CCHCR1 is up-regulated in skin cancer and associated with EGFR expression

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Suomela, Sari ^a   Elomaa, Outi ^b   Skoog, Tiina ^f,g   Ala Aho, Risto ^d,e   Jeskanen, Leila ^a   Pärssinen, Jenita ^a   Latonen, Leena ^c   Grénman, Reider ^d   Kere, Juha ^b,f   Kähäri, Veli Matti ^d,e   Saarialho Kere, Ulpu ^a,g  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF TURKU   (Finland)

^f KAROLINSKA INSTITUTE   (Sweden)

^g STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

COILED COIL ALPHA HELICAL ROD PROTEIN 1; CYCLIN D1; KI 67 ANTIGEN; MENADIONE; OKADAIC ACID; ONCOPROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; CCHCR1 PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR RECEPTOR; SIGNAL PEPTIDE;

ARTICLE; BOWEN DISEASE; CANCER CELL CULTURE; CANCER INVASION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY INFILTRATE; KERATINOCYTE; KERATOACANTHOMA; LYMPHOCYTIC INFILTRATION; PSORIASIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CANCER; SQUAMOUS CELL CARCINOMA; UPREGULATION; BIOLOGICAL MODEL; BIOSYNTHESIS; GENETICS; INFLAMMATION; LYMPHOCYTE; METABOLISM; METHODOLOGY; PHYSIOLOGY; SKIN TUMOR; TUMOR CELL LINE;

MUS MUSCULUS;

CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KI-67 ANTIGEN; LYMPHOCYTES; MODELS, BIOLOGICAL; PSORIASIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; UP-REGULATION;

EID: 67650320993     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006030     Document Type: Article

References (42)

