Hemoglobin concentration is inversely associated with erythrocyte folate concentrations in Colombian school-age children, especially among children with low vitamin B12 status

European Journal of Clinical Nutrition

Volumn 63, Issue 7, 2009, Pages 842-849

  Arsenault, J E ^a   Mora Plazas, M ^b   Forero, Y ^c   Lopez Arana, S ^d   Baylin, A ^e   Villamor, E ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d San Rafael Clinic   (Colombia)

^e BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; FERRITIN; FOLIC ACID; HEMOGLOBIN; RETINOL; TRACE ELEMENT;

ANEMIA; ARTICLE; CHILD; COLOMBIA; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYANOCOBALAMIN DEFICIENCY; FEMALE; FERRITIN BLOOD LEVEL; FOLIC ACID BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON DEFICIENCY; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL ASSESSMENT; PREVALENCE; RETINOL DEFICIENCY; SEX DIFFERENCE; SOCIAL STATUS; VITAMIN BLOOD LEVEL;

ANEMIA; CHILD; CHILD, PRESCHOOL; COLOMBIA; CROSS-SECTIONAL STUDIES; ERYTHROCYTES; FEMALE; FERRITINS; FOLIC ACID; HEMOGLOBINS; HUMANS; MALE; VITAMIN A; VITAMIN B 12;

EID: 67650218135     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2008.50     Document Type: Article

References (42)

