Does eczema lead to asthma?

Journal of Asthma

Volumn 46, Issue 5, 2009, Pages 429-436

  Burgess, John A ^a   Lowe, Adrian J ^a   Matheson, Melanie C ^a   Varigos, George ^b   Abramson, Michael J ^c   Dharmage, Shyamali C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Atopic march; Causation; Eczema; Incident asthma

Indexed keywords

ALLERGEN; CALCINEURIN INHIBITOR; CYTOKINE; FILAGGRIN; PIMECROLIMUS; PLACEBO; PROBIOTIC AGENT; TACROLIMUS; INTERMEDIATE FILAMENT PROTEIN;

ALLERGIC ASTHMA; ALLERGIC RHINITIS; ASTHMA; ATOPIC DERMATITIS; ATOPY; BREAST FEEDING; CELL DIFFERENTIATION; CHILDHOOD DISEASE; CIGARETTE SMOKING; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DRUG EFFICACY; ECZEMA; ENVIRONMENTAL FACTOR; EPIDERMIS; FOOD ALLERGY; GENE MUTATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; ICHTHYOSIS VULGARIS; IMMUNE RESPONSE; KERATINOCYTE; MAST CELL DEGRANULATION; NONHUMAN; ONSET AGE; PREGNANT WOMAN; RESPIRATORY TRACT ALLERGY; REVIEW; SENSITIZATION; SKIN; WHEEZING; ENVIRONMENT; EPIDEMIOLOGY; GENETICS; HAY FEVER; PERENNIAL RHINITIS; PREVALENCE; PROSPECTIVE STUDY; RISK FACTOR;

ASTHMA; CAUSALITY; DERMATITIS, ATOPIC; ENVIRONMENT; HUMANS; INTERMEDIATE FILAMENT PROTEINS; PREVALENCE; PROSPECTIVE STUDIES; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; RISK FACTORS; SKIN;

EID: 67650337858     PISSN: 02770903     EISSN: 15324303     Source Type: Journal    
DOI: 10.1080/02770900902846356     Document Type: Review

References (113)

1. Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee. Lancet 1998; 351(9111):1225-1232.
2. Williams H, Robertson C, Stewart A, Ait-Khaled N, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the International Study of Asthma and Allergies in Childhood. J Allergy Clin Immunol 1999; 103(1 Pt 1):125-138.
3. European Community Respiratory Health Survey. Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 1996; 9:687-695.
4. Moorman JE, Rudd RA, Johnson CA, King M, et al. Centers for Disease Control and Prevention. National Surveillance for Asthma - United States, 1980-2004. Surveillance Summaries, October 19. MMWR 2007; 56(SS-8), 2007.
5. Simpson EL, Hanifin JM. Atopic dermatitis. Med Clin North Am 2006; 90:149-167, ix.
6. Asher MI, Montefort S, Bjorksten B, Lai CK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 2006; 368(9537):733- 743.
7. Sly RM. Changing prevalence of allergic rhinitis and asthma. Ann Allergy Asthma Immunol 1999; 82:233-248; quiz 248-252.
8. Pearce N, Douwes J. The global epidemiology of asthma in children. Int J Tuberc Lung Dis 2006; 10:125-132.
9. Robertson CF, Roberts MF, Kappers JH. Asthma prevalence in Melbourne schoolchildren: have we reached the peak? Med J Aust 2004; 180:273-276.
10. Ponsonby AL, Glasgow N, Pezic A, Dwyer T, et al. A temporal decline in asthma but not eczema prevalence from 2000 to 2005 at school entry in the Australian Capital Territory with further consideration of country of birth. Int J Epidemiol 2008; 37:559-569.
11. Pearce N, Ait-Khaled N, Beasley R, Mallol J, et al. Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 2007; 62:758- 766.
12. Bergmann RL, Edenharter G, Bergmann KE, Forster J, et al., Atopic dermatitis in early infancy predicts allergic airway disease at 5 years. Clin Exp Allergy 1998; 28:965-970.
13. Gustafsson D, Sjoberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis - a prospective follow-up to 7 years of age. Allergy 2000; 55:240-245.
14. van der Hulst AE, Klip H, Brand PL. Risk of developing asthma in young children with atopic eczema: A systematic review. J Allergy Clin Immunol 2007; 120:565-569.
15. Hanifin JM, Reed ML. A population-based survey of eczema prevalence in the United States. Dermatitis 2007; 18:82-91.
16. Martin Fernandez-Mayoralas D, Martin Caballero JM, Garcia-Marcos Alvarez L. [Association between atopic dermatitis, allergic rhinitis and asthma in schoolchildren aged 13-14 years old]. An Pediatr (Barc) 2004; 60:236-242.
17. Hakansson K, Thomsen SF, Ulrik CS, Porsbjerg C, et al. Increase in the prevalence of rhinitis among Danish children from 1986 to 2001. Pediatr Allergy Immunol, 2007; 18:154-159.
18. Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol 2003; 112(6 suppl):S118-127.
19. Simpson EL, Hanifin JM. Atopic dermatitis. J Am Acad Dermatol 2005; 53:115-128.
20. Food Allergy, Atopic Dermatitis and the Allergy March. Proceedings of a symposiumin honourofProfessor Luisa Businco. Venice, Italy, November 17-19, 2000. Pediatr Allergy Immunol 2001; 12 (suppl 14):5-107.
21. Wüthrich B. Clinical aspects, epidemiology, and prognosis of atopic dermatitis. Ann Allergy Asthma Immunol 1999; 83:464-470.
22. Wüthrich B, Schudel P. [Atopic neurodermatitis after childhood stage; follow-up study of 121 cases]. Z Hautkr 1983; 58:1013-1023.
23. Kissling S, Wüthrich B. [Follow-up of atopic dermatitis after early childhood]. Hautarzt 1993; 44:569-573.
24. Illi S, von Mutius E, Lau S, Nickel R, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004; 113:925-931.
25. Lowe AJ, Abramson MJ, Hosking CS, Carlin JB, et al. The temporal sequence of allergic sensitization and onset of infantile eczema. Clin Exp Allergy 2007; 37:536-542.
26. Almqvist C, Li Q, Britton WJ, Kemp AS, et al. Early predictors for developing allergic disease and asthma: examining separate steps in the 'allergic march'. Clin Exp Allergy 2007; 37:1296-1302.
27. Lowe AJ, Carlin JB, Bennett CM, Hosking CS, et al. Do boys do the atopic march while girls dawdle? J Allergy Clin Immunol 2008; 121: 1190-1195.
28. Burgess JA, Dharmage SC, Byrnes G.B, Matheson MC, et al. Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle age. J Allergy Clin Immunol 2008; 122:280-285.
29. Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 2005; 6:328-340.
