A comparative investigation of fetal skeletal anomalies in rats induced by acetylsalicylic acid with single- and double-staining techniques

Regulatory Toxicology and Pharmacology

Volumn 54, Issue 3, 2009, Pages 308-313

  Dodo, Tetsushi ^a,b   Fukuta, Tetsuya ^a   Uchida, Keiji ^a   Mineshima, Hiroshi ^a   Okuda, Yasuyuki ^a   Okada, Fumihiro ^a   Katsutani, Naruo ^a   Hirano, Kazuyuki ^b   Aoki, Toyohiko ^a  

^a EISAI CO LTD   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acetylsalicylic acid; Developmental toxicity; Fetal skeletal anomalies; Single and double staining

Indexed keywords

ACETYLSALICYLIC ACID; ALCIAN BLUE; ALIZARIN RED S;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHONDROPATHY; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; FETUS; FETUS DISEASE; GESTATIONAL AGE; HISTOPATHOLOGY; LUMBAR VERTEBRA; MOUSE; NEWBORN; NONHUMAN; OSSIFICATION; PREGNANCY; PRIORITY JOURNAL; RIB MALFORMATION; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; SKELETON MALFORMATION; STAINING; TERATOGENESIS; THORAX MALFORMATION; VERTEBRA MALFORMATION;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BONE AND BONES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; STAINING AND LABELING;

RATTUS;

EID: 67650266251     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2009.05.014     Document Type: Article

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