Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor

Journal of Biological Chemistry

Volumn 284, Issue 23, 2009, Pages 15557-15563

  McKinstry, William J ^a,b,e   Polekhina, Galina ^a   Diefenbach Jagger, Hannelore ^a   Ho, Patricia W M ^a   Sato, Koh ^c   Onuma, Etsuro ^c   Gillespie, Matthew T ^a,b,f   Martin, T John ^a,b   Parker, Michael W ^b,d  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Chugai Pharmaceutical   (Japan)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e CSIRO   (Australia)

^f HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; BONE METASTASIS; BREAST CANCER CELLS; EMBRYONIC DEVELOPMENT; HELICAL STRUCTURES; LOCAL PRODUCTION; NEUTRALIZING ANTIBODIES; PARATHYROID HORMONE RECEPTORS; PARATHYROID HORMONES; POINT OF CONTACT; RECEPTOR BINDING SITE; STRUCTURAL BASIS;

BINDING ENERGY; BINDING SITES; BONE; CRYSTAL STRUCTURE; ENDOCRINOLOGY; HORMONES; PATHOLOGY;

ANTIBODIES;

MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RECEPTOR 1; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN [1-34]; UNCLASSIFIED DRUG; CYCLIC AMP; LIGAND; MESSENGER RNA; PTHR1 PROTEIN, HUMAN;

ALPHA HELIX; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY COMBINING SITE; ANTIBODY STRUCTURE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ANTIGEN RECOGNITION; ARTICLE; CRYSTAL STRUCTURE; HORMONE RECEPTOR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RESIDUE ANALYSIS; STRUCTURE ANALYSIS; ANIMAL; ANTIBODY SPECIFICITY; BINDING SITE; BONE TUMOR; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; IMMUNOLOGY; METABOLISM; OSTEOSARCOMA; PROTEIN CONFORMATION; SERODIAGNOSIS; SURFACE PROPERTY; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION;

ANIMALIA;

ANIMALS; ANTIBODY SPECIFICITY; BINDING SITES; BONE NEOPLASMS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; HUMANS; LIGANDS; MODELS, MOLECULAR; NEUTRALIZATION TESTS; OSTEOSARCOMA; PROTEIN CONFORMATION; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RNA, MESSENGER; SURFACE PROPERTIES; X-RAY DIFFRACTION;

EID: 67650142898     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900044200     Document Type: Article

References (45)