30. McGrath JA, Uitto J. The filaggrin story: novel insights into skin-barrier function and disease. Trends Mol Med 2008; 14:20-27.
31. Nicotera P, Melino G. Caspase-14 and epidermis maturation. Nat Cell Biol 2007; 9:621-622.
32. Jakasa I, de Jongh CM, Verberk MM, Bos JD, et al. Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. Br J Dermatol 2006; 155:104-109.
33. Jakasa I, Verberk MM, Esposito M, Bos JD, et al. Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. J Invest Dermatol 2007; 127:129-134.
34. Arikawa J, Ishibashi M, Kawashima M, Takagi Y., et al. Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerabilityofthe stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus. J Invest Dermatol 2002; 119:433- 439.
35. Imokawa G, Abe A, Jin K, Higaki Y, et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991; 96:523-526.
36. Strid J, Hourihane J, Kimber I, Callard R, et al. Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response. Eur J Immunol 2004; 34:2100-2109.
37. Spergel JM, Mizoguchi E, Brewer JP, Martin TR, et al. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest 1998; 101:1614-1622.
38. Lowe AJ, Hosking CS, Bennett CM, Carlin JB, et al., Skin prick test can identify eczematous infants at risk of asthma and allergic rhinitis. Clin Exp Allergy 2007; 37:1624-1631.
39. Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003; 348:977-985.
40. Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 2000; 105:860-876.
41. Lee Y.A, Wahn U, Kehrt R, Tarani L, et al. A major susceptibility locus for atopic dermatitis maps to chromosome 3q21. Nat Genet 2000; 26:470-473.
42. Cookson WO, Ubhi B, Lawrence R, Abecasis GR, et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat Genet 2001; 27:372-373.
43. Bradley M, Soderhall C, Luthman H, Wahlgren, CF, et al. Susceptibility loci for atopic dermatitis onchromosomes3,13, 15,17 and18 inaSwedish population. Hum Mol Genet 2002; 11:1539-1548.
44. Haagerup A, Bjerke T, Schiotz PO, Dahl R, et al. Atopic dermatitis - a total genome-scan for susceptibility genes. Acta Derm Venereol 2004; 84:346-352.
45. Hoffjan S, Epplen JT. The genetics of atopic dermatitis: recent findings and future options. J Mol Med 2005; 83:682-692.
46. Hoffjan S, Ober C. Genetic factors, in Lung biology in health and disease, C. Lenfant, ed. 2005, Marcel Dekker: New York.
47. Chien YH, Hwu WL, Chiang BL. The genetics of atopic dermatitis. Clin Rev Allergy Immunol 2007; 33:178-190.
48. Mischke D, Korge BP, Marenholz I, Volz A, et al. Genes encoding structural proteins of epidermal cornification and S100 calcium-binding proteins form a gene complex ("epidermal differentiation complex") on human chromosome 1q21. J Invest Dermatol 1996; 106:989-992.
49. Compton JG, DiGiovanna JJ, Johnston KA, Fleckman P, et al. Mapping of the associated phenotype of an absent granular layer in ichthyosis vulgaris to the epidermal differentiation complex on chromosome 1. Exp Dermatol 2002; 11:518-526.
50. Smith FJ, Irvine AD, Terron-Kwiatkowski A. Sandilands A, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet 2006; 38:337-342.
51. Wells, R.S., Kerr, C.B., Clinical features of autosomal dominant and sex-linked ichthyosis in an English population. BMJ 1966; 1:947-950.
52. Seguchi T, Cui CY, Kusuda S, Takahashi M, et al. Decreased expression of filaggrin in atopic skin. Arch Dermatol Res 1996; 288:442- 446.
53. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006; 38:441- 446.
54. Ruether A, Stoll M, Schwarz T, Schreiber S, et al. Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of Northern Germany. Br J Dermatol 2006; 155:1093-1094.
55. Barker JN, Palmer CN, Zhao Y, Liao H, et al. Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J Invest Dermatol 2007; 127:564- 567.
56. Stemmler S, Parwez Q, Petrasch-Parwez E, Epplen JT, et al. Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis. J Invest Dermatol 2007; 127:722-724.
57. Weidinger S, Rodriguez E, Stahl C, Wagenpfeil S, et al. Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis. J Invest Dermatol 2007; 127:724-726.
58. Irvine AD. Fleshing out filaggrin phenotypes. J Invest Dermatol 2007; 127:504-507.
59. Morar N, Cookson WO, Harper JI, Moffatt MF. Filaggrin mutations in children with severe atopic dermatitis. J Invest Dermatol 2007; 127:1667- 1672.