1. Alcaldía Mayor de Bogotá (2006). Secretaría de Educación. Estadísticas del sector educativo de Bogotá 2005 years avances 2006.
2. Anonymous (2004). Recommended levels of folic acid and vitamin B12 fortification. Proceedings of a Technical Consultation Convened by the Food and Nutrition Program of the Pan American Health Organization, the March of Dimes, and the Centers for Disease Control and Prevention; 23-24 January 2003; Washington, DC, USA. Nutr Rev 62, S1-S64.
3. Chen LT, Rivera MA (2004). The Costa Rican experience: Reduction of neural tube defects following food fortification programs. Nutr Rev 62, S40-S43.
4. Cole TJ, Flegal KM, Nicholls D, Jackson AA (2007). Body mass index cut offs to define thinness in children and adolescents: International survey. BMJ 335, 194.
5. de Pee S, Dary O (2002). Biochemical indicators of vitamin A deficiency: serum retinol and serum retinol binding protein. J Nutr 132, 2895S-2901S.
6. Evans T (2005). Regulation of hematopoiesis by retinoid signaling. Exp Hematol 33, 1055-1061.
7. Fitzmaurice GM, Laird NM, Ware JH (2004). Applied Longitudinal Analysis. Wiley: Hoboken, NJ.
8. Herbert V, Bigaouette J (1997). Call for endorsement of a petition to the food and drug administration to always add vitamin B-12 to any folate fortification or supplement. Am J Clin Nutr 65, 572-573.
9. Hertrampf E, Cortes F (2004). Folic acid fortification of wheat flour: Chile. Nutr Rev 62, S44-S48.
10. Institute of Medicine (1998). Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press: Washington, DC.
11. Instituto Colombiano de Bienestar Familiar (2005). Encuesta Nacional de la Situacion Nutricional en Colombia. Instituto Colombia de Bienestar Familiar: Bogotá, Colombia.
12. Isanaka S, Mora-Plazas M, Lopez-Arana S, Baylin A, Villamor E (2007). Food insecurity is highly prevalent and predicts underweight but not overweight in adults and school children from Bogota, Colombia. J Nutr 137, 2747-2755.
13. Jones KM, Ramirez-Zea M, Zuleta C, Allen LH (2007). Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet. J Nutr 137, 1307-1313.
14. Koury MJ, Ponka P (2004). New insights into erythropoiesis: The roles of folate, vitamin B12, and iron. Annu Rev Nutr 24, 105-131.
15. Lohman TG, Roche AF, Martorell R. (eds) (1988). Anthropometric Standardization Reference Manual. Human Kinetics Books: Champaign, IL.
16. Majia LA, Hodges RE, Arroyave G, Viteri F, Torun B (1977). Vitamin A deficiency and anemia in Central American children. Am J Clin Nutr 30, 1175-1184.
17. Morris MS, Jacques PF, Rosenberg IH, Selhub J (2007). Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 85, 193-200.
18. Nestle P (2002). Adjusting Hemoglobin Values in Program Surveys. INACG: Washington, DC.
19. Neufeld L, García-Guerra A, Sánchez-Francia D, Newton-Sánchez O, Ramírez-Villalobos MD, Rivera-Dommarco J (2002). Hemoglobin measured by Hemocue and a reference method in venous and capillary blood: A validation study. Salud Publ Mex 44, 219-227.
20. Omer A, Finlayson NDC, Shearman DJC, Samson RR, Girdwood RH (1970). Plasma and erythrocyte folate in iron deficiency and folate deficiency. Blood 35, 821-828.
21. Pellis L, Dommels Y, Venema D, van Polanen A, Lips E, Baykus H et al. (2008). High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr 99, 703-708.
22. Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ (2005). Biochemical indicators of B vitamin status in the US population after folic acid fortification: Results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 82, 442-450.
23. Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E et al. (2006). Identification of an intestinal folate transporter and the molecular basis for hereditary folatemalabsorption. Cell 127 917-928.
24. Refsum H, Smith AD (2008). Are we ready for mandatory fortification with vitamin B-12? Am J Clin Nutr 88, 253-254.
25. Reissmann KR (1964). Protein metabolism and erythropoiesis. I. The anemia of protein deprivation. Blood 23, 137-145.
26. Rodríguez SC, Hotz C, Rivera JA (2007). Bioavailable dietary iron is associated with hemoglobin concentration in Mexican preschool children. J Nutr 137, 2304-2310.
27. Rogers LM, Boy E, Miller JW, Green R, Casterline Sabel J, Allen LH (2003). High prevalence of cobalamin deficiency in Guatemalan schoolchildren: Associations with low plasma holotranscobalamin II and elevated serum methylmalonic acid and plasma homocysteine concentrations. Am J Clin Nutr 77, 433-440.
28. Saraya AK, Choudhry VP, Ghai OP (1973). Interrelationships of vitamin B12, folic acid, and iron in anemia of infancy and childhood: Effect of vitamin B12 and iron therapy on folate metabolism. Am J Clin Nutr 26, 640-646.
29. Scott JM (1999). Folate and vitamin B12. Proc Nutr Soc 58, 441-448.
30. Selhub J, Morris MC, Jacques PF (2007). In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations. Proc Natl Acad Sci USA 104 19995-20000.
31. Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N et al. (2005). Identification of an intestinal heme transporter. Cell 122, 789-801.
32. Staab DB, Hodges RE, Metcalf WK, Smith JC (1984). Relationship between vitamin A and iron in the liver. J Nutr 114, 840-844.
33. Stoltzfus RJ (2001). Summary: Implications for research and programs. J Nutr 131, 697S-701S.
34. Suh JR, Herbig AK, Stover PJ (2001). New perspectives on folate catabolism. Annu Rev Nutr 21, 255-282.
35. Villalpando S, Perez-Exposito AB, Shamah-Levy T, Rivera JA (2006). Distribution of anemia associated with micronutrient deficiencies other than iron in a probabilistic sample of Mexican children. Ann Nutr Metab 50, 506-511.
36. Vitale JJ, Restrepo A, Velez H, Riker JB, Hellerstein EE (1966). Secondary folate deficiency induced in the rat by dietary iron deficiency. J Nutr 88, 315-322.
37. WHO Expert Committee on Physical Status (1995). Physical Status: The Use and Interpretation of Anthropometry. WHO: Geneva.
38. WHO/UNICEF/UNU (2001). Iron Deficiency Anemia: Assessment, Prevention, and Control. A Guide for Programme Managers. World Health Organization: Geneva.
39. Woeller CF, Fox JT, Perry C, Stover PJ (2007). A ferritin-responsive internal ribosome entry site regulates folate metabolism. J Biol Chem 282, 29927-29935.
40. World Health Organization (1983). Measuring Change in Nutritional Status. WHO: Geneva, Switzerland.
41. Yajnik CS, Deshpande SS, Jackson AA, Refsum H, Rao S, Fisher DJ et al. (2008). Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: The Pune Maternal Nutrition Study. Diabetologia 51, 29-38.
42. Zimmermann MB, Hurrell RF (2007). Nutritional iron deficiency. Lancet 370, 511-520.