Induction of empathy by the smell of anxiety

PLoS ONE

Volumn 4, Issue 6, 2009, Pages

  Prehn Kristensen, Alexander ^a   Wiesner, Christian ^a   Bergmann, Til Ole ^a   Wolff, Stephan ^b   Jansen, Olav ^b   Mehdorn, Hubertus Maximilian ^b   Ferstl, Roman ^a   Pause, Bettina M ^c  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ANXIETY; ARTICLE; BREATHING; CEREBELLUM; CEREBELLUM VERMIS; CINGULATE GYRUS; CONTROLLED STUDY; DENTATE GYRUS; EMOTION; EMPATHY; ERGOMETER; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INSULA; MALE; NERVE CELL; NORMAL HUMAN; ODOR; OLFACTOMETER; OLFACTORY DISCRIMINATION; OLFACTORY SYSTEM; PERCEPTIVE THRESHOLD; PREFRONTAL CORTEX; SENSORY STIMULATION; SIGNAL TRANSDUCTION; SOCIAL ASPECT; SPORT; SWEATING; THALAMUS; TRAINING; BRAIN; BRAIN MAPPING; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; TIME;

INVERTEBRATA; VERTEBRATA;

ADULT; ANXIETY; BRAIN; BRAIN MAPPING; EMOTIONS; EMPATHY; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; ODORS; SMELL; TIME FACTORS;

EID: 67650249531     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005987     Document Type: Article

References (54)

