RNA polymerase II subunit 3 is retained in the cytoplasm by its interaction with HCR, the psoriasis vulgaris candidate gene product

Journal of Cell Science

Volumn 118, Issue 18, 2005, Pages 4253-4260

  Corbi, Nicoletta ^a   Bruno, Tiziana ^b   De Angelis, Roberta ^b   Di Padova, Monica ^b   Libri, Valentina ^a   Di Certo, Maria Grazia ^a,c   Spinardi, Laura ^d   Floridi, Aristide ^c   Fanciulli, Maurizio ^b,e   Passananti, Claudio ^a,e  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d UNIVERSITY OF MILANO BICOCCA   (Italy)

^e AIRC Roman Oncogenomic Center   (Italy)

Author keywords

HCR; Muscle differentiation; Psoriasis vulgaris; RNAP II; RPB3; SBP

Indexed keywords

CYTOPLASM PROTEIN; GENE PRODUCT; PROTEIN HCR; RNA POLYMERASE II; RNA POLYMERASE II SUBUNIT 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MUSCLE DEVELOPMENT; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PSORIASIS VULGARIS; REGULATORY MECHANISM; RNA INTERFERENCE;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CYTOPLASM; HELA CELLS; HUMANS; MICE; MICE, TRANSGENIC; MYOBLASTS; NIH 3T3 CELLS; PROTEIN STRUCTURE, TERTIARY; PROTEINS; PSORIASIS; RNA INTERFERENCE; RNA POLYMERASE II;

ANIMALIA;

EID: 27144457418     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02545     Document Type: Article

References (39)

