botulinum neurotoxin in the treatment of autonomic disorders and pain (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • Naumann M, So Y, Argoff CE, et al. Assessment: botulinum neurotoxin in the treatment of autonomic disorders and pain (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2008;70: 1707-1714.
    • (2008) Neurology , vol.70 , pp. 1707-1714
    • Naumann, M.1    So, Y.2    Argoff, C.E.3
  • 2
    • 43149083728 scopus 로고    scopus 로고
    • Assessment: Botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • Simpson DM, Blitzer A, Brashear A, et al. Assessment: botulinum neurotoxin for the treatment of movement disorders (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2008;70: 1699-1706.
    • (2008) Neurology , vol.70 , pp. 1699-1706
    • Simpson, D.M.1    Blitzer, A.2    Brashear, A.3
  • 3
    • 43149099933 scopus 로고    scopus 로고
    • Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • Simpson DM, Gracies JM, Graham HK, et al. Assessment: botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2008;70:1691-1698.
    • (2008) Neurology , vol.70 , pp. 1691-1698
    • Simpson, D.M.1    Gracies, J.M.2    Graham, H.K.3
  • 4
    • 0028355349 scopus 로고
    • Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus
    • Schiavo G, Rossetto O, Benfenati F, Poulain B, Montecucco C. Tetanus and botulinum neurotoxins are zinc proteases specific for components of the neuroexocytosis apparatus. Ann NY Acad Sci 1994;710:65-75.
    • (1994) Ann NY Acad Sci , vol.710 , pp. 65-75
    • Schiavo, G.1    Rossetto, O.2    Benfenati, F.3    Poulain, B.4    Montecucco, C.5
  • 5
    • 0028131916 scopus 로고
    • Serial neurophysiological studies of intramuscular botulinum-A toxin in humans
    • Hamjian JA, Walker FO. Serial neurophysiological studies of intramuscular botulinum-A toxin in humans. Muscle Nerve 1994;17:1385-1392.
    • (1994) Muscle Nerve , vol.17 , pp. 1385-1392
    • Hamjian, J.A.1    Walker, F.O.2
  • 6
    • 0025863552 scopus 로고
    • Distant effects of locally injected botulinum toxin: A double-blind study of single fiber EMG changes
    • Lange DJ, Rubin M, Greene PE, et al. Distant effects of locally injected botulinum toxin: a double-blind study of single fiber EMG changes. Muscle Nerve 1991;14:672-675.
    • (1991) Muscle Nerve , vol.14 , pp. 672-675
    • Lange, D.J.1    Rubin, M.2    Greene, P.E.3
  • 8
    • 0014278352 scopus 로고
    • Effects of intraperitoneally injected botulinum toxin on rat cerebral cortex levels of acetylcholine
    • Simpson LI. Effects of intraperitoneally injected botulinum toxin on rat cerebral cortex levels of acetylcholine. J Neurochem 1968;15:359-360.
    • (1968) J Neurochem , vol.15 , pp. 359-360
    • Simpson, L.I.1
  • 9
    • 0018119950 scopus 로고
    • Pharmacokinetic and histoautoradiographic evidence for the intraaxonal movement of toxin in the pathogenesis of tetanus
    • Habermann E, Erdmann G. Pharmacokinetic and histoautoradiographic evidence for the intraaxonal movement of toxin in the pathogenesis of tetanus. Toxicon 1978;16: 611-623.
    • (1978) Toxicon , vol.16 , pp. 611-623
    • Habermann, E.1    Erdmann, G.2
  • 10
    • 0019826882 scopus 로고
    • Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord
    • Bigalke H, Heller I, Bizzini B, Habermann E. Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord. Arch Pharmacol 1981;316:244-251.
    • (1981) Arch Pharmacol , vol.316 , pp. 244-251
    • Bigalke, H.1    Heller, I.2    Bizzini, B.3    Habermann, E.4
  • 11
    • 0028310404 scopus 로고
    • Mechanism of action of tetanus and botulinum neurotoxins
    • Montecucco C, Schiavo G. Mechanism of action of tetanus and botulinum neurotoxins. Mol Microbiol 1994;13: 1-8.