60. Novak N, Baurecht H, Schafer T, Rodriguez E, et al. Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. J Invest Dermatol 2008; 128:1430-1435.
61. Ekelund E, Lieden A, Link J, Lee SP, et al. Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families. Acta Derm Venereol 2008; 88:15-19.
62. Henderson J, Northstone K, Lee SP, Liao H, et al. The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study. J Allergy Clin Immunol 2008; 121:872-877 e9.
63. Nomura T, Sandilands A, Akiyama M, Liao H, et al. Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. J Allergy Clin Immunol 2007; 119:434-440.
64. Gruber R, Janecke AR, Fauth C, Utermann G, et al. Filaggrin mutations p.R501X and c.2282del4 in ichthyosis vulgaris. Eur J Hum Genet 2007; 15:179-184.
65. Hamada T, Sandilands A, Fukuda S, Sakaguchi S, et al. De novo occurrence of the filaggrin mutation p.R501X with prevalent mutation c.3321delA in a Japanese family with ichthyosis vulgaris complicated by atopic dermatitis. J Invest Dermatol 2008; 128:1323-1325.
66. Brown SJ, Sandilands A, Zhao Y, Liao H, et al. Prevalent and low-frequency null mutations in the filaggrin gene are associated with early-onset and persistent atopic eczema. J Invest Dermatol 2008; 128:1591- 1594.
67. Giardina E, Paolillo N, Sinibaldi C, Novelli G. R501X and 2282del4 filaggrin mutations do not confer susceptibility to psoriasis and atopic dermatitis in Italian patients. Dermatology 2008; 216:83-84.
68. Cookson WO, Moffatt MF. The genetics of atopic dermatitis. Curr Opin Allergy Clin Immunol 2002; 2:383-387.
69. Marenholz I, Nickel R, Ruschendorf F, Schulz F, et al. Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol 2006; 118:866-871.
70. Weidinger S, O'Sullivan M, Illig T, Baurecht H, et al. Filaggrin mutations, atopic eczema, hay fever, and asthma in children. J Allergy Clin Immunol 2008; 121:1203-1209, e1.
71. Brown SJ, Relton CL, Liao H, Zhao Y, et al. Filaggrin null mutations and childhood atopic eczema: a population-based case-control study. J Allergy Clin Immunol 2008; 121:940-946, e3.
72. Gdalevich M, Mimouni D, David M, Mimouni M. Breast-feeding and the onset of atopic dermatitis in childhood: a systematic review and meta-analysis of prospective studies. J Am Acad Dermatol 2001; 45:520-527.
73. Gdalevich M, Mimouni D, Mimouni M. Breast-feeding and the risk of bronchial asthma in childhood: a systematic review with meta-analysis of prospective studies. J Pediatr 2001; 139:261-266.
74. Bergmann RL, Diepgen TL, Kuss O, Bergmann KE, et al. Breastfeeding duration is a risk factor for atopic eczema. Clin Exp Allergy 2002; 32:205-209.
75. Matheson MC, Erbas B, Balasuriya A, Jenkins MA, Wharton CL, Tang MLK, Abramson MJ, Walters EH, Hopper JL, Dharmage SC. Breastfeeding and Atopic Disease: A Cohort Study from Childhood to Middle-age. J Allergy Clin Immunol (provisionally accepted).
76. Sears MR, Greene JM, Willan AR, Taylor DR, et al. Long-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal study. Lancet 2002; 360(9337):901-907.
77. Lowe AJ, Carlin JB, Bennett CM, Abramson MJ, et al. Atopic disease and breast-feeding-cause or consequence? J Allergy Clin Immunol 2006; 117:682-687.
78. Kramer MS, Matush L, Vanilovich I, Platt R, et al. Effect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trial. BMJ 2007; 335(7624):815.
79. Douwes J, Pearce N. Asthma and the westernization "package." Int J Epidemiol 2002; 31:1098-1102.
80. Braun-Fahrlander C. Environmental exposure to endotoxin and other microbial products and the decreased risk of childhood atopy: evaluating developments since April 2002. Curr Opin Allergy Clin Immunol 2003; 3:325-329.
81. Illi S, von Mutius E, Lau S, Bergmann R, et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001; 322(7283):390-395.
82. Strachan DP, Taylor EM, Carpenter RG. Family structure, neonatal infection, and hay fever in adolescence. Arch Dis Child 1996; 74:422- 426.
83. Strachan DP. Allergy and family size: a riddle worth solving. Clin Exp Allergy 1997; 27:235-236.
84. Oddy WH, de Klerk NH, Sly PD, and Holt PG. The effects of respiratory infections, atopy, and breastfeeding on childhood asthma. Eur Respir J 2002; 19:899-905.
85. Hesselmar B, Aberg N, Aberg B, Eriksson B, et al. Does early exposure to cat or dog protect against later allergy development? Clin Exp Allergy 1999; 29:611-617.
