Okadaic acid-induced EGF receptor and MAP kinase activation does not require reactive oxygen species in primary keratinocytes

Archives of Dermatological Research

Volumn 294, Issue 5, 2002, Pages 243-245

  Meves, Alexander ^a,b,c   Peus, Dominik ^a,b   Pittelkow, Mark R ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Carcinogenesis; Lipid peroxidation; Phosphatases; Reactive oxygen species

Indexed keywords

4 (3 BROMOANILINO) 6,7 DIMETHOXYQUINAZOLINE; 7 DIHYDROXYPHENOXAZINE; ACETYLCYSTEINE; ANTIOXIDANT; ASCORBIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; GALLIC ACID PROPYL ESTER; HORSERADISH PEROXIDASE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHENOXAZINE DERIVATIVE; PHOSPHOPROTEIN PHOSPHATASE; REACTIVE OXYGEN METABOLITE; RHODAMINE; SERINE; STRESS ACTIVATED PROTEIN KINASE; THREONINE; UNCLASSIFIED DRUG; 4 ((3 BROMOPHENYL)AMINO) 6,7 DIMETHOXYQUINAZOLINE; 4-((3-BROMOPHENYL)AMINO)-6,7-DIMETHOXYQUINAZOLINE; CARCINOGEN; QUINAZOLINE DERIVATIVE;

ARTICLE; CELL ASSAY; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; EXPOSURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KERATINOCYTE; LIPID PEROXIDATION; MEDIATOR; OXIDATION REDUCTION REACTION; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME; ULTRAVIOLET B RADIATION; BIOSYNTHESIS; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM;

CARCINOGENS; CELLS, CULTURED; ENZYME ACTIVATION; HUMANS; KERATINOCYTES; LIPID PEROXIDATION; MITOGEN-ACTIVATED PROTEIN KINASES; OKADAIC ACID; QUINAZOLINES; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 0036020331     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00403-002-0315-1     Document Type: Article

References (9)

1. Okadaic acid: A new probe for the study of cellular regulation
2. Okadaic acid-induced hyperphosphorylation of the epidermal growth factor receptor . Comparison with receptor phosphorylation and functions affected by another tumor promoter, 12-O-tetradecanoylphorbol-13-acetate
3. Oxygen reactive radicals production in cell culture by okadaic acid and their implication in protein synthesis inhibition
4. 2 mediates oxidative stress-induced epidermal growth factor receptor phosphorylation
5. 2 is an important mediator of UVB-induced EGF-receptor phosphorylation in cultured keratinocytes
6. 2 is required for UVB-induced EGF receptor and downstream signaling pathway activation
7. Anti-psoriatic drug anthralin activates JNK via lipid peroxidation: Mononuclear cells are more sensitive than keratinocytes
8. Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B
9. Activation of the epidermal growth factor receptor by skin tumor promoters and in skin tumors from SENCAR mice