메뉴 건너뛰기




Volumn 15, Issue 2, 2009, Pages 125-132

Neuroscience basis of clinical depression: Implications for future antidepressant drug development

Author keywords

Amygdala; Antidepressant drug development; Brain imaging; Clinical depression; Genetics; Hippocampus; Neuroscience

Indexed keywords

ANTIDEPRESSANT AGENT; NEUROTRANSMITTER;

EID: 67650360863     PISSN: 15274160     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pra.0000348365.96300.07     Document Type: Review
Times cited : (11)

References (48)
  • 1
    • 0022930826 scopus 로고
    • Parallel organization of functionally segregated circuits linking basal ganglia and cortex
    • Alexander GE, DeLong MR, Strick PL. Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 1986;9:357-81.
    • (1986) Annu Rev Neurosci , vol.9 , pp. 357-381
    • Alexander, G.E.1    DeLong, M.R.2    Strick, P.L.3
  • 3
    • 0040246220 scopus 로고    scopus 로고
    • The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans
    • Ongür D, Price JL. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb Cortex 2000;10:206-19.
    • (2000) Cereb Cortex , vol.10 , pp. 206-219
    • Ongür, D.1    Price, J.L.2
  • 6
    • 34848912806 scopus 로고    scopus 로고
    • Serotonin-1A receptor imaging in recurrent depression: Replication and literature review
    • Drevets WC, Thase ME, Moses-Kolko EL, et al. Serotonin-1A receptor imaging in recurrent depression: Replication and literature review. Nucl Med Biol 2007;34:865-77.
    • (2007) Nucl Med Biol , vol.34 , pp. 865-877
    • Drevets, W.C.1    Thase, M.E.2    Moses-Kolko, E.L.3
  • 7
    • 0034625673 scopus 로고    scopus 로고
    • Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control
    • MacDonald AW 3rd, Cohen JD, Stenger VA, et al. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 2000;288:1835-8.
    • (2000) Science , vol.288 , pp. 1835-1838
    • MacDonald 3rd, A.W.1    Cohen, J.D.2    Stenger, V.A.3
  • 8
    • 0141426853 scopus 로고    scopus 로고
    • Affective neuroscience and psychophysiology: Toward a synthesis
    • Davidson RJ. Affective neuroscience and psychophysiology: Toward a synthesis. Psychophysiology 2003;40:655-65.
    • (2003) Psychophysiology , vol.40 , pp. 655-665
    • Davidson, R.J.1
  • 9
    • 0035312686 scopus 로고    scopus 로고
    • Neuroimaging and neuropathological studies of depression: Implications for the cognitive-emotional features of mood disorders
    • Drevets WC. Neuroimaging and neuropathological studies of depression: Implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol 2001;11: 240-9.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 240-249
    • Drevets, W.C.1
  • 10
    • 0034058460 scopus 로고    scopus 로고
    • Contextual fear, gestalt memories, and the hippocampus
    • Fanselow MS. Contextual fear, gestalt memories, and the hippocampus. Behav Brain Res 2000;110:73-81.
    • (2000) Behav Brain Res , vol.110 , pp. 73-81
    • Fanselow, M.S.1
  • 11
    • 0022922296 scopus 로고
    • Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis
    • Reul JM, de Kloet ER. Anatomical resolution of two types of corticosterone receptor sites in rat brain with in vitro autoradiography and computerized image analysis. J Steroid Biochem 1986;24:269-72.
    • (1986) J Steroid Biochem , vol.24 , pp. 269-272
    • Reul, J.M.1    de Kloet, E.R.2
  • 12
    • 0002284207 scopus 로고    scopus 로고
    • The medial temporal lobe, the hippocampus, and the memory systems of the brain
    • Gazzaniga MS, ed, 2nd ed. Cambridge, MA: The MIT Press;
    • Squire LR, Knowlton BJ. The medial temporal lobe, the hippocampus, and the memory systems of the brain. In: Gazzaniga MS, ed. The new cognitive neurosciences, 2nd ed. Cambridge, MA: The MIT Press; 2000:765-76.
    • (2000) The new cognitive neurosciences , pp. 765-776
    • Squire, L.R.1    Knowlton, B.J.2
  • 13
    • 0036895345 scopus 로고    scopus 로고
    • Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism
    • Drevets WC, Bogers W, Raichle ME. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsychopharmacol 2002;12:527-44.
    • (2002) Eur Neuropsychopharmacol , vol.12 , pp. 527-544