1. Dicke M, Agrawal AA, Bruin J (2003) Plants talk, but are they deaf? Trends Plant Sci 8: 403-405.
2. Wyatt TD (2003) Pheromones and Animal Behaviour. Cambridge: Cambridge University Press.
3. Abel EL (1994) The pituitary mediates production or release of an alarm chemosignal in rats. Horm Behav 28: 139-145.
4. Brechbühl J, Klaey M, Broillet MC (2008) Grueneberg ganglion cells mediate alarm pheromone detection in mice. Science 321: 1092-1095.
5. Kiyokawa Y, Kikusui T, Takeuchi Y, Mori Y (2007) Removal of the vomeronasal organ blocks the stress-induced hyperthermia response to alarm pheromone in male rats. Chem Senses 32: 57-64.
6. Kobayakawa K, Kobayakawa R, Matsumoto H, Oka Y, Imai T, et al. (2007) Innate versus learned odour processing in the mouse olfactory bulb. Nature 450: 503-508.
7. Liberles SD, Buck LB (2006) A second class of chemosensory receptors in the olfactory epithelium. Nature 442: 645-650.
8. Suh GS, Wong AM, Hergarden AC, Wang JW, Simon AF, et al. (2004) A single population of olfactory sensory neurons mediates an innate avoidance behaviour in Drosophila. Nature 431: 854-859.
9. Frisch Kv (1941) Über einen Schreckstoff der Fischhaut und seine biologische Bedeutung. Z Vergl Physiol 29: 46-145.
10. Zalaquett C, Thiessen D (1991) The effects of odors from stressed mice on conspecific behaviour. Physiol Behav 50: 221-227.
11. Fanselow MS (1985) Odors released by stressed rats produce opioid analgesia in unstressed rats. Behav Neurosci 99: 589-592.
12. Moynihan JA, Karp JD, Cohen N, Ader R (2000) Immune deviation following stress odor exposure: role of endogenous opioids. J Neuroimmunol 102: 145-153.
13. Chen D, Katdare A, Lucas N (2006) Chemosignals of fear enhance cognitive performance in humans. Chem Senses 31: 415-423.
14. Pause BM, Ohrt A, Prehn A, Ferstl R (2004) Positive emotional priming of facial affect perception in females is diminished by chemosensory anxiety signals. Chem Senses 29: 797-805.
15. Prehn A, Ohrt A, Sojka B, Ferstl R, Pause BM (2006) Chemosensory anxiety signals augment the startle reflex in humans. Neurosci Letters 394: 127-130.
16. Inagaki H, Kiyokawa Y, Kikusui T, Takeuchi Y, Mori Y (2008) Enhancement of the acoustic startle reflex by an alarm pheromone in male rats. Physiol Behav 93: 606-611.
17. Ackerl K, Atzmueller M, Grammer K (2002) The scent of fear. Neuroendocrinol Letters 23: 79-84.
18. Chen D, Haviland-Jones J (2000) Human olfactory communication of emotion. Percept Motor Skills 91: 771-781.
19. Jacob S, Kinnumen L H, Metz J, Cooper M, McClintock MK (2001) Sustained human chemosignal unconsciously alters brain function. NeuroReport 12: 2391-2394.
20. Sobel N, Prabhakaran V, Hartley CA, Desmond JE, Glover GH, et al. (1999) Blind smell: brain activation induced by an undetected air-borne chemical. Brain 122: 209-217.
21. Savic I, Berglund H, Gulyas B, Roland P (2001) Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron 31: 661-668.
22. Lundström JN, Boyle JA, Zatorre RJ, Jones-Gotman M (2008) Functional neuronal processing of body odors differs from that of similar common odors. Cereb Cortex 18: 1466-1474.
23. Lundström JN, Boyle JA, Zatorre RJ, Jones-Gotman M (2008) The neuronal substrates of human olfactory based kin recognition. Hum Brain Mapp 2008 Dec 9. [Epub ahead of print].
24. Mujica-Parodi LR, Strey HH, Frederick B, Savoy R, Cox DD, et al. (2008) Second-Hand Stress: Neurobiological Evidence for a Human Alarm Pheromone. Nature Precedings, .
25. Zhou W, Chen D (2008) Encoding human sexual chemosensory cues in the orbitofrontal and fusiform cortices. J Neurosci 28: 14416-14421.
26. Lukins R, Davan IGP, Drummond D (1997) A cognitive behavioural approach to preventing anxiety during magnetic resonance imaging. J Behav Ther Exp Psychiatry 28: 97-104.
27. Laux L, Schaffner P, Glanzmann P, Spielberger CD (1981) Das State-Trait Angstinventar (STAI). Weinheim: Beltz Testgesellschaft.
28. Bradley MM, Lang PJ (1994) Measuring emotion: the Self-Assessment Manikin and the Semantic Differential. J Behav Ther Exp Psychiatry 25: 49-59.
29. Lorig TS, Elmes DG, Zald DH, Pardo JV (1999) A computer-controlled olfactometer for fMRI and electrophysiological studies of olfaction. Behav Res Meth Instr Comp 31: 370-375.
30. Vigouroux M, Bertrand B, Farget V, Plailly J, Royet JP (2005) A stimulation method using odors suitable for PET and fMRI studies with recording of physiological and behavioral signals. J Neurosci Methods 142: 35-44.
31. Kimberley TJ, Birkholz DD, Hancock RA, Von Bank SM, Werth TN (2008) Reliability of fMRI during a continuous motor task: assessment of analysis techniques. J Neuroimaging 18: 18-27.
32. Ashburner J, Friston KJ (2005) Unified segmentation. Neuroimage 26: 839-851.
33. Sobel N, Johnson BN, Mainland J, Yousem DM (2003) Functional neuroimaging of human olfaction. In: Doty RL, ed (2003) Handbook of Olfaction and Gustation. New York: Marcel Dekker. pp 251-273.
34. Britton JC, Phan KL, Taylor SF, Welsh RC, Berridge KC, et al. (2006) Neural correlates of social and nonsocial emotions: An fMRI study. Neuroimage 15: 397-409.
35. van de Riet WA, Grezes J, de Gelder B (2009) Specific and common brain regions involved in the perception of faces and bodies and the representation of their emotional expressions. Soc Neurosci 4: 101-120.
36. Jabbi M, Swart M, Keysers C (2007) Empathy for positive and negative emotions in the gustatory cortex. Neuroimage 34: 1744-1753.
37. Damasio AR (2003) Looking for Spinoza. Sorrow, and the feeling brain. Orlando: Harcourt.
38. Paulus MP, Stein MB (2006) An insular view of anxiety. Biol Psychiatry 60: 383-387.
39. Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129: 564-583.
40. Gobbini MI, Leibenluft E, Santiago N, Haxby JV (2004) Social and emotional attachment in the neural representation of faces. Neuroimage 22: 1628-1635.
41. Britton JC, Taylor SF, Sudheimer KD, Liberzon I (2006) Facial expressions and complex IAPS pictures: common and differential networks. Neuroimage 31: 906-919.
42. Völlm BA, Taylor AN, Richardson P, Corcoran R, Stirling J, McKie S, Deakin JF, Elliott R (2006) Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task. Neuroimage 29: 90-98.
43. Saxe R (2006) Uniquely human social cognition. Curr Opin Neurobiol 16: 235-239.
44. Snow JC, Allen HA, Rafal RD, Humphreys GW (2009) Impaired attentional selection following lesions to human pulvinar: evidence for homology between human and monkey. Proc Natl Acad Sci U S A 106: 4054-4059.
45. Vuilleumier P, Pourtois G (2007) Distributed and interactive brain mechanisms during emotion face perception: evidence from functional neuroimaging. Neuropsychologia 45: 174-194.
46. LaBar KS, Crupain MJ, Voyvodic JT, McCarthy G (2003) Dynamic perception of facial affect and identity in the human brain. Cereb Cortex 13: 1023-1033.
47. Hadjikhani N, de Gelder B (2003) Seeing fearful body expressions activates the fusiform cortex and amygdala. Curr Biol 13: 2201-2205.
48. Schutter DJ, van Honk J (2005) The cerebellum on the rise in human emotion. Cerebellum 4: 290-294.
49. Savic I, Gulyas B, Larsson M, Roland P (2000) Olfactory functions are mediated by parallel and hierarchical processing. Neuron 26: 735-745.
50. Bunzeck N, Düzel E (2006) Absolute coding of stimulus novelty in the human substantia nigra/VTA. Neuron 51: 369-379.
51. Krebs M, Schott BH, Düzel E (2009) Personality traits are differentially associated with patterns of reward and novelty processing in the human substantia nigra/ventral tegmental area. Biol Psychiatry 65: 103-110.
52. Corbetta M, Shulman GL (2002) Control of goal-directed and stimulus-driven attention in the brain. Nature Rev Neurosci 3: 201-215.
53. Kinomura S, Larsson J, Gulyás B, Roland PE (1996) Activation by attention of the human reticular formation and thalamic intralaminar nuclei. Science 271: 512-515.
54. Fuster JM (2001) The prefrontal cortex - an update: time is of the essence. Neuron 30: 319-333.