A new minimal-stress freely-moving rat model for preclinical studies on intranasal administration of CNS drugs

Pharmaceutical Research

Volumn 26, Issue 8, 2009, Pages 1911-1917

  Stevens, Jasper ^a   Suidgeest, Ernst ^a   Van Der Graaf, Piet Hein ^b   Danhof, Meindert ^a   De Lange, Elizabeth C M ^c  

^a LEIDEN UNIVERSITY   (Netherlands)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Acetaminophen; Brain; Intranasal infusion; Microdialysis; Pharmacokinetics

Indexed keywords

BIOLOGICAL MARKER; CORTICOSTERONE; EVANS BLUE; PARACETAMOL; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CANNULA; CLINICAL EVALUATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DIALYSATE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; EXPOSURE; MALE; MICRODIALYSIS; MOLECULAR PROBE; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; RAT; STRESS; TIME;

ADMINISTRATION, INTRANASAL; ANIMALS; BIOLOGICAL MARKERS; CENTRAL NERVOUS SYSTEM; CORTICOSTERONE; MALE; MODELS, ANIMAL; RADIOIMMUNOASSAY; RATS; RATS, WISTAR; STRESS, PHYSIOLOGICAL;

EID: 67650096347     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9907-1     Document Type: Article

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