1. Suomela S, Elomaa O, Asumalahti K, Kariniemi A-L, Karvonen S-L, et al. (2003) HCR, a Candidate Gene for Psoriasis, is Expressed Differently in Psoriasis and Other Hyperproliferative Skin Disorders and is Downregulated by IFN-γ in Keratinocytes. J Invest Dermatol 121: 1360-4.
2. Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Hölttä-Vuori M, et al. (2007) The CCHCR1 gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes. J Mol Med 85: 589-601.
3. Tiala I, Wakkinen J, Suomela S, Puolakkainen P, Tammi R, et al. (2008) The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice. Hum Mol Genet 17: 1043-51.
4. Asumalahti K, Veal C, Laitinen T, Suomela S, Allen M, et al. (2002) Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus. Hum Mol Genet 11: 589-97.
5. Zenz R, Wagner EF (2006) Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors. Int J Biochem Cell Biol 38: 1043-49.
6. Nickoloff BJ (2001) Creation of psoriatic plaques: the ultimate tumor suppressor pathway. A new model for an ancient T-cell-mediated skin disease. Viewpoint. J Cutan Pathol 28: 57-64.
7. Paltiel O, Adler B, Herschko K, Tsukrov B, David M (2004) Are patients with psoriasis susceptible to the classic risk factors for actinic keratoses? Arch Dermatol 140: 805-10.
8. Schneider MR, Werner S, Paus R, Wolf E (2008) Beyond wavy hairs: The epidermal growth factor receptor and its ligands in skin biology and pathology. Am J Pathol 173: 14-24.
9. El-Abaseri TB, Putta S, Hansen LA (2006) Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis 27: 225-31.
10. Rittié L, Kansra S, Stoll SW, Li Y, Gudjonsson JE, et al. (2007) Differential ErbB1 signaling in squamous cell versus basal cell carcinoma of the skin. Am J Pathol 170: 2089-99.
11. Zorzou MP, Stratigos A, Efstathiou E, Bamias A (2004) Exacerbation of psoriasis after treatment with an EGFR tyrosine kinase inhibitor. Acta Derm Venereol 84: 308-9.
12. Wierzbicka E, Tourani JM, Guillet G (2006) Improvement of psoriasis and cutaneous side-effects during tyrosine kinase inhibitor therapy for renal metastatic adenocarcinoma. A role for epidermal growth factor receptor (EGFR) inhibitors in psoriasis? Br J Dermatol 155: 213-4.
13. DeAngelis T, Noe A, Chatterjee M, Mulholland J (2002) Stromelysin-1 Activation Correlates with Invasiveness in Squamous Cell Carcinoma. J Invest Dermatol 118: 759-66.
14. Pivarcsi A, Szell M, Kemeny L, Dobozy A, Bata-Csörgo Z (2001) Serum factors regulate the expression of the proliferation-related genes alpha5 integrin and keratin 10, in HaCaT keratinocytes. Arch Dermatol Res 293: 206-13.
15. Skoog T, Elomaa O, Pasonen-Seppaänen SM, Forsberg S, et al. (2009) Matrix metalloproteinase-21 expression is associated with keratinocyte differentiation and upregulated by retinoic acid in HaCaT cells. J Invest Dermatol 129: 119-30.
16. Verdier-Sevrain S, Yaar M, Cantatore J, Traish A, Gilchrest BA (2004) Estradiol induces proliferation of keratinocytes via a receptor mediated mechanism. FASEB J 18: 1252-4.
17. Quadros MR, Peruzzi F, Kari C, Rodeck U (2004) Complex Regulation of Signal Transducers and Activators of Transcription 3 Activation in Normal and Malignant Keratinocytes. Cancer Res 64: 3934-9.
18. Schontal AH (1995) Regulation of gene expression by serine/threonine protein phosphatases. Semin Cancer Biol 6: 239-48.
19. Westermarck J, Lohi J, Keski-Oja J, Kähäri V-M (1994) Okadaic acid-elicited transcriptional activation of collagenase gene expression in HT-1080 fibrosarcoma cells is mediated by JunB. Cell Growth Differ 5: 1205-13.
20. Westermarck J, Holmström TH, Ahonen M, Eriksson JE, Kähäri V-M (1998) Enhancement of fibroblast collagenase-1 (MMP-1) gene expression by tumor promoter okadaic acid is mediated by stress-activated protein kinases Jun N-terminal kinase and p38. Matrix Biol 17: 547-57.
21. Rosenberger SF, Finch JS, Gupta A, Bowden GT (1999) Extracellular signal-regulated kinase 1/2-mediated phosphorylation of junD and fosB is required for okadaic acid-induced activator protein 1 activation. J Biol Chem 274: 1124-30.
22. Freeman MR, Cinar B, Kim J, Mukhopadhyay NK, Di Vizio D, et al. (2007) Transit of hormonal and EGF receptor-dependent signals through cholesterol-rich membranes. Steroids 72: 210-7.
23. Lebeau S, Masouye I, Berti M, Augsburger E, Saurat JH, et al. (2005) Comparative analysis of the expression of ERBIN and Erb-B2 in normal human skin and cutaneous carcinomas. Br J Dermatol 152: 1248-55.
24. Meves A, Peus D, Pittelkow MR (2002) Okadaic acid-induced EGF receptor and MAP kinase activation does not require reactive oxygen species in primary keratinocytes. Arch Dermatol Res 294: 243-5.
25. Beier JI, von Montfort C, Sies H, Klotz L-O (2006) Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: Role of EGFR and protein tyrosine phosphatases. FEBS Letters 580: 1859-64.
26. Schmidt KN, Traenckner EB, Meier B, Baeuerle PA (1995) Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B. J Biol Chem 270: 27136-42.
27. Matias WG, Traore A, Bonini M, Sanni A, Creppy EE (1999) Oxygen reactive radicals production in cell culture by okadaic acid and their implication in protein synthesis inhibition. Hum Exp Toxicol 18: 634-9.
28. Beachy PA, Karhadkar SS, Berman DM (2004) Tissue repair and stem cell renewal in carcinogenesis. Nature 432: 324-31.
29. Nickoloff BJ, Bonish BK, Marble DJ, Schriedel KA, DiPietro LA, et al. (2006) Lessons Learned from Psoriatic Plaques Concerning Mechanisms of Tissue Repair, Remodeling, and Inflammation. J Invest Dermatol Symp Proceed 11: 16-29.
30. Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, et al. (2004) Transgenic mouse models support HCR as an effector gene in the PSORS1 locus. Hum Mol Genet 13: 1551-61.
31. Cordero JB, Cozzolino M, Lu Y, Vidal M, Slatopolsky E, et al. (2002) 1,25-Dihydroxyvitamin D down-regulates cell membrane growth- and nuclear growth-promoting signals by the epidermal growth factor receptor. J Biol Chem 277: 38965-71.
32. Corbi N, Bruno T, De Angelis R, Di Padova M, Libri V, et al. (2005) RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product. J Cell Sci 118: 4253-60.
33. De Angelis R, Iezzi S, Bruno T, Corbi N, Di Padova, et al. (2003) Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). FEBS Lett 547: 15-19.
34. Mielnicki LM, Hughes RG, Chevray PM, Pruitt SC (1996) Mutated Atf4 suppresses c-ha-ras oncogene transcript levels and cellular transformation in NIH3T3 fibroblasts. Biochem Biophys Res Commun 228: 586-95.
35. Hai T, Hartman MG (2001) The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis. Gene 273: 1-11.
36. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, et al. (1988) Normal keratinisation in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106: 761-71.
37. Ahokas K, Lohi J, Illman SA, Llano E, Elomaa O, et al. (2003) Matrix Metalloproteinase-21 Is Expressed Epithelially During Development and in Cancer and Is Up-Regulated by Transforming Growth Factor-beta1 in Keratinocytes. Lab Invest 83: 1887-99.
38. Lansdorf CD, Grénman R, Bier H, Somers KD, Kim SY, et al. (1999) Head and neck cancers. In: Masters J, Palsson B, eds. Human Cell Culture. Dordrecht: Kluwer Academic Press. pp 185-255.
39. Junttila MR, Ala-aho R, Jokilehto T, Peltonen J, Kallajoki M, et al. (2007) p38alpha and p38delta mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells. Oncogene 26: 5267-79.
40. Skoog T, Ahokas K, Orsmark C, Jeskanen L, Isaka K, et al. (2006) MMP-21 is expressed by macrophages and fibroblasts in vivo and in culture. Exp Dermatol 15: 775-83.
41. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, et al. (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19: 245-54.
42. Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki M, Suomela S, et al. (2000) A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Hum Mol Genet 9: 1533-42.