Encoding human sexual chemosensory cues in the orbitofrontal and fusiform cortices

Journal of Neuroscience

Volumn 28, Issue 53, 2008, Pages 14416-14421

  Zhou, Wen ^a   Chen, Denise ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

Chemosensory; Emotion; fMRI; Human; Olfactory; Sex

Indexed keywords

ADULT; ARTICLE; BRAIN CORTEX; CHEMOSENSITIVITY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; ORBITAL CORTEX; PRIORITY JOURNAL; SEXUAL BEHAVIOR; SWEAT TEST;

ANALYSIS OF VARIANCE; BRAIN MAPPING; CEREBRAL CORTEX; CUES; EMOTIONS; FUNCTIONAL LATERALITY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; ODORS; OXYGEN; PAIN MEASUREMENT; PHOTIC STIMULATION; SEX ATTRACTANTS; STIMULATION, CHEMICAL; SWEAT;

EID: 58149385227     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3148-08.2008     Document Type: Article

References (57)

1. Adolphs R (2002) Neural systems for recognizing emotion. Curr Opin Neurobiol 12:169-177.
2. Anderson AK, Christoff K, Stappen I, Panitz D, Ghahremani DG, Glover G, Gabrieli JD, Sobel N (2003) Dissociated neural representations of intensity and valence in human olfaction. Nat Neurosci 6:196-202.
3. Bensafi M, Tsutsui T, Khan R, Levenson RW, Sobel N (2004) Sniffing a human sex-steroid derived compound affects mood and autonomic arousal in a dose-dependent manner. Psychoneuroendocrinology 29:1290-1299.
4. Blonder LX, Bowers D, Heilman KM (1991) The role of the right hemisphere in emotional communication. Brain 114:1115-1127.
5. Brand G, Millot JL (2001) Sex differences in human olfaction: between evidence and enigma. Q J Exp Psychol B 54:259-270.
6. Broday LR, Hall JA (2000) Gender, emotion, and expression. In: Handbook of emotions, Ed 2 (Lewis M, Haviland-Jones J, eds), pp 338-349. New York: Guilford.
7. Brooksbank BW, Wilson DA, MacSweeney DA (1972) Fate of androsta-4,16-dien-3-one and the origin of 3-hydroxy-5-androst-16-ene in man. J Endocrinol 52:239-251.
8. Cancelliere AE, Kertesz A (1990) Lesion localization in acquired deficits of emotional expression and comprehension. Brain Cogn 13:133-147.
9. Chen D, Haviland-Jones J (2000) Human olfactory communication of emotion. Percept Mot Skills 91:771-781.
10. Chen D, Katdare A, Lucas N (2006) Chemosignals of fear enhance cognitive performance in humans. Chem Senses 31:415-423.
11. Cox RW (1996) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29:162-173.
12. Friston KJ, Buechel C, Fink GR, Morris J, Rolls E, Dolan RJ (1997) Psychophysiological and modulatory interactions in neuroimaging. Neuroimage 6:218-229.
13. Gottfried JA (2006) Smell: central nervous processing. Adv Otorhinolaryngol 63:44-69.
14. Gottfried JA, Dolan RJ (2004) Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value. Nat Neurosci 7:1144-1152.
15. Gottfried JA, Zald DH (2005) On the scent of human olfactory orbitofrontal cortex: meta-analysis and comparison to non-human primates. Brain Res Rev 50:287-304.
16. Gottfried JA, Deichmann R, Winston JS, Dolan RJ (2002a) Functional heterogeneity in human olfactory cortex: An event-related functional magnetic resonance imaging study. J Neurosci 22:10819-10828.
17. Gottfried JA, O'Doherty J, Dolan RJ (2002b) Appetitive and aversive olfactory learning in humans studied using event-related functional magnetic resonance imaging. J Neurosci 22:10829-10837.
18. Gottfried JA, Smith AP, Rugg MD, Dolan RJ (2004) Remembrance of odors past: human olfactory cortex in cross-modal recognition memory. Neuron 42:687-695.
19. Gower DB, Holland KT, Mallet AI, Rennie PJ, Watkins WJ (1994) Comparison of 16-androstene steroid concentrations in sterile apocrine sweat and axillary secretions: interconversions of 16-androstenes by the axillary microflora - a mechanism for axillary odour production in man? J Steroid Biochem Mol Biol 48:409-418.
20. Gulyás B, Kéri S, O'Sullivan BT, Decety J, Roland PE (2004) The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition. Neurochem Int 44:595-600.
21. Hadjikhani N, de Gelder B (2003) Seeing fearful body expressions activates the fusiform cortex and amygdala. Curr Biol 13:2201-2205.
22. Heekeren HR, Marrett S, Bandettini PA, Ungerleider LG (2004) A general mechanism for perceptual decision-making in the human brain. Nature 431:859-862.
23. Jacob S, McClintock MK (2000) Psychological state and mood effects of steroidal chemosignals in women and men. Horm Behav 37:57-78.
24. Jacob S, Hayreh DJS, McClintock MK (2001a) Context-dependent effects of steroid chemosignals on human physiology and mood. Physiol Behav 74:15-27.
25. Jacob S, Kinnunen LH, Metz J, Cooper M, McClintock MK (2001b) Sustained human chemosignal unconsciously alters brain function. Neuroreport 12:2391-2394.
26. Kanwisher N, McDermott J, Chun MM (1997) The fusiform face area: a module in human extrastriate cortex specialized for face perception. J Neurosci 17:4302-4311.