86. Remes ST, Castro-Rodriguez JA, Holberg CJ, Martinez FD, et al. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol 2001; 108:509-515.
87. Svanes C, Jarvis D, Chinn S, Burney P. Childhood environment and adult atopy: results from the European Community Respiratory Health Survey. J Allergy Clin Immunol 1999; 103(3 Pt 1):415-420.
88. Svanes C, Heinrich J, Jarvis D, Chinn S, et al. Pet-keeping in childhood and adult asthma and hay fever: European community respiratory health survey. J Allergy Clin Immunol 2003; 112:289-300.
89. Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis." Thorax 2000; 55 (suppl 1):S2-10.
90. Jackson DJ, Gangnon RE, Evans MD, Roberg KA, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med 2008; 178:667-672.
91. Kusel MM, de Klerk NH, Kebadze T, Vohma V, et al. Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma. J Allergy Clin Immunol 2007; 119:1105- 1110.
92. Stein RT, Sherrill D, Morgan WJ, Holberg CJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 1999; 354(9178):541-545.
93. Platts-Mills T, de Weck A. Dust mite allergens and asthma-a worldwide problem. J Allergy Clin Immunol 1989; 83(2 Pt 1):416-427.
94. Sporik R, Holgate ST, Platts-Mills TA, Cogswell JJ. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N Engl J Med 1990; 323:502-507.
95. Marks GB, Mihrshahi S, Kemp AS, Tovey ER, et al. Prevention of asthma during the first 5 years of life: a randomized controlled trial. J Allergy Clin Immunol 2006; 118:53-61.
96. Chan-Yeung M, Ferguson A, Watson W, Dimich-Ward H, et al. The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol 2005; 116:49-55.
97. Woodcock A, Lowe LA, Murray CS, Simpson BM, et al. Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med 2004; 170:433-439.
98. Arshad SH, Bateman B, Matthews SM. Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomised controlled study. Thorax 2003; 58:489-493.
99. Horak F Jr, Matthews S, Ihorst G, Arshad SH, et al. Effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study - 24 months results of the Study of Prevention of Allergy in Children in Europe. Clin Exp Allergy 2004; 34:1220-1225.
100. Hill AB. The Environment and Disease: Association or Causation? Proc R Soc Med 1965; 58:295-300.
101. Rothman KJ, Poole C. A strengthening programme for weak associations. Int J Epidemiol 1988; 17:955-959.
102. Rothman KJ, Greenland S, in Modern Epidemiology. 1998, Lippincott:Raven: Philadelphia, p. 295.
103. Lack, G., Epidemiologic risks for food allergy. J Allergy Clin Immunol 2008; 121:1331-1336.
104. Wahn U. Allergic factors associated with the development of asthma and the influence of cetirizine in a double-blind, randomised, placebo-controlled trial: first results of ETAC. Early Treatment of the Atopic Child. Pediatr Allergy Immunol 1998; 9:116-124.
105. Ross T, Ross G, Varigos G. Eczema-practical management issues. Aust Fam Phys 2005; 34:319-324.
106. Chamlin SL, Kao J, Frieden IJ, Sheu MY, et al. Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J Am Acad Dermatol 2002; 47:198-208.
107. Cheer SM, Plosker GL. Tacrolimus ointment. A review of its therapeutic potential as a topical therapy in atopic dermatitis. Am J Clin Dermatol 2001; 2:389-406.
108. Nakagawa H. Comparison of the efficacy and safety of 0.1% tacrolimus ointment with topical corticosteroids in adult patients with atopic dermatitis: review of randomised, double-blind clinical studies conducted in Japan. Clin Drug Investig 2006; 26:235-246.
109. Singalavanija S, Noppakun N, Limpongsanuruk W, Wisuthsarewong W, et al. Efficacy and safety of tacrolimus ointment in pediatric Patients with moderate to severe atopic dermatitis. J Med Assoc Thai 2006; 89:1915- 1922.
110. Wahn U, Bos JD, Goodfield M, Caputo R, et al. Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children. Pediatrics 2002; 110(1 Pt 1): e2.
111. Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, Murrell DF, et al. Probiotics for treating eczema. Cochrane Database Syst Rev 2008: CD006135.
112. Betsi GI, Papadavid E, Falagas ME. Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. Am J Clin Dermatol 2008; 9:93-103.
113. Wickens K, Black PN, Stanley TV, Mitchell E, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol 2008; 122:788- 794.