1. Suva, L. J., Winslow, G. A., Wettenhall, R. E., Hammonds, R. G., Moseley, J. M., Difenbach-Jagger, H., Rodda, C. P., Kemp, B. E., Rodriquez, H., Chen, E. Y., Hudson, P. J., Martin, T. J., and Wood, W. I. (1987) Science 237, 893-896
2. Moseley, J. M., and Gillespie, M. T. (1995) CRC Crit. Rev. Clin. Lab. Sci. 32, 299-343
3. Clemens, T. L., Cormier, S., Eichinger, A., Endlich, K., Fiaschi-Taesch, N., Fischer, E., Friedman, P. A., Karaplis, A. C., Massfelder, T., Rossert, J., Schlüter, K. D., Silve, C., Stewart, A. F., Takane, K., and Helwig, J. J. (2001) Br. J. Pharmacol. 134, 1113-1136
4. Mannstadt, M., Jüppner, H., and Gardella, T. J. (1999) Am. J. Physiol. Renal Physiol. 277, 665-675
5. Barden, J. A., and Kemp, B. E. (1989) Eur. J. Biochem. 184, 379-394
6. Barden, J. A., Cuthbertson, R. M., Jia-Zhen, W., Moseley, J. M., and Kemp, B. E. (1997) J. Biol. Chem. 272, 29572-29578
7. Chen, Z., Xu, P., Barbier, J. R., Willick, G., and Ni, F. (2000) Biochemistry 39, 12766-12777
8. Gensure, R. C., Gardella, T. J., and Jüppner, H. (2001) J. Biol. Chem. 276, 28650-28658
9. Bergwitz, C., Gardella, T. J., Flannery, M. R., Potts, J. T., Jr., Kronenberg, H. M., Goldring, S. R., and Jüppner, H. (1996) J. Biol. Chem. 271, 26469-26472
10. Moseley, J. M., Kubota, M., Diefenbach-Jagger, H., Wettenhall, R. E., Kemp, B. E., Suva, L. J., Rodda, C. P., Ebeling, P. R., Hudson, P. J., Zajac, J. D., and Martin, T. J. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 5048-5052
11. Kukreja, S. C., Rosol., T. J., Wimbiscus, S. A., Shevrin, D. H., Grill, V., Barengolts, E. I., and Martin, T. J. (1990) Endocrinology 127, 305-310
12. Kukreja, S. C., Shevrin, D. H., Wimbiscus, S. A., Ebeling, P. R., Danks, J. A., Rodda, C. P., Wood, W. I., and Martin, T. J. (1988) J. Clin. Investig. 82, 1798-1802
13. Sato, K., Yamakawa, Y., Shizume, K., Satoh, T., Nohtomi, K., Demura, H., Akatsu, T., Nagata, N., Kasahara, T., Ohkawa, H., and Ohsumi, K. (1993) J. Bone Miner. Res. 8, 849-860
14. Powell, G. J., Southby, J., Danks, J. A., Stillwell, R. G., Hayman, J. A., Henderson, M. A., Bennett, R. C., and Martin, T. J. (1991) Cancer Res. 51, 3059-3061
15. Guise, T. A., and Mundy, G. R. (1996) Curr. Opin. Nephrol. Hypertens. 5, 307-315
16. Guise, T. A., Yin, J. J., Taylor, S. D., Kumagai, Y., Dallas, M., Boyce, B. F., Yoneda, T., and Mundy, G. R. (1996) J. Clin. Investig. 98, 1544-1549
17. Yoneda, T., Michigami, T., Yi, B., Williams, P. J., Niewolna, M., and Hiraga, T. (2000) Cancer 88, 2979-2988
18. Saito, H., Tsunenari, T., Onuma, E., Sato, K., Ogata, E., and Yamada-Okabe, H. (2005) Anticancer Res. 25, 3817-3823
19. Onuma, E., Tsunenari, T., Saito, H., Sato, K., Yamada-Okabe, H., and Ogata, E. (2005) Int. J. Cancer 116, 471-478
20. Iguchi, H., Onuma, E., Sato, K., Sato, K., and Ogata, E. (2001) Int. J. Cancer 94, 24-27
21. Suda, N., Gillespie, M. T., Traianedes, K., Zhou, H., Ho, P. W. M., Hards, D. K., Allan E. H., Martin, T. J., and Moseley, J. M. (1996) J. Cell. Physiol. 166, 94-104
22. Hammonds, R. G., Jr., McKay, P., Winslow, G. A., Diefenbach-Jagger, H., Grill, V., Glatz, J., Rodda, C. P., Moseley, J. M., Wood, W. I., and Martin, T. J. (1989) J. Biol. Chem. 264, 14806-14811
23. Otwinowski, Z., and Minor, W. (1997) Methods Enzymol. 276, 307-326
24. Navaza, J. (1994) Acta Crystallogr. Sect. A 50, 157-163
25. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D 54, 905-921
26. Onuma, E., Sato, K., Saito, H., Tsunenari, T., Ishii, K., Esaki, K., Yabuta, N., Wakahara, Y., Yamada-Okabe, H., and Ogata, E. (2004) Anticancer Res. 24, 2665-2674
27. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
28. Pellegrini, M., Royo, M., Rosenblatt, M., Chorev, M., and Mierke, D. F. (1998) J. Biol. Chem. 273, 10420-10427
29. Gardella, T. J., and Jüppner, H. (2001) Trends Endocrinol. Metab. 12, 210-217
30. Jin, L., Briggs, S. L., Chandrasekhar, S., Chirgadze, N. Y., Clawson, D. K., Schevitz, R. W., Smiley, D. L., Tashjian, A. H., and Zhang, F. (2000) J. Biol. Chem. 275, 27238-27244
31. Gardella, T. J., Wilson, A. K., Keutmann, H. T., Oberstein, R., Potts, J. T., Jr., Kronenberg, M., and Nussbaum, S. R. (1993) Endocrinology 132, 2024-2030
32. Shimizu, M., Carter, P. H., Khatri, A., Potts, J. T., Jr., and Gardella, T. J. (2001) Endocrinology 142, 3068-3074
33. Gardella, T. J., Luck, M. D., Jensen, G. S., Usdin, T. B., and Juüppner, H. (1996) J. Biol. Chem. 271, 19888-19893
34. Gardella, T. J., Luck, M. D., Wilson, A. K., Keutmann, H. T., Nussbaum, S. R., Potts, J. T., Jr., and Kronenberg, H. M. (1995) J. Biol. Chem. 270, 6584-6588
35. Pioszak, A. A., and Xu, H. E. (2008) Proc. Natl. Acad. Sci. U. S. A. 105, 5034-5039
36. Lawrence, M. C., and Colman, P. M. (1993) J. Mol. Biol. 234, 946-950
37. Dean, T., Vilardaga, J.-P., Potts, J. T. Jr., and Gardella, T. J. (2008) Mol. Endocrinol. 22, 156-166
38. Dean, T., Linglart, A., Mahon, M. J., Bastepe, M., Jüppner, H., Potts, J. T., Jr., and Gardella, T. J. (2006) Mol. Endocrinol. 20, 931-942
39. Henderson, M. A., Danks, J. A., Slavin, J., Byrnes, G. B., Choong, P. M. F., Spillane, J. B., Hopper, J. L., and Martin, T. (2006) Cancer Res. 66, 2250-2256
40. Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J. Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., Wang, O., and Mitlak, B. H. (2001) N. Engl. J. Med. 344, 1434-1441
41. Bakre, M. M., Zhu, Y., Yin, H., Burton, D. W., Terkeltaub, R., Deftos, L. J., and Varner, J. A. (2002) Nat. Med. 8, 995-1003
42. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
43. Merritt, E. A., and Bacon, D. J. (1997) Methods Enzymol. 277, 505-524
44. Lawrence, M. C., and Bourke, P. (2000) J. Appl. Crystallogr. 33, 990-991
45. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296