Dose-dependent, central effects of botulinum neurotoxin type A: A pilot study in the alert behaving cat

Neurology

Volumn 48, Issue 2, 1997, Pages 456-464

  Moreno Lopez B ^a   Pastor, A M ^a   De La Cruz, R R ^a   Delgado Garcia J M ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN A;

ABDUCENS NERVE; ANIMAL EXPERIMENT; ARTICLE; CAT; CONTROLLED STUDY; DOSE RESPONSE; EYE MOVEMENT CONTROL; FEMALE; INTRAOCULAR DRUG ADMINISTRATION; MOTONEURON; MUSCLE POTENTIAL; NERVE PARALYSIS; NONHUMAN; OCULOMOTOR SYSTEM; PRIORITY JOURNAL;

EID: 0342275192     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.48.2.456     Document Type: Article

References (54)

1. Dolly JO, de Paiva A, Foran P, Lawrence G, Daniels-Holgate P, Ashton AC. Probing the process of transmitter release with botulinum and tetanus neurotoxins. Semin Neurosci 1994;6: 149-158.
2. Habermann E, Dreyer F. Clostridial neurotoxins: handling and action at the cellular and molecular level. Curr Top Microbiol Immunol 1986;129:93-179.
3. Simpson LL. Molecular pharmacology of botulinum toxin and tetanus toxin. Annu Rev Pharmacol Toxicol 1986;26:427-453.
4. Molgo J, Comella JX, Angaut-Petit D, et al. Presynaptic actions of botulinal neurotoxins at vertebrate neuromuscular junctions. J Physiol (Paris) 1990;84:152-166.
5. Hambleton P. Clostridium botulinum toxins: a general review of involvement in disease, structure, mode of action and preparation for clinical use. J Neurol 1992;239:16-20.
6. Simpson LL. The origin, structural and pharmacological activity of botulinum toxin. Pharmacol Rev 1981;33:155-88.
7. Blasi J, Chapman ER, Link E, et al. Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25 Nature 1993;365:160-163.
8. Schiavo G, Benfenati F, Poulain B, et al. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature 1992;359:832-835.
9. Scott AB. Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery. Ophthalmology 1980; 87:1044-1049.
10. Scott AB, Kennedy RA, Stubbs HA. Botulinum A toxin injection as a treatment for blepharospasm. Arch Ophthalmol 1985;103:347-350.
11. Albanese A, Colosimo C, Carretta D, Dickmann A, Bentivoglio AR, Tonali P. Botulinum toxin as a treatment for blepharospasm, spasmodic torticollis and hemifacial spasm. Eur Neurol 1992;32:112-117.
12. Frueh BR, Musch DC. Treatment of facial spasm with botulinum toxin. Ophthalmology 1986;93:917-923.
13. Tsoy EA, Buckley EG, Dutton JJ. Treatment of blepharospasm with botulinum toxin. Am J Ophthalmol 1985;99:176-179.
14. Valls-Sole J, Tolosa ES, Ribera G. Neurophysiological observations on the effects of botulinum toxin treatment in patients with dystonic blepharospasm. J Neurol Neurosurg Psychiatry 1991;54:310-313.
15. Boghen D, Flanders M. Effectiveness of botulinum toxin in the treatment of spasmodic torticollis. Eur Neurol 1993;33:199-203.
16. Gelb DJ, Yoshimura DM, Olney RK, Lowenstein DH, Aminoff MJ. Change in pattern of muscle activity following botulinum toxin injections for torticollis. Ann Neurol 1991;29:370-376.
17. Moore AP, Blumhardt LD. A double-blind trial of botulinum toxin 'A' in torticollis, with one-year follow-up. J Neurol Neurosurg Psychiatry 1991;54:813-816.
18. Aronson AE, McCaffrey TV, Litchy WJ, Lipton RJ. Botulinum toxin injection for adductor spastic dysphonia: patient self-ratings of voice and phonatory effort after three successive injections. Laryngoscope 1993;103:683-692.
19. Kobayashi T, Niimi S, Kumada M, Kosaki H, Hirose H. Botulinum toxin treatment for spasmodic dysphonia. Acta Otolaryngol (Stockh) 1993;504:155-157.
20. Zwirner P, Murry T, Woodson GE. A comparison of bilateral and unilateral botulinum toxin treatments for spasmodic dysphonia. Eur Arch Otorhinolaryngol 1993;250:271-276.
21. Jankovic J, Schwartz K, Donovan DT. Botulinum toxin treatment of cranial-cervical dystonia, spasmodic dysphonia, other focal dystonias and hemifacial spasm. J Neurol Neurosurg Psychiatry 1990;53:633-639.
22. Tolosa E, Marti MJ, Kulisevsky J. Botulinum toxin injection therapy for hemifacial spasm. Adv Neurol 1988;49:479-491.
23. Mémin B, Pollak P, Hommel M, Perret J. Traitement de la spasticité par la toxine botulinique. Rev Neurol (Paris) 1992; 3:212-214.
24. Dengler R, Neyer U, Wohlfarth K, Betting U, Janzik HH. Local botulinum toxin in the treatment of spastic drop foot. J Neurol 1992;239:375-378.
25. Davis D, Jabbari B. Significant improvement of stiff-person syndrome after paraspinal injection of botulinum toxin A. Mov Disord 1993;8:371-373.
26. Newman NJ, Lambert SR. Botulinum toxin treatment of supranuclear ocular motility disorders. Neurology 1992;42-1391-1393.
27. 125I-labeled neurotoxin from Clostridium botulinum A: preparation, binding to synaptosomes and ascent to the spinal cord. Naunyn-Schmiedebergs Arch Pharmacol 1974;281:47-56.
