Role of inositol polyphosphates in programmed cell death

Molecular and Cellular Biochemistry

Volumn 328, Issue 1-2, 2009, Pages 155-165

  Agarwal, Rakhee ^a   Mumtaz, Hamid ^a   Ali, Nawab ^a  

^a UNIVERSITY OF ARKANSAS AT LITTLE ROCK   (United States)

Author keywords

Apoptosis; Cancer; Cell signaling; Inositol; Inositol polyphosphates

Indexed keywords

ANTIMYCIN A1; CASPASE 3; CASPASE 4; CYTOCHROME C; ETOPOSIDE; FLUORIDE SODIUM; INOSITOL HEXASULFATE; INOSITOL POLYPHOSPHATE; INOSITOL POLYPHOSPHATE 4; INOSITOL POLYPHOSPHATE 5; INOSITOL POLYPHOSPHATE 6; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CARBOHYDRATE ANALYSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DNA DEGRADATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION;

ANIMALS; ANTIMYCIN A; APOPTOSIS; CASPASES; CELL LINE; CYTOCHROMES C; INOSITOL PHOSPHATES; MICE; OSTEOBLASTS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SODIUM FLUORIDE;

EID: 67650249238     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0085-6     Document Type: Article

References (52)

1. Berridge MJ, Irvine RF (1989) Inositol phosphates and cell signaling. Nature 341:197-205. doi: 10.1038/341197a0
2. Ali N, Craxton A, Sumner M, Shears SB (1995) Effects of aluminum on the hepatic inositol polyphosphate phosphatase. Biochem J 305:557-561
3. Saiardi A, Sciambi C, McCaffery JM, Wendland B, Snyder SH (2002) Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci USA 99:14206-14211. doi: 10.1073/pnas.212527899
4. Luo HR, Saiardi A, Yu H, Nagata E, Ye K, Snyder SH (2002) Inositol pyrophosphates are required for DNA hyper-recombination in protein kinase C1 mutant yeast. Biochemistry 41:2509-2515. doi: 10.1021/bi0118153
5. Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D, West SC (2000) Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair. Cell 102:721-729. doi: 10.1016/S0092-8674(00)00061-1
6. York JD, Odom AR, Murphy R, Ives EB, Wente SR (1999) A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science 285:96-100. doi: 10.1126/ science.285.5424.96
7. Menniti FS, Miller RN, Putney JW Jr, Shears SB (1993) Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells. J Biol Chem 268:3850-3856
8. Shears SB, Ali N, Craxton A, Bembenek ME (1995) Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo. J Biol Chem 270:10489-10497. doi: 10.1074/jbc.270.18.10489
9. Jimenez C, Jones DR, Rodriguez-Viciana P et al (1998) Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. EMBO J 17:743-753. doi: 10.1093/emboj/ 17.3.743
10. Razzini G, Berrie CP, Vignati S et al (2000) Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines. FASEB J 14:1179-1187
11. Janeb M, Thompson LU (2000) Phytic acid in wheat bran affects colon morphology, cell differentiation and apoptosis. Carcinogenesis 21:1547-1552. doi: 10.1093/carcin/21.8.1547
12. Vucenik I, Shamsuddin AM (2003) Cancer inhibition by inositol hexaphosphate and inositol: From laboratory to clinic. J Nutr 133:3778S-3784S
13. Vucenik I, Shamsuddin AM (2006) Protection against cancer by dietary IP 6 and inositol. Nutr Cancer 55:109-125. doi: 10.1207/s15327914nc5502_1
14. Sharma G, Singh RP, Agarwal R (2003) Growth inhibitory and apoptotic effects of inositol hexaphosphate in transgenic adenocarcinoma of mouse prostate (TRAMP-C1) cells. Int J Oncol 23:1413-1418
15. Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R (2003) Inositol hexaphosphate inhibits constitutive activation of NF-kappa B in androgen-independent human prostate carcinoma DU145 cells. Anticancer Res 23:3855-3861
16. Singh RP, Sharma G, Mallikarjuna GU, Dhanalakshmi S, Agarwal C, Agarwal R (2004) In vivo suppression of hormone-refractory prostate cancer growth by inositol hexaphosphate: Induction of insulin-like growth factor binding protein-3 and inhibition of vascular endothelial growth factor. Clin Cancer Res 10:244-250. doi: 10.1158/1078-0432.CCR-1080-3
17. Agarwal C, Dhanalakshmi S, Singh RP, Agarwal R (2004) Inositol hexaphosphate inhibits growth and induces G1 arrest and apoptotic death of androgen-dependent human prostate carcinoma LNCaP cells. Neoplasia 6:646-659. doi: 10.1593/neo.04232
18. Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res Treat 91:35-45. doi: 10.1007/ s10549-004-6456-5
19. Dorsey M, Benghuzzi H, Tucci M, Cason Z (2005) Growth and cell viability of estradiol and IP-6 treated Hep-2 laryngeal carcinoma cells. Biomed Sci Instrum 41:205-210
20. 6): A novel treatment for pancreatic cancer. J Surg Res 126:199-203. doi: 10.1016/j.jss.2005.01.022
21. Piccolo E, Vignati S, Maffucci T et al (2004) Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene 23:1754-1765. doi: 10.1038/sj.onc.1207296
22. Maffucci T, Piccolo E, Cumashi A et al (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer Res 65:8339-8349. doi: 10.1158/0008-5472.CAN-05-0121
23. Ferry S, Matsuda M, Yoshida H, Hirata M (2002) Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFκB-mediated cell survival pathway. Carcinogenesis 23:2031-2041. doi: 10.1093/carcin/23.12.2031