27. Kringelbach ML (2005) The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci 6:691-702.
28. Labows JN, Preti G (1992) Human semiochemicals. In: Fragrance: the psychology and biology of perfume (Van Toller S, Dodd GH, eds), pp 69-90. New York: Elsevier Science.
29. Lorig TS, Elmes DG, Zald DH, Pardo JV (1999) A computer-controlled olfactometer for fMRI and electrophysiological studies of olfaction. Behav Res Methods Instrum Comput 31:370-375.
30. Lundström JN, Gonçalves M, Esteves F, Olsson MJ (2003) Psychological effects of subthreshold exposure to the putative human pheromone 4,16-androstadien-3-one. Horm Behav 44:395-401.
31. Lundström JN, Boyle JA, Zatorre RJ, Jones-Gotman M (2008) Functional neuronal processing of body odors differs from that of similar common odors. Cereb Cortex 18:1466-1474.
32. Mai JK, Assheuer J, Paxinos G (1997) Atlas of the human brain. San Diego: Academic.
33. O'Craven KM, Kanwisher N (2000) Mental imagery of faces and places activates corresponding stiimulus-specific brain regions. J Cogn Neurosci 12:1013-1023.
34. Pause BM, Ohrt A, Prehn A, Ferstl R (2004) Positive emotional priming of facial affect perception in females is diminished by chemosensory anxiety signals. Chem Senses 29:797-805.
35. Peelen MV, Atkinson AP, Andersson F, Vuilleumier P (2007) Emotional modulation of body-selective visual areas. Soc Cogn Affect Neurosci 2:274-283.
36. Plailly J, Bensafi M, Pachot-Clouard M, Delon-Martin C, Kareken DA, Rouby C, Segebarth C, Royet JP (2005) Involvement of right piriform cortex in olfactory familiarity judgments. Neuroimage 24:1032-1041.
37. Poellinger A, Thomas R, Lio P, Lee A, Makris N, Rosen BR, Kwong KK (2001) Activation and habituation in olfaction - an fmri study. Neuroimage 13:547-560.
38. Prehn A, Ohrt A, Sojka B, Ferstl R, Pause BM (2006) Chemosensory anxiety signals augment the startle reflex in humans. Neurosci Lett 394:127-130.
39. Russell MJ (1976) Human olfactory communication. Nature 260:520-522.
40. Savic I, Berglund H, Gulyas B, Roland P (2001) Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron 31:661-668.
41. Savic I, Berglund H, Lindström P (2005) Brain response to putative pheromones in homosexual men. Proc Natl Acad Sci U S A 102:7356-7361.
42. Schwarzlose RF, Baker CI, Kanwisher N (2005) Separate face and body selectivity on the fusiform gyrus. J Neurosci 25:11055-11059.
43. Sobel N, Prabhakaran V, Desmond JE, Glover GH, Sullivan EV, Gabrieli JD (1997) A method for functional resonance imaging of olfaction. J Neurosci Methods 78:115-123.
44. Sobel N, Prabhakaran V, Zhao Z, Desmond JE, Glover GH, Sullivan EV, Gabrieli JD (2000) Time course of odorant-induced activation in the human primary olfactory cortex. J Neurophysiol 83:537-551.
45. Stables LA, Kennan RP, Gore JC (1998) Asymmetric spin-echo imaging of magnetically inhomogeneous systems: theory, experiment, and numerical studies. Magn Reson Med 40:432-442.
46. Stern K, McClintock MK (1998) Regulation of ovulation by human pheromones. Nature 392:177-179.
47. Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain: 3-dimensional proportional system: an approach to cerebral imaging. Stuttgart, Germany: Thieme.
48. von Kriegstein K, Kleinschmidt A, Sterzer P, Giraud AL (2005) Interaction of face and voice areas during speaker recognition. J Cogn Neurosci 17:367-376.
49. Vuilleumier P, Armony JL, Driver J, Dolan RJ (2001) Effects of attention and emotion on face processing in the human brain: an event-related fmri study. Neuron 30:829-841.
50. Vuilleumier P, Richardson MP, Armony JL, Driver J, Dolan RJ (2004) Distant influences of amygdala lesion on visual cortical activation during emotional face processing. Nat Neurosci 7:1271-1278.
51. Ward BD (2000) Simultaneous inference for fmri data. In: Afni 3ddeconvolve documentation. Milwaukee, WI: Medical College of Wisconsin.
52. Wyart C, Webster WW, Chen JH, Wilson SR, McClary A, Khan RM, Sobel N (2007) Smelling a single component of male sweat alters levels of cortisol in women. J Neurosci 27:1261-1265.
53. Wyatt TD (2003) Pheromones and animal behavior: communication by smell and taste. London: Cambridge UP.
54. Zald DH, Pardo JV (2000) Functional neuroimaging of the olfactory system in humans. Int J Psychophysiol 36:165-181.
55. Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E (1992) Functional localization and lateralization of human olfactory cortex. Nature 360:339-340.
56. Zeng XN, Leyden JJ, Lawley HJ, Sawano K, Nohara I, Preti G (1991) Analysis of characteristic odors from human male axillae. J Chem Ecol 17:1469-1492.
57. Zhou W, Chen D (2009) Fear-related chemosignal modulates fear recognition in ambiguous facial expressions. Psychol Sci, in press.