    • (1994) Mol Microbiol , vol.13 , pp. 1-8
    • Montecucco, C.1    Schiavo, G.2
  • 12
    • 0017315001 scopus 로고
    • 125I-labelled botulinum A neurotoxin: Pharmacokinetics in cats after intramuscular injection
    • Wiegand H, Erdmann G, Wellhoner HH. 125I-labelled botulinum A neurotoxin: pharmacokinetics in cats after intramuscular injection. Arch Pharmacol 1976;292:161-165.
    • (1976) Arch Pharmacol , vol.292 , pp. 161-165
    • Wiegand, H.1    Erdmann, G.2    Wellhoner, H.H.3
  • 13
    • 0016392380 scopus 로고
    • 125I-labeled neurotoxin from Clostridium botulinum A: Preparation, binding to synaptosomes and ascent to the spinal cord
    • Habermann E. 125I-labeled neurotoxin from Clostridium botulinum A: preparation, binding to synaptosomes and ascent to the spinal cord. Arch Pharmacol 1974;281:47-56.
    • (1974) Arch Pharmacol , vol.281 , pp. 47-56
    • Habermann, E.1
  • 14
    • 2942581451 scopus 로고    scopus 로고
    • Central effects of botulinum toxin type A: Evidence and supposition
    • Curra A, Trompetto C, Abbruzzese G, Berardelli A. Central effects of botulinum toxin type A: evidence and supposition. Mov Disord 2004;19 suppl 8:S60-S64.
    • (2004) Mov Disord , vol.19 , Issue.SUPPL. 8
    • Curra, A.1    Trompetto, C.2    Abbruzzese, G.3    Berardelli, A.4
  • 15
    • 0030710177 scopus 로고    scopus 로고
    • The mechanism of action of botulinum toxin type A in focal dystonia is most probably through its dual effect on efferent (motor) and afferent pathways at the injected site
    • Giladi N. The mechanism of action of botulinum toxin type A in focal dystonia is most probably through its dual effect on efferent (motor) and afferent pathways at the injected site. J Neurol Sci 1997;152:132-135.
    • (1997) J Neurol Sci , vol.152 , pp. 132-135
    • Giladi, N.1
  • 16
    • 33747200488 scopus 로고    scopus 로고
    • Neurophysiological effects of botulinum toxin type A
    • Abbruzzese G, Berardelli A. Neurophysiological effects of botulinum toxin type A. Neurotox Res 2006;9:109-114.
    • (2006) Neurotox Res , vol.9 , pp. 109-114
    • Abbruzzese, G.1    Berardelli, A.2
  • 17
    • 33747185889 scopus 로고    scopus 로고
    • Action of botulinum neurotoxins in the central nervous system: Antiepileptic effects
    • Bozzi Y, Costantin L, Antonucci F, Caleo M. Action of botulinum neurotoxins in the central nervous system: antiepileptic effects. Neurotox Res 2006;9:197-203.
    • (2006) Neurotox Res , vol.9 , pp. 197-203
    • Bozzi, Y.1    Costantin, L.2    Antonucci, F.3    Caleo, M.4
  • 18
    • 0016746639 scopus 로고
    • On the question of permeability of the blood-brain barrier to botulinum toxin
    • Boroff DA, Chen GS. On the question of permeability of the blood-brain barrier to botulinum toxin. Int Arch Allergy Appl Immunol 1975;48:495-504.
    • (1975) Int Arch Allergy Appl Immunol , vol.48 , pp. 495-504
    • Boroff, D.A.1    Chen, G.S.2
  • 19
    • 0018395948 scopus 로고
    • Binding of Clostridium botulinum neurotoxin to the presynaptic membrane in the central nervous system
    • Hirokawa N, Kitamura M. Binding of Clostridium botulinum neurotoxin to the presynaptic membrane in the central nervous system. J Cell Biol 1979;81:43-49.
    • (1979) J Cell Biol , vol.81 , pp. 43-49
    • Hirokawa, N.1    Kitamura, M.2
  • 20
    • 0342275192 scopus 로고    scopus 로고
    • Dose-dependent, central effects of botulinum neurotoxin type A: A pilot study in the alert behaving cat
    • Moreno-Lopez B, Pastor AM, de la Cruz RR, Delgado- Garcia JM. Dose-dependent, central effects of botulinum neurotoxin type A: a pilot study in the alert behaving cat. Neurology 1997;48:456-464.