    • Drevets, W.C.1    Bogers, W.2    Raichle, M.E.3
  • 14
    • 3042710247 scopus 로고    scopus 로고
    • Neuroimaging studies of depression
    • Charney DS, Nestler EJ, Bunney BS, eds, 2nd edition, New York: Oxford University Press;
    • Drevets WC, Gadde KM, Krishnan RR. Neuroimaging studies of depression. In: Charney DS, Nestler EJ, Bunney BS, eds. The neurobiological foundation of mental illness, 2nd edition, New York: Oxford University Press; 2004: 461-90.
    • (2004) The neurobiological foundation of mental illness , pp. 461-490
    • Drevets, W.C.1    Gadde, K.M.2    Krishnan, R.R.3
  • 15
    • 0034975128 scopus 로고    scopus 로고
    • Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression
    • Kennedy SH, Evans KR, Krüger S, et al. Changes in regional brain glucose metabolism measured with positron emission tomography after paroxetine treatment of major depression. Am J Psychiatry 2001;158:899-905.
    • (2001) Am J Psychiatry , vol.158 , pp. 899-905
    • Kennedy, S.H.1    Evans, K.R.2    Krüger, S.3
  • 16
    • 0014186152 scopus 로고
    • Development of a rating scale for primary depressive illness
    • Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967;6:278-96.
    • (1967) Br J Soc Clin Psychol , vol.6 , pp. 278-296
    • Hamilton, M.1
  • 17
    • 84880073904 scopus 로고    scopus 로고
    • Emotional disorders: Depression and the brain
    • Squire LR, ed, fourth edition, Oxford: Academic Press;
    • Drevets WC, Furey ML. Emotional disorders: Depression and the brain. In: Squire LR, ed. Encyclopedia of neuroscience, fourth edition, volume 3. Oxford: Academic Press; 2009: 459-70.
    • (2009) Encyclopedia of neuroscience , vol.3 , pp. 459-470
    • Drevets, W.C.1    Furey, M.L.2
  • 18
    • 0034667293 scopus 로고    scopus 로고
    • 3D MRI studies of neuroanatomic changes in unipolar major depression: The role of stress and medical comorbidity
    • Sheline YI. 3D MRI studies of neuroanatomic changes in unipolar major depression: The role of stress and medical comorbidity. Biol Psychiatry 2000;48:791-800.
    • (2000) Biol Psychiatry , vol.48 , pp. 791-800
    • Sheline, Y.I.1
  • 19
    • 0346461630 scopus 로고    scopus 로고
    • Glutamate and depression: Clinical and preclinical studies
    • Paul IA, Skolnick P. Glutamate and depression: Clinical and preclinical studies. Ann N Y Acad Sci 2003;1003: 250-72.
    • (2003) Ann N Y Acad Sci , vol.1003 , pp. 250-272
    • Paul, I.A.1    Skolnick, P.2
  • 20
    • 34447629382 scopus 로고    scopus 로고
    • Physiology and neurobiology of stress and adaptation: Central role of the brain
    • McEwen BS. Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiol Rev 2007; 87:873-904.
    • (2007) Physiol Rev , vol.87 , pp. 873-904
    • McEwen, B.S.1
  • 21
    • 67650135637 scopus 로고    scopus 로고
    • Results of the STAR*D study: Implications for clinicians and drug developers
    • Preskorn SH. Results of the STAR*D study: Implications for clinicians and drug developers. J Psychiatr Pract 2009;15:45-9.
    • (2009) J Psychiatr Pract , vol.15 , pp. 45-49
    • Preskorn, S.H.1
  • 22
    • 0037470082 scopus 로고    scopus 로고
    • Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
    • Walker DL, Toufexis DJ, Davis M. Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 2003;463:199-216.
    • (2003) Eur J Pharmacol , vol.463 , pp. 199-216
    • Walker, D.L.1    Toufexis, D.J.2    Davis, M.3
  • 23
    • 0032780713 scopus 로고    scopus 로고
    • The extended amygdala: Are the central nucleus of the amygdala and the bed nucleus of the stria terminalis differentially involved in fear versus anxiety?
    • Davis M, Shi C. The extended amygdala: Are the central nucleus of the amygdala and the bed nucleus of the stria terminalis differentially involved in fear versus anxiety? Ann N Y Acad Sci 1999;877:281-91.
    • (1999) Ann N Y Acad Sci , vol.877 , pp. 281-291
    • Davis, M.1    Shi, C.2
  • 24
    • 34250021031 scopus 로고    scopus 로고
    • Cerebral blood flow in immediate and sustained anxiety
    • Hasler G, Fromm S, Alvarez RP, et al. Cerebral blood flow in immediate and sustained anxiety. J Neurosci 2007;27: 6313-9.