24. 3H]-Phytic acid (Inositol hexaphosphate) is absorbed and distributed to various tissues in rats. J Nutr 123:713-720
25. 3H]-Inositol hexaphosphate (phytic acid) is rapidly absorbed and metabolized by murine and human malignant cells in vitro. J Nutr 124:861-868
26. Stephens LR, Jackson TR, Hawkins PT (1993) Agonist-stimulated synthesis of phosphatidylinositol(3, 4, 5)-triphosphate: A new intracellular signaling system? Biochim Biophys Acta 1179:27-75. doi: 10.1016/ 0167-4889(93)90072-W
27. Klippel A, Escobedo MA, Washowicz MS et al (1998) Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol Cell Biol 18:5699-5711
28. Nagata E, Luo HR, Saiardi A, Bae BII, Suzuki N, Snyder SH (2005) Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem 280:1634-1640. doi: 10.1074/jbc.M409416200
29. Bellido T, Huening M, Raval-Pandya M, Manolagas SC, Christakos S (2000) Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. J Biol Chem 275:26328-26332. doi: 10.1074/jbc.M003600200
30. Tang SY, Xie H, Yuan LQ et al (2007) Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. Peptides 28:708-718. doi: 10.1016/ j.peptides.2006.10.005
31. Safrany ST, Shears SB (1998) Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta2adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism. EMBO J 17:1710-1716. doi: 10.1093/emboj/17.6.1710
32. Raina K, Rajamanickam S, Singh RP, Agarwal R (2008) Chemopreventive efficacy of inositol hexaphosphate against prostate tumor growth and progression in TRAMP mice. Clin Cancer Res 14:3177-3184. doi: 10.1158/ 1078-0432.CCR-07-5275
33. Shamsuddin AM, Baten A, Lalwani ND (1992) Effect of inositol hexaphosphate on growth and differentiation in K-562 erythroleukemia cell line. Cancer Lett 64:195-202. doi: 10.1016/0304-3835(92)90043-U
34. 3) in malignant cells, tissues and biological fluids. Life Sci 71:1535-1546. doi: 10.1016/S0024-3205(02)01927-6
35. 6 levels in tissues and biological fluids depending on dietary phytate. J Nutr Biochem 12:595-601. doi: 10.1016/S0955-2863(01)00178-4
36. 6 or phytate) in humans. Biofactors 15:53-61. doi: 10.1002/biof.5520150105
37. Grases F, Costa-Bauza A, Prieto RM (2005) Intracellular and extracellular myo-inositol hexakisphosphate (InsP6), from rats to humans. Anticancer Res 25:2593-2597
38. Graf E, Eaton JW (1990) Antioxidant functions of phytic acid. Free Radic Biol Med 8:61-69. doi: 10.1016/0891-5849(90)90146-A
39. Thompson LU, Zhang L (1991) Phytic acid and minerals: Effect on early markers of risk for mammary and colon carcinogenesis. Carcinogenesis 12:2041-2045. doi: 10.1093/carcin/12.11.2041
40. 6) inhibits key events of cancer metastasis: In vitro studies of adhesion, migration and invasion of MDA-MB 231 human breast cancer cells. Anticancer Res 23:3671-3680
41. Elliott J, Scarpello JH, Morgan NG (2002) Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. J Endocrinol 172:137-143. doi: 10.1677/joe.0.1720137
42. Refsnes M, Schwarze PE, Holme JA, Lag M (2003) Fluoride-induced apoptosis in human epithelial lung cells (A549 cells): Role of different G-protein-linked signal systems. Hum Exp Toxicol 22:111-123. doi: 10.1191/0960327103ht322oa
43. Anuradha CD, Kanno S, Hirano S (2001) Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells. Free Radic Biol Med 31:367-373. doi: 10.1016/ S0891-5849(01)00591-3
44. Thrane EV, Refsnes M, Thoresen GH, Lag M, Schwarze PE (2001) Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinase p38 and possibly JNK. Toxicol Sci 61:83-91. doi: 10.1093/ toxsci/61.1.83
45. Batty IH, Nahorsky SR (1992) Analysis of [3H]inositol phosphate formation and metabolism in cerebral-cortical slices. Evidence for a dual metabolism of inositol 1, 4-bisphosphate. Biochem J 288:807-811
46. Safrany ST, Caffrey JJ, Yang X et al (1998) A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. EMBO J 17:6599-6607. doi: 10.1093/emboj/ 17.22.6599
47. King MA, Radicchi-Mastroianni MA (2002) Antimycin A induced apoptosis of HL-60 cells. Cytometry 49:106-112. doi: 10.1002/cyto.10156
48. Han YH, Kim SH, Kim SZ, Park WH (2008) Antimycin A as a mitochondrial electron transport inhibitor prevents the growth of human lung cancer A549 cells. Oncol Rep 20:689-693
49. Formigli L, Papucci L, Tani A et al (2000) Aponecrosis: Morphological and biochemical exploration of a syncretic process of cell death sharing apoptosis and necrosis. J Cell Physiol 182:41-49. doi: 10.1002/ (SICI)1097-4652(200001)182:1<41::AID-JCP5>3.0.CO;2-7
50. Poggioli J, Weiss SJ, McKinney JS, Putney JW Jr (1983) Effects of antimycin A on receptor-activated calcium mobilization and phosphoinositide metabolism in rat parotid gland. Mol Pharmacol 23:71-77
51. Sugiya H, Putney JW Jr (1988) Substance P receptor desensitization requires receptor activation but not phospholipase C. Am J Physiol 255:C149-C154
52. Oliver KG, Putney JW Jr, Obie JF, Shears SB (1992) The interconversion of inositol 1, 3, 4, 5, 6-pentakisphosphate and inositol tetrakisphosphates in AR4-2J cells. J Biol Chem 267:21528-21534