Innate immune response after resuscitation with hemoglobin-based oxygen carrier and recombinant factor VIIA in uncontrolled hemorrhagic shock in a swine model

Journal of Trauma - Injury, Infection and Critical Care

Volumn 64, Issue 6, 2008, Pages 1498-1510

  Malkevich, Nina V ^a   Dong, Feng ^a   Vandermolen, Christine A ^a   Philbin, Nora B ^a   Rice, Jennifer P ^a   Scultetus, Anke ^a   Hong, Jiang ^a   Arnaud, Francoise ^a   Hall, Carrie H ^a   McGwin, Gerald ^b,c   Pearce, L Bruce ^d   Handrigan, M ^a   Ahlers, Stephen ^a   McCarron, Richard M ^a   Freilich, Daniel ^a  

^a NAVAL MEDICAL RESEARCH CENTER   (United States)

^b Section of Trauma   (United States)

^c University of Alabama at Birmingham   (United States)

^d Biopure Corporation   (United States)

Author keywords

HBOC 201; Hemorrhagic shock; Innate immunity; Multifunctional blood substitutes; Recombinant factor VIIa; Resuscitation; Swine

Indexed keywords

ALPHA4 INTEGRIN; CD11B ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; POLYMERIZED HEMOGLOBIN; RECOMBINANT BLOOD CLOTTING FACTOR 7A; TUMOR NECROSIS FACTOR ALPHA; BLOOD CLOTTING FACTOR 7A; BLOOD SUBSTITUTE; HEMOGLOBIN; RECOMBINANT FVIIA; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CD4 CD8 RATIO; DISEASE FREE SURVIVAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HEMORRHAGIC SHOCK; IMMUNOMODULATION; INNATE IMMUNITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTHROMBIN TIME; RESUSCITATION; SWINE; ANIMAL; DISEASE MODEL; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECT; IMMUNOLOGY; KAPLAN MEIER METHOD; METHODOLOGY; MORTALITY; PROBABILITY; RANDOMIZATION; SENSITIVITY AND SPECIFICITY; SURVIVAL RATE;

ANIMALS; BLOOD SUBSTITUTES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FACTOR VIIA; HEMOGLOBINS; IMMUNITY, NATURAL; KAPLAN-MEIERS ESTIMATE; PROBABILITY; RANDOM ALLOCATION; RECOMBINANT PROTEINS; RESUSCITATION; SENSITIVITY AND SPECIFICITY; SHOCK, HEMORRHAGIC; SURVIVAL RATE; SWINE;

EID: 67650337004     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181454a05     Document Type: Article

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