    • (2007) J Neurosci , vol.27 , pp. 6313-6319
    • Hasler, G.1    Fromm, S.2    Alvarez, R.P.3
  • 25
    • 0142043000 scopus 로고    scopus 로고
    • The neurobiology of emotion perception I: Towards an understanding of the neural basis of normal emotion perception
    • Phillips ML, Drevets, WC, Rauch, SL, et al. The neurobiology of emotion perception I: Towards an understanding of the neural basis of normal emotion perception. Biol Psychiatry 2003;54:504-14.
    • (2003) Biol Psychiatry , vol.54 , pp. 504-514
    • Phillips, M.L.1    Drevets, W.C.2    Rauch, S.L.3
  • 26
    • 0027200692 scopus 로고
    • The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress
    • Diorio D, Viau V, Meaney MJ. The role of the medial prefrontal cortex (cingulate gyrus) in the regulation of hypothalamic-pituitary-adrenal responses to stress. J Neurosci 1993;13:3839-47.
    • (1993) J Neurosci , vol.13 , pp. 3839-3847
    • Diorio, D.1    Viau, V.2    Meaney, M.J.3
  • 27
    • 0033969685 scopus 로고    scopus 로고
    • Antidepressant effects of ketamine in depressed patients
    • Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000;47:351-4.
    • (2000) Biol Psychiatry , vol.47 , pp. 351-354
    • Berman, R.M.1    Cappiello, A.2    Anand, A.3
  • 28
    • 33746896935 scopus 로고    scopus 로고
    • A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression
    • Zarate CA Jr, Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006;63: 856-64.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 856-864
    • Zarate Jr, C.A.1    Singh, J.B.2    Carlson, P.J.3
  • 29
    • 59049098262 scopus 로고    scopus 로고
    • An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder
    • Preskorn SH, Baker B, Kolluri S, et al. An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder. J Clin Psychopharmacol 2008;28:631-7.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 631-637
    • Preskorn, S.H.1    Baker, B.2    Kolluri, S.3
  • 30
    • 0031822289 scopus 로고    scopus 로고
    • The relationship of depression to cardiovascular disease: Epidemiology, biology, and treatment
    • Musselman DL, Evans DL, Nemeroff CB. The relationship of depression to cardiovascular disease: Epidemiology, biology, and treatment. Arch Gen Psychiatry 1998;55: 580-92.
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 580-592
    • Musselman, D.L.1    Evans, D.L.2    Nemeroff, C.B.3
  • 31
    • 0032958781 scopus 로고    scopus 로고
    • The endocrinology of melancholic and atypical depression: Relation to neurocircuitry and somatic consequences
    • Gold PW, Chrousos GP. The endocrinology of melancholic and atypical depression: Relation to neurocircuitry and somatic consequences. Proc Assoc Am Physicians 1999;111: 22-34.
    • (1999) Proc Assoc Am Physicians , vol.111 , pp. 22-34
    • Gold, P.W.1    Chrousos, G.P.2
  • 33
    • 33745712727 scopus 로고    scopus 로고
    • Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder
    • Cannon DM, Carson RE, Nugent AC, et al. Reduced muscarinic type 2 receptor binding in subjects with bipolar disorder. Arch Gen Psychiatry 2006;63:741-7.
    • (2006) Arch Gen Psychiatry , vol.63 , pp. 741-747
    • Cannon, D.M.1    Carson, R.E.2    Nugent, A.C.3
  • 34
    • 67650442637 scopus 로고    scopus 로고
    • Preskorn SH. What to do if the patient does not respond well to initial antidepressant therapy. In: Preskorn SH. Outpatient management of depression. Caddo, OK: Professional Communications; 2009: 223-55.
    • Preskorn SH. What to do if the patient does not respond well to initial antidepressant therapy. In: Preskorn SH. Outpatient management of depression. Caddo, OK: Professional Communications; 2009: 223-55.
  • 35
    • 0032521829 scopus 로고    scopus 로고
    • Regulation of serotonin 1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression
    • Lopez JF, Chalmers DT, Little KY, et al. Regulation of serotonin 1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression. Biol Psychiatry 1998;43: 547-73.
    • (1998) Biol Psychiatry , vol.43 , pp. 547-573
    • Lopez, J.F.1    Chalmers, D.T.2    Little, K.Y.3