    • (1997) Neurology , vol.48 , pp. 456-464
    • Moreno-Lopez, B.1    Pastor, A.M.2    de la Cruz, R.R.3    Delgado- Garcia, J.M.4
  • 21
    • 36549053560 scopus 로고    scopus 로고
    • Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism
    • Delaney AJ, Crane JW, Sah P. Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism. Neuron 2007;56:880-892.
    • (2007) Neuron , vol.56 , pp. 880-892
    • Delaney, A.J.1    Crane, J.W.2    Sah, P.3
  • 23
    • 0029042106 scopus 로고
    • Physiological effects produced by botulinum toxin treatment of upper limb dystonia. Changes in reciprocal inhibition between forearm muscles
    • Priori A, Berardelli A, Mercuri B, Manfredi M. Physiological effects produced by botulinum toxin treatment of upper limb dystonia. Changes in reciprocal inhibition between forearm muscles. Brain 1995;118:801-807.
    • (1995) Brain , vol.118 , pp. 801-807
    • Priori, A.1    Berardelli, A.2    Mercuri, B.3    Manfredi, M.4
  • 24
    • 0031722465 scopus 로고    scopus 로고
    • Blink reflex recovery cycle in patients with blepharospasm unilaterally treated with botulinum toxin
    • Grandas F, Traba A, Alonso F, Esteban A. Blink reflex recovery cycle in patients with blepharospasm unilaterally treated with botulinum toxin. Clin Neuropharmacol 1998;21:307-311.
    • (1998) Clin Neuropharmacol , vol.21 , pp. 307-311
    • Grandas, F.1    Traba, A.2    Alonso, F.3    Esteban, A.4
  • 25
    • 0033945711 scopus 로고    scopus 로고
    • Effects of botulinum toxin type A on intracortical inhibition in patients with dystonia
    • Gilio F, Curra A, Lorenzano C, Modugno N, Manfredi M, Berardelli A. Effects of botulinum toxin type A on intracortical inhibition in patients with dystonia. Ann Neurol 2000;48:20-26.
    • (2000) Ann Neurol , vol.48 , pp. 20-26
    • Gilio, F.1    Curra, A.2    Lorenzano, C.3    Modugno, N.4    Manfredi, M.5    Berardelli, A.6
  • 26
    • 0038747080 scopus 로고    scopus 로고
    • Reversible reorganisation of the motor cortical representation of the hand in cervical dystonia
    • Thickbroom GW, Byrnes ML, Stell R, Mastaglia FL. Reversible reorganisation of the motor cortical representation of the hand in cervical dystonia. Mov Disord 2003;18: 395-402.
    • (2003) Mov Disord , vol.18 , pp. 395-402
    • Thickbroom, G.W.1    Byrnes, M.L.2    Stell, R.3    Mastaglia, F.L.4
  • 27
    • 38549138978 scopus 로고    scopus 로고
    • Molding the sensory cortex: Spatial acuity improves after botulinum toxin treatment for cervical dystonia
    • Walsh R, Hutchinson M. Molding the sensory cortex: spatial acuity improves after botulinum toxin treatment for cervical dystonia. Mov Disord 2007;22:2443-2446.
    • (2007) Mov Disord , vol.22 , pp. 2443-2446
    • Walsh, R.1    Hutchinson, M.2
  • 28
    • 33745820860 scopus 로고    scopus 로고
    • Botulinum toxin changes intrafusal feedback in dystonia: A study with the tonic vibration reflex
    • Trompetto C, Curra A, Buccolieri A, Suppa A, Abbruzzese G, Berardelli A. Botulinum toxin changes intrafusal feedback in dystonia: a study with the tonic vibration reflex. Mov Disord 2006;21:777-782.
    • (2006) Mov Disord , vol.21 , pp. 777-782
    • Trompetto, C.1    Curra, A.2    Buccolieri, A.3    Suppa, A.4    Abbruzzese, G.5    Berardelli, A.6
  • 29
    • 2642704247 scopus 로고    scopus 로고
    • Kanovsky P, Streitova H, Dufek J, Znojil V, Daniel P, Rektor I. Change in lateralization of the P22/N30 cortical component of median nerve somatosensory evoked potentials in patients with cervical dystonia after successful treatment with botulinum toxin A. Mov Disord 1998;13:108-117.
