Dissection of the critical binding determinants of cellular retinoic acid binding protein II by mutagenesis and fluorescence binding assay

Proteins: Structure, Function and Bioinformatics

Volumn 76, Issue 2, 2009, Pages 281-290

  Vasileiou, Chrysoula ^a   Lee, Kin Sing Stephen ^a   Crist, Rachael M ^a   Vaezeslami, Soheila ^a   Goins, Sarah M ^a   Geiger, James H ^a   Borhan, Babak ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

All trans retinoic acid; Carboxylic acid dimer; Electrostatic interactions; Hydrophobic effect; Ordered water network

Indexed keywords

AMINO ACID; CARBOXYLIC ACID; CELLULAR RETINOL BINDING PROTEIN; CELLULAR RETINOL BINDING PROTEIN II; DIMER; GLUTAMIC ACID; RETINOIC ACID; RETINOIC ACID BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; DIMERIZATION; ELECTRICITY; FLUORESCENCE; HUMAN; HUMAN CELL; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

ARGININE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTORS, RETINOIC ACID; TRETINOIN;

EID: 67650242489     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22334     Document Type: Article

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