28. 125I-labelled botulinum A neurotoxin: pharmacokinetics in cats after intramuscular injection. Naunyn-Schmiedebergs Arch Pharmacol 1976; 292:161-165.
29. Wiegand H, Wellhöner HH. The action of botulinum A neurotoxin on the inhibition by antidromic stimulation of the lumbar monosynaptic reflex. Naunyn-Schmiedebergs Arch Pharmacol 1977;298:235-238.
30. de la Cruz RR, Pastor AM, Delgado-García JM. Effects of target depletion on adult mammalian central neurons: morphological correlates. Neuroscience 1994;58:59-79.
31. de la Cruz RR, Pastor AM, Delgado-García JM. Effects of target depletion on adult mammalian central neurons: functional correlates. Neuroscience 1994;58:81-97.
32. Delgado-García JM, del Pozo F, Baker R. Behavior of neurons in the abducens nucleus of the alert cat. I. Motoneurons. Neuroscience 1986;17:929-952.
33. Delgado-García JM, del Pozo F, Baker R. Behavior of neurons in the abducens nucleus of the alert cat. II. Internuclear neurons. Neuroscience 1986;17:953-973.
34. Berman AL. The brain stem of the cat: a cytoarchitectonic atlas with stereotaxic coordinates. Madison: The University of Wisconsin Press, 1968.
35. Fuchs AF, Robinson DA. A method for measuring horizontal and vertical eye movement chronically in the monkey. J Appl Physiol 1966;21:1068-1070.
36. de la Cruz RR, Baker R, Delgado-García JM. Behavior of cat abducens motoneurons following the injection of toxic ricin into the lateral rectus muscle. Brain Res 1991;544:260-268.
37. Poulain B, Tauc L, Maisey EA, Wadsworth JDF, Mohan PM, Dolly JO. Neurotransmitter release is blocked intracellularly by botulinum neurotoxin, and this requires uptake of both toxin polypeptides by a process mediated by the larger chain. Proc Natl Acad Sci USA 1988;85:4090-4094.
38. Moreno-López B, de la Cruz RR, Pastor AM, Delgado-García JM. Botulinum neurotoxin alters the discharge characteristics of abducens motoneurons in the alert cat. J Neurophysiol 1994;72:2041-2044.
39. Mesulam MM. Tetramethylbenzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 1978;26:106-117.
40. Horn AKE, Porter JD, Evinger C. Botulinum toxin paralysis of the orbicularis oculi muscle: types and time course of alterations in muscle structure, physiology and lid kinematics. Exp Brain Res 1993;96:39-53.
41. Spencer RF, McNeer KW. Botulinum toxin paralysis of adult monkey extraocular muscle. Arch Ophthalmol 1987-105-1703-1711.
42. Fuchs AF, Scudder CA, Kaneko CRS. Discharge patterns and recruitment order of identified motoneurons and internuclear neurons in the monkey abducens nucleus. J Neurophysiol 1988;60:1874-1895.
43. Delgado-Garcia JM, del Pozo F, Spencer RF. Baker R. Behavior of neurons in the abducens nucleus of the alert cat. III. Axotomized motoneurons. Neuroscience 1988;24:143-160.
44. Abercrombie M. Estimation of nuclear population from microtome section. Anat Rec 1946;94:239-247.
45. Jankovic J, Brin MF. Therapeutic uses of botulinum toxin. N Engl J Med 1991;324:1186-1194.
46. Wellhöner HH. Clostridial toxins and the central nervous system: studies on in situ tissues. In: Simpson LL, ed. Botulinum neurotoxin and tetanus toxin. San Diego: Academic Press 1989:231-253.
47. Bigalke H, Dreyer F, Bergey G. Botulinum A neurotoxin inhibits non-cholinergic synaptic transmission in mouse spinal cord neurons in culture. Brain Res 1985;360:318-324.
48. 3H]GABA from rat brain homogenate. Experientia 1988;44:224-226.
49. Mellamby J. Comparative activities of tetanus and botulinum toxins. Neuroscience 1984;11:29-34.
50. Rabasseda X, Blasi J, Marsal J, Dunant Y, Casanova A, Bizzini B. Tetanus and botulinum toxins block the release of acetylcholine from slices of rat striatum and from the isolated electric organ of Torpedo at different concentrations. Toxicon 1988;26:329-336.
51. Bergey GK, Bigalke H, Nelson PG. Differential effects of tetanus toxin on inhibitory and excitatory synaptic transmission in mammalian spinal cord neurons in culture: a presynaptic locus of action for tetanus toxin. J Neurophysiol 1987;57:121-131.
52. Davies JR, Morgan RS, Wright EA, Payling Wright G. The results of direct injections of botulinum toxin into the central nervous system of rabbits. J Physiol (Lond) 1953-120-618-623.
53. Escudero M, Delgado-García JM. Behavior of reticular, vestibular and prepositus neurons terminating in the abducens nucleus of the alert cat. Exp Brain Res 1988;71:218-222.
54. Pinter MJ, Vanden Noven S, Muccio D, Wallace N. Axotomy-like changes in cat motoneuron electrical properties elicited by botulinum toxin depend on the complete elimination of neuromuscular transmission. J Neurosci 1991;11:657-666.