    • Kanovsky P, Streitova H, Dufek J, Znojil V, Daniel P, Rektor I. Change in lateralization of the P22/N30 cortical component of median nerve somatosensory evoked potentials in patients with cervical dystonia after successful treatment with botulinum toxin A. Mov Disord 1998;13:108-117.
  • 30
    • 33747161909 scopus 로고    scopus 로고
    • Botulinum toxin therapy for cervical dystonia
    • Jankovic J. Botulinum toxin therapy for cervical dystonia. Neurotox Res 2006;9:145-148.
    • (2006) Neurotox Res , vol.9 , pp. 145-148
    • Jankovic, J.1
  • 31
    • 54849435847 scopus 로고    scopus 로고
    • Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain
    • Ranoux D, Attal N, Morain F, Bouhassira D. Botulinum toxin type A induces direct analgesic effects in chronic neuropathic pain. Ann Neurol 2008;64:274-283.
    • (2008) Ann Neurol , vol.64 , pp. 274-283
    • Ranoux, D.1    Attal, N.2    Morain, F.3    Bouhassira, D.4
  • 33
    • 34247513103 scopus 로고    scopus 로고
    • Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity
    • Caleo M, Restani L, Gianfranceschi L, et al. Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity. J Neurosci 2007; 27:4530-4540.
    • (2007) J Neurosci , vol.27 , pp. 4530-4540
    • Caleo, M.1    Restani, L.2    Gianfranceschi, L.3
  • 34
    • 0018099922 scopus 로고
    • In search of a tonic vibration reflex in the human lip
    • Folkins JW, Larson CR. In search of a tonic vibration reflex in the human lip. Brain Res 1978;151:409-412.
    • (1978) Brain Res , vol.151 , pp. 409-412
    • Folkins, J.W.1    Larson, C.R.2
  • 35
    • 0021353161 scopus 로고
    • Orofacial fine motor control impairments in congenital spasticity: Evidence against hypertonus-related performance deficits
    • Barlow SM, Abbs JH. Orofacial fine motor control impairments in congenital spasticity: evidence against hypertonus-related performance deficits. Neurology 1984;34:145-150.
    • (1984) Neurology , vol.34 , pp. 145-150
    • Barlow, S.M.1    Abbs, J.H.2
  • 36
    • 0032242861 scopus 로고    scopus 로고
    • Oro-facial muscles: Internal structure, function and ageing
    • McComas AJ. Oro-facial muscles: internal structure, function and ageing. Gerodontology 1998;15:3-14.
    • (1998) Gerodontology , vol.15 , pp. 3-14
    • McComas, A.J.1
  • 38
    • 33745764454 scopus 로고    scopus 로고
    • Short-term reorganization of input-deprived motor vibrissae representation following motor disconnection in adult rats
    • Franchi G, Veronesi C. Short-term reorganization of input-deprived motor vibrissae representation following motor disconnection in adult rats. J Physiol 2006;574: 457-476.
    • (2006) J Physiol , vol.574 , pp. 457-476
    • Franchi, G.1    Veronesi, C.2
  • 40
    • 0031559898 scopus 로고    scopus 로고
    • Effects of botulinum neurotoxin type A on abducens motoneurons in the cat: Ultrastructural and synaptic alterations
    • Pastor AM, Moreno-Lopez B, De La Cruz RR, Delgado- Garcia JM. Effects of botulinum neurotoxin type A on abducens motoneurons in the cat: ultrastructural and synaptic alterations. Neuroscience 1997;81:457-478.
    • (1997) Neuroscience , vol.81 , pp. 457-478
    • Pastor, A.M.1    Moreno-Lopez, B.2    De La Cruz, R.R.3    Delgado- Garcia, J.M.4
  • 41
    • 0023846021 scopus 로고
    • Behavior of neurons in the abducens nucleus of the alert cat: III: axotomized motoneurons
    • Delgado-Garcia JM, Del Pozo F, Spencer RF, Baker R. Behavior of neurons in the abducens nucleus of the alert cat: III: axotomized motoneurons. Neuroscience 1988;24: 143-160.