  • 36
    • 0030839470 scopus 로고    scopus 로고
    • Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: Implication for the pathogenesis of depression
    • Meijer OC, Van Oosten RV, De Kloet ER. Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: Implication for the pathogenesis of depression. Neuroscience 1997;80:419-26.
    • (1997) Neuroscience , vol.80 , pp. 419-426
    • Meijer, O.C.1    Van Oosten, R.V.2    De Kloet, E.R.3
  • 37
    • 34848912806 scopus 로고    scopus 로고
    • Serotonin-1A receptor imaging in recurrent depression: Replication and literature review
    • Drevets WC, Thase M, Moses-Kolko E, et al. Serotonin-1A receptor imaging in recurrent depression: Replication and literature review. Nucl Med Biol 2007;34:865-77.
    • (2007) Nucl Med Biol , vol.34 , pp. 865-877
    • Drevets, W.C.1    Thase, M.2    Moses-Kolko, E.3
  • 38
    • 0037135137 scopus 로고    scopus 로고
    • Serotonin transporter genetic variation and the response of the human amygdala
    • Hariri AR, Mattay VS, Tessitore A, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002;297:400-3.
    • (2002) Science , vol.297 , pp. 400-403
    • Hariri, A.R.1    Mattay, V.S.2    Tessitore, A.3
  • 39
    • 0031736757 scopus 로고    scopus 로고
    • Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine
    • Smeraldi E, Zanardi R, Benedetti F, et al. Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Mol Psychiatry 1998;3:508-11.
    • (1998) Mol Psychiatry , vol.3 , pp. 508-511
    • Smeraldi, E.1    Zanardi, R.2    Benedetti, F.3
  • 40
    • 0033807374 scopus 로고    scopus 로고
    • Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression
    • Pollock BG, Ferrell RE, Mulsant BH, et al. Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression. Neuropsychopharmacology 2000;23:587-90.
    • (2000) Neuropsychopharmacology , vol.23 , pp. 587-590
    • Pollock, B.G.1    Ferrell, R.E.2    Mulsant, B.H.3
  • 41
    • 0037624040 scopus 로고    scopus 로고
    • Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
    • Caspi A, Sugden K, Moffitt TE, et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-9.
    • (2003) Science , vol.301 , pp. 386-389
    • Caspi, A.1    Sugden, K.2    Moffitt, T.E.3
  • 43
    • 0032819263 scopus 로고    scopus 로고
    • Serotonin and hippocampal neurogenesis
    • Gould E. Serotonin and hippocampal neurogenesis. Neuropsychopharmacology 1999;21(2 suppl):46S-51S.
    • (1999) Neuropsychopharmacology , vol.21 , Issue.2 SUPPL.
    • Gould, E.1
  • 45
    • 0036018097 scopus 로고    scopus 로고
    • Pre- and post-synaptic modification by neurotrophins
    • Kojima M, Klein RL, Hatanaka H. Pre- and post-synaptic modification by neurotrophins. Neurosci Res 2002;43: 193-9.
    • (2002) Neurosci Res , vol.43 , pp. 193-199
    • Kojima, M.1    Klein, R.L.2    Hatanaka, H.3
  • 46
    • 7044284913 scopus 로고    scopus 로고
    • Functional consequences of stress related suppression of adult hippocampal neurogenesis - a novel hypothesis on the neurobiology of burnout
    • Eriksson PS, Wallin L. Functional consequences of stress related suppression of adult hippocampal neurogenesis - a novel hypothesis on the neurobiology of burnout. Acta Neurol Scand 2004;110:275-80.
    • (2004) Acta Neurol Scand , vol.110 , pp. 275-280
    • Eriksson, P.S.1    Wallin, L.2
  • 47
    • 0038771149 scopus 로고    scopus 로고
    • Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants
    • Shimizu E, Hashimoto K, Okamura N, et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003;54:70-5.
    • (2003) Biol Psychiatry , vol.54 , pp. 70-75
    • Shimizu, E.1    Hashimoto, K.2    Okamura, N.3
  • 48
    • 67650454593 scopus 로고    scopus 로고
    • Modern drug development and the human genome project. Series of columns published between 2000 and 2002 in the Journal of Psychiatric Practice. Available at www.preskorn.com/column4.html.
    • Modern drug development and the human genome project. Series of columns published between 2000 and 2002 in the Journal of Psychiatric Practice. Available at www.preskorn.com/column4.html.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.