1. Asumalahti, K., Laitinen, T., Itkonen-Vatjus, R., Lokki, M. L., Suomela, S., Snellman, E., Saarialho-Kere, U. and Kere, J. (2000). A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Hum. Mol. Genet. 9, 1533-1542.
2. Asumalahti, K., Veal, C., Laitinen, T., Suomela, S., Allen, M., Elomaa, O., Moser, M., de Cid, R., Ripatti, S., Vorechovsky, I. et al. (2002). Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus. Hum. Mol. Genet. 11, 589-597.
3. Bushnell, D. A. and Kornberg, R. D. (2003). Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: implications for the initiation of transcription. Proc. Natl. Acad. Sci. USA 100, 6969-6973.
4. Brummelkamp, T. R., Bernards, R. and Agami, R. (2002). Stable suppression of tumorigenicity by virus-mediated RNA interference. Science 296, 550-553.
5. Corbi, N., Di Padova, M., De Angelis, R., Bruno, T., Libri, V., Iezzi, S., Floridi, A., Fanciulli, M. and Passananti, C. (2002). The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor Myogenin. FASEB J. 16, 1639-1641.
6. Cramer, P., Bushnell, D. A., Fu, J., Gnatt, A. L., Maier-Davis, B., Thompson, N. E., Burgess, R. R., Edwards, A. M., David, P. R. and Kornberg, R. D. (2000). Architecture of RNA polymerase II and implications for the transcription mechanism. Science 288, 640-649.
7. Davis, J. A., Takagi, Y., Kornberg, R. D. and Asturias, F. A. (2002). Structure of the yeast RNA polymerase II holoenzyme: mediator conformation and polymerase interaction. Mol. Cell 10, 409-415.
8. De Angelis, R., Iezzi, S., Bruno, T., Corbi, N., Di Padova, M., Floridi, A., Fanciulli, M. and Passananti, C. (2003). Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4). FEBS Lett. 547, 15-19.
9. Dorjsuren, D., Lin, Y., Wei, W., Yamashita, T., Nomura, T., Hayashi, N. and Murakami, S. (1998). RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Mol. Cell Biol. 18, 7546-7555.
10. Elomaa, O., Majuri, I., Suomela, S., Asumalahti, K., Jiao, H., Mirzaei, Z., Rozell, B., Dahlman-Wright, K., Pispa, J., Kere, J. and Saarialho-Kere, U. (2004). Transgenic mouse models support HCR as an effector gene in the PSORS1 locus. Hum. Mol. Genet. 13, 1551-1561.
11. Fanciulli, M., Bruno, T., Cerboni, C., Bonetto, F., Iacobini, C., Frati, L., Piccoli, M., Floridi, A., Santoni, A. and Punturieri, A. (1996). Cloning of a novel human RNA polymerase II subunit downregulated by doxorubicin: new potential mechanisms of drug related toxicity. FEBS Lett. 384, 48-52.
12. Fanciulli, M., Bruno, T., Di Padova, M., De Angelis, R., Lovari, S., Floridi, A. and Passananti, C. (1998). The interacting RNA polymerase II subunits, hRPB11 and hRPB3, are coordinately expressed in adult human tissues and down-regulated by doxorubicin. FEBS Lett. 427, 236-240.
13. Fanciulli, M., Bruno, T., Di Padova, M., De Angelis, R., Iezzi, S., Iacobini, C., Floridi, A. and Passananti, C. (2000). Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb. FASEB J. 14, 904-912.
14. Farago, M., Nahari, T., Hammel, C., Cole, C. N. and Choder, M. (2003). Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress. Mol. Biol. Cell 14, 2744-2755.
15. Gietz, D., St Jean, A., Woods, R. A. and Schiestl, R. H. (1992). Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res. 20, 1425.
16. Gnatt, A. (2002). Elongation by RNA polymerase II: structure-function relationship. Biochim. Biophys. Acta 1577, 175-190.
17. Gnatt, A. L., Cramer, P., Fu, J., Bushnell, D. A. and Kornberg, R. D. (2001). Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 Å resolution. Science 292, 1876-1882.
18. Hai, T. and Hartman, M. G. (2001). The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273, 1-11.
19. Harlow, Ed. and Lane, D. (1988). Antibodies: A Laboratory Manual. Cold Spring Harbor New York: Cold Spring Harbor Laboratory Press.
20. Howe, K. J. (2002). RNA polymerase II conducts a symphony of pre-mRNA processing activities. Biochim. Biophys. Acta 1577, 308-324.
21. Jeronimo, C., Langelier, M. F., Zeghouf, M., Cojocaru, M., Bergeron, D., Baali, D., Forget, D., Mnaimneh, S., Davierwala, A. P., Pootoolal, J. et al. (2004). RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. Mol. Cell Biol. 24, 7043-7058.
22. Jones, S. (2004). An overview of the basic helix-loop-helix proteins. Genome Biol. 5, 226.
23. Kimura, M., Sakurai, H. and Ishihama, A. (2001). Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe. Eur. J. Biochem. 268, 612-619.
24. Lin, Y., Nomura, T., Cheong, J., Dorjsuren, D., Iida, K. and Murakami, S. (1997). Hepatitis B virus X protein is a transcriptional modulator that communicates with transcription factor IIB and the RNA polymerase II subunit 5. J. Biol. Chem. 272, 7132-7139.
25. Miyao, T. and Woychik, N. A. (1998). RNA polymerase subunit RPB5 plays a role in transcriptional activation. Proc. Natl. Acad. Sci. USA 95, 15281-15286.
26. Molkentin, J. D. and Olson, E. N. (1996). Combinatorial control of muscle development by basic helix-loop-helix and MADS-box transcription factors. Curr. Opin. Genet. Dev. 6, 445-453.
27. Myers, L. C. and Kornberg, R. D. (2000). Mediator of transcriptional regulation. Annu. Rev. Biochem. 69, 729-749.
28. O'Brien, K. P., Holm, S. J., Nilsson, S., Carlen, L., Rosenmuller, T., Enerback, C., Inerot, A. and Stahle-Backdahl, M. (2001). The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene. J. Invest. Dermatol. 116, 750-754.
29. Oka, A., Tamiya, G., Tomizawa, M., Ota, M., Katsuyama, Y., Makino, S., Shiina, T., Yoshitome, M., Iizuka, M., Sasao, Y. et al. (1999). Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. Hum. Mol. Genet. 8, 2165-2170.
30. Petermann, R., Mossier, B. M., Aryee, D. N., Khazak, V., Golemis, E. A. and Kovar, H. (1998). Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II. Oncogene 17, 603-610.
31. Schaller, S., Grandemange, S., Shpakovski, G. V., Golemis, E. A., Kedinger, C. and Vigneron, M. (1999). Interactions between the full complement of human RNA polymerase II subunits. FEBS Lett. 461, 253-257.
32. Schlegel, B. P., Green, V. J., Ladias, J. A. and Parvin, J. D. (2000). BRCA1 interaction with RNA polymerase II reveals a role for hRPB2 and hRPB10alpha in activated transcription. Proc. Natl. Acad. Sci. USA 97, 3148-3153.
33. Schneider, S., Buchert, M. and Hovens, C. M. (1996). An in vitro assay of beta-galactosidase from yeast. BioTechniques 20, 960-962.
34. Sims, R. J., III, Mandal, S. S. and Reinberg, D. (2004). Recent highlights of RNA-polymerase-II-mediated transcription. Curr. Opin. Cell Biol. 16, 263-271.
35. Sugawara, T., Shimizu, H., Hoshi, N., Nakajima, A. and Fujimoto, S. (2003). Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system J. Biol. Chem. 278, 42487-42494.
36. Suomela, S., Elomaa, O., Asumalahti, K., Kariniemi, A. L., Karvonen, S. L., Peltonen, J., Kere, J. and Saarialho-Kere, U. (2003). HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes. J. Invest. Dermatol. 121, 1360-1364.
37. Tan, Q., Linask, K. L., Ebright, R. H. and Woychik, N. A. (2000). Activation mutants in yeast RNA polymerase II subunit RPB3 provide evidence for a structurally conserved surface required for activation in eukaryotes and bacteria. Genes Dev. 14, 339-348.
38. Woychik, N. A. and Hampsey, M. (2002). The RNA polymerase II machinery: structure illuminates function. Cell 108, 453-463.
39. Woychik, N. A., McKune, K., Lane, W. S. and Young, R. A. (1993). Yeast RNA polymerase II subunit RPB11 is related to a subunit shared by RNA polymerase I and III. Gene Expr. 3, 77-82.