    • (1988) Neuroscience , vol.24 , pp. 143-160
    • Delgado-Garcia, J.M.1    Del Pozo, F.2    Spencer, R.F.3    Baker, R.4
  • 42
    • 0030025541 scopus 로고    scopus 로고
    • Unilateral injection of botulinum toxin in blepharospasm: Single fiber electromyography and blink reflex study
    • Girlanda P, Quartarone A, Sinicropi S, Nicolosi C, Messina C. Unilateral injection of botulinum toxin in blepharospasm: single fiber electromyography and blink reflex study. Mov Disord 1996;11:27-31.
    • (1996) Mov Disord , vol.11 , pp. 27-31
    • Girlanda, P.1    Quartarone, A.2    Sinicropi, S.3    Nicolosi, C.4    Messina, C.5
  • 43
    • 0028359333 scopus 로고
    • Treatment with botulinum toxin injections does not change brainstem interneuronal excitability in patients with cervical dystonia
    • Valls-Sole J, Tolosa ES, Marti MJ, Allam N. Treatment with botulinum toxin injections does not change brainstem interneuronal excitability in patients with cervical dystonia. Clin Neuropharmacol 1994;17:229-235.
    • (1994) Clin Neuropharmacol , vol.17 , pp. 229-235
    • Valls-Sole, J.1    Tolosa, E.S.2    Marti, M.J.3    Allam, N.4
  • 44
    • 0025752737 scopus 로고
    • Neurophysiological observations on the effects of botulinum toxin treatment in patients with dystonic blepharospasm
    • Valls-Sole J, Tolosa ES, Ribera G. Neurophysiological observations on the effects of botulinum toxin treatment in patients with dystonic blepharospasm. J Neurol Neurosurg Psychiatry 1991;54:310-313.
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 310-313
    • Valls-Sole, J.1    Tolosa, E.S.2    Ribera, G.3
  • 46
    • 0242593737 scopus 로고    scopus 로고
    • Vibrissa movement elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory whisking
    • Berg RW, Kleinfeld D. Vibrissa movement elicited by rhythmic electrical microstimulation to motor cortex in the aroused rat mimics exploratory whisking. J Neurophysiol 2003;90:2950-2963.
    • (2003) J Neurophysiol , vol.90 , pp. 2950-2963
    • Berg, R.W.1    Kleinfeld, D.2
  • 47
    • 4143067045 scopus 로고    scopus 로고
    • Current flow in vibrissa motor cortex can phase-lock with exploratory rhythmic whisking in rat
    • Ahrens KF, Kleinfeld D. Current flow in vibrissa motor cortex can phase-lock with exploratory rhythmic whisking in rat. J Neurophysiol 2004;92:1700-1707.
    • (2004) J Neurophysiol , vol.92 , pp. 1700-1707
    • Ahrens, K.F.1    Kleinfeld, D.2
  • 48
    • 0035879274 scopus 로고    scopus 로고
    • Whisker deafferentation and rodent whisking patterns: Behavioral evidence for a central pattern generator
    • Gao P, Bermejo R, Zeigler HP. Whisker deafferentation and rodent whisking patterns: behavioral evidence for a central pattern generator. J Neurosci 2001;21:5374-5380.
    • (2001) J Neurosci , vol.21 , pp. 5374-5380
    • Gao, P.1    Bermejo, R.2    Zeigler, H.P.3
  • 50
    • 0037074054 scopus 로고    scopus 로고
    • Functional circuitry involved in the regulation of whisker movements
    • Hattox AM, Priest CA, Keller A. Functional circuitry involved in the regulation of whisker movements. J Comp Neurol 2002;442:266-276.
    • (2002) J Comp Neurol , vol.442 , pp. 266-276
    • Hattox, A.M.1    Priest, C.A.2    Keller, A.3
  • 51
    • 0042964819 scopus 로고    scopus 로고
    • Serotonin regulates rhythmic whisking
    • Hattox A, Li Y, Keller A. Serotonin regulates rhythmic whisking. Neuron 2003;39:343-352.
    • (2003) Neuron , vol.39 , pp. 343-352
    • Hattox, A.1    Li, Y.